polymer-lipid membranes; block copolymer membranes; block copolymer vesicles; amphiphilic block copolymers; self-assembly; controlled encapsulation and release; molecular recognition; smart surfaces
Gaitzsch Jens, Hirschi Stephan, Freimann Sven, Fotiadis Dimitrios, Meier Wolfgang (2019), Directed Insertion of Light-Activated Proteorhodopsin into Asymmetric Polymersomes from an ABC Block Copolymer, in Nano Letters
, 19(4), 2503-2508.
Garni Martina, Wehr Riccardo, Avsar Saziye Yorulmaz, John Christoph, Palivan Cornelia, Meier Wolfgang (2019), Polymer membranes as templates for bio-applications ranging from artificial cells to active surfaces, in European Polymer Journal
, 112, 346-364.
Konishcheva Evgeniia V., Daubian Davy, Rigo Serena, Meier Wolfgang P. (2019), Probing membrane asymmetry of ABC polymersomes, in Chemical Communications
, 55(8), 1148-1151.
Yorulmaz Avsar Saziye, Kyropoulou Myrto, Di Leone Stefano, Schoenenberger Cora-Ann, Meier Wolfgang P., Palivan Cornelia G. (2019), Biomolecules Turn Self-Assembling Amphiphilic Block Co-polymer Platforms Into Biomimetic Interfaces, in Frontiers in Chemistry
, 6(1), 1.
Idrissi Mohamed El, Meyer Claire Elsa, Zartner Luisa, Meier Wolfgang (2018), Nanosensors based on polymer vesicles and planar membranes: a short review, in Journal of Nanobiotechnology
, 16(1), 63-63.
Goers Roland, Thoma Johannes, Ritzmann Noah, Di Silvestro Alfredo, Alter Claudio, Gunkel-Grabole Gesine, Fotiadis Dimitrios, Müller Daniel J., Meier Wolfgang (2018), Optimized reconstitution of membrane proteins into synthetic membranes, in Communications Chemistry
, 1(1), 35-35.
Garni Martina, Einfalt Tomaz, Goers Roland, Palivan Cornelia G., Meier Wolfgang (2018), Live Follow-Up of Enzymatic Reactions Inside the Cavities of Synthetic Giant Unilamellar Vesicles Equipped with Membrane Proteins Mimicking Cell Architecture, in ACS Synthetic Biology
, 7(9), 2116-2125.
Gunkel-Grabole Gesine, Meier Wolfgang (2018), Biomimetic Polymer Architectures, in CHIMIA International Journal for Chemistry
, 72(7), 548-548.
Draghici Camelia, Mikhalevich Viktoria, Gunkel-Grabole Gesine, Kowal Justyna, Meier Wolfgang, Palivan Cornelia G. (2018), Biomimetic Planar Polymer Membranes Decorated with Enzymes as Functional Surfaces, in Langmuir
, 34(30), 9015-9024.
Gaitzsch Jens, Welsch Pascale C., Folini Jenny, Schoenenberger Cora-Ann, Anderson James C., Meier Wolfgang P. (2018), Revisiting monomer synthesis and radical ring opening polymerization of dimethylated MDO towards biodegradable nanoparticles for enzymes, in European Polymer Journal
, 101, 113-119.
Konishcheva Evgeniia, Daubian Davy, Gaitzsch Jens, Meier Wolfgang (2018), Synthesis of Linear ABC Triblock Copolymers and Their Self-Assembly in Solution, in Helvetica Chimica Acta
, 101(2), e1700287-e1700287.
Lanzilotto Angelo, Kyropoulou Myrto, Constable Edwin C., Housecroft Catherine E., Meier Wolfgang P., Palivan Cornelia G. (2018), Porphyrin-polymer nanocompartments: singlet oxygen generation and antimicrobial activity, in JBIC Journal of Biological Inorganic Chemistry
, 23(1), 109-122.
Gaitzsch Jens, Messager Lea, Morecroft Eloise, Meier Wolfgang (2017), Vesicles in Multiple Shapes: Fine-Tuning Polymersomes’ Shape and Stability by Setting Membrane Hydrophobicity, in Polymers
, 9(12), 483-483.
Mikhalevich Viktoria, Craciun Ioana, Kyropoulou Myrto, Palivan Cornelia G., Meier Wolfgang (2017), Amphiphilic Peptide Self-Assembly: Expansion to Hybrid Materials, in Biomacromolecules
, 18(11), 3471-3480.
Konishcheva Evgeniia V., Zhumaev Ulmas E., Kratt Maximilian, Oehri Valentin, Meier Wolfgang (2017), Complex Self-Assembly Behavior of Bis-hydrophilic PEO- b -PCL- b -PMOXA Triblock Copolymers in Aqueous Solution, in Macromolecules
, 50(18), 7155-7168.
Edlinger Christoph, Einfalt Tomaz, Spulber Mariana, Car Anja, Meier Wolfgang, Palivan Cornelia G. (2017), Biomimetic Strategy To Reversibly Trigger Functionality of Catalytic Nanocompartments by the Insertion of pH-Responsive Biovalves, in Nano Letters
, 17(9), 5790-5798.
Baumann Patric, Spulber Mariana, Fischer Ozana, Car Anja, Meier Wolfgang (2017), Investigation of Horseradish Peroxidase Kinetics in an “Organelle-Like” Environment, in Small
, 13(17), 1603943-1603943.
Gunkel-Grabole Gesine, Palivan Cornelia, Meier Wolfgang (2017), Nanostructured Surfaces through Immobilization of Self-Assembled Polymer Architectures Using Thiol-Ene Chemistry, in Macromolecular Materials and Engineering
, 302(4), 1600363-1600363.
Chuard Nicolas, Gasparini Giulio, Moreau Dimitri, Lörcher Samuel, Palivan Cornelia, Meier Wolfgang, Sakai Naomi, Matile Stefan (2017), Strain-Promoted Thiol-Mediated Cellular Uptake of Giant Substrates: Liposomes and Polymersomes, in Angewandte Chemie International Edition
, 56(11), 2947-2950.
Lörcher Samuel, Meier Wolfgang (2017), Cosolvent fractionation of PMOXA-b-PDMS-b-PMOXA: Bulk separation of triblocks from multiblocks, in European Polymer Journal
, 88, 575-585.
Konishcheva Evgeniia V., Zhumaev Ulmas E., Meier Wolfgang P. (2017), PEO- b -PCL- b -PMOXA Triblock Copolymers: From Synthesis to Microscale Polymersomes with Asymmetric Membrane, in Macromolecules
, 50(4), 1512-1520.
Liu Juan, Postupalenko Viktoriia, Lörcher Samuel, Wu Dalin, Chami Mohamed, Meier Wolfgang, Palivan Cornelia G. (2016), DNA-Mediated Self-Organization of Polymeric Nanocompartments Leads to Interconnected Artificial Organelles, in Nano Letters
, 16(11), 7128-7136.
Konishcheva Evgeniia, Häussinger Daniel, Lörcher Samuel, Meier Wolfgang (2016), Key aspects to yield low dispersity of PEO-b-PCL diblock copolymers and their mesoscale self-assembly, in European Polymer Journal
, 83, 300-310.
Vasquez Daniela, Einfalt Tomaz, Meier Wolfgang, Palivan Cornelia G. (2016), Asymmetric Triblock Copolymer Nanocarriers for Controlled Localization and pH-Sensitive Release of Proteins, in Langmuir
, 32(40), 10235-10243.
Harder Daniel, Hirschi Stephan, Ucurum Zöhre, Goers Roland, Meier Wolfgang, Müller Daniel J., Fotiadis Dimitrios (2016), Engineering a Chemical Switch into the Light-driven Proton Pump Proteorhodopsin by Cysteine Mutagenesis and Thiol Modification, in Angewandte Chemie International Edition
, 55(31), 8846-8849.
Garni Martina, Einfalt Tomaž, Lomora Mihai, Car Anja, Meier Wolfgang, Palivan Cornelia G. (2016), Artificial Organelles: Reactions inside Protein–Polymer Supramolecular Assemblies, in CHIMIA International Journal for Chemistry
, 70(6), 424-427.
Hirschi Stephan, Stauffer Mirko, Harder Daniel, Müller Daniel J., Meier Wolfgang, Fotiadis Dimitrios (2016), Engineering and Assembly of Protein Modules into Functional Molecular Systems, in CHIMIA International Journal for Chemistry
, 70(6), 398-401.
Zhang Xiaoyan, Lomora Mihai, Einfalt Tomaz, Meier Wolfgang, Klein Noreen, Schneider Dirk, Palivan Cornelia G. (2016), Active surfaces engineered by immobilizing protein-polymer nanoreactors for selectively detecting sugar alcohols, in Biomaterials
, 89, 79-88.
Töpper Tino, Lörcher Samuel, Weiss Florian, Müller Bert (2016), Tailoring the mass distribution and functional group density of dimethylsiloxane-based films by thermal evaporation, in APL Materials
, 4(5), 056101-056101.
Najer Adrian, Thamboo Sagana, Palivan Cornelia G., Beck Hans-Peter, Meier Wolfgang (2016), Giant Host Red Blood Cell Membrane Mimicking Polymersomes Bind Parasite Proteins and Malaria Parasites, in CHIMIA International Journal for Chemistry
, 70(4), 288-291.
Gunkel-Grabole Gesine, Car Anja, Naik Vikrant V., Marot Laurent, Ferk Gregor, Palivan Cornelia, Meier Wolfgang (2016), PEG Brushes on Porous, PDMS-Coated Surfaces and Their Interaction with Carbon Dioxide, in Macromolecular Chemistry and Physics
, 217(8), 966-973.
Najer Adrian, Wu Dalin, Nussbaumer Martin G., Schwertz Geoffrey, Schwab Anatol, Witschel Matthias C., Schäfer Anja, Diederich François, Rottmann Matthias, Palivan Cornelia G., Beck Hans-Peter, Meier Wolfgang (2016), An amphiphilic graft copolymer-based nanoparticle platform for reduction-responsive anticancer and antimalarial drug delivery, in Nanoscale
, 8(31), 14858-14869.
Palivan Cornelia G., Goers Roland, Najer Adrian, Zhang Xiaoyan, Car Anja, Meier Wolfgang (2016), Bioinspired polymer vesicles and membranes for biological and medical applications, in Chemical Society Reviews
, 45(2), 377-411.
Dinu Ionel A., Duskey Jason T., Car Anja, Palivan Cornelia G., Meier Wolfgang (2016), Engineered non-toxic cationic nanocarriers with photo-triggered slow-release properties, in Polymer Chemistry
, 7(20), 3451-3464.
The development of new systems able to produce desired molecules with spatial and temporal precision, to rapidly identify specific molecules, to generate multifunctional membranes, and to engineer devices at the nanometer scale represent a key strategy for various domains, including medicine, environmental science, catalysis, and electronics. Of particular interest are amphiphilic block copolymers that self-assemble in aqueous media into a variety of supramolecular assemblies with specific properties, and which can be tuned chemically to support their interfacing with bioactive compounds, such as proteins, enzymes and mimics. This bottom-up approach yields new soft, hybrid materials that benefit from the robustness of polymers and the functionality of biomolecules.We propose to synthesize new amphiphilic diblock and triblock copolymers with combined stimuli-responsive behaviour, and different functional end-groups that allow specific interactions with biomolecules. These amphiphilic functionalized copolymers will generate 3D supramolecular assemblies in solution (vesicles, micelles), and horizontally/vertically hybrid membranes (lipid-polymer and polymer-polymer) on solid supports. Structural changes in the synthetic superstructures by external stimuli (pH, light, temperature) will provide “on demand” release of bioactive compounds entrapped in the synthetic assemblies, or improve their accessibility through the membranes. The multifunctionality of the block copolymers should favour the formation of domains with specific properties, and the simultaneous interaction with different biomolecules to develop complex hybrid assemblies and membranes. In addition, molecular recognition interactions due to the presence of specific molecules exposed at the hydrophilic surface, as for example chiral molecules, will enable control of the self-assembled architecture.Such biomolecule-polymer supramolecular assemblies can support complex reactions in protected spaces at the nanoscale, and allow specific targeting approaches. Multifunctional membranes could function as tools for membrane protein characterization, and as new devices for biosensing. The combination of polymers with lipids, or of polymers with different properties in a variety of ratios and conditions, will provide an extended approach to modulate their phase separation for developing nanostructured interfaces. Inhomogeneity introduced at the surface level will support specific combination with a variety of bioactive molecules to engineer “smart” complex surfaces. A second approach to expand polymer membranes on pore-containing solid supports will generate domains of planar membranes with different flexibility and accessibility to support the simultaneous insertion of different types of membrane protein for the development of multifunctional membranes.