Project

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A stimuli responsive disassembly strategy as versatile tool for analytical applications

English title A stimuli responsive disassembly strategy as versatile tool for analytical applications
Applicant Zelder Felix
Number 169216
Funding scheme Project funding
Research institution Institut für Chemie Universität Zürich
Institution of higher education University of Zurich - ZH
Main discipline Inorganic Chemistry
Start/End 01.01.2017 - 28.02.2021
Approved amount 253'209.00
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Keywords (4)

biologically important analytes; Reaction based probe; Disassembly Strategy; fluorescence detection

Lay Summary (German)

Lead
Das Forschungsprojekt hat das Ziel, neue Verbindungen für die Detektion biologisch wichtiger Stoffe in lebenden Systemen zu entwickeln.
Lay summary

Die Verwendung von fluoreszierenden, molekularen Sonden spielt eine wichtige Rolle für die Aufklärung biologischer Prozesse.
Das Ziel dieses Projektes ist es, neue Verbindungen zu entwickeln, die schwierige, biologische Targets selektiv adressieren und detektieren können.
Es wird erwartet, dass die Ergebnisse neue Einblicke in wichtige metabolische Prozesse gewähren werden.

Direct link to Lay Summary Last update: 09.11.2016

Responsible applicant and co-applicants

Employees

Name Institute

Publications

Publication
Induced fit activity-based sensing: a mechanistic study of pyrophosphate detection with a “flexible” Fe-salen complex
Yadav Prerna, Blacque Olivier, Roodt Andreas, Zelder Felix (2021), Induced fit activity-based sensing: a mechanistic study of pyrophosphate detection with a “flexible” Fe-salen complex, in Inorganic Chemistry Frontiers, asap.
Fe III –Salen‐Based Probes for the Selective and Sensitive Detection of E450 in Foodstuff
Yadav Prerna, Jakubaszek Marta, Spingler Bernhard, Goud Bruno, Gasser Gilles, Zelder Felix (2020), Fe III –Salen‐Based Probes for the Selective and Sensitive Detection of E450 in Foodstuff, in Chemistry – A European Journal, 26(25), 5717-5723.
Metal-Salen-based Probes for the Selective Detection of Phosphates via a Disassembly Approach
Yadav Prerna, Zelder Felix (2020), Metal-Salen-based Probes for the Selective Detection of Phosphates via a Disassembly Approach, in CHIMIA International Journal for Chemistry, 74(4), 252-256.

Collaboration

Group / person Country
Types of collaboration
Blacque Switzerland (Europe)
- Publication
Prof. Gasser/ University of Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel
Proof. Roodt South Africa (Africa)
- Publication

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Koordinationschemikertreffen Talk given at a conference FeIII–salen based Probes for the Selective and Sensitive Detection of E450 in Foodstuff 03.03.2020 Freiburg, Germany Yadav Prerna;
Swiss Chemical Society (SCS) Fall Meeting Poster A Disassembly Approach for Imaging Endogenous Pyrophosphate in Living Cells using FeIII-Salen Complexes 06.09.2019 Zurich, Switzerland Yadav Prerna;
SABC15 Talk given at a conference FeIII-salen Complexes for Detecting Endogenous Pyrophosphate 03.06.2019 Nara, Japan Zelder Felix;
Koordinationschemikertreffen Poster A Disassembly Approach for Imaging Endogenous Pyrophosphate in Living Cells using FeIII-Salen Complexes 03.03.2019 München, Germany Yadav Prerna;
Swiss Chemcial Society (SCS) Fall Meeting Poster A Disassembly Approach for Imaging Endogenous Pyrophosphate in Living Cells using Iron-Salen Complexes 07.07.2018 Lausanne, Switzerland Yadav Prerna;
CHanalysis 2018 Talk given at a conference Disassembly of Metal-Salen Complexes for Pyrophosphate Detection” 12.04.2018 Beatenberg, Switzerland Zelder Felix;
Swiss Chemical Society (SCS) Fall Meeting Poster A Disassembly Approach for Imaging Endogenous Pyrophosphate in Living Cells using Metal-Salen Complexes 22.08.2017 Bern, Switzerland Yadav Prerna;


Awards

Title Year
Best Poster Presentation Award, SCS Fall Meeting 2019 at UZH/ Switzerland 2019

Abstract

The project `A Stimuli Responsive Disassembly Strategy as Versatile Tool for Analytical Applications` proposes a strategy for detecting biologically important analytes in vitro and in vivo. In particular, new chemical compounds will be developed as turn-on fluorescent probes for detecting biologically important analytes in cells.
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