Project

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Impact of chronic metabolic stress on T cell function

English title Impact of chronic metabolic stress on T cell function
Applicant Löliger Jordan
Number 171143
Funding scheme MD-PhD fellowships (funded by SNSF)
Research institution
Institution of higher education University of Basel - BS
Main discipline Immunology, Immunopathology
Start/End 01.01.2017 - 31.12.2019
Approved amount 180'000.00
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All Disciplines (2)

Discipline
Immunology, Immunopathology
Nutritional Research, Vitaminology

Keywords (6)

immunology; immunometabolism; chronic low-grade inflammation; Type 2 diabetes; metabolic syndrome; T cells

Responsible applicant and co-applicants

Publications

Publication
SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1–Nrf2
Burgener Anne-Valérie, Bantug Glenn R., Meyer Benedikt J., Higgins Rebecca, Ghosh Adhideb, Bignucolo Olivier, Ma Eric H., Loeliger Jordan, Unterstab Gunhild, Geigges Marco, Steiner Rebekah, Enamorado Michel, Ivanek Robert, Hunziker Danielle, Schmidt Alexander, Müller-Durovic Bojana, Grählert Jasmin, Epple Raja, Dimeloe Sarah, Lötscher Jonas, Sauder Ursula, Ebnöther Monika, Burger Bettina, Heijnen Ingmar, et al. (2019), SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1–Nrf2, in Nature Immunology, 20(10), 1311-1321.
Tumor-derived TGF-β inhibits mitochondrial respiration to suppress IFN-γ production by human CD4 + T cells
Dimeloe Sarah, Gubser Patrick, Loeliger Jordan, Frick Corina, Develioglu Leyla, Fischer Marco, Marquardsen Florian, Bantug Glenn R., Thommen Daniela, Lecoultre Yannic, Zippelius Alfred, Langenkamp Anja, Hess Christoph (2019), Tumor-derived TGF-β inhibits mitochondrial respiration to suppress IFN-γ production by human CD4 + T cells, in Science Signaling, 12(599), eaav3334-eaav3334.
Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8 + T Cells
Bantug Glenn R., Fischer Marco, Grählert Jasmin, Balmer Maria L., Unterstab Gunhild, Develioglu Leyla, Steiner Rebekah, Zhang Lianjun, Costa Ana S.H., Gubser Patrick M., Burgener Anne-Valérie, Sauder Ursula, Löliger Jordan, Belle Réka, Dimeloe Sarah, Lötscher Jonas, Jauch Annaïse, Recher Mike, Hönger Gideon, Hall Michael N., Romero Pedro, Frezza Christian, Hess Christoph (2018), Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8 + T Cells, in Immunity, 48(3), 542-555.e6.

Collaboration

Group / person Country
Types of collaboration
Russlle Jones, McGill University, Montreal Canada (North America)
- in-depth/constructive exchanges on approaches, methods or results

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
MD-PhD Retreat 2019 Individual talk The rolle of PHGDH in immune cell subsets and beyond 13.11.2019 Kandersteg, Switzerland Löliger Jordan;
University of Basel Immunology Community Retreat (UBICO) 2019 Individual talk Memory T cells are serine auxotrophs 25.03.2019 Engelberg, Switzerland Löliger Jordan;
DBM PhD retreat 2018 Poster Memory CD8 T cells are serine auxothrophs 07.06.2018 Einsiedeln, Switzerland Löliger Jordan;


Self-organised

Title Date Place
6th European MD-PhD conference and Swiss MD-PhD conference 13.10.2017 Basel (Departement of Biomedicine), Switzerland

Awards

Title Year
Preis für bestes Poster bei dem DBM (Departement Biomedizin) PhD Retreat 2018 2018

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