Project

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Physiology of pro-inflammatory cytokines and islet resident immune cells in insulin secretion

English title Physiology of pro-inflammatory cytokines and islet resident immune cells in insulin secretion
Applicant Donath Marc Yves
Number 166519
Funding scheme Project funding (Div. I-III)
Research institution Departement Biomedizin Universität Basel
Institution of higher education University of Basel - BS
Main discipline Immunology, Immunopathology
Start/End 01.04.2016 - 31.03.2019
Approved amount 600'000.00
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All Disciplines (4)

Discipline
Immunology, Immunopathology
Internal Medicine
Clinical Endocrinology
Pathophysiology

Keywords (2)

Diabetes; Inflammation

Lay Summary (French)

Lead
Au cours de nos études passées, nous avons démontré le rôle de l’inflammation dans le diabète de type 2. Cependant peu d’intérêt a été porté sur le possible rôle physiologique de l’inflammation.
Lay summary

L’objectif générale de l’étude proposée est d’étudier comment le system immunitaire inné contribue à l’adaptation des cellules qui produisent l’insuline dans différentes situations incluant l’apport de nourriture au cours d’un repas, ainsi que des situations stressantes comme l’obésité et le diabète.

Direct link to Lay Summary Last update: 25.03.2016

Responsible applicant and co-applicants

Employees

Publications

Publication
The role of IL-1 in postprandial fatigue
Lehrskov Louise L., Dorph Emma, Widmer Andrea M., Hepprich Matthias, Siegenthaler Judith, Timper Katharina, Donath Marc Y. (2018), The role of IL-1 in postprandial fatigue, in Molecular Metabolism, 12, 107-112.
β Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs β Cell Proliferation and Insulin Secretion
Böni-Schnetzler Marianne, Häuselmann Stéphanie P., Dalmas Elise, Meier Daniel T., Thienel Constanze, Traub Shuyang, Schulze Friederike, Steiger Laura, Dror Erez, Martin Praxedis, Herrera Pedro L., Gabay Cem, Donath Marc Y. (2018), β Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs β Cell Proliferation and Insulin Secretion, in Cell Reports, 22(7), 1774-1786.
The Role of Inflammation in β-cell Dedifferentiation
Nordmann Thierry M., Dror Erez, Schulze Friederike, Traub Shuyang, Berishvili Ekaterine, Barbieux Charlotte, Böni-Schnetzler Marianne, Donath Marc Y. (2017), The Role of Inflammation in β-cell Dedifferentiation, in Scientific Reports, 7(1), 6285-6285.
Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production
Dalmas Elise, Lehmann Frank M., Dror Erez, Wueest Stephan, Thienel Constanze, Borsigova Marcela, Stawiski Marc, Traunecker Emmanuel, Lucchini Fabrizio C., Dapito Dianne H., Kallert Sandra M., Guigas Bruno, Pattou Francois, Kerr-Conte Julie, Maechler Pierre, Girard Jean-Philippe, Konrad Daniel, Wolfrum Christian, Böni-Schnetzler Marianne, Finke Daniela, Donath Marc Y. (2017), Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production, in Immunity, 47(5), 928-942.e7.
Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation
Dror Erez, Dalmas Elise, Meier Daniel T, Wueest Stephan, Thévenet Julien, Thienel Constanze, Timper Katharina, Nordmann Thierry M, Traub Shuyang, Schulze Friederike, Item Flurin, Vallois David, Pattou Francois, Kerr-Conte Julie, Lavallard Vanessa, Berney Thierry, Thorens Bernard, Konrad Daniel, Böni-Schnetzler Marianne, Donath Marc Y (2017), Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation, in Nature Immunology, 18(3), 283-292.
Pancreatic α Cell-Derived Glucagon-Related Peptides Are Required for β Cell Adaptation and Glucose Homeostasis
Traub Shuyang, Meier Daniel T., Schulze Friederike, Dror Erez, Nordmann Thierry M., Goetz Nicole, Koch Norina, Dalmas Elise, Stawiski Marc, Makshana Valmir, Thorel Fabrizio, Herrera Pedro L., Böni-Schnetzler Marianne, Donath Marc Y. (2017), Pancreatic α Cell-Derived Glucagon-Related Peptides Are Required for β Cell Adaptation and Glucose Homeostasis, in Cell Reports, 18(13), 3192-3203.
Interleukin-1 antagonism in type 1 diabetes of long duration
Seelig E., Timper K., Falconnier C., Stoeckli R., Bilz S., Oram R., McDonald T.J., Donath M.Y. (2016), Interleukin-1 antagonism in type 1 diabetes of long duration, in Diabetes & Metabolism, 42(6), 453-456.
Glucose-Dependent Insulinotropic Peptide Stimulates Glucagon-Like Peptide 1 Production by Pancreatic Islets via Interleukin 6, Produced by α Cells
Timper Katharina, Dalmas Elise, Dror Erez, Rütti Sabine, Thienel Constanze, Sauter Nadine S., Bouzakri Karim, Bédat Benoit, Pattou Francois, Kerr-Conte Julie, Böni-Schnetzler Marianne, Donath Marc Y. (2016), Glucose-Dependent Insulinotropic Peptide Stimulates Glucagon-Like Peptide 1 Production by Pancreatic Islets via Interleukin 6, Produced by α Cells, in Gastroenterology, 151(1), 165-179.

Collaboration

Group / person Country
Types of collaboration
Prof. Pedro L. Herrera / Université de Genève Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Prof. Jens J. Brüning / University of Cologne Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Prof. Daniel Konrad, University of Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Prof. François Pattou, Université de Lille 2 France (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Prof. Andrew McKenzie, University of Cambridge Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Prof. Cem Gabay / Université de Genève Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication

Associated projects

Number Title Start Funding scheme
160766 Immunologic consequences of time-graded exposure to an 'obesity-diabetes milieu' 01.08.2015 Sinergia
164240 Understanding the PROtectiVe Inflammation in DiabEtes 01.01.2016 Project funding (Div. I-III)

Abstract

The deleterious role of chronic activation of the innate immune system in type 2 diabetes is well documented. However, little attention has been paid to a possible physiological role of the immune system in metabolism. The general objective of the present project is to uncover mechanisms on how the innate immune system contributes to the adaption of pancreatic islet function under various physiological and stressful (obesity and diabetes) situations
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