Project

Back to overview

The Swiss Transplant Cohort Study (STCS)

English title The Swiss Transplant Cohort Study (STCS)
Applicant Steiger Jürg Ulrich
Number 201385
Funding scheme Cohort Studies Large
Research institution Klinik für Transplantationsimmunologie und Nephrologie Universitätsspital
Institution of higher education University of Basel - BS
Main discipline Clinical Immunology and Immunopathology
Start/End 01.07.2021 - 31.12.2024
Approved amount 5'250'000.00
Show all

All Disciplines (22)

Discipline
Clinical Immunology and Immunopathology
Dermatology
Respiratory Diseases
Clinical Endocrinology
Internal Medicine
Clinical Pharmacology
Medico-Social Problems of Youth
Cardiovascular Diseases
Clinical Cancer Research
Medico-Social Problems of the Elderly
Health
Paediatrics
Methods of Epidemiology and Preventive Medicine
Surgery
Metabolic Disorders
Clinical Pathophysiology
Clinical Cardiovascular Research
Infectious Diseases
Medical Statistics
Cancer
Occupational Medicine, Ergonomy
Public Health and Health Services

Keywords (17)

Heart transplantation; Epidemiology; Liver transplantation; Lung transplantation; Research infrastructure; Psychosocial aspects; Personalized medicine; Genomic medicine; Islet transplantation; Transplantation; Pancreas transplantation; Semantic interoperability; Patient-reported outcomes; Immunology; Kidney transplantation; Infectious diseases; FAIR principles and Open Data

Lay Summary (German)

Lead
Oft ist eine Organtransplantation die letzte Möglichkeit, Patienten mit terminalem Organversagen zu retten und deren Lebensqualität zu verbessern. Trotz medizinischen Fortschritten stellt die Transplantation auch heute noch eine grosse Herausforderung dar und die stetige Verbesserung der hochkomplexen Versorgung ist von grosser Bedeutung. Voraussetzung für eine funktionierende Transplantationsmedizin ist aber auch die Verfügbarkeit und optimale Nutzung von Spenderorganen. Nebst grundlegendem medizinischen Forschungsbedarf bewegen elementare ethische Fragen zu Organspende und Transplantation die Öffentlichkeit. Im 2007 wurde daher die Schweizerische Transplantationskohorten-Studie (Swiss Transplant Cohort Study, STCS) gegründet mit dem Ziel, die Forschung in der Transplantationsmedizin zu fördern und den Behandlungserfolg nach Organtransplantation schweizweit aufzuzeigen.
Lay summary

Die STCS wird seit ihrer Gründung im Jahr 2007 vom Schweizerischen Nationalfonds (SNF) und den Universitätsspitälern sowie dem Kantonsspital St. Gallen als longitudinale Studie in der Transplantationsmedizin finanziell unterstützt. Neu freut sich die STCS in der nächsten SNF Förderungsphase (2021 bis 2024) für die Entwicklung hin zu einer sog. forschungsorientierten Dateninfrastruktur und Service (DIS) von nationaler Bedeutung unterstützt zu werden.

Seit 13 Jahren erfasst die STCS erfolgreich qualitativ hochwertige Daten und führt die engmaschige Nachbeobachtung aller Patienten durch, welche in der Schweiz eine Organtransplantation erhalten. Es gelang der STCS dies in allen Transplantationszentren der Schweiz operativ umzusetzen und resultierte in mehr als 170 wissenschaftlichen Projekten, welche mit den Daten der STCS durchgeführt werden. Durch hochrangige Publikationen hat sich die STCS in den letzten Jahren als international anerkannte Kohorte und Forschungsplattform etabliert. Im Weiteren ist die STCS verantwortlich für die Qualitätskontrolle in der Transplantationsmedizin wie sie im Schweizerischen Transplantationsgesetz vorgeschrieben ist.

Der Aufbau des neuen DIS bedeutet einen wichtigen Strategiewechsel hin zum Aufbau einer Open Science Strategie mit einer nationalen Dateninfrastruktur und Service für alle Interessierten, die im Bereich Transplantationsmedizin Forschung betreiben wollen. Die STCS arbeitet dabei eng mit anderen Schweizerischen Kohorten wie z.B. der Schweizerischen HIV Kohorte, dem Swiss Personalized Health Network, aber auch mit internationalen Partnern zusammen. Das DIS der STCS wird sich auch der breiteren Öffentlichkeit, insbesondere Patientinnen und Patienten, als Informations-Infrastruktur öffnen.

Weitere Informationen oder den umfassenden jährlichen Bericht mit den Erfolgszahlen in der Transplantationsmedizin finden Sie auf www.stcs.ch.

Direct link to Lay Summary Last update: 22.06.2021

Responsible applicant and co-applicants

Employees

Associated projects

Number Title Start Funding scheme
205494 Implementation of a new model of care for supporting adherence in people starting a new medication for a long-term condition (myCare Start project) - An implementation-effectiveness science study 01.09.2022 COST (European Cooperation in Science and Technology)
177522 Swiss Transplant Cohort Study 01.02.2018 Cohort Studies Large

Abstract

The STCS is an investigator-initiated, multisite, national cohort study with a primary interest in clinical research and quality control of outcomes and clinical care. Although the STCS has been operative in accordance with applicable laws and regulations since its initiation, the STCS adapted all documents and process according to the new (2014) Swiss Human Research Act (HRA) and its Ordinance (HRO). As an important milestone, our regulatory amendment was accepted on a national level in November 2019. In this respect, the STCS plays a pioneering role among the national cohorts in Switzerland. Moreover, in 2018 the STCS started to involve patients in the Scientific Committee and representation of patients in governing committees is foreseen in the coming years.The STCS was operationally as successful in the current funding period as in previous periods. Between May 2008 and June 2020, 6141 transplantations have been performed in 5879 patients of which 290 were pediatric patients. By end of June 2020, the size of the active cohort was 4839 patients. This important figure corresponds size of the cohort actively followed by the centers on an everyday basis. A total of 149 scientific project are completed or currently run on the data. More than 30 national or international collaborations are in place. Seventy peer-reviewed papers were published or are accepted in total. Representatives of the Swiss Personalized Health Network (SPHN) have become members of the STCS and a close collaboration with the Swiss Biobanking Platform (SBP) is established. During the current funding period, the different working groups achieved 22 of 33 previously stated milestones. The reminder could not be pursued or are yet ongoing. The Data Center is the responsible provider of the STCS data infrastructure. The main tasks include the management of the complex data structure of the STCS, to provide comprehensive public outcome reporting and to support researchers in data management and statistical analysis. In 2020, the data center took moreover the responsibility to act as the scientific IT provider after our current provider had decided to gradually discontinue its activities. Professional data services are essential for the STCS since transplantation is a highly complex medical intervention. Complex processes range from donor recruitment, organ allocation, and organ procurement, to the process of transplantation and post-transplant care. Distinct systems are interrelated and making demanding data integration processes necessary. The STCS is operating a decentralized, center-based Biobank of recipient samples. Since its creation, the STCS harvested 14’448 plasma, 14’297 viable cell samples and 5791 DNA samples in consenting patients. Fifteen percent of all nested projects (NP) used the Biobank over the past years. The genetic dataset of the STCS has been enlarged to 3000 patients with genome-wide data, making the STCS one of the largest cohorts of SOT recipients with long-term follow-up, accurate clinical-, psychosocial-, and genome-wide data. STCS data are available "open access" for research within the framework of the Scientific Committee guidelines and upon EC approval. Next funding period:The current application involves a research-oriented Data Infrastructure and Service (DIS). The described scientific aims only represent a crude summary of the working groups’ aims and of the aims of the DIS. In the next period, the scientific strategy of the STCS will mainly consist on consolidating its current scientific groups and study domains, and to build upon and expand on new and timely issues that have become important in transplantation. Moreover, new research initiatives in the personalized medicine area will represent a key aim in future research. The STCS is well positioned to contribute significantly in this regard due to important structure work and networking that took place during the last years. Hence the focus of our research will be on traditional and deep learning methods. A further aim will be to assess the role of Covid-19 in immunosuppressed SOT recipients. A successfully launched SNF-supported platform trials project in collaboration with SHCS is in the set-up phase. A large update of the immunology datasets and the implementation of a new, integrated phenotyping system will add to the clinical interpretation of our transplant immunology research and the use of genetic data to predict immunologic phenotypes is planned. This shall be achieved through candidate gene studies or GWAS. The interdisciplinary Psychosocial Interest Group (PSIG) will analyze psychosocial and behavioral outcomes over the transplant continuum and invest in innovative e-health supported care models allowing personalized health approaches. The Oncology group plans association studies across various types of transplantations and evaluates the progression frequency of patients with previously known monoclonal gammopathy. In collaboration with the STCS Psychosocial Interest Group (PSIG) the oncology group plans to collect information on SOT patients subsequently developing cancer and their risk of poor quality of life and psychosocial status.The Data Center will mainly be in charge of further developing the data infrastructure and services. This includes the following core tasks and challenges: -Development of a structure for the sharing of sensitive patient data between transplant hospitals and the STCS. The SPHN/BioMedIT supported IDEAL project plays a key role in this process.-Implementation of semantic interoperability standards and FAIR principles. Due to the complexity and the new territory for a patient-centered research system, the STCS proposes to conduct the "STCS semantic mapping and FAIRification project”.-To develop and extend support services for researchers that enable them to better manage the complexity of the STCS data. A not-for-profit system for reimbursement will be developed. -Development of services provided to patients (mobile health applications)The STCS Biobank plans important developments regarding standardization, FAIR principles implementation and a new personalized sampling approach:-A certain limitation in the current sampling scheme of the STCS is that sampling is solely based on fixed sampling time-points. A novel approach plans to expand the current scheme with an additional event-triggered sampling protocol. This will allow a more personalized sampling alongside of relevant events -Participate in the eCatalogue project of SBP and adopt FAIR principles to improve the findability of samples-Standardization of the preanalytical processesTransplantation medicine often offers the only solution for patients with end-stage organ failure and is in the public interest with its central ethical questions about organ donation and limited organ availability. The field of transplantation medicine is of importance and will be of continued significance in the future. The STCS, together with other institutions, makes a central and important contribution to this field.
-