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Advancing 7T multinuclear magnetic resonance spectroscopy in the human brain: boosting its clinical potential and bridging preclinical and clinical research

English title Advancing 7T multinuclear magnetic resonance spectroscopy in the human brain: boosting its clinical potential and bridging preclinical and clinical research
Applicant Xin Lijing
Number 189064
Funding scheme Project funding (Div. I-III)
Research institution Centre d'Imagerie BioMédicale EPFL SB CIBM-AIT
Institution of higher education EPF Lausanne - EPFL
Main discipline Biophysics
Start/End 01.02.2020 - 31.01.2024
Approved amount 563'368.00
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All Disciplines (2)

Discipline
Biophysics
Other disciplines of Engineering Sciences

Keywords (4)

13C MRS; 31P MRS; human brain ; magnetic resonance spectroscopy

Lay Summary (French)

Lead
La spectroscopie multi-nucléaire par résonance magnétique (SRM) utilisant les noyaux 1H, 13C et 31P permet des mesures non-invasive des événements neurochimiques, métaboliques et physiologiques dans le cerveau vivant. Actuellement, l’augmentation en sensitivité et résolution est la cause de l’utilisation des scanners à très hauts champs. Cependant, afin d’exploiter au mieux ces avantages, un scanner à très haut champs pour humain a d’abord besoins de développement de méthodologies avancées. De ce fait, ce projet se concentrera sur la résolution de ces soucis techniques, au développement de nouvelles méthodes et capacités SRM multi-nucléaire pour les scanners RM humains at au champ magnétique.
Lay summary

L’objectif général de ce projet est de développer, implémenter et valider des méthodes d’acquisitions et de quantification faisable pour la SRM 1H, 31P et 13C au scanner humain à 7T. Cela sera fait grâce à trois projets: (1) établir des mesures fiables, reproductibles et robustes d’acide γ-aminobutyrique et de glutathion; (2) développer les méthodes d’acquisitions et de traitement de données nécessaires pour la cartographie rapide du métabolisme de l’ATP et du statu d’oxydation-réduction; (3) entreprendre des mesures non-invasives des flux métaboliques cérébraux, incluant la neurotransmission . 

Le succès du projet va augmenter le potentiel de la SRM à 7T et améliorer l’interface clinique – sciences de base pour les études du cerveau, fournissant de ce fait à la communauté scientifique les moyens pour effectuer des mesures neurochimiques, métaboliques et physiologiques qui vont permettre l’avancement des sciences du vivant et la promotion de la santé publique.

Direct link to Lay Summary Last update: 20.01.2020

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Associated projects

Number Title Start Funding scheme
197687 Promoting the modulatory capacity of intracortical inhibition in young and old: interrelation of physical exercise and sleep 01.11.2020 Project funding (Div. I-III)

Abstract

Currently, there is an increasingly urgent need from academic and industrial partners for the continued development of non-invasive and non-ionizing techniques to study the human brain, and key components involved in brain function, physiology and pathophysiology: inhibitory neurotransmitter metabolites, neuroenergetics, redox systems and neurotransmission. Multinuclear (1H, 13C and 31P) magnetic resonance spectroscopy (MRS) is an appropriate and powerful tool, offering the possibility for such measurements, in vivo. The increase in sensitivity and resolution is currently driving the use of ultra-high magnetic field scanners. Advanced multinuclear MRS methods, including those developed by us, have been successfully performed on ultra-high field preclinical scanners, whereas the multinuclear MRS functionality of clinical scanners is still far behind, due to the need to overcome multiple technical challenges, e.g. low sensitivity, stringent RF deposition regulations and long acquisition times. Only a few research laboratories in the world have developed experimental set-ups that fully exploit the multinuclear capabilities of high magnetic field human scanners. The 7T MR scanner at the EPFL is the only available high magnetic field human scanner in the Lemanic region of Switzerland, so advancing the multinuclear methodologies used with this scanner is beneficial for all fundamental and clinical research projects in the area. Our project therefore aims to focus on surmounting the aforementioned technical issues, and advancing the multinuclear MRS capability of our 7T human MR scanner. This will be achieved by: (1) establishing reliable, reproducible and robust measurements of gamma-aminobutyric acid and glutathione (1H MRS); (2) developing the necessary acquisition and data processing methods for fast mapping of ATP metabolism and redox state (31P MRS); and (3) undertaking non-invasive measurements of cerebral metabolic fluxes, including neurotransmission (13C MRS). Developments will include simulations based on density matrix formalism and Bloch-McConnell equations, novel pulse sequences and RF pulse design. To reduce the long acquisition times, fast acquisition based on the MR fingerprinting concept and compressed sensing will also be incorporated. By exploiting the state-of-the-art techniques already developed on our preclinical platform, the detection limits of the human 7T MR scanner will be assessed, in particular for 13C MRS in the context of achieving accurate metabolic measurements, routinely. The success of this project will boost the clinical potential of 7T MRS and complete the translational clinical-basic science interface for brain studies, thereby providing the scientific community in Switzerland and beyond with the means for performing neurochemical, metabolic and physiological measurements that ultimately, enabling advances in the life sciences and in promoting public health.
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