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Nanostructured Polymers

English title Nanostructured Polymers
Applicant Meier Wolfgang
Number 169189
Funding scheme Project funding
Research institution Physikalische Chemie Departement Chemie Universität Basel
Institution of higher education University of Basel - BS
Main discipline Physical Chemistry
Start/End 01.10.2016 - 30.09.2019
Approved amount 750'000.00
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Keywords (8)

polymer-lipid membranes; block copolymer membranes; block copolymer vesicles; amphiphilic block copolymers; self-assembly; controlled encapsulation and release; molecular recognition; smart surfaces

Lay Summary (German)

Lead
In der heutigen Forschung ist die Entwicklung oder Verbesserung von molekularen Strukturen für verschiedene Forschungsbereiche, wie beispielsweise in der Medizin und den Lebenswissenschaften, von herausragender Bedeutung. Es ist sehr erfolgsversprechend auf molekularer Ebene Informationen einzubauen, die an bestimmten Orten oder zu definierten Zeiten ausgenützt werden können. In dieser Hinsicht sind selbstorganisierte Strukturen aus amphiphilen Block-Copolymeren ein sehr wichtiges Forschungsgebiet, da diese in wässrigen Lösungen definierte Strukturen (z.B. Mizellen, Vesikel, künstliche Membranen) bilden können.
Lay summary
Unser Ziel ist es eine Reihe neuer Polymerstrukturen zu entwickeln, die es  erlauben eine gezielte Verkapselung und/oder Freisetzung von Molekülen, Wechselwirkung mit Zellen, sowie den Einbau biologischer oder synthetischer Kanäle. 
Mit unserem Ansatz erwarten wir neuartige Biohybridstrukturen, welche die Stabilität von Polymeren und die Funktionalität von Biomolekülen kombinieren.
Eine Stärke der Polymerchemie ist auch, dass zusätzliche Funktionalitäten in dünne Membranen eingebaut werden können. Das Material kann dann auf äussere Veränderung reagieren und so gezielt Wirkstoffe freisetzen oder ein eingeschlossenes Katalysatoren aktivieren. Ob Licht, Temperatur oder pH - je nachdem welches Polymer verwendet wird - kann jeder dieser Faktoren zu einer solchen Veränderung führen. Darüber hinaus werden Sensormoleküle oder Farbstoffe an das Polymer und deren selbstorganisierten Strukturen angebunden. Diese werden damit optisch sichtbar, ‚verfolgbar’ und können auch von Zellen erkannt und gezielt aufgenommen werden. Sind diese auch noch mit einem reaktiven Polymer ausgestattet, ist es beispielsweise auch möglich, eingeschlossene Katalysatoren gezielt in der Zelle zu aktivieren.
 
Direct link to Lay Summary Last update: 27.09.2016

Responsible applicant and co-applicants

Employees

Publications

Publication
Directed Insertion of Light-Activated Proteorhodopsin into Asymmetric Polymersomes from an ABC Block Copolymer
Gaitzsch Jens, Hirschi Stephan, Freimann Sven, Fotiadis Dimitrios, Meier Wolfgang (2019), Directed Insertion of Light-Activated Proteorhodopsin into Asymmetric Polymersomes from an ABC Block Copolymer, in Nano Letters, 19(4), 2503-2508.
Polymer membranes as templates for bio-applications ranging from artificial cells to active surfaces
Garni Martina, Wehr Riccardo, Avsar Saziye Yorulmaz, John Christoph, Palivan Cornelia, Meier Wolfgang (2019), Polymer membranes as templates for bio-applications ranging from artificial cells to active surfaces, in European Polymer Journal, 112, 346-364.
Probing membrane asymmetry of ABC polymersomes
Konishcheva Evgeniia V., Daubian Davy, Rigo Serena, Meier Wolfgang P. (2019), Probing membrane asymmetry of ABC polymersomes, in Chemical Communications, 55(8), 1148-1151.
Biomolecules Turn Self-Assembling Amphiphilic Block Co-polymer Platforms Into Biomimetic Interfaces
Yorulmaz Avsar Saziye, Kyropoulou Myrto, Di Leone Stefano, Schoenenberger Cora-Ann, Meier Wolfgang P., Palivan Cornelia G. (2019), Biomolecules Turn Self-Assembling Amphiphilic Block Co-polymer Platforms Into Biomimetic Interfaces, in Frontiers in Chemistry, 6(1), 1.
Nanosensors based on polymer vesicles and planar membranes: a short review
Idrissi Mohamed El, Meyer Claire Elsa, Zartner Luisa, Meier Wolfgang (2018), Nanosensors based on polymer vesicles and planar membranes: a short review, in Journal of Nanobiotechnology, 16(1), 63-63.
Optimized reconstitution of membrane proteins into synthetic membranes
Goers Roland, Thoma Johannes, Ritzmann Noah, Di Silvestro Alfredo, Alter Claudio, Gunkel-Grabole Gesine, Fotiadis Dimitrios, Müller Daniel J., Meier Wolfgang (2018), Optimized reconstitution of membrane proteins into synthetic membranes, in Communications Chemistry, 1(1), 35-35.
Live Follow-Up of Enzymatic Reactions Inside the Cavities of Synthetic Giant Unilamellar Vesicles Equipped with Membrane Proteins Mimicking Cell Architecture
Garni Martina, Einfalt Tomaz, Goers Roland, Palivan Cornelia G., Meier Wolfgang (2018), Live Follow-Up of Enzymatic Reactions Inside the Cavities of Synthetic Giant Unilamellar Vesicles Equipped with Membrane Proteins Mimicking Cell Architecture, in ACS Synthetic Biology, 7(9), 2116-2125.
Biomimetic Polymer Architectures
Gunkel-Grabole Gesine, Meier Wolfgang (2018), Biomimetic Polymer Architectures, in CHIMIA International Journal for Chemistry, 72(7), 548-548.
Biomimetic Planar Polymer Membranes Decorated with Enzymes as Functional Surfaces
Draghici Camelia, Mikhalevich Viktoria, Gunkel-Grabole Gesine, Kowal Justyna, Meier Wolfgang, Palivan Cornelia G. (2018), Biomimetic Planar Polymer Membranes Decorated with Enzymes as Functional Surfaces, in Langmuir, 34(30), 9015-9024.
Revisiting monomer synthesis and radical ring opening polymerization of dimethylated MDO towards biodegradable nanoparticles for enzymes
Gaitzsch Jens, Welsch Pascale C., Folini Jenny, Schoenenberger Cora-Ann, Anderson James C., Meier Wolfgang P. (2018), Revisiting monomer synthesis and radical ring opening polymerization of dimethylated MDO towards biodegradable nanoparticles for enzymes, in European Polymer Journal, 101, 113-119.
Synthesis of Linear ABC Triblock Copolymers and Their Self-Assembly in Solution
Konishcheva Evgeniia, Daubian Davy, Gaitzsch Jens, Meier Wolfgang (2018), Synthesis of Linear ABC Triblock Copolymers and Their Self-Assembly in Solution, in Helvetica Chimica Acta, 101(2), e1700287-e1700287.
Porphyrin-polymer nanocompartments: singlet oxygen generation and antimicrobial activity
Lanzilotto Angelo, Kyropoulou Myrto, Constable Edwin C., Housecroft Catherine E., Meier Wolfgang P., Palivan Cornelia G. (2018), Porphyrin-polymer nanocompartments: singlet oxygen generation and antimicrobial activity, in JBIC Journal of Biological Inorganic Chemistry, 23(1), 109-122.
Vesicles in Multiple Shapes: Fine-Tuning Polymersomes’ Shape and Stability by Setting Membrane Hydrophobicity
Gaitzsch Jens, Messager Lea, Morecroft Eloise, Meier Wolfgang (2017), Vesicles in Multiple Shapes: Fine-Tuning Polymersomes’ Shape and Stability by Setting Membrane Hydrophobicity, in Polymers, 9(12), 483-483.
Amphiphilic Peptide Self-Assembly: Expansion to Hybrid Materials
Mikhalevich Viktoria, Craciun Ioana, Kyropoulou Myrto, Palivan Cornelia G., Meier Wolfgang (2017), Amphiphilic Peptide Self-Assembly: Expansion to Hybrid Materials, in Biomacromolecules, 18(11), 3471-3480.
Complex Self-Assembly Behavior of Bis-hydrophilic PEO- b -PCL- b -PMOXA Triblock Copolymers in Aqueous Solution
Konishcheva Evgeniia V., Zhumaev Ulmas E., Kratt Maximilian, Oehri Valentin, Meier Wolfgang (2017), Complex Self-Assembly Behavior of Bis-hydrophilic PEO- b -PCL- b -PMOXA Triblock Copolymers in Aqueous Solution, in Macromolecules, 50(18), 7155-7168.
Biomimetic Strategy To Reversibly Trigger Functionality of Catalytic Nanocompartments by the Insertion of pH-Responsive Biovalves
Edlinger Christoph, Einfalt Tomaz, Spulber Mariana, Car Anja, Meier Wolfgang, Palivan Cornelia G. (2017), Biomimetic Strategy To Reversibly Trigger Functionality of Catalytic Nanocompartments by the Insertion of pH-Responsive Biovalves, in Nano Letters, 17(9), 5790-5798.
Investigation of Horseradish Peroxidase Kinetics in an “Organelle-Like” Environment
Baumann Patric, Spulber Mariana, Fischer Ozana, Car Anja, Meier Wolfgang (2017), Investigation of Horseradish Peroxidase Kinetics in an “Organelle-Like” Environment, in Small, 13(17), 1603943-1603943.
Nanostructured Surfaces through Immobilization of Self-Assembled Polymer Architectures Using Thiol-Ene Chemistry
Gunkel-Grabole Gesine, Palivan Cornelia, Meier Wolfgang (2017), Nanostructured Surfaces through Immobilization of Self-Assembled Polymer Architectures Using Thiol-Ene Chemistry, in Macromolecular Materials and Engineering, 302(4), 1600363-1600363.
Strain-Promoted Thiol-Mediated Cellular Uptake of Giant Substrates: Liposomes and Polymersomes
Chuard Nicolas, Gasparini Giulio, Moreau Dimitri, Lörcher Samuel, Palivan Cornelia, Meier Wolfgang, Sakai Naomi, Matile Stefan (2017), Strain-Promoted Thiol-Mediated Cellular Uptake of Giant Substrates: Liposomes and Polymersomes, in Angewandte Chemie International Edition, 56(11), 2947-2950.
Cosolvent fractionation of PMOXA-b-PDMS-b-PMOXA: Bulk separation of triblocks from multiblocks
Lörcher Samuel, Meier Wolfgang (2017), Cosolvent fractionation of PMOXA-b-PDMS-b-PMOXA: Bulk separation of triblocks from multiblocks, in European Polymer Journal, 88, 575-585.
PEO- b -PCL- b -PMOXA Triblock Copolymers: From Synthesis to Microscale Polymersomes with Asymmetric Membrane
Konishcheva Evgeniia V., Zhumaev Ulmas E., Meier Wolfgang P. (2017), PEO- b -PCL- b -PMOXA Triblock Copolymers: From Synthesis to Microscale Polymersomes with Asymmetric Membrane, in Macromolecules, 50(4), 1512-1520.
DNA-Mediated Self-Organization of Polymeric Nanocompartments Leads to Interconnected Artificial Organelles
Liu Juan, Postupalenko Viktoriia, Lörcher Samuel, Wu Dalin, Chami Mohamed, Meier Wolfgang, Palivan Cornelia G. (2016), DNA-Mediated Self-Organization of Polymeric Nanocompartments Leads to Interconnected Artificial Organelles, in Nano Letters, 16(11), 7128-7136.
Key aspects to yield low dispersity of PEO-b-PCL diblock copolymers and their mesoscale self-assembly
Konishcheva Evgeniia, Häussinger Daniel, Lörcher Samuel, Meier Wolfgang (2016), Key aspects to yield low dispersity of PEO-b-PCL diblock copolymers and their mesoscale self-assembly, in European Polymer Journal, 83, 300-310.
Asymmetric Triblock Copolymer Nanocarriers for Controlled Localization and pH-Sensitive Release of Proteins
Vasquez Daniela, Einfalt Tomaz, Meier Wolfgang, Palivan Cornelia G. (2016), Asymmetric Triblock Copolymer Nanocarriers for Controlled Localization and pH-Sensitive Release of Proteins, in Langmuir, 32(40), 10235-10243.
Engineering a Chemical Switch into the Light-driven Proton Pump Proteorhodopsin by Cysteine Mutagenesis and Thiol Modification
Harder Daniel, Hirschi Stephan, Ucurum Zöhre, Goers Roland, Meier Wolfgang, Müller Daniel J., Fotiadis Dimitrios (2016), Engineering a Chemical Switch into the Light-driven Proton Pump Proteorhodopsin by Cysteine Mutagenesis and Thiol Modification, in Angewandte Chemie International Edition, 55(31), 8846-8849.
Artificial Organelles: Reactions inside Protein–Polymer Supramolecular Assemblies
Garni Martina, Einfalt Tomaž, Lomora Mihai, Car Anja, Meier Wolfgang, Palivan Cornelia G. (2016), Artificial Organelles: Reactions inside Protein–Polymer Supramolecular Assemblies, in CHIMIA International Journal for Chemistry, 70(6), 424-427.
Engineering and Assembly of Protein Modules into Functional Molecular Systems
Hirschi Stephan, Stauffer Mirko, Harder Daniel, Müller Daniel J., Meier Wolfgang, Fotiadis Dimitrios (2016), Engineering and Assembly of Protein Modules into Functional Molecular Systems, in CHIMIA International Journal for Chemistry, 70(6), 398-401.
Active surfaces engineered by immobilizing protein-polymer nanoreactors for selectively detecting sugar alcohols
Zhang Xiaoyan, Lomora Mihai, Einfalt Tomaz, Meier Wolfgang, Klein Noreen, Schneider Dirk, Palivan Cornelia G. (2016), Active surfaces engineered by immobilizing protein-polymer nanoreactors for selectively detecting sugar alcohols, in Biomaterials, 89, 79-88.
Tailoring the mass distribution and functional group density of dimethylsiloxane-based films by thermal evaporation
Töpper Tino, Lörcher Samuel, Weiss Florian, Müller Bert (2016), Tailoring the mass distribution and functional group density of dimethylsiloxane-based films by thermal evaporation, in APL Materials, 4(5), 056101-056101.
Giant Host Red Blood Cell Membrane Mimicking Polymersomes Bind Parasite Proteins and Malaria Parasites
Najer Adrian, Thamboo Sagana, Palivan Cornelia G., Beck Hans-Peter, Meier Wolfgang (2016), Giant Host Red Blood Cell Membrane Mimicking Polymersomes Bind Parasite Proteins and Malaria Parasites, in CHIMIA International Journal for Chemistry, 70(4), 288-291.
PEG Brushes on Porous, PDMS-Coated Surfaces and Their Interaction with Carbon Dioxide
Gunkel-Grabole Gesine, Car Anja, Naik Vikrant V., Marot Laurent, Ferk Gregor, Palivan Cornelia, Meier Wolfgang (2016), PEG Brushes on Porous, PDMS-Coated Surfaces and Their Interaction with Carbon Dioxide, in Macromolecular Chemistry and Physics, 217(8), 966-973.
An amphiphilic graft copolymer-based nanoparticle platform for reduction-responsive anticancer and antimalarial drug delivery
Najer Adrian, Wu Dalin, Nussbaumer Martin G., Schwertz Geoffrey, Schwab Anatol, Witschel Matthias C., Schäfer Anja, Diederich François, Rottmann Matthias, Palivan Cornelia G., Beck Hans-Peter, Meier Wolfgang (2016), An amphiphilic graft copolymer-based nanoparticle platform for reduction-responsive anticancer and antimalarial drug delivery, in Nanoscale, 8(31), 14858-14869.
Bioinspired polymer vesicles and membranes for biological and medical applications
Palivan Cornelia G., Goers Roland, Najer Adrian, Zhang Xiaoyan, Car Anja, Meier Wolfgang (2016), Bioinspired polymer vesicles and membranes for biological and medical applications, in Chemical Society Reviews, 45(2), 377-411.
Engineered non-toxic cationic nanocarriers with photo-triggered slow-release properties
Dinu Ionel A., Duskey Jason T., Car Anja, Palivan Cornelia G., Meier Wolfgang (2016), Engineered non-toxic cationic nanocarriers with photo-triggered slow-release properties, in Polymer Chemistry, 7(20), 3451-3464.

Collaboration

Group / person Country
Types of collaboration
Cornelia Palivan /Uni Basel Chemistry Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
SNI Annual event Talk given at a conference Solid Supported Polymer-Lipids Hybrid Membranes as Bio-Interfaces for Improving the Activity of Proteins 12.09.2019 Lenzerheide, Switzerland Meier Wolfgang;
Swiss Soft Day (SSD25) Talk given at a conference Self-assembly of Peptide Nanoparticles for Efficient and Save DNA Delivery 27.08.2019 Zürich, Switzerland Meier Wolfgang;
Tethered membranes and other supramolecular architectures Talk given at a conference The many faces of self-assembling block copolymers from polymersomes to planar membranes 24.07.2019 Tulln, Austria Meier Wolfgang;
Nanoscience in the Snow Talk given at a conference Nanometer-sized 2D factories 25.01.2019 Braunwald, Switzerland Meier Wolfgang;
PCC symposium 2018 Poster Complex self-assembly of PEP-b-PEHOx: MCMs, pseudo-vesicles and yolk/shell nanoparticles 07.12.2018 Basel, Switzerland Meier Wolfgang; Gaitzsch Jens;
pcc Christmas Symposium Poster Microwave-Assisted Synthesis of PDMS-PMOXA as Amphiphilic Diblock Copolymer 07.12.2018 Basel, Switzerland Meier Wolfgang; Gaitzsch Jens; Wehr Riccardo Pascal;
Christmas Symposium at University of Basel Poster Reduction-Triggered Enzymatic Reaction in Subcompartmentalized Giant Polymersomes 07.12.2018 Basel, Switzerland Meier Wolfgang; Thamboo Sagana;
Seminar for Teachers Talk given at a conference Modern Research on Polymer Chemistry: Self-Assembly of Triblock Copolymers and Radical Ring-Opening Polymerisation 21.11.2018 Basel, Switzerland Meier Wolfgang; Gaitzsch Jens;
10th ECNP Conference Poster Radical Ring-Opening Polymerisation for Biodegradable Nanoparticles and Temporary Enzyme Protection 19.10.2018 San Sebastian , Spain Meier Wolfgang; Gaitzsch Jens;
10th ECNP Conference Poster ABC Triblock Copolymers in Self-Assembly: Creating Patches and Asymmetric Membranes for Protein Insertion 09.10.2018 San Sebastian , Spain Meier Wolfgang; Gaitzsch Jens;
The 4th International Conference on Bioinspired and Biobased Chemistry&Materials Talk given at a conference Biomimetic Assemblies based on Subcompartmentalized Giant Polymersomes 06.10.2018 Nice, France Thamboo Sagana; Meier Wolfgang;
Clariant Chemistry Day 2018 Poster New polymer membranes for bioethanol dehydration 04.10.2018 Basel, Switzerland Meier Wolfgang;
8th ECNP Pre-Conference and short Course Talk given at a conference Radical Ring-Opening Polymerisation for Biodegradable Nanoparticles and Temporary Enzyme Protection 01.10.2018 San Sebastian, Spain Gaitzsch Jens; Meier Wolfgang;
Swiss Soft Days, ETH Zürich Talk given at a conference Microwave-Assisted Synthesis of PDMS-b-PMOXA Diblock Copolymers 28.09.2018 Zürich, Switzerland Meier Wolfgang; Wehr Riccardo Pascal;
23rd edition of the Swiss Soft Days Poster Stimuli-responsive Assemblies based on Subcompartmentalized Giant Polymersomes 28.09.2018 Zürich, Switzerland Meier Wolfgang; Thamboo Sagana;
Swiss Soft Days 2018 Poster Self-assembling behaviour of poly(ethylene oxide)-block-poly(butylene oxide) (PEO-b-PBO) in aqueous media 28.09.2018 Zürich, Switzerland Gaitzsch Jens; John Christoph Marcel; Meier Wolfgang;
GDCh Fachgruppentagung Makromolekulare Chemie Talk given at a conference Bio-functional surfaces with polymeric nanoreactors that catalyze metabolic reactions 25.09.2018 Karsruhe, Germany Meier Wolfgang; Gunkel-Grabole Gesine;
SCS Fall Meeting 2018 Talk given at a conference Radical Ring-Opening Polymerisation for Biodegradable Nanoparticles and Temporary Enzyme Protection 07.09.2018 Lausanne, Switzerland Meier Wolfgang; Gaitzsch Jens;
SCS Fall Meeting 2018 Poster Microwave-Assisted Synthesis of PDMS-PMOXA as Amphiphilic Diblock Copolymer 07.09.2018 Lausanne, Switzerland Meier Wolfgang; Gaitzsch Jens; Wehr Riccardo Pascal;
Macro18-IUPAC World Polymer Congress Talk given at a conference Radical Ring-Opening Polymerisation for Biodegradable Nanoparticles and Temporary Enzyme Protection 03.07.2018 Cairns, Australia Meier Wolfgang; Gaitzsch Jens;
Macro18-IUPAC World Polymer Congress Talk given at a conference ABC Triblock Copolymers in Self-Assembly: Creating Patches and Asymmetric Membranes for Protein Insertion 03.07.2018 Cairns, Australia Meier Wolfgang; Gaitzsch Jens;
Novartis Individual talk Vesicles and Membranes formed by amphiphilic block copolymers 06.06.2018 Basel, Switzerland Meier Wolfgang;
NCCR Fellow Retreat 2018 Talk given at a conference Engineering Artificial Nanoreactors 29.05.2018 Magglingen, Switzerland Gaitzsch Jens; Meier Wolfgang;
NCCR Fellow Retreat 2018 Talk given at a conference Porphyrin polymer nanocompartments: Singlet oxygen generation and antimicrobial activity 28.05.2018 Magglingen, Switzerland Meier Wolfgang;
SamstagsUni Individual talk Nanomedizin 21.04.2018 Sissach, Switzerland Meier Wolfgang;
Swiss Soft Days, Paul Sherrer Institut Talk given at a conference Light responsive polymer nanocompartments 02.03.2018 Villingen, Switzerland Meier Wolfgang;
Ringberg Castle Symposium 2017 on 4D Molecular Systems Engineering Talk given at a conference Functional Polymer Membranes 17.12.2017 Ringberg Castle,, Germany Meier Wolfgang;
EDC 2017 Talk given at a conference Functional Polymer Membranes 18.10.2017 Berlin, Germany Meier Wolfgang;
Industry Meeting (Mifa AG) Talk given at a conference Polymer Membranes 29.09.2017 Frenkendorf, Switzerland Meier Wolfgang;
SNI-Meeting Talk given at a conference Functional Polymer Membranes 06.09.2017 Lenzerheide, Switzerland Meier Wolfgang;
International Conference on Molecular Systems Engineering Talk given at a conference Functional surfaces with nanometer-sized polymeric reaction compartments 29.08.2017 Basel, Switzerland Meier Wolfgang;
ACS Fall
Meeting Poster Radical Ring-Opening Polymerisation:
New and Improved Monomoer Synthesis for Biodegradable Vesicles from Polyesters 22.08.2017 Washington D.C, United States of America Meier Wolfgang; Gaitzsch Jens;
ACS Fall Meeting Talk given at a conference Patchy and Degradable Polymersomes Enabled by a Miktoarm Star Terpolymers and Polypeptoids 22.08.2017 Washington D.C, Armenia Meier Wolfgang; Gaitzsch Jens;
Swiss Chemical Society Fall Meeting Talk given at a conference Functional surfaces through immobilization of polymersome nanocompartments 21.08.2017 Bern, Switzerland Gunkel-Grabole Gesine; Meier Wolfgang; Lörcher Samuel;
NCCR Molecular Systems Engineering - Lunch Meeting Talk given at a conference ABC Polymers and Protein insertion 19.07.2017 Basel, Switzerland Wehr Riccardo Pascal; Meier Wolfgang;
14th International Conference on N&N Talk given at a conference Biomimetic Planar Membranes decorated with Enzymes for Phenol Sensing 06.07.2017 Thesaloniki, Greece Meier Wolfgang;
European Polymer Congress Individual talk Polymersomes of an ABC Triblock Copolymer to
Produce Asymmetric Membranes 05.07.2017 Lyon, France Gaitzsch Jens; Meier Wolfgang;
European Polymer Congress Talk given at a conference Radical Ring-Opening-Polymerisation: New and Improved Monomer Synthesis for Biodegradable Polyesters 04.07.2017 Lyon, France Gaitzsch Jens; Meier Wolfgang;
New Horizon in Membranes Talk given at a conference Functional Polymer Membranes 04.06.2017 Frankfurt, Germany Meier Wolfgang;
NCCR Molecular Systems Engineering Retreat 2017 Talk given at a conference Engineering Artificial Nanoreactors with Undirectional Protein Insertion 04.05.2017 Grindelwald, Switzerland Meier Wolfgang; Gaitzsch Jens;
NCCR fellow retreat 2017 Talk given at a conference Porphyrin modules for singlet oxygen generation 03.05.2017 Grindelwald, Switzerland Meier Wolfgang;
Industry Meeting Talk given at a conference Polymer Membranes 15.02.2017 Basel, Switzerland Meier Wolfgang;
15th Swiss Snow Symposium Talk given at a conference Making Polymersomes Great Again - With the Help of Organic Chemistry 27.01.2017 Saas-Fee, Switzerland Gaitzsch Jens; Meier Wolfgang;
NCCR Technology Apero 2016 Poster Controlled Radical Ring Opening Polymerisation forSmart and Degradable Polyesters 10.11.2016 Basel, Switzerland Meier Wolfgang; Gaitzsch Jens;
3rd Technology Apero of the NCCR Molecular Systems Engineering: Molecular Machines: Chemistry Meet Biology 2016 Poster Bio-hybrid synthetic compartments 10.11.2016 Basel, Switzerland Meier Wolfgang;
1st Swiss Industrial Chemistry Symposium (SICS'16) Poster Cosolvent fractionation of PMOXA-PDMS-PMOXA: a bulk separation method of triblocks from multiblocks 28.10.2016 Basel, Switzerland Meier Wolfgang; Lörcher Samuel;


Communication with the public

Communication Title Media Place Year
Media relations: print media, online media Der Motor für molekulare Fabriken läuft International German-speaking Switzerland 2018
Video/Film From molecular hoovers and frameworks: A love story International German-speaking Switzerland 2018
Media relations: print media, online media http://barfi.ch/News-Basel/Der-Motor-fuer-molekulare-Fabriken-laeuft barfi.ch German-speaking Switzerland International 2018
Media relations: print media, online media Crowded Work: Enzyme Kinetics in an Organelle-Like Environment Advanced Science News International 2017
Media relations: print media, online media Die Welt ganz klein: Wolfgang Meiers Nano-Forschung Tages Woche International German-speaking Switzerland 2017
Media relations: print media, online media Forscher ahmen molekulares Gedränge nach bionity.com International German-speaking Switzerland 2017
Media relations: print media, online media Forscher ahmen molekulares Gedränge nach UniBasel webpage International German-speaking Switzerland 2017
Media relations: radio, television Molekulares Gedränge SRF German-speaking Switzerland International 2017
Media relations: print media, online media Steuerbare Nano-Kapseln dank Bioventil UniBasel webpage International German-speaking Switzerland 2017
Media relations: print media, online media Winzlinge mit Wirkungsmacht Tages Woche German-speaking Switzerland International 2017
Media relations: print media, online media Chemiker erzeugen durch Nachahmung der Natur Organellen-Cluster International German-speaking Switzerland 2016
Media relations: print media, online media Organellen-Cluster durch Nachahmung der Natur erzeugt LABO International German-speaking Switzerland 2016

Associated projects

Number Title Start Funding scheme
188392 Nanostructured Polymers 01.10.2019 Project funding
141825 NCCR MSE: Molecular Systems Engineering (phase I) 01.07.2014 National Centres of Competence in Research (NCCRs)
150059 Nanostructured Polymers 01.10.2013 Project funding

Abstract

The development of new systems able to produce desired molecules with spatial and temporal precision, to rapidly identify specific molecules, to generate multifunctional membranes, and to engineer devices at the nanometer scale represent a key strategy for various domains, including medicine, environmental science, catalysis, and electronics. Of particular interest are amphiphilic block copolymers that self-assemble in aqueous media into a variety of supramolecular assemblies with specific properties, and which can be tuned chemically to support their interfacing with bioactive compounds, such as proteins, enzymes and mimics. This bottom-up approach yields new soft, hybrid materials that benefit from the robustness of polymers and the functionality of biomolecules.We propose to synthesize new amphiphilic diblock and triblock copolymers with combined stimuli-responsive behaviour, and different functional end-groups that allow specific interactions with biomolecules. These amphiphilic functionalized copolymers will generate 3D supramolecular assemblies in solution (vesicles, micelles), and horizontally/vertically hybrid membranes (lipid-polymer and polymer-polymer) on solid supports. Structural changes in the synthetic superstructures by external stimuli (pH, light, temperature) will provide “on demand” release of bioactive compounds entrapped in the synthetic assemblies, or improve their accessibility through the membranes. The multifunctionality of the block copolymers should favour the formation of domains with specific properties, and the simultaneous interaction with different biomolecules to develop complex hybrid assemblies and membranes. In addition, molecular recognition interactions due to the presence of specific molecules exposed at the hydrophilic surface, as for example chiral molecules, will enable control of the self-assembled architecture.Such biomolecule-polymer supramolecular assemblies can support complex reactions in protected spaces at the nanoscale, and allow specific targeting approaches. Multifunctional membranes could function as tools for membrane protein characterization, and as new devices for biosensing. The combination of polymers with lipids, or of polymers with different properties in a variety of ratios and conditions, will provide an extended approach to modulate their phase separation for developing nanostructured interfaces. Inhomogeneity introduced at the surface level will support specific combination with a variety of bioactive molecules to engineer “smart” complex surfaces. A second approach to expand polymer membranes on pore-containing solid supports will generate domains of planar membranes with different flexibility and accessibility to support the simultaneous insertion of different types of membrane protein for the development of multifunctional membranes.
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