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Implantable Autonomous Wireless Bio-Electronics for High-Resolution Monitoring and Detection of Epilepsy in-vivo, Part-II

English title Implantable Autonomous Wireless Bio-Electronics for High-Resolution Monitoring and Detection of Epilepsy in-vivo, Part-II
Applicant Schmid Alexandre
Number 175790
Funding scheme Project funding
Research institution Laboratoire de systèmes microélectroniques EPFL - STI - IEL - LSM
Institution of higher education EPF Lausanne - EPFL
Main discipline Microelectronics. Optoelectronics
Start/End 01.03.2018 - 28.02.2019
Approved amount 188'477.00
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All Disciplines (2)

Discipline
Microelectronics. Optoelectronics
Biomedical Engineering

Keywords (3)

Cortical microelectronic implants; Bio-electronic interfaces; Wireless cortical implants

Lay Summary (French)

Lead
Système autonome à transmission sans fil permettant le contrôle d'épilepsie
Lay summary
L’observation de signaux électriques générés pas l’activité du cortex dans le cadre de patients épileptiques a pour but la preparation de methodes permettant le contrôle et la suppression de l’épisode épileptique ainsi que l’étude de signaux corticaux spécifique, par exemple à fin de permettre la detection avancée ou la prediction. Cerains systèmes commerciaux ont été récement approuvés par les autorités de certification.
Le project courant fait suite au project supporté par le SNSF No. 200021-157090 sur une période d’une année afin de permettre la confirmation et l’extension au niveau système des résultats obtenus. Une hyporthèse de travaille formule la nécessité d’autonomie du patient par rapport au materiel supportant la detection et le contrôle de l’épisode épileptique par stimulation électrique. Une station externe placée sur un casque-porteur léger communique avec une station de base logée dans le trou excavé à fin de chirurgie.
Les but scientifiques suivants sont proposes pour l’année finale de la recherché, étant donnée que la recherché constitue une suite naturelle au project formel precedent.
- études et amelioration de la consommation;
- contrôle d’un système complet, au niveau prototype de laboratoire;
- continuation de l’étude des algorithme de detection, de la station de base externe;
- tests in-vitro et in-vivo.
Ce project est présenté comme une partie de recherché à long terme des participants.

Direct link to Lay Summary Last update: 29.09.2017

Responsible applicant and co-applicants

Employees

Publications

Publication
All Wireless, 16-channel Epilepsy Control System with Sub-uW/channel and Closed-loop Stimulation Using a Switched-Capacitor-Based Active Charge Balancing Method
RanjandishReza (2018), All Wireless, 16-channel Epilepsy Control System with Sub-uW/channel and Closed-loop Stimulation Using a Switched-Capacitor-Based Active Charge Balancing Method, in 2018 IEEE European Solid-State Circuits conference (ESSCIRC 2018), IEEE, Dresden, Germany.
Area and Power Efficient Ultra-Wideband Transmitter Based on Active Inductor
KerimTüre, ADevos, FrancoMaloberti (2018), Area and Power Efficient Ultra-Wideband Transmitter Based on Active Inductor, in International Symposium on Integrated Circuits and Systems (ISICAS), IEEE, Taormina, IT.
Sub-µW/channel, 16-channel Seizure Detection and Signal Acquisition SoC Based on Multichannel Compressive Sensing
RanjandishReza, SchmidAlexandre (2018), Sub-µW/channel, 16-channel Seizure Detection and Signal Acquisition SoC Based on Multichannel Compressive Sensing, in International Symposium on Integrated Circuits and Systems (ISICAS), IEEE, Taormina, IT.

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Workshop on Implantable Closed-Loop Neuro-Modulation Systems Talk given at a conference Circuit and System Techniques for Low-Power Cortical Implants Aiming at Closed-Loop Epilepsy Control 13.07.2018 Hsinchu, Taiwan Schmid Alexandre;


Associated projects

Number Title Start Funding scheme
157090 Implantable Autonomous Wireless Bio-Electronics for High-Resolution Monitoring and Detection of Epilepsy in-vivo 01.03.2015 Project funding
182548 Autonomous implanted patches for reliable closed-loop epilepsy control, APRICO 01.10.2019 Project funding

Abstract

Monitoring epileptogenic cortical areas in-vivo has been carried out in clinical environment within the context of epilepsy treatment consisting in detecting and subsequently resecting incriminated areas. The determination of the epileptogenic areas as well as the development of implantable systems aiming at early detection or prediction of the seizure both are in need of autonomous implantable recording systems that enable patients to be monitored in their home environment. To this extent, portable and autonomous solutions to cortical implantable recording systems must be provided. This area of research has been intensively tackled over the past few years, and research groups have proposed block-level solutions, efficiently implementing some parts of the system. To date, the efficient operation and implementation of several blocks pertaining to cortical implants have been achieved resulting in a fair understanding of block-level engineering issues and their potential solution. Two FDA-approved implantable systems for epilepsy control exists at the moment of writing. Both have received their approval recently, and thus offer solutions that may be improved in very significant ways. A true system-level approach is needed to enable the systematic study and further development of cortical implants. The current project is proposed as the one-year continuation of the currently SNSF-funded project No. 200021-157090 named “Implantable Autonomous Wireless Bio-Electronics for High-Resolution Monitoring and Detection of Epilepsy in-vivo,” and formally existing over 03/2015 through 03/2018, and aims at extending and confirming the results obtained towards a system-level implementation. The founding hypothesis of the proposed research remains consisting of the necessity to provide the implant time-based partial autonomy with respect to its external base station. For example, the patients must be allowed to disconnect themselves from the external base station for several hours while trusting the implant to continue operation in automatically adapted state. This fundamental constraint on the operation of the dual consisting of the external base station and the implanted system has tremendous impact on the way the system must be conceived and controlled. The additional one-year research intends to construct over the results that have been achieved during the first three year of research in order to complete the research along the following lines of research and aiming at the additional following scientific goals•Goal 1, study of power optimization modes of the internal and external sub-modules, and implementation of the algorithms into MCU and FPGA;•Goal 2, general control of the internal and external sub-modules;•Goal 3, epilepsy feature extraction classification based on support vector machine, and its implementation into FPGA as part of the internal sub-module;•Goal 4, study of analog front-end techniques enabling simultaneous stimulation and recording;•Goal 5, study, design and test of the external unit by using discrete components;•Goal 6, test in-vitro and then in-vivo of the narrow band downlink data communication from the external unit to the implanted central system;•Goal 7, test in-vitro and then in-vivo of the narrow band and of the ultra-wide band uplink data communication from the implanted central system to the external unit;•Goal 8, design and test of the battery charger by using commercial components. Selection of a medical grade rechargeable battery;•Goal 9, animal experiments studying the effectiveness of high-density readout electrodes, the developed patches, and study of epileptogenic signal capture and seizure detection using the proposed system.The project aims at gathering the theoretical and development parts into one comprehensive system and methodology, that is applied to epilepsy study in-vivo and that will conduct to implantable system with the capacity of modulating or suppressing seizures. This research project is presented as part of long-term goals of the research groups, which have been active and have collaborated in the domain for several years.
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