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3D printing manufacturing of patient-tailored drug releasing stents

Applicant Leroux Jean-Christophe
Number 177178
Funding scheme Sinergia
Research institution Institut für Pharmazeutische Wissenschaften ETH Zürich
Institution of higher education ETH Zurich - ETHZ
Main discipline Interdisciplinary
Start/End 01.09.2018 - 31.08.2022
Approved amount 2'364'948.00
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All Disciplines (4)

Discipline
Interdisciplinary
Material Sciences
Biomedical Engineering
Pharmacology, Pharmacy

Keywords (4)

3D Printing; Drug Delivery; Airway Stents; Personalized medicine

Lay Summary (French)

Lead
Bien que l’impression tridimensionnelle (impression 3D) soit appelée à jouer un rôle important en médecine, l’absence de matériaux adéquats pour la production de dispositifs médicaux par ce procédé freine considérablement son développement. Le projet apporte une solution à ce problème.
Lay summary

Contenu et objectifs du travail de recherche

Au cours des dernières années, l’impression 3D a connu un essor considérable dans des domaines d’application variés allant de l’aéronautique aux sciences pharmaceutiques. L’objectif principal de ce programme de recherche Sinergia consiste à développer et exploiter plus avant une technique d’impression 3D appelée la stéréolithographie, pour la production de dispositifs médicaux contenant des médicaments. Un des avantages majeurs de ce procédé est la possibilité de générer avec une grande précision des structures complexes adaptées aux besoins du patient.  Pour atteindre cet objectif, il est nécessaire, dans un premier temps, de mettre au point et de caractériser de façon approfondie les biomatériaux qui permettront l’impression 3D de ces dispositifs médicaux. Dans une deuxième phase, les matériaux générés serviront à la production et à l’évaluation préclinique de prototypes de prothèses trachéales. De telles prothèses sont utilisées en clinique pour le traitement de l’obstruction des voies respiratoires pouvant survenir lors d’accidents, d’infections, de maladies congénitales ou de cancer. L’impression 3D de prothèses trachéales biocompatibles, parfaitement adaptées à l’anatomie du patient et capables de libérer de manière contrôlée un ou plusieurs médicaments représenterait un progrès considérable par rapport aux modalités thérapeutiques actuellement disponibles.

 

Contexte scientifique et social du projet de recherche

Ce projet relève de la recherche fondamentale (développement et caractérisation de nouveaux matériaux pour impression 3D) et appliquée (production de prototypes de dispositifs médicaux innovants). Il vise à étendre l’énorme potentiel de l’impression 3D au domaine biomédical.

Direct link to Lay Summary Last update: 01.12.2017

Responsible applicant and co-applicants

Employees

Publications

Publication
Challenges and Opportunities in 3D Printing of Biodegradable Medical Devices by Emerging Photopolymerization Techniques
Bao Yinyin, Paunović Nevena, Leroux Jean‐Christophe (2022), Challenges and Opportunities in 3D Printing of Biodegradable Medical Devices by Emerging Photopolymerization Techniques, in Advanced Functional Materials, 2109864-2109864.
Solvent-Free Three-Dimensional Printing of Biodegradable Elastomers Using Liquid Macrophotoinitiators
Sandmeier Matthias, Paunović Nevena, Conti Riccardo, Hofmann Leopold, Wang Jieping, Luo Zhi, Masania Kunal, Wu Na, Kleger Nicole, Coulter Fergal Brian, Studart André R., Grützmacher Hansjörg, Leroux Jean-Christophe, Bao Yinyin (2021), Solvent-Free Three-Dimensional Printing of Biodegradable Elastomers Using Liquid Macrophotoinitiators, in Macromolecules, 54(17), 7830-7839.
Digital Light 3D Printing of Biodegradable Elastomers for Personalized DevicesPolymer and Colloid Highlights
Bao Yinyin, Paunović Nevena, Franzen Daniel, Studart André R., Leroux Jean-Christophe (2021), Digital Light 3D Printing of Biodegradable Elastomers for Personalized DevicesPolymer and Colloid Highlights, 75(5), 438-438, Swiss Chemical Society, Switzerland 75(5), 438-438.
Digital light 3D printing of customized bioresorbable airway stents with elastomeric properties
Paunović Nevena, Bao Yinyin, Coulter Fergal Brian, Masania Kunal, Geks Anna Karoline, Klein Karina, Rafsanjani Ahmad, Cadalbert Jasmin, Kronen Peter W., Kleger Nicole, Karol Agnieszka, Luo Zhi, Rüber Fabienne, Brambilla Davide, von Rechenberg Brigitte, Franzen Daniel, Studart André R., Leroux Jean-Christophe (2021), Digital light 3D printing of customized bioresorbable airway stents with elastomeric properties, in Science Advances, 7(6), abe9499.

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Galenus NanoGVA symposium 2021 Talk given at a conference Polymer-gold nanorods composites for 3D printing of bioresorbable stents for photothermal therapy 13.10.2021 Geneva, Switzerland Bao Yinyin; Coulter Fergal; Studart André R.; Franzen Daniel; Paunovic Nevena; Klein Karina; Leroux Jean-Christophe; Kleger Nicole Suzanne;
6th European Symposium of Photopolymer Science Talk given at a conference 3D Printing of Biodegradable Photopolymers for Personalized Medical Devices 15.06.2021 online, Austria Rüber Fabienne Alessandra; Leroux Jean-Christophe; Bao Yinyin; Studart André R.; Kleger Nicole Suzanne; Klein Karina; Paunovic Nevena; Geks Anna; Coulter Fergal; Kronen Peter; Franzen Daniel;
ACS National Meeting & Exposition Spring 2021 Talk given at a conference Digital light 3D printing of biodegradable photopolymers with tunable elastomeric properties 05.04.2021 online, United States of America Paunovic Nevena; Leroux Jean-Christophe; Rüber Fabienne Alessandra; Bao Yinyin; Coulter Fergal; Studart André R.; Geks Anna; Franzen Daniel; Kleger Nicole Suzanne;
the 4th Polymers and Nanomedicine Webinar Individual talk 3D printing of biodegradable photopolymers for personalized medicine 09.03.2021 the Max Planck Institute for Polymer Research (online), Germany Bao Yinyin;
SAMCE Launch event 2021 Talk given at a conference Fabrication of Personalized Bioresorbable Airway Stents by 3D Printing 21.01.2021 online, Switzerland Coulter Fergal; Studart André R.; Kronen Peter; Klein Karina; Bao Yinyin; Rüber Fabienne Alessandra; Franzen Daniel; Paunovic Nevena; Kleger Nicole Suzanne; Geks Anna; Leroux Jean-Christophe;
SSC/SSCS SSP/SSTS Joint Annual Meeting 2020 Talk given at a conference Development of an Animal Model to Induce Airway Stenosis and the Placement of a 3D Printed Airway Stent 23.09.2020 Bern, Switzerland Geks Anna; Coulter Fergal; Kleger Nicole Suzanne; Leroux Jean-Christophe; Bao Yinyin; Klein Karina; Kronen Peter; Franzen Daniel; Studart André R.; Rüber Fabienne Alessandra; Paunovic Nevena;
Invited seminar Individual talk Engineering Biodegradable Polymers for 3D Printing of Personalized Medical Devices 11.03.2020 ETH, Switzerland Bao Yinyin;
Invited seminar Individual talk Engineering Synthetic Polymers for Biomedical 3D Printing 03.01.2020 Tsinghua University, China Bao Yinyin;
The POLYDAYS 2019 conference Talk given at a conference The Development of Bioresorbable Personalized Airway Stents by Digital Light Processing 11.09.2019 Berlin, Germany Paunovic Nevena; Franzen Daniel; Geks Anna; Kleger Nicole Suzanne; Bao Yinyin; Leroux Jean-Christophe; Kronen Peter; Coulter Fergal; Studart André R.; Klein Karina;
2019 Fall Meeting of the Swiss Chemical Society Talk given at a conference 3D Printing of Personalized Biodegradable Airway Stents via Vat Photopolymerization 06.09.2019 Zurich, Switzerland Kleger Nicole Suzanne; Franzen Daniel; Kronen Peter; Paunovic Nevena; Leroux Jean-Christophe; Studart André R.; Coulter Fergal; Bao Yinyin; Geks Anna; Klein Karina;
Swiss Galenic Meeting 2019 Talk given at a conference Fabrication of Personalized Bioresorbable Airway Stents by 3D Printing 29.08.2019 Basel, Switzerland Kronen Peter; Leroux Jean-Christophe; Geks Anna; Klein Karina; Studart André R.; Franzen Daniel; Coulter Fergal; Paunovic Nevena; Bao Yinyin; Kleger Nicole Suzanne;
12th Swiss Pharma Science Day Poster Development of Personalized Biodegradable Airway Stents by 3D Printing 28.08.2019 Bern, Switzerland Kronen Peter; Leroux Jean-Christophe; Paunovic Nevena; Coulter Fergal; Geks Anna; Klein Karina; Bao Yinyin; Studart André R.; Franzen Daniel; Kleger Nicole Suzanne;
ETH MaP Graduate Symposium 2019 Poster Polymeric Materials for 3D printing of Personalized Biodegradable Airway stents 03.07.2019 Zurich, Switzerland Kronen Peter; Bao Yinyin; Geks Anna; Klein Karina; Leroux Jean-Christophe; Paunovic Nevena; Studart André R.; Franzen Daniel; Coulter Fergal; Kleger Nicole Suzanne;
Elsevier Frontiers in Polymer Science Talk given at a conference 3D Printing of Biodegradable Personalized Biomedical Devices 05.05.2019 Budapest, Hungary Leroux Jean-Christophe; Klein Karina; Kleger Nicole Suzanne; Bao Yinyin; Franzen Daniel; Paunovic Nevena; Coulter Fergal; Kronen Peter; Geks Anna; Studart André R.;
11th Swiss Chemical Industry Symposium Poster New Materials for 3D Printing of Biodegradable Personalized Airway Stents 24.01.2019 Zürich, Switzerland Studart André R.; Klein Karina; Franzen Daniel; Coulter Fergal; Paunovic Nevena; Kleger Nicole Suzanne; Geks Anna; Leroux Jean-Christophe; Bao Yinyin; Kronen Peter;


Communication with the public

Communication Title Media Place Year
Talks/events/exhibitions Swissnex Connected webinar series International 2020

Awards

Title Year
Best oral presentation at SSC/SSCS SSP/SSTS Joint Annual Meeting 2020 2020
Galenus Supports 2020 from Galenus-Privatstiftung 2020
Best poster award (1st place) at ETH MaP graduate symposium 2020 2019

Associated projects

Number Title Start Funding scheme
204614 Animate Materials enabled by Directed Evolution of Microorganisms 01.10.2021 Project funding (Div. I-III)

Abstract

There is a unique opportunity for innovation in medical sciences with the ongoing three-dimensional (3D) printing revolution. We propose to translate and advance one of the main 3D printing technologies, namely stereolithography (SLA), as platform to manufacture innovative drug-eluting devices with unprecedented customizability. The technologies’ versatility will enable selecting the drug, the dose loaded and the release kinetics, as well as tailoring the size and geometry of the device to completely accommodate the anatomic features and medical needs of patients. To achieve this, we will expand the available range of printable, biocompatible materials that can endure the printing and post-processing conditions, and we will establish manufacturing and characterization guidelines. For this purpose, we will explore the fabrication of drug-eluting tracheal stent for the treatment of airways stenosis, which can arise due to a number of causes including accidental compression, intubation-related injuries, congenital malformations, infections, inflammatory diseases and malignant or benign tumors. The device prototypes will carry relevant model drugs with anti-proliferative or anti-microbial properties. They will be produced in an iterative process of printable material development, 3D prototype design and fabrication, in vitro characterization and in vivo evaluation. Through this process, we will generate a library of printable “pharmaceutical inks”, a comprehensive database of their properties and the procedures that can be used to 3D print and characterize drug-delivering devices as well as test their performances in relevant animal models. To achieve this ambitious goal, this Sinergia project will bring together three key Swiss laboratories with outstanding experience in drug delivery, material sciences, preclinical experimentation and clinical studies. Notably, the output of this project will be translatable to other devices and medical applications, as well as other 3D printing technologies. Demonstrating the feasibility of customizing drug-eluting devices through 3D printing would represent a seminal contribution to personalized medicine, where the “one-size-fits-all” approach could be soon replaced by a truly patient-tailored one. This highly interdisciplinary project has no contender in Switzerland and will set the basis for appointing the Country at the forefront of stents manufacturing and pharma-3D printing technologies.
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