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Brainstem Circuits Controlling Movement

English title Brainstem Circuits Controlling Movement
Applicant Arber Silvia
Number 179403
Funding scheme Project funding (Div. I-III)
Research institution Abteilung Zellbiologie Biozentrum Universität Basel
Institution of higher education University of Basel - BS
Main discipline Neurophysiology and Brain Research
Start/End 01.04.2018 - 31.03.2022
Approved amount 1'112'000.00
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Keywords (3)

Motor control; Neuronal circuits; Mouse genetics

Lay Summary (German)

Lead
Obwohl fast alle Aktivitäten des Nervensystems zu Bewegungsänderungen führen, weiss man derzeit noch sehr wenig darüber, wie Netzwerke von Nervenzellen diese Bewegungen steuern und beeinflussen. Regionen im Hirnstamm kommunizieren dabei mit Netzwerken im Rückenmark. Wie aber Netzwerke im Hirnstamm die Steuerung bestimmter Bewegungen regulieren, ist nur ungenügend verstanden. Ziel unserer Forschung ist es deshalb, die Organisation und Funktion von Netzwerken im Hirnstamm zu ergründen, welche die Bewegungen des Körpers kontrollieren. Dieses Projekt leistet dazu einen Beitrag.
Lay summary

In diesem Projekt werden wir ergründen, wie die motorischen neuronalen Netzwerke im Hirnstamm verknüpft sind und funktionieren. Wir werden die Verschaltungen von Nervenzellen im Hirnstamm sichtbar machen und funktionell untersuchen, um zu verstehen, wie spezifische Nervenzellen Informationen untereinander austauschen. Insbesondere werden wir versuchen zu verstehen, wie verschiedene Verhaltensmuster der Bewegung entstehen über die gezielte Aktivierung von Nervenzellen, und somit eine Bewegung ausgeführt werden kann (z. B. Gehen) und eine andere unterdrückt werden kann (z.B. Armbewegung). Ausserdem werden wir untersuchen, wie höhere Gehirnzentren mit Hirnstammregionen kommunizieren. Unsere Arbeiten werden dazu beitragen, Prinzipien über die Organisation von neuronalen Netzwerken und deren Funktionen aufzudecken. Wir erwarten, dass diese Erkenntnisse auch wichtige Einsichten darüber liefern werden, wie Bewegungsabläufe bei Krankheiten wie z. B. Parkinsons nicht mehr richtig funktionieren, und zu eventuellen Interventionen zur Verbesserung der Bewegung führen könnten.

Direct link to Lay Summary Last update: 31.03.2018

Responsible applicant and co-applicants

Employees

Publications

Publication
A census of cell types in the brain's motor cortex.
Winnubst Johan, Arber Silvia (2021), A census of cell types in the brain's motor cortex., in Nature, 598(7879), 33-34.
Functional diversity for body actions in the mesencephalic locomotor region
Ferreira-Pinto Manuel J., Kanodia Harsh, Falasconi Antonio, Sigrist Markus, Esposito Maria S., Arber Silvia (2021), Functional diversity for body actions in the mesencephalic locomotor region, in Cell, 184(17), 4564-4578.e18.
A functional map for diverse forelimb actions within brainstem circuitry
Ruder Ludwig, Schina Riccardo, Kanodia Harsh, Valencia-Garcia Sara, Pivetta Chiara, Arber Silvia (2021), A functional map for diverse forelimb actions within brainstem circuitry, in Nature, 590(7846), 445-450.
Postmitotic Hoxa5 Expression Specifies Pontine Neuron Positional Identity and Input Connectivity of Cortical Afferent Subsets
Maheshwari Upasana, Kraus Dominik, Vilain Nathalie, Holwerda Sjoerd J.B., Cankovic Vanja, Maiorano Nicola A., Kohler Hubertus, Satoh Daisuke, Sigrist Markus, Arber Silvia, Kratochwil Claudius F., Di Meglio Thomas, Ducret Sebastien, Rijli Filippo M. (2020), Postmitotic Hoxa5 Expression Specifies Pontine Neuron Positional Identity and Input Connectivity of Cortical Afferent Subsets, in Cell Reports, 31(11), 107767-107767.
Brainstem Circuits Controlling Action Diversification.
Ruder Ludwig, Arber Silvia (2019), Brainstem Circuits Controlling Action Diversification., in Annual review of neuroscience, 42, 485-504.
Functional Local Proprioceptive Feedback Circuits Initiate and Maintain Locomotor Recovery after Spinal Cord Injury
Takeoka Aya, Arber Silvia (2019), Functional Local Proprioceptive Feedback Circuits Initiate and Maintain Locomotor Recovery after Spinal Cord Injury, in Cell Reports, 27(1), 71-85.e3.
Connecting Circuits for Supraspinal Control of Locomotion.
Ferreira-Pinto Manuel J, Ruder Ludwig, Capelli Paolo, Arber Silvia (2018), Connecting Circuits for Supraspinal Control of Locomotion., in Neuron, 100(2), 361-374.
Mouse Motor Cortex Coordinates the Behavioral Response to Unpredicted Sensory Feedback.
Heindorf Matthias, Arber Silvia, Keller Georg B (2018), Mouse Motor Cortex Coordinates the Behavioral Response to Unpredicted Sensory Feedback., in Neuron, 99(5), 1040-1054.e5.
Connecting neuronal circuits for movement.
Arber Silvia, Costa Rui M (2018), Connecting neuronal circuits for movement., in Science (New York, N.Y.), 360(6396), 1403-1404.

Collaboration

Group / person Country
Types of collaboration
Botond Roska/Institute of Molecular and Clinical Opthalmology Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Aya Takeoka/NERF - NeuroElectronics Research Flanders Belgium (Europe)
- Publication
Fan Wang/Institute for Brain Sciences, Duke University United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
Ed Callaway/Systems Neurobiology, Salk Institute for Biological Studies United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
Rui M. Costa/Zuckerman Institute at Columbia University United States of America (North America)
- Publication
Martyn Goulding/Systems Neurobiology, Salk Institute for Biological Studies United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
Jeremy Dasen/NYU Neuroscience Institute, New York University School of Medicine United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
Flavio Donato/Biozentrum, University of Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Pico Caroni/Friedrich Miescher Institute for Biomedical Research Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Andreas Lüthi/Friedrich Miescher Institute for Biomedical Research Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Karl-Klaus Conzelmann/Gene Ctr, Ludwig-Maximilians-University Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Miami Project to Cure Paralysis - Gail F. Beach Memorial Visiting Lectureship Series for the 2021-2022 Academic Year. Talk given at a conference Disentangling Neuronal Circuits for Motor Control 15.12.2021 University of Miami, Miller school of Medicine, Miami, United States of America Arber Silvia;
Max Planck Institute for Brain Research online Neuroscience Lectures 2021 Talk given at a conference Disentangling descending circuits for motor control 08.09.2021 Virtual lecture based at MPI for Brain Research, Frankfurt, Germany Arber Silvia;
French Neurosciences Meeting – NeuroFrance 2021 Talk given at a conference Paul Broca Lecture: Circuit solutions for programming actions 19.05.2021 Virtual event based in Strasbourg, France Arber Silvia;
2020/2021 Seminar Series for the Centre for Developmental Neurobiology at King's College London Talk given at a conference Disentangling descending circuits for motor control 25.03.2021 Webinar based in KCL, London, Great Britain and Northern Ireland Arber Silvia;
Barrells XXXIII Meeting Talk given at a conference Dientangling Brainstem Motor Circuits 21.10.2020 Virtual Meeting, United States of America Arber Silvia;
Freiburg Neuroscience Lecture Series / Excellence Cluster Brain Links - Brain Tools Individual talk Circuit solutions for programming actions 16.05.2020 Albert Ludwigs University, Freiburg i. Br., Germany Arber Silvia;
2019 Rita Levi-Montalcini Lecture at 2nd joint EBRI – Hebrew University of Jerusalem – McGill University Symposium Individual talk Circuit Solutions for Programming Actions 28.10.2019 Italian Academy of Sciences & Humanities, Rome, Italy Arber Silvia;
Crick Lecture Individual talk Circuit solutions for programming actions 11.07.2019 Crick Institute, London, Great Britain and Northern Ireland Arber Silvia;
DZNE Lecture Series 2019 Individual talk Disentangling neuronal circuits for motor control 26.06.2019 German Center for Neurodegenerative Diseases, Bonn, Germany Arber Silvia;
MedART 2019 Talk given at a conference Neuronale Netzwerke für Begegnung 21.06.2019 ZLF, University Hospital Basel, Basel, Switzerland Arber Silvia;
Erice Course 2018: The Neural Bases of Action – from cellular microcircuits to large-scale networks and modelling Talk given at a conference The brainstem control of action 11.12.2018 Erice, Sicily, Italy Arber Silvia;
EPFL Brain Mind Institute Symposium 2018 «Controlling Behavior in Animals and Robots » Talk given at a conference Circuit solutions for programming actions 03.12.2018 EPFL, Lausanne, Switzerland Arber Silvia;
Munich Neuroscience Lecture Individual talk Disentangling neuronal circuits for motor control 29.11.2018 LMU Biocenter/MPI of Neurobiology, Germany Arber Silvia;
CSHL Neuroscience Seminar Series Individual talk Circuit solutions for programming actions 09.11.2018 Cold Spring Harbor Laboratory, NY, United States of America Arber Silvia;
Journée Francois Jacob : Behaviour and Cognition Individual talk Circuit solutions for programming actions 24.09.2018 Collège de France, Paris, France Arber Silvia;
20th Fens Forum 2018 Poster Basal Ganglia-Brainstem Interactions for the Control of Locomotion 07.07.2018 Berlin, Germany Arber Silvia; Yang Wuzhou; Neves Ferreira Pinto Manuel;
Symposium for Bror Alstermark:– Motor control – from neural circuits to behavior Talk given at a conference Circuit solutions for programming actions 30.05.2018 Vindeln, Sweden Arber Silvia;
MIT Department of Brain and Cognitive Sciences Colloquium: Hans-Lukas Teuber Lecture Individual talk Circuit solutions for programming actions 26.04.2018 MIT, Cambridge, MA, United States of America Arber Silvia;
Janelia Conference: Neural Circuits of the Insect Ventral Nerve Cord Talk given at a conference Organization and function of descending motor circuits in mice 21.04.2018 Janelia Research Campus, Ashburn, VI, United States of America Arber Silvia;


Self-organised

Title Date Place
Gatsby Conference on The Assembly and Function of Neuronal Circuits 29.09.2019 Monte Verita , Ascona, Switzerland

Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
Wissenschaft Pestalozzi Schulcamps Talk 18.11.2021 Trogen, Switzerland Arber Silvia;
19. Life Sciences Schülerkongress 2021 Talk 17.06.2021 Virtual event - based in Kreisgymnasium Bad Krozingen, Germany, Switzerland Arber Silvia;


Awards

Title Year
Member of the American National Academy of Sciences 2020
Betty and David Koetser Award for Brain Research 2019
ESKAS-Swiss Government Excellence Scholarships for Foreign Scholars and Artists 2019
Grand Prix Charles-Léopold Mayer 2019 2019
International Prize of the Fyssen Foundation 2018 2019
Lelio Orci Award 2019 2019
The Physiological Soceity Annual Review Prize Lecture 2019
8th FENS EJN Award & Special Lecture 2018
W. Alden Spencer Award 2018 2018

Associated projects

Number Title Start Funding scheme
160339 Entwicklung und Funktion von motorischen Netzwerken 01.04.2015 Project funding (Div. I-III)
140625 Entwicklung und Funktion von motorischen Netzwerken 01.04.2012 Project funding (Div. I-III)
208214 Brainstem Circuits Controlling Movement 01.04.2022 Project funding (Div. I-III)

Abstract

One of the most important tasks of the nervous system is the generation of specific forms of movement as behavioral output, allowing animals or humans to interact with their surroundings appropriately according to motor plans and/or in response to influence from the environment. The motor system is broadly distributed across the nervous system, including areas close to actual motor program execution in the spinal cord, all the way up to regions of the nervous system involved in decision making and planning of motor acts. The brainstem is a key intermediary structure between higher motor centers and spinal circuits, and we have hypothesized that distinct subpopulations of brainstem neurons mediate selective motor programs. The goal of this work is to unravel key defining features of brainstem neurons involved in the regulation of diverse forms of movement, and to understand how a particular behavior is chosen over others. Our project will contribute to uncovering organizational principles of neuronal circuits in the motor output system of mice, as well as the contributions of these circuits to behavioral function.
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