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Multisensory integration and associative learning in thalamic circuits

Applicant Gründemann Jan
Number 170672
Funding scheme SNSF Professorships
Research institution Departement Biomedizin Universität Basel
Institution of higher education University of Basel - BS
Main discipline Neurophysiology and Brain Research
Start/End 01.01.2018 - 31.12.2021
Approved amount 1'428'107.00
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All Disciplines (2)

Discipline
Neurophysiology and Brain Research
Cellular Biology, Cytology

Keywords (6)

Associative learning; Multimodal sensory integration; Miniature microscope; Thalamus; Deep brain calcium imaging; Neuroscience

Lay Summary (German)

Lead
Multisensorische Integration in thalamischen neuronalen Schaltkreisen
Lay summary
Die Neurowissenschaften haben ein gutes Verständnis von Lernmechanismen und sensorischer Integration in höheren Hirnarealen wie dem Cortex. Ungeachtet dessen wissen wir nur wenig über die Rolle des Thalamus, dem sensorischen Hub unseres Gehirns, während  dieser Lernprozesse. Mittels neuer bildgebender Verfahren für tiefe Hirnstrukturen können wir nun zum ersten Mal multisensorische Integration und Verarbeitung im Thalamus auf dem Level von identifizierten einzelnen Neuronen sowie neuronalen Population während der Lernprozesse beobachten. Dies erlaubt uns generelle Konzepte thalamischer multisensorischer Signalverarbeitung neu zu betrachten und unser Verständnis der Rolle des Thalamus in Lernprozessen sowie neuronalen Erkrankungen wie generalisierte Angststörungen und Schizophrenie zu erforschen.
Direct link to Lay Summary Last update: 21.09.2017

Responsible applicant and co-applicants

Employees

Collaboration

Group / person Country
Types of collaboration
Prof Bernhard Bettler / Uni Basel Switzerland (Europe)
- Research Infrastructure
Prof Tania Rinaldi Barkat / Uni Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Prof Mark Schnitzer / Stanford University United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Prof Benjamin Grewe / Uni Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Fear Learning EPFL Symposium Talk given at a conference Auditory Response Plasticity in Thalamic Circuits 25.11.2019 Lausanne, Switzerland Gründemann Jan; Taylor James Alexander;
SFN Meeting Poster Auditory Response Plasticity in Thalamic Circuits 19.10.2019 Chicago, United States of America Hasegawa Masashi; Gründemann Jan;
Cold Spring Harbor Asia Meeting Talk given at a conference Imaging deep: Sensory and state coding in deep brain circuits 14.09.2019 Souzhou, China Gründemann Jan;
Neural Circuits Meeting Poster Auditory response plasticity in thalamic circuits 30.08.2019 Ascona, Switzerland Gründemann Jan;
Giessbach Neuroscience Meeting Talk given at a conference Sensory learning and state coding in deep brain areas 23.05.2019 Giessbach, Switzerland Gründemann Jan;
Neuroscience Winter Conference Talk given at a conference Sensory and state coding in subcortical circuits 31.03.2019 Solden, Austria Gründemann Jan;
COSYNE Talk given at a conference Amygdala ensembles dynamically encode behavioural states 27.02.2019 Lisbon, Portugal Gründemann Jan;
SNF Annual Meeting, San Diego Poster Amygdala neuronal ensembles dynamically encode behavioral states 03.11.2018 San Diego, United States of America Gründemann Jan;
Berkeley Neuroscience Seminar Individual talk Mapping the neuronal code of fear 02.11.2018 Berkeley, United States of America Gründemann Jan;
FENS Meeting Berlin 2018 Talk given at a conference Mapping the neuronal code of fear 07.07.2018 Berlin, Germany Gründemann Jan; Taylor James Alexander;
EPFL Neuroseminar Individual talk Mapping the neuronal code of fear 03.07.2018 EPFL Lausanne, Switzerland Gründemann Jan;
Giessbach Neuroscience Meeting Talk given at a conference Amygdala neuronal ensembles dynamically encode behavioral states 24.05.2018 Giessbach, Switzerland Gründemann Jan;
Joint Meeting of Austrian Neuroscience Consortia Talk given at a conference Calcium imaging to evaluate neural ensemble dynamics in freely moving animals using a miniature microscope 07.05.2018 Alpbach, Austria Gründemann Jan;


Communication with the public

Communication Title Media Place Year
Talks/events/exhibitions Brain Awareness Week German-speaking Switzerland 2019

Associated projects

Number Title Start Funding scheme
154765 Mapping the neuronal code of fear 01.01.2015 Ambizione

Abstract

Although we are starting to decipher how higher brain areas are involved in learning and memory, the role of sensory integration during associative learning in the brain’s major input hub, the thalamus, is only poorly understood. Novel deep brain imaging techniques will now allow us for the first time to investigate multimodal sensory integration and thalamic function on both, the cellular as well as population and computational level. This enables us to revisit and revise fundamental concepts of thalamic sensory function and broaden our understanding of the role of thalamus in learning and memory as well as associated diseases like generalised anxiety disorders and schizophrenia.
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