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Investigating the interplay of job exposures, ambient air pollution and living environment as drivers of the chronic lung disease epidemic The Large-scale LuftiBus-SNC Cohort

English title Investigating the interplay of job exposures, ambient air pollution and living environment as drivers of the chronic lung disease epidemic The Large-scale LuftiBus-SNC Cohort
Applicant Puhan Milo
Number 173043
Funding scheme Project funding (special)
Research institution Institut für Epidemiologie, Biostatistik und Prävention Universität Zürich
Institution of higher education University of Zurich - ZH
Main discipline Respiratory Diseases
Start/End 01.01.2018 - 30.04.2021
Approved amount 479'994.00
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Keywords (9)

large nested project SNC; pollution; lung function; large nested project SNC; occupational exposure; mortality; record linkage; COPD; cohort study

Lay Summary (German)

Lead
Luftibus-Swiss National Cohort zur Erforschung von Risikofaktoren für die Lungengesundheit
Lay summary

Je nach Land sind 10-20% der Weltbevölkerung von der chronisch-obstruktiven Lungenerkrankung (COPD), Asthma und anderen chronischen Lungenerkrankungen betroffen. Es gibt immer mehr Hinweise dafür, dass nicht nur das Rauchen sondern auch andere Faktoren wie Belastungen am Arbeitsplatz oder Luftverschmutzung für einen wesentlichen Anteil an chronischen Lungenerkrankungen verantwortlich sind. Es gibt nur wenige Langzeitstudien, welche untersuchen können, welche Risikofaktoren sowohl einen Einfluss auf die Lunge wie auch auf die Sterblichkeit haben, da sie zu klein waren.

Mit der Kombination der Swiss National Cohort (SNC), die seit Jahren vom Schweizerischen Nationalfonds und vom Bundesamt für Statistik unterstützt wird, und den Luftibus-Daten konnten wir eine große Kohorte von rund 34,000 Erwachsenen gewinnen, die es erlaubt, Risikofaktoren für die Lungengesundheit und die Sterblichkeit zu untersuchen. Mit der Verlinkung von Luftibus zur SNC können mit der Luftibus-SNC folgende wichtigen wissenschaftlichen Fragen verfolgt werden: Welche Umwelteinflüsse und Belastungen am Arbeitsplatz und welche Verhaltensweisen beeinträchtigen die Lungengesundheit und sind mit erhöhter Sterblichkeit verbunden? In diesem Antrag fokussieren wir uns auf den Einfluss von Belastungen am Arbeitsplatz (Gase, Stäube, Dämpfe und Räuche) auf die Lungenfunktion und die Sterblichkeit. Die Luftibus-SNC bietet eine effiziente Möglichkeit, eine einzigartige und große Kohorte von Menschen zu analysieren, für die es viele Angaben zu Risikofaktoren, mehreren Lungenfunktionsparametern sowie Angaben zur Sterblichkeit gibt. Aufgrund der Resultate dieser Studie wird es möglich sein, präventive Massnahmen am Arbeitsplatz zu entwickeln und zu helfen, die Lungengesundheit der Bevölkerung zu erhalten.

Direct link to Lay Summary Last update: 04.04.2017

Responsible applicant and co-applicants

Employees

Project partner

Publications

Publication
Combining heterogeneous spatial datasets with process-based spatial fusion models: A unifying framework
Wang Craig, Furrer Reinhard (2021), Combining heterogeneous spatial datasets with process-based spatial fusion models: A unifying framework, in Computational Statistics & Data Analysis, 161, 107240-107240.
NO2 and PM2.5 Exposures and Lung Function in Swiss Adults: Estimated Effects of Short-Term Exposures and Long-Term Exposures with and without Adjustment for Short-Term Deviations
Strassmann Alexandra, de Hoogh Kees, Röösli Martin, Haile Sarah R., Turk Alexander, Bopp Matthias, Puhan Milo A. (2021), NO2 and PM2.5 Exposures and Lung Function in Swiss Adults: Estimated Effects of Short-Term Exposures and Long-Term Exposures with and without Adjustment for Short-Term Deviations, in Environmental Health Perspectives, 129(1), 017009-017009.
Occupational exposure and the risk of airway obstruction and mortality
Strassmann Alexandra, Kaufmann Marco, Dressel Holger, Turk Alexander, Röösli Martin, de Hoogh Kees, Sadhra Steven S., Bopp Matthias, Puhan Milo A. (2020), Occupational exposure and the risk of airway obstruction and mortality, in International Journal of Public Health.
Increase in Airway Obstruction between 1993 and 2012 in Switzerland. An Observational Study
West Erin A., Strassmann Alexandra, Wang Craig, Turk Alexander, de Hoogh Kees, Röösli Martin, Bopp Matthias, Buist A. Sonia, Dressel Holger, Puhan Milo A. (2020), Increase in Airway Obstruction between 1993 and 2012 in Switzerland. An Observational Study, in Annals of the American Thoracic Society, 17(4), 457-465.
Predicting Fine-Scale Daily NO 2 for 2005–2016 Incorporating OMI Satellite Data Across Switzerland
de Hoogh Kees, Saucy Apolline, Shtein Alexandra, Schwartz Joel, West Erin A., Strassmann Alexandra, Puhan Milo, Röösli Martin, Stafoggia Massimo, Kloog Itai (2019), Predicting Fine-Scale Daily NO 2 for 2005–2016 Incorporating OMI Satellite Data Across Switzerland, in Environmental Science & Technology, 53(17), 10279-10287.
Generalized spatial fusion model framework for joint analysis of point and areal data
Wang Craig, Puhan Milo A., Furrer Reinhard (2018), Generalized spatial fusion model framework for joint analysis of point and areal data, in Spatial Statistics, 23, 72-90.

Awards

Title Year
Poster Discussion Award at the Swiss Society of Pulmonology (SGP) 2018
SSPH+ PhD Award for the best abstract at the Swiss Public Health Conference in Neuchâtel (Switzerland) 2018

Associated projects

Number Title Start Funding scheme
166524 Tracking of Urgent Risks in Swiss Travellers (TOURIST) to improve travel advice in Swiss travel clinics 01.04.2017 Project funding (Div. I-III)
139309 Medical end-of-life decisions: prevalence and trends in Switzerland 01.03.2013 NRP 67 End of Life
173330 Novel methods for investigating acute and long term effects of transportation noise on health 01.08.2017 Project funding (special)
149496 Learning from failure - Understanding the mechanisms of trial discontinuation 01.12.2013 Project funding (Div. I-III)
115216 Risk assessment for chronic ostructive pulmonary disease in orimary care: research should solve the dilemma 01.03.2007 Ambizione
148415 The Swiss National Cohort 2.0: a platform for longitudinal research in Switzerland 01.07.2014 Cohort Studies Large
201272 Toward prevention of health effects from acute and chronic noise exposure 01.08.2021 Project funding (special)

Abstract

A global epidemic of chronic lung diseases has developed over the last 20 years. Across countries, 10-20% of the population is affected by chronic obstructive pulmonary disease (COPD), asthma and other chronic lung diseases, which are associated with tremendous morbidity, mortality and cost. There is increasing evidence that factors other than smoking (i.e. job exposures, ambient air pollution and living environment), to which humans are exposed daily and for years, account for a substantial proportion of chronic lung diseases. Because lung diseases are so prevalent and are associated with poor quality of life, poor prognosis and high societal cost, even small reductions in underlying causes of chronic lung disease can make a big impact on a population level. There is a lack of large, population-based studies that investigate the (combined) effects of job exposures, ambient air pollution and living environment on the lungs and, subsequently, to what extent the subsequent lung damage affects mortality in the long run.With the combination of the Swiss National Cohort (SNC) and LuftiBus data we have derived a large cohort of 43,558 adults with mid to long-term follow-up that allows us to examine the association of job exposures, ambient air pollution and living environment with lung function, COPD and mortality. The following important scientific questions will be pursued: In part 1, we will assess if job exposures, ambient air pollution and living environment are associated with impaired lung function, COPD and mortality. We will measure the extent to which these effects on mortality are mediated through impaired lung function (while adjusting for smoking). We will use mediation survival analyses to assess the relative contribution of job exposures (based on the job-exposure matrix), ambient air pollution (several parameters, based on spatiotemporal models) and living environment (based on data from the LuftiBus cohort and the 2000 census). In part 2, we will evaluate the interplay between job exposures, ambient air pollution and living environment and if specific participant-level characteristics modify these associations. These analyses will elucidate which combinations of job exposures, ambient air pollution and living environment and which participant-level characteristics put individuals at particularly high risk for chronic lung disease and mortality.The LuftiBus-SNC cohort offers an efficient way to derive a large, unique cohort of people for whom rich job exposure, ambient air pollution and living environment data, several lung function parameters and mortality data are available. The LuftiBus-SNC cohort provides evidence for these crucial questions that are difficult - if not impossible - to address by conventional cohort studies because of their limited sample size or focus on specific exposures (e.g. only job exposures or ambient air pollution). Our study will, through its cohort study design and sample size, provide a more solid scientific basis for prioritizing preventive actions according their potential to reduce the burden from chronic lung disease and mortality. Public health authorities will benefit from this information in order to make evidence-based decisions on how to prioritize preventive measures. Health care professionals can inform patients about risk factors other than smoking that contribute to lung disease. Employers and accident insurance will be informed how to make the workplace safer and prevent the employees from getting work-related lung diseases. Finally, patients and healthy individuals will learn about potential hazards that impact lung disease and increase mortality. Thereby, they can make informed decisions regarding how to minimize their risk for lung diseases, in addition to being protected by public health interventions.
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