Ageing; Biomarkers; Chronic kidney Disease; Metabolomic; Renal Function
Boccard Julien, Schvartz Domitille, Codesido Santiago, Hanafi Mohamed, Gagnebin Yoric, Ponte Belén, Jourdan Fabien, Rudaz Serge (2021), Gaining Insights Into Metabolic Networks Using Chemometrics and Bioinformatics: Chronic Kidney Disease as a Clinical Model, in Frontiers in Molecular Biosciences
, 8, 13.
Gagnebin Yoric, Jaques David A., Rudaz Serge, de Seigneux Sophie, Boccard Julien, Ponte Belén (2020), Exploring blood alterations in chronic kidney disease and haemodialysis using metabolomics, in Scientific Reports
, 10(1), 19502-19502.
Jaques David A., Pruijm Menno, Ackermann Daniel, Vogt Bruno, Guessous Idris, Burnier Michel, Pechere-Bertschi Antoinette, Bochud Murielle, Ponte Belen (2020), Sodium Intake Is Associated With Renal Resistive Index in an Adult Population-Based Study, in Hypertension
, 76(6), 1898-1905.
Ponte Belen, Devuyst Olivier (2020), Circulating Uromodulin and Risk of Cardiovascular Events and Kidney Failure, in Clinical Journal of the American Society of Nephrology
, 15(5), 589-591.
Dhayat Nasser A, Pruijm Menno, Ponte Belen, Ackermann Daniel, Leichtle Alexander Benedikt, Devuyst Olivier, Ehret Georg, Guessous Idris, Pechère-Bertschi Antoinette, Pastor Johanne, Martin Pierre-Yves, Burnier Michel, Fiedler Georg-Martin, Vogt Bruno, Moe Orson W, Bochud Murielle, Fuster Daniel G (2020), Parathyroid Hormone and Plasma Phosphate Are Predictors of Soluble α-Klotho Levels in Adults of European Descent, in The Journal of Clinical Endocrinology & Metabolism
, 105(4), e1135-e1143.
Ponte Belen, Pruijm Menno, Pasch Andreas, Dufey-Teso Anne, Martin Pierre-Yves, de Seigneux Sophie (2020), Dialysis initiation improves calcification propensity, in Nephrology Dialysis Transplantation
, 35(3), 495-502.
Gagnebin Yoric, Pezzatti Julian, Lescuyer Pierre, Boccard Julien, Ponte Belen, Rudaz Serge (2020), Combining the advantages of multilevel and orthogonal partial least squares data analysis for longitudinal metabolomics: Application to kidney transplantation, in Analytica Chimica Acta
, 1099, 26-38.
Gagnebin Yoric, Pezzatti Julian, Lescuyer Pierre, Boccard Julien, Ponte* Belén, Rudaz* Serge (2019), Toward a better understanding of chronic kidney disease with complementary chromatographic methods hyphenated with mass spectrometry for improved polar metabolome coverage, in Journal of Chromatography B
, 1116, 9-18.
Deriaz Denis, Guessous Idris, Vollenweider Peter, Devuyst Olivier, Burnier Michel, Bochud Murielle, Ponte Belen (2019), Estimated 24-h urinary sodium and sodium-to-potassium ratio are predictors of kidney function decline in a population-based study, in Journal of Hypertension
Ackermann Daniel, Groessl Michael, Pruijm Menno, Ponte Belen, Escher Geneviève, d’Uscio Claudia H., Guessous Idris, Ehret Georg, Pechère-Bertschi Antoinette, Martin Pierre-Yves, Burnier Michel, Dick Bernhard, Vogt Bruno, Bochud Murielle, Rousson Valentin, Dhayat Nasser A. (2019), Reference intervals for the urinary steroid metabolome: The impact of sex, age, day and night time on human adult steroidogenesis, in PLOS ONE
, 14(3), e0214549-e0214549.
Gagnebin Yoric, Julien Boccard, Belén Ponte, Serge Rudaz (2018), Metabolomics in chronic kidney disease: Strategies for extended metabolome coverage, in Journal of Pharmaceutical and Biomedical Analysis
, 161, 313-325.
Chronic kidney disease (CKD) is associated with increased mortality and morbidity. Currently, the estimation of renal function (RF) is estimated by equations, which integrate serum creatinine to calculate a glomerular filtration rate (GFR). A GFR<60ml/min is considered as CKD independently of the age or the presence of any associated complications. However, by using equations, the prevalence of CKD has dramatically increased in the elderly population. Whether the decline in GFR in elderly is really associated with complications associated with CKD is not clear so far. There are some evidences that RF decreases with age as shown by some functional, structural and morphological changes. However, we should find more comprehensive markers of RF which are not restrain to GFR only. The identification of new biomarkers is not only necessary to detect CKD at an early stage or to be more specific about its detection, it is also an approach to find new biological pathways helping understanding disease mechanisms. The availability of mass spectrometers to perform metabolomic analysis in blood, urine or tissue, has led to numerous findings and the discovery of many proteins. However, for some of them, their true function and their relation with the kidney still need to be determined. Whether metabolomic analysis will help understanding and predicting age-related RF decline still needs to be determined. Efforts to understand the age-related changes and mechanisms would help identifying potential targets for early interventions aiming at preventing CKD-related morbidity and mortality. In addition, a better understanding of age-related RF decline would help clarifying whenever such decline should be considered as worrisome. In this project, we aim at using metabolomic analyses to understand the decline of RF associated with ageing and see whether CKD patients exhibit different metabolic profiles that patients without CKD or RF decline.