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LYRICA: Lifestyle Prevention of Cardiovascular Ageing

English title LYRICA: Lifestyle Prevention of Cardiovascular Ageing
Applicant Franco Oscar
Number 189235
Funding scheme Project funding (Div. I-III)
Research institution Institut für Sozial- und Präventivmedizin Universität Bern
Institution of higher education University of Berne - BE
Main discipline Cardiovascular Diseases
Start/End 01.09.2020 - 31.08.2024
Approved amount 700'000.00
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Keywords (5)

Cardiovascular ageing; Prevention; Lifestyle ; Gender; Ethnicity

Lay Summary (German)

Lead
Professor Oscar H. FrancoDirector of the Institute of Social and Preventive Medicine (ISPM)University of Bern
Lay summary
Leitung
Kennen Sie jemanden, der einen Herzinfarkt erlitten hat, obwohl er keinen offensichtlichen Risikofaktor wie Bluthochdruck oder Rauchen hat? Die kardiovaskuläre Alterung kann das Herz und die Blutgefäße beeinträchtigen, aber noch nicht klinisch auftreten lassen. Derzeit beginnen die Präventions- und Behandlungsbemühungen oftmals, nachdem die Krankheit begonnen hat. Um Herz-Kreislauf-Erkrankungen vorzubeugen, müssen wir die kardiovaskuläre Alterung definieren und wissen, welche Faktoren letztere beeinflussen, bevor sie sich zu einer Herz-Kreislauf-Erkrankung entwickelt.
Inhalt und Ziele der Forschungsprojekte
Dieses Projekt wird das kardiovaskuläre Altern bei 20.000 Erwachsenen im Alter zwischen 18 und 70 Jahren aus fünf ethnischen Gruppen in den Niederlanden untersuchen. Wir werden mittels Ultraschall und Magnetresonanztomographie des Herzens und der Blutgefäße, untersuchen, wie Lebensstil-Faktoren wie Ernährung und körperliche Aktivität das kardiovaskuläre Altern in verschiedenen Gruppen nach Alter, Geschlecht und Ethnie beeinflussen. Aufgrund dessen lässt sich verstehen, wie bestimmte Grade des kardiovaskulären Alterns das Überleben und die Lebenserwartung beeinflussen. Alle diese Informationen werden in einem Instrument zur Verbesserung der Prävention von Herz-Kreislauf-Erkrankungen zusammengefasst. 
Wissenschaftlicher und gesellschaftlicher Kontext des Forschungsprojekts
Die Ergebnisse dieses Projekts werden genutzt, um die Prävention und Behandlung von Herzerkrankungen zu verbessern. Durch die Bereitstellung von Instrumenten und Empfehlungen, die spezifisch für Alter, Geschlecht und ethnische Zugehörigkeit sind, kann die Prävention von Herz-Kreislauf-Erkrankungen auch zu einem früheren Zeitpunkt beginnen, was die Gesundheitskosten senkt und es den Menschen ermöglicht, länger mit besserer Gesundheit zu leben.
 
Direct link to Lay Summary Last update: 22.11.2019

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Abstract

Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide. Traditional risk factors for CVD include hypertension, dyslipidaemia, smoking history, and diabetes mellitus, yet up to one-quarter of patients having a cardiovascular event do not present with any of these. This suggests that an underlying cardiovascular ageing (CVA) process exists, which consists of slowly progressive structural changes and functional decline of the heart and blood vessels. Prevention and treatment strategies to identify persons with high risk of CVD intervene too late in the pathophysiology of a disease that is already established and often manifested, and do not engage the underlying CVA process for which we have no well-defined and comprehensive definition. Defining CVA and establishing practical tools to assess it are of paramount importance to being able to address this precursor of CVD before clinical manifestation of CVD.Lifestyle is clearly involved in CVA and thus also in CVD. The various roles of lifestyle factors including diet, physical activity, and smoking in preventing or causing CVD are well known, yet their impact on CVA remains unclear. CVD risk factors and CVD mortality differ across sexes, ages, and ethnic groups, yet the majority of studies investigating markers of CVA have targeted mainly white populations over age 50. Generalization and application of results from studies of white, middle-aged and elderly populations is not fully appropriate to others and enter the progression of disease far too late. More detailed and comprehensive evaluation of the CVA process among different sexes, ages and ethnicities is therefore essential to creating an evidence framework for precise cardiovascular prevention and treatment.LYRICA, by using data from a large multiethnic population-based cohort, aims to define cardiovascular ageing as a precursor of cardiovascular disease across sex, age, and major ethnic groups. By clarifying the link between lifestyle factors and cardiovascular ageing, LYRICA can improve CVD prevention by providing the evidence framework for tailored prevention strategies across subgroups of the population. More specifically, LYRICA will (i) define the key components and markers of CVA including reference values of normality to develop a comprehensive assessment score of CVA specific to subpopulations of age, sex, and ethnicity; (ii) combine information on six individual lifestyle factors, nutrition, physical activity, smoking, alcohol consumption, body mass index, and sleep, into an overall lifestyle score, and evaluate the association of individual and combined lifestyle factors with CVA to develop precise prevention strategies for CVA; (iii) evaluate the diagnostic and predictive value of CVA parameters and score identified in LYRICA and validate it in an external, multiethnic population based cohort study; and (iv) measure the population and lifelong impact of degrees of cardiovascular ageing on mortality, life expectancy, and years of life lived with and without CVD. LYRICA findings will provide the information required for precise actions, prevention, and care of CVA tailored by age, gender, and ethnicity to improve healthcare and prevent CVD by reducing morbidity, mortality, and health care costs, while increasing life expectancy and quality of life.
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