hematology; infectiology; medical microbiology; imaging; confocal laser scanning microscope
Gomariz Alvaro, Helbling Patrick M., Isringhausen Stephan, Suessbier Ute, Becker Anton, Boss Andreas, Nagasawa Takashi, Paul Grégory, Goksel Orcun, Székely Gábor, Stoma Szymon, Nørrelykke Simon F., Manz Markus G., Nombela-Arrieta César (2018), Quantitative spatial analysis of haematopoiesis-regulating stromal cells in the bone marrow microenvironment by 3D microscopy, in
Nature Communications, 9(1), 2532-2532.
Welin Amanda, Weber Stephen, Hilbi Hubert (2018), Quantitative Imaging Flow Cytometry of Legionella -Infected Dictyostelium Amoebae Reveals the Impact of Retrograde Trafficking on Pathogen Vacuole Composition, in
Applied and Environmental Microbiology, 84(11), e00158-18.
Steiner Bernhard, Weber Stephen, Kaech Andres, Ziegler Urs, Hilbi Hubert (2018), The large GTPase atlastin controls ER remodeling around a pathogen vacuole, in
Communicative & Integrative Biology, 11(2), 1-5.
Scaiola Alain, Peña Cohue, Weisser Melanie, Böhringer Daniel, Leibundgut Marc, Klingauf‐Nerurkar Purnima, Gerhardy Stefan, Panse Vikram Govind, Ban Nenad (2018), Structure of a eukaryotic cytoplasmic pre‐40S ribosomal subunit, in
The EMBO Journal, 37(7), e98499-e98499.
Swart A. Leoni, Harrison Christopher F., Eichinger Ludwig, Steinert Michael, Hilbi Hubert (2018), Acanthamoeba and Dictyostelium as Cellular Models for Legionella Infection, in
Frontiers in Cellular and Infection Microbiology, 8, 61.
Khajuria Rajiv K., Munschauer Mathias, Ulirsch Jacob C., Fiorini Claudia, Ludwig Leif S., McFarland Sean K., Abdulhay Nour J., Specht Harrison, Keshishian Hasmik, Mani D.R., Jovanovic Marko, Ellis Steven R., Fulco Charles P., Engreitz Jesse M., Schütz Sabina, Lian John, Gripp Karen W., Weinberg Olga K., Pinkus Geraldine S., Gehrke Lee, Regev Aviv, Lander Eric S., Gazda Hanna T., Lee Winston Y., et al. (2018), Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis, in
Cell, 173(1), 90-103.e19.
Steiner Bernhard, Weber Stephen, Hilbi Hubert (2018), Formation of the Legionella -containing vacuole: phosphoinositide conversion, GTPase modulation and ER dynamics, in
International Journal of Medical Microbiology, 308(1), 49-57.
Bärlocher Kevin, Hutter Cedric A. J., Swart A. Leoni, Steiner Bernhard, Welin Amanda, Hohl Michael, Letourneur François, Seeger Markus A., Hilbi Hubert (2017), Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5, in
Nature Communications, 8(1), 1543-1543.
Bärlocher Kevin, Welin Amanda, Hilbi Hubert (2017), Formation of the Legionella Replicative Compartment at the Crossroads of Retrograde Trafficking, in
Frontiers in Cellular and Infection Microbiology, 7, 482.
Steiner Bernhard, Swart Anna Leoni, Welin Amanda, Weber Stephen, Personnic Nicolas, Kaech Andres, Freyre Christophe, Ziegler Urs, Klemm Robin W, Hilbi Hubert (2017), ER remodeling by the large GTPase atlastin promotes vacuolar growth of Legionella pneumophila, in
EMBO reports, 18(10), 1817-1836.
Takizawa Hitoshi, Fritsch Kristin, Kovtonyuk Larisa V., Saito Yasuyuki, Yakkala Chakradhar, Jacobs Kurt, Ahuja Akshay K., Lopes Massimo, Hausmann Annika, Hardt Wolf-Dietrich, Gomariz Álvaro, Nombela-Arrieta César, Manz Markus G. (2017), Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness, in
Cell Stem Cell, 21(2), 225-240.e5.
Zhu Haiyan, Kwak Hyun-Jeong, Liu Peng, Bajrami Besnik, Xu Yuanfu, Park Shin-Young, Nombela-Arrieta Cesar, Mondal Subhanjan, Kambara Hiroto, Yu Hongbo, Chai Li, Silberstein Leslie E., Cheng Tao, Luo Hongbo R. (2017), Reactive Oxygen Species–Producing Myeloid Cells Act as a Bone Marrow Niche for Sterile Inflammation–Induced Reactive Granulopoiesis, in
The Journal of Immunology, 198(7), 2854-2864.
Hilbi Hubert, Nagai Hiroki, Kubori Tomoko, Roy Craig R. (2017),
Type IV Secretion in Gram-Negative and Gram-Positive Bacteria, Springer International Publishing, Cham.
Nombela-Arrieta Cesar, Manz Markus G. (2017), Quantification and three-dimensional microanatomical organization of the bone marrow, in
Blood Advances, 1(6), 407-416.
Nombela-Arrieta César, Isringhausen Stephan (2017), The Role of the Bone Marrow Stromal Compartment in the Hematopoietic Response to Microbial Infections, in
Frontiers in Immunology, 7, 689.
Life science research at the University of Zurich (UZH) and University Hospital Zurich (USZ) has a very broad scope. Of major importance are cellular and molecular aspects of various biological systems. Imaging is key to many of these research topics. Over the last years a number of new microscopy techniques (e.g. super resolution microscopy or selective plane illumination microscopy) have evolved that allow new approaches of fluorescent imaging of individual cells, tissue and whole organisms. However, classical 3D microscopy employing a confocal laser scanning microscope (CLSM) is still one of the most frequently and widely used approaches. New developments have made this well-established technique even more powerful: novel detectors allow for faster imaging with decreased phototoxicity at improved resolution. We would like to offer such a new CLSM for the life science research community at the University of Zurich and the University Hospital of Zurich. To this end, we propose to purchase an advanced, state-of-the-art CLSM and install it in the framework of the Center for Microscopy and Image Analysis (ZMB) at the Institute of Medical Microbiology, located at the city campus of the UZH/USZ.