psychiatry; Genetics; weight gain; metabolic syndrome; pharmacogenetics; antipsychotics; psychotropic drugs; Personnalized medicine; dyslipidemia; hypertension; diabetes
Delacrétaz Aurélie, Glatard Anaïs, Dubath Céline, Gholam Mehdi, Gamma Franziska, van Gunten Armin, Conus Philippe, Eap Chin B. (2021), Valproate is associated with early decrease of high‐density lipoprotein cholesterol levels in the psychiatric population, in Basic & Clinical Pharmacology & Toxicology
, 129(1), 26-35.
Alameda Luis, Levier Axel, Gholam-Rezaee Mehdi, Golay Philippe, Vandenberghe Frederik, Delacretaz Aurélie, Baumann Philipp, Glatard Anaïs, Dubath Céline, Herane-Vives Andres, Rodriguez Victoria, Solida Alessandra, Do Kim Q., Eap Chin B., Conus Philippe (2020), Psychological trauma occurring during adolescence is associated with an increased risk of greater waist circumference in Early Psychosis patients treated with psychotropic medication, in PLOS ONE
, 15(12), e0242569.
Glatard Anaïs, Guidi Monia, Delacrétaz Aurélie, Dubath Céline, Grosu Claire, Laaboub Nermine, von Gunten Armin, Conus Philippe, Csajka Chantal, Eap Chin B. (2020), Amisulpride: Real-World Evidence of Dose Adaptation and Effect on Prolactin Concentrations and Body Weight Gain by Pharmacokinetic/Pharmacodynamic Analyses, in Clinical Pharmacokinetics
, 59(3), 371-382.
Dubath Céline, Delacrétaz Aurélie, Glatard Anaïs, Vollenweider Peter, Preisig Martin, Richard-Lepouriel Hélène, Hasler Roland, Gamma Franziska, Solida Alessandra, Thonney Jacques, Fassassi Sylfa, von Gunten Armin, Conus Philippe, Eap Chin B. (2020), Evaluation of Cardiometabolic Risk in a Large Psychiatric Cohort and Comparison With a Population-Based Sample in Switzerland, in The Journal of Clinical Psychiatry
, 81(3), 19m12796.
Delacrétaz Aurélie, Glatard Anaïs, Dubath Céline, Gholam-Rezaee Mehdi, Sanchez-Mut Jose Vicente, Gräff Johannes, von Gunten Armin, Conus Philippe, Eap Chin B. (2019), Psychotropic drug-induced genetic-epigenetic modulation of CRTC1 gene is associated with early weight gain in a prospective study of psychiatric patients, in Clinical Epigenetics
, 11(1), 198.
Saigi-Morgui Núria, Quteineh Lina, Bochud Pierre-Yves, Crettol Severine, Kutalik Zoltán, Mueller Nicolas J., Binet Isabelle, Van Delden Christian, Steiger Jürg, Mohacsi Paul, Dufour Jean-francois, Soccal Paola M., Pascual Manuel, Eap Chin B. (2019), Genetic and clinic predictors of new onset diabetes mellitus after transplantation, in The Pharmacogenomics Journal
, 19(1), 53-64.
Quteineh Lina, Wójtowicz Agnieszka, Bochud Pierre-Yves, Crettol Severine, Vandenberghe Frederik, Venetz Jean-Pierre, Manuel Oriol, Golshayan Dela, Lehmann Roger, Mueller Nicolas J., Binet Isabelle, van Delden Christian, Steiger Jürg, Mohacsi Paul, Dufour Jean-Francois, Soccal Paola M., Kutalik Zoltan, Marques-Vidal Pedro, Vollenweider Peter, Recher Mike, Hess Christoph, Pascual Manuel, Eap Chin B. (2019), Genetic immune and inflammatory markers associated with diabetes in solid organ transplant recipients, in American Journal of Transplantation
, 19(1), 238-246.
Delacrétaz Aurélie, Vandenberghe Frederik, Glatard Anaïs, Dubath Céline, Levier Axel, Gholam-Rezaee Mehdi, Holzer Laurent, Ambresin Anne-Emmanuelle, Conus Philippe, Eap Chin B. (2019), Lipid Disturbances in Adolescents Treated With Second-Generation Antipsychotics Clinical Determinants of Plasma Lipid Worsening and New-Onset Hypercholesterolemia, in The Journal of Clinical Psychiatry
, 80(3), e1-e9.
AnsermotNicolas, BochatayMeredith, SchläpferJürg, GholamMehdi, GonthierAriane, ConusPhilippe, EapChin B (2019), Prevalence of ECG abnormalities and risk factors for QTc interval prolongation in hospitalized psychiatric patients, in Therapeutic Advances in Psychopharmacology
, 9, 1-13.
Delacrétaz Aurélie, Vandenberghe Frederik, Glatard Anaïs, Levier Axel, Dubath Céline, Ansermot Nicolas, Crettol Séverine, Gholam-Rezaee Mehdi, Guessous Idris, Bochud Murielle, von Gunten Armin, Conus Philippe, Eap Chin B. (2018), Association Between Plasma Caffeine and Other Methylxanthines and Metabolic Parameters in a Psychiatric Population Treated With Psychotropic Drugs Inducing Metabolic Disturbances, in Frontiers in Psychiatry
, 9, 573.
Vandenberghe Frederik, Najar-Giroud Alexandra, Holzer Laurent, Conus Philippe, Eap Chin B., Ambresin Anne-Emmanuelle (2018), Second-Generation Antipsychotics in Adolescent Psychiatric Patients: Metabolic Effects and Impact of an Early Weight Change to Predict Longer Term Weight Gain, in Journal of Child and Adolescent Psychopharmacology
, 28(4), 258-265.
Delacrétaz Aurélie, Vandenberghe Frederik, Gholam-Rezaee Mehdi, Saigi Morgui Nuria, Glatard Anais, Thonney Jacques, Solida-Tozzi Alessandra, Kolly Stephane, Gallo Sylfa Fassassi, Baumann Philipp, Berney Sylvie, Zulauff Sandrine Valloton, Aubry Jean-Michel, Hasler Roland, Ebbing Karsten, von Gunten Armin, Conus Philippe, Eap Chin B (2018), Early changes of blood lipid levels during psychotropic drug treatment as predictors of long-term lipid changes and of new onset dyslipidemia, in Journal of Clinical Lipidology
, 12(1), 219-229.
Delacrétaz Aurélie, Lagares Santos Patricia, Saigi Morgui Nuria, Vandenberghe Frederik, Glatard Anaïs, Gholam-Rezaee Mehdi, von Gunten Armin, Conus Philippe, Eap Chin B (2017), Influence of polygenic risk scores on lipid levels and dyslipidemia in a psychiatric population receiving weight gain-inducing psychotropic drugs, in Pharmacogenetics and genomics
, 27(12), 464-472.
Delacrétaz Aurélie, Zdralovic Adna, Vandenberghe Frederik, Saigi-Morgui Nuria, Glatard Anaïs, Quteineh Lina, Gholam-Rezaee Mehdi, Raffoul Wassim, Applegate Lee Ann, Jafari Paris, Gamma Franziska, von Gunten Armin, Conus Philippe, Eap Chin B (2017), Association of variants in SH2B1 and RABEP1 with worsening of low-density lipoprotein and glucose parameters in patients treated with psychotropic drugs, in Gene
, 628, 8-15.
This SNF project constitutes the continuation of our two previous SNF projects (320030-120686 and 324730-144064). Weight gain (WG) and metabolic complications are major side effects induced by some psychotropic drugs, and increase the risk of cardiovascular events and long term morbidity and mortality in psychiatric populations. >1460 patients were included and a very large data base with variables from the metabolic syndrome has been collected. Very interesting clinical as well as genetic results have been published in high impact journals thanks to the previous SNF project. A prize (Lundbeck Psychiatry award 2014) was awarded to Dr Choong for her paper published in JAMA Psychiatry (2013) and results have been accepted for oral presentations in 3 international congresses.The primary aims of the present project are to continue the analysis on the extensive clinical and genetic data presently collected, in particular on the following topics:- To continue the analysis of associations between genetic factors and metabolic symptoms. Thus, until now, mostly WG has been investigated. Analyses will be extended to hyperglycaemia and/or type 2 diabetes (T2D), hypercholesterolemia, hypertriglyceridemia and hypertension.- To extend (+540 patients) the number of included patients (adult and old age) to further increase the power of the study and to use the additional patients as a replication cohort for some genetic markers- To determine possible changes of DNA methylation induced by antipsychotic drugs and to determine the potential influence of such changes on metabolic parametersThe secondary aims are:- To extend PK-POP and PK-PD analysis to other psychotropic drugs of interest- To analyze changes during treatment of endogenous compounds in plasma using metabolomic approachesBecause of the experience acquired during the previous project, the feasibility of the present project appears optimal. Very large data sets from the presently included patients are already available. To further increase the number of patients, the number of sites of inclusion has been recently extended. To determine whether positive associations detected in psychiatric cohorts are also valid in the general populations, collaborations with investigators from very large consortia of populations based cohorts (i.e. GIANT, MAGIC, UK-Biobank, Genome Wide Associations Scans for Total Cholesterol, HDL-C, LDL-C and triglycerides) will be continued, thus widening the implication of our findings.