travellers; drug resistance; local population; extended-spectrum beta-lactamase; Enterobacteriaceae; colonization; food chain; environment; animals
Moser Aline I., Kuenzli Esther, Campos-Madueno Edgar I., Büdel Thomas, Rattanavong Sayaphet, Vongsouvath Manivanh, Hatz Christoph, Endimiani Andrea (2021), Antimicrobial-Resistant Escherichia coli Strains and Their Plasmids in People, Poultry, and Chicken Meat in Laos, in Frontiers in Microbiology
, 12, 1-15.
Moser Aline I, Kuenzli Esther, Büdel Thomas, Campos-Madueno Edgar I, Bernasconi Odette J, DeCrom-Beer Susan, Jakopp Barbara, Mohammed Ali Haji, Hassan Nadir Khatib, Fehr Jan, Zinsstag Jakob, Hatz Christoph, Endimiani Andrea (2020), Travellers returning from the island of Zanzibar colonized with MDR Escherichia coli strains: assessing the impact of local people and other sources., in The Journal of antimicrobial chemotherapy
Endimiani Andrea, Bernasconi Odette J., Büdel Thomas, Campos-Madueno Edgar I., Kuenzli Esther, Hatz Christoph, Carattoli Alessandra (2020), Whole-genome characterization of a Shewanella algae strain co-harboring blaCTX-M-15 and armA genes on a novel IncC plasmid, in Antimicrobial Agents and Chemotherapy
Büdel Thomas, Kuenzli Esther, Campos-Madueno Edgar I, Mohammed Ali Haji, Hassan Nadir Khatib, Zinsstag Jakob, Hatz Christoph, Endimiani Andrea (2020), On the island of Zanzibar people in the community are frequently colonized with the same MDR Enterobacterales found in poultry and retailed chicken meat, in Journal of Antimicrobial Chemotherapy
Büdel Thomas, Kuenzli Esther, Clément Mathieu, Bernasconi Odette J, Fehr Jan, Mohammed Ali Haji, Hassan Nadir Khatib, Zinsstag Jakob, Hatz Christoph, Endimiani Andrea (2019), Polyclonal gut colonization with extended-spectrum cephalosporin- and/or colistin-resistant Enterobacteriaceae: a normal status for hotel employees on the island of Zanzibar, Tanzania, in Journal of Antimicrobial Chemotherapy
Background - Extended-spectrum cephalosporin (ESC-R-Ent) and carbapenem-resistant Enterobacteriaceae (Carb-R-Ent) are an increasing problem worldwide. Moreover, the recent emergence of colistin-resistant Enterobacteriaceae (Col-R-Ent) carrying the plasmid-mediated mechanism mcr-1 represents another life-threatening attack of multidrug-resistant (MDR) bacteria against our antibiotic armamentarium. The importance of MDR Gram-negative bacteria (MDR GNB) was taken up in the Swiss Strategy “Antibiotikaresistenzen” (StAR) of the Swiss Government. While initially considered to be mainly health-care-related, the experience of recent years has shown that a high proportion of infections, especially with extended-spectrum ß-lactamase-producing Enterobacteriaceae (ESBL-Ent), are community-acquired. Among potential factors facilitating the emergence and the spread of these MDR GNB are the extensive use of antibiotics in animal farming and international travel. However, the exact impact of the different factors, as well as the underlying mechanism, is still poorly understood. An integrated “One Health” study on Swiss travellers to Tanzania and Thailand, local people working in the tourism industry, broiler chicken and chicken meat will provide new insights into the spread of ESC-R-, Carb-R-, and/or Col-R-Ent, not only through international travel but also at the human-human and the animal-human interface.Tanzania and Thailand are both major travel destinations for Swiss travellers. Travellers returning from these two countries are frequently colonized with ESBL-Ent. However, data regarding the spread of Col-R-Ent carrying mcr-1 in travellers are needed. Aim - To evaluate the impact of international travel on the spread of ESC-R-, Carb-R- and/or Col-R-Ent at the human-human- and animal-human interface.Objectives - i) Determining incidence and prevalence of colonization with ESC-R-, Carb-R and/or Col-R-Ent as well as associated risk factors in travellers, local people and chicken/chicken meat; ii) Comparing microbiological characteristics of the MDR Enterobacteriaceae found in the host groups and evaluate them with regard to potential transmission dynamics.Setting - Recruiting Travel Clinics: Zurich and Basel. Microbiological analyses: Institute for Infectious Diseases, University of Bern. Local collaborators: Zanzibar Food and Drug Board, Zanzibar Ministry of Health, Tanzania, and Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.Participants - Travellers presenting for pre-travel medical advice at the travel clinics in Zurich and Basel. Healthy people working in the tourism industry in Tanzania and Thailand. Broiler chicken and chicken meat produced and sold locally.Study Design - The study includes a cohort study in travellers and a cross-sectional study of the population, chicken and chicken meat locally, assessing i) the colonization incidence in travellers as well as the colonization prevalence in the local population and associated risk factors; ii) colonization prevalence in broiler chicken and chicken meat. Expected Outcome - Incidence and prevalence of colonization in travellers and the local population and associated animal source risk factors. Knowledge and epidemiological pattern of microbiological characteristics, genetic distances and homologies (sequencing types, resistance genes and plasmids) of the Enterobacteriaceae found in travellers, local people, broiler chicken and chicken meat.