Project

Back to overview

Age-dependent Remodelling of the Female Heart - Protective or Detrimental?

English title Age-dependent Remodelling of the Female Heart - Protective or Detrimental?
Applicant Gebhard Catherine
Number 163892
Funding scheme SNSF Professorships
Research institution
Zentrum für Molekulare Kardiologie Universität Zürich
Institut für Nuklearmedizin Universitätsspital Zürich
Institution of higher education University of Zurich - ZH
Main discipline Cardiovascular Research
Start/End 01.06.2016 - 31.05.2020
Approved amount 1'599'531.00
Show all

Keywords (8)

Left ventricular function; Gender; Heart failure; Cardiac imaging; Sympathetic nervous system; Sex hormones; Age; Myocardial infarction

Lay Summary (German)

Lead
Neueste Studien zeigen, dass die Sterblichkeit bei Herzinsuffizienz (Herzmuskelschwäche) und nach Herzinfarkten bei Frauen deutlich höher liegt als bei Männern. Derzeit ist jedoch unzureichend erforscht, welche Besonderheiten der weibliche Herzmuskel, vor allem im Alter, aufweist und was ihn anfälliger für Erkrankungen macht. Dieses Projekt soll die bestehende Wissenslücke schließen.
Lay summary

Inhalt und Ziele des Forschungsprojektes

Erst kürzlich haben mehrere Studien gezeigt, dass sich Frauen- und Männerherzen im Alter unterschiedlich entwickeln. Während die Pumpfunktion des Herzens bei älteren Männern unverändert bleibt oder lediglich leicht abnimmt, wurde bei postmenopausalen Frauen eine starke Zunahme beobachtet. Warum es zu diesen Unterschieden kommt und inwiefern diese in Zusammenhang mit der erhöhten Sterblichkeit bei Frauen nach Herzinfarkt oder Herzschwäche stehen, ist nicht bekannt. Dieses Projekt untersucht  deshalb Mechanismen, die den oben genannten geschlechts-spezifischen Veränderungen des alternden Herzmuskels zugrunde liegen könnten. Hierzu zählen hormonelle Veränderungen im Alter und Unterschiede bei der Ausschüttung von Stresshormonen durch das vegetative Nervensystem. Komplementär dazu müssen auch geschlechts-spezifische Verhaltens- und Lebensweisen im Alter berücksichtigt werden. Ersteres wird anhand eines experimentellen Maus-Modelles untersucht werden, während der Zusammenhang zwischen Herzfunktion und Lifestyle im Rahmen einer klinischen Studie erforscht werden wird.

Wissenschaftlicher und gesellschaftlicher Kontext des Forschungsprojektes

Um die Besonderheiten des weiblichen Herzens und die Unterschiede zum männlichen Herz im Alter zu verstehen, ist es wichtig, die Reaktion des Herzens auf Geschlechts- und Stresshormone sowie Lifestyle-bedingte Einflüsse besser zu kennen. Bisherige Untersuchungen lieferten hierzu keine Daten, auch deswegen weil der Frauenanteil in herzbezogenen Studien bei nur 24% liegt. Unsere Untersuchungen werden dazu beitragen, Steuerungsmechanismen auf zellulärer Ebene zu finden, die für die erhöhte Sterblichkeit durch Herzerkrankungen bei Frauen verantwortlich sind. Dies wiederum wird die Entwicklung spezifischer und wirkungsvoller Behandlungsmethoden für Frauen ermöglichen.

Direct link to Lay Summary Last update: 29.05.2016

Responsible applicant and co-applicants

Employees

Publications

Publication
Myocardial 18F-FDG Uptake Pattern for Cardiovascular Risk Stratification in Patients Undergoing Oncologic PET/CT
Haider Ahmed, Bengs Susan, Schade Katharina, Wijnen Winandus J., Portmann Angela, Etter Dominik, Fröhlich Sandro, Warnock Geoffrey I., Treyer Valerie, Burger Irene A., Fiechter Michael, Kudura Ken, Fuchs Tobias A., Pazhenkottil Aju P., Buechel Ronny R., Kaufmann Philipp A., Meisel Alexander, Stolzmann Paul, Gebhard Catherine (2020), Myocardial 18F-FDG Uptake Pattern for Cardiovascular Risk Stratification in Patients Undergoing Oncologic PET/CT, in Journal of Clinical Medicine, 9(7), 2279-2279.
Women in radiology: why is the pipeline still leaking and how can we plug it?
Weigel Katharina S, Kubik-Huch Rahel A, Gebhard Catherine (2020), Women in radiology: why is the pipeline still leaking and how can we plug it?, in Acta Radiologica, 61(6), 743-748.
[ 18 F]Flurpiridaz: Facile and Improved Precursor Synthesis for this Next‐Generation Cardiac Positron Emission Tomography Imaging Agent
Ahmed Hazem, Haider Ahmed, Gisler Livio, Schibli Roger, Gebhard Catherine, Ametamey Simon M. (2020), [ 18 F]Flurpiridaz: Facile and Improved Precursor Synthesis for this Next‐Generation Cardiac Positron Emission Tomography Imaging Agent, in ChemMedChem, 15(12), 1040-1043.
Microvascular dysfunction and sympathetic hyperactivity in women with supra-normal left ventricular ejection fraction (snLVEF)
Maredziak Monika, Bengs Susan, Portmann Angela, Haider Ahmed, Wijnen Winandus J., Warnock Geoffrey I., Etter Dominik, Froehlich Sandro, Fiechter Michael, Meisel Alexander, Treyer Valerie, Fuchs Tobias A., Pazhenkottil Aju P., Buechel Ronny R., Kaufmann Philipp A., Gebhard Catherine (2020), Microvascular dysfunction and sympathetic hyperactivity in women with supra-normal left ventricular ejection fraction (snLVEF), in European Journal of Nuclear Medicine and Molecular Imaging, 1.
Imaging inflammation in atherosclerosis: Exploring all avenues
Haider Ahmed, Bengs Susan, Gebhard Catherine (2020), Imaging inflammation in atherosclerosis: Exploring all avenues, in Journal of Nuclear Cardiology, 1.
Increased long-term mortality in women with high left ventricular ejection fraction: data from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) long-term registry
Gebhard Catherine, Maredziak Monika, Messerli Michael, Buechel Ronny R, Lin Fay, Gransar Heidi, Achenbach Stephan, Al-Mallah Mouaz H, Andreini Daniele, Bax Jeroen J, Berman Daniel S, Budoff Matthew J, Cademartiri Filippo, Callister Tracy Q, Chang Hyuk-Jae, Chinnaiyan Kavitha, Chow Benjamin J W, Cury Ricardo C, DeLago Augustin, Feuchtner Gudrun, Hadamitzky Martin, Hausleiter Joerg, Kim Yong-Jin, Leipsic Jonathon, et al. (2020), Increased long-term mortality in women with high left ventricular ejection fraction: data from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) long-term registry, in European Heart Journal - Cardiovascular Imaging, 1.
Sex and gender in cardiovascular medicine: presentation and outcomes of acute coronary syndrome
Haider Ahmed, Bengs Susan, Luu Judy, Osto Elena, Siller-Matula Jolanta M, Muka Taulant, Gebhard Catherine (2019), Sex and gender in cardiovascular medicine: presentation and outcomes of acute coronary syndrome, in European Heart Journal, 1.
Sex-dependent association between inflammation, neural stress responses, and impaired myocardial function
Fiechter Michael, Haider Ahmed, Bengs Susan, Marędziak Monika, Burger Irene A., Roggo Andrea, Portmann Angela, Schade Katharina, Warnock Geoffrey I., Treyer Valerie, Messerli Michael, Fuchs Tobias A., Pazhenkottil Aju P., Buechel Ronny R., Kaufmann Philipp A., Gebhard Catherine (2019), Sex-dependent association between inflammation, neural stress responses, and impaired myocardial function, in European Journal of Nuclear Medicine and Molecular Imaging, 1.
Metabolic Activity in Central Neural Structures of Patients With Myocardial Injury
Fiechter Michael, Roggo Andrea, Haider Ahmed, Bengs Susan, Burger Irene A., Marędziak Monika, Portmann Angela, Treyer Valerie, Becker Anton S., Messerli Michael, Mühlematter Urs J., Kudura Ken, von Felten Elia, Benz Dominik C., Fuchs Tobias A., Gräni Christoph, Pazhenkottil Aju P., Buechel Ronny R., Kaufmann Philipp A., Gebhard Catherine (2019), Metabolic Activity in Central Neural Structures of Patients With Myocardial Injury, in Journal of the American Heart Association, 8(19), 1.
Association between vertebral bone mineral density, myocardial perfusion, and long-term cardiovascular outcomes: A sex-specific analysis
Fiechter Michael, Bengs Susan, Roggo Andrea, Haider Ahmed, Marędziak Monika, Portmann Angela, Treyer Valerie, Burger Irene A., Messerli Michael, Patriki Dimitri, von Felten Elia, Benz Dominik C., Fuchs Tobias A., Gräni Christoph, Pazhenkottil Aju P., Buechel Ronny R., Kaufmann Philipp A., Gebhard Catherine (2019), Association between vertebral bone mineral density, myocardial perfusion, and long-term cardiovascular outcomes: A sex-specific analysis, in Journal of Nuclear Cardiology, 1.
Heart rate reserve is a long-term risk predictor in women undergoing myocardial perfusion imaging
Gebhard Caroline E., Marędziak Monika, Portmann Angela, Bengs Susan, Haider Ahmed, Fiechter Michael, Herzog Bernhard A., Messerli Michael, Treyer Valerie, Kudura Ken, von Felten Elia, Benz Dominik C., Fuchs Tobias A., Gräni Christoph, Pazhenkottil Aju P., Buechel Ronny R., Kaufmann Philipp A., Gebhard Catherine (2019), Heart rate reserve is a long-term risk predictor in women undergoing myocardial perfusion imaging, in European Journal of Nuclear Medicine and Molecular Imaging, 1.
Sex Differences in the Association between Inflammation and Ischemic Heart Disease
Fiechter Michael, Haider Ahmed, Bengs Susan, Marȩdziak Monika, Burger Irene A., Roggo Andrea, Portmann Angela, Warnock Geoffrey I., Schade Katharina, Treyer Valerie, Becker Anton S., Messerli Michael, Felten Elia von, Benz Dominik C., Fuchs Tobias A., Gräni Christoph, Pazhenkottil Aju P., Buechel Ronny R., Kaufmann Philipp A., Gebhard Catherine (2019), Sex Differences in the Association between Inflammation and Ischemic Heart Disease, in Thrombosis and Haemostasis, 1.
Heart rate reserve during pharmacological stress is a significant negative predictor of impaired coronary flow reserve in women
Haider Ahmed, Bengs Susan, Maredziak Monika, Messerli Michael, Fiechter Michael, Giannopoulos Andreas A., Treyer Valerie, Schwyzer Moritz, Kamani Christel Hermann, Patriki Dimitri, von Felten Elia, Benz Dominik C., Fuchs Tobias A., Gräni Christoph, Pazhenkottil Aju P., Kaufmann Philipp A., Buechel Ronny R., Gebhard Catherine (2019), Heart rate reserve during pharmacological stress is a significant negative predictor of impaired coronary flow reserve in women, in European Journal of Nuclear Medicine and Molecular Imaging, 46(6), 1257-1267.
Benefits of a factorial design focusing on inclusion of female and male animals in one experiment
Buch Thorsten, Moos Katharina, Ferreira Filipa M., Fröhlich Holger, Gebhard Catherine, Tresch Achim (2019), Benefits of a factorial design focusing on inclusion of female and male animals in one experiment, in Journal of Molecular Medicine, 97(6), 871-877.
Association between resting amygdalar activity and abnormal cardiac function in women and men: a retrospective cohort study
Fiechter Michael, Roggo Andrea, Burger Irene A, Bengs Susan, Treyer Valerie, Becker Anton, Marȩdziak Monika, Haider Ahmed, Portmann Angela, Messerli Michael, Patriki Dimitri, Mühlematter Urs J, von Felten Elia, Benz Dominik C, Fuchs Tobias A, Gräni Christoph, Pazhenkottil Aju P, Buechel Ronny R, Kaufmann Philipp A, Gebhard Catherine (2019), Association between resting amygdalar activity and abnormal cardiac function in women and men: a retrospective cohort study, in European Heart Journal - Cardiovascular Imaging, 20(6), 625-632.
Association between beta-adrenoceptor antagonist-induced sympathicolysis and severity of coronary artery disease as assessed by coronary computed tomography angiography (CCTA)
Messerli Michael, Maredziak Monika, Bengs Susan, Haider Ahmed, Giannopoulos Andreas A., Schwyzer Moritz, Benz Dominik C., von Felten Elia, Kudura Ken, Treyer Valerie, Fiechter Michael, Gräni Christoph, Fuchs Tobias A., Pazhenkottil Aju P., Buechel Ronny R., Kaufmann Philipp A., Gebhard Catherine (2019), Association between beta-adrenoceptor antagonist-induced sympathicolysis and severity of coronary artery disease as assessed by coronary computed tomography angiography (CCTA), in The International Journal of Cardiovascular Imaging, 35(5), 927-936.
Enhanced radiation exposure associated with anterior–posterior X-ray tube position in young women undergoing cardiac computed tomography
Messerli Michael, Panadero Anne-Laurène, Giannopoulos Andreas A., Schwyzer Moritz, Benz Dominik C., Gräni Christoph, Bauer Ralf W., Pazhenkottil Aju P., Gaemperli Oliver, Buechel Ronny R., Kaufmann Philipp A., Gebhard Cathérine (2019), Enhanced radiation exposure associated with anterior–posterior X-ray tube position in young women undergoing cardiac computed tomography, in American Heart Journal, 1.
Quantification of intrathoracic fat adds prognostic value in women undergoing myocardial perfusion imaging
Haider Ahmed, Possner Mathias, Messerli Michael, Bengs Susan, Osto Elena, Maredziak Monika, Portmann Angela, Fiechter Michael, Giannopoulos Andreas A., Treyer Valerie, Gaisl Thomas, von Felten Elia, Patriki Dimitri, Benz Dominik C., Fuchs Tobias A., Gräni Christoph, Pazhenkottil Aju P., Buechel Ronny R., Kaufmann Philipp A., Gebhard Catherine (2019), Quantification of intrathoracic fat adds prognostic value in women undergoing myocardial perfusion imaging, in International Journal of Cardiology, 1.
Age- and sex-dependent changes in sympathetic activity of the left ventricular apex assessed by 18F-DOPA PET imaging
Gebhard Catherine (2018), Age- and sex-dependent changes in sympathetic activity of the left ventricular apex assessed by 18F-DOPA PET imaging, in Plos One, 1.
Temporal changes in outcomes of women and men undergoing percutaneous coronary intervention for chronic total occlusion: 2005–2013
Toma Aurel, Stähli Barbara E., Gick Michael, Ferenc Miroslaw, Mashayekhi Kambis, Buettner Heinz Joachim, Neumann Franz-Josef, Gebhard Catherine (2018), Temporal changes in outcomes of women and men undergoing percutaneous coronary intervention for chronic total occlusion: 2005–2013, in Clinical Research in Cardiology, 107(6), 449-459.
Sex differences in the long-term prognostic value of 13N-ammonia myocardial perfusion positron emission tomography
Gebhard Catherine, Fiechter Michael, Herzog Bernhard A., Lohmann Christine, Bengs Susan, Treyer Valerie, Messerli Michael, Benz Dominik C., Giannopoulos Andreas A., Gräni Christoph, Pazhenkottil Aju P., Buechel Ronny R., Kaufmann Philipp A. (2018), Sex differences in the long-term prognostic value of 13N-ammonia myocardial perfusion positron emission tomography, in European Journal of Nuclear Medicine and Molecular Imaging, 1.
Ischemic stroke across sexes: What is the status quo?
Liberale Luca, Carbone Federico, Montecucco Fabrizio, Gebhard Cathérine, Lüscher Thomas F., Wegener Susanne, Camici Giovanni G. (2018), Ischemic stroke across sexes: What is the status quo?, in Frontiers in Neuroendocrinology, 1.
Sex and age differences in the association of heart rate responses to adenosine and myocardial ischemia in patients undergoing myocardial perfusion imaging
Gebhard Catherine, Messerli Michael, Lohmann Christine, Treyer Valerie, Bengs Susan, Benz Dominik C., Giannopoulos Andreas A., Kudura Ken, von Felten Elia, Schwyzer Moritz, Gaemperli Oliver, Gräni Christoph, Pazhenkottil Aju P., Buechel Ronny R., Kaufmann Philipp A. (2018), Sex and age differences in the association of heart rate responses to adenosine and myocardial ischemia in patients undergoing myocardial perfusion imaging, in Journal of Nuclear Cardiology, 1.
Women and acute coronary syndromes: still up to no good
Gebhard Catherine (2017), Women and acute coronary syndromes: still up to no good, in European Heart Journal, 38(14), 1066-1068.
Imaging of cardiac sympathetic activity in heart failure: Not out of the woods yet
Gebhard Catherine (2017), Imaging of cardiac sympathetic activity in heart failure: Not out of the woods yet, in Journal of Nuclear Cardiology, 1.

Collaboration

Group / person Country
Types of collaboration
Center for Magnetic Resonance in Biology and Medicine, Aix-Marseille Université, France France (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Department of Neurology, Prof. Susanne Wegener Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Beaulieu-Saucier Pharmacogenomics Center, Montreal Heart Institute, Prof. Jean-Claude Tardif Canada (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Department of Nuclear Medicine, PET chemistry group, Prof. Philipp Kaufmann Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Experimental Imaging and Neuroenergetics, Institute of Pharmacology and Toxicology, Prof.Bruno Weber Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Weill Cornell Medical College, New York Presbyterian, New York, US, Prof. James Min United States of America (North America)
- Publication
University Heart Centre-Freiburg Bad Krozingen Germany (Europe)
- Publication
Institute for Gender in Medicine, Charité University Medicine, Berlin, Prof. Vera Regitz-Zagrosek Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Cardiometabolic Health, Institute of Social and Preventive Medicine (ISPM), University of Berne Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Centre for Radiopharmaceutical Science, ETH Zurich, Prof. Roger Schibli, Prof. Simon Ametamey Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Policlinique Médicale Universitaire Lausanne, Carole Clair, MD, MSc Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Radiochemistry and Imaging Science, Department of Chemistry, UZH, Prof. Jason Holland Switzerland (Europe)
- Research Infrastructure
Canadian Alliance for Healthy Hearts and Minds Canada (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Gender Medicine Unit, Medical University of Vienna, Austria, Prof. Alexandra Kautzky-Willer Austria (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
C3 Meeting Vienna Individual talk Update on non-invasice coronary imaging 16.02.2020 Vienna, Austria Gebhard Catherine;
International Society of Gender Medicine (IGM) Congress, Vienna, Austria Talk given at a conference Gender differences in heart-brain interactions: is it all in the mind? 05.07.2019 Vienna, Austria Gebhard Catherine;
UniBE Cluster for Cardiovascular Research Individual talk Ischemic Heart Disease: Do we Need a Gender-specific Treatment 04.07.2019 Bern, Switzerland Gebhard Catherine;
Annual Meeting of the European Association of Nuclear Medicine, Barcelona, Spain Talk given at a conference Sex Hormones Preserve Cardiac Sympathetic Integrity Following Myocardial Injury 28.06.2019 Barcelona, Spain Haider Ahmed; Gebhard Catherine;
Departementfortbildung Innere Medizin, Kantonsspital Baden Individual talk Männerherzen und Frauenherzen: Kleiner Unterschied – Grosse Folgen 01.05.2019 Baden, Switzerland Gebhard Catherine;
Annual Meeting of the German Society of Cardiology (DGK), Mannheim, Germany Talk given at a conference Quantification of intrathoracic fat adds prognostic value in women undergoing myocardial perfusion imaging 24.04.2019 Mannheim, Germany Haider Ahmed; Gebhard Catherine;
51st IDKD Diagnostic Imaging Courses Davos Talk given at a conference Imaging of Coronary Artery Disease in Women: How and When 03.04.2019 Davos, Switzerland Gebhard Catherine;
51st IDKD Diagnostic Imaging Courses Davos, Davos, Switzerland Talk given at a conference Women in Radiology – Why is the Pipeline Still Leaking and How can we Plug it? 03.04.2019 Davos, Switzerland Gebhard Catherine;
International Prostate Cancer Conference, Vienna, Austria Talk given at a conference Is Testosterone Prognostic? The Cardiologists Standpoint 30.03.2019 Vienna, Austria Gebhard Catherine;
Seminars on Drug Discovery and Development, ETH Zurich Individual talk Female and Male Heart Attacks: Do we Need a Gender-specific Treatment? 27.03.2019 Zurich, Switzerland Gebhard Catherine;
Jahreskongress der Schweizerischen Gesellschaft für Nuklearmedizin Talk given at a conference Age- and Sex-dependent Changes in Sympathetic Activity of the Left Ventricular Apex Assessed by 18F-DOPA PET Imaging 12.05.2018 Lausanne, Switzerland Gebhard Catherine;
18th Day of Clinical Research, University of Zurich Poster Age- and Sex-dependent Changes in Sympathetic Activity of the Left Ventricular Apex Assessed by 18F-DOPA PET Imaging 05.04.2018 Zurich, Switzerland Gebhard Catherine; Bengs Susan;
Antrittsvorlesung Individual talk Männerherzen und Frauenherzen: kleiner Unterschied – grosse Folgen 16.12.2017 Zürich, Switzerland Gebhard Catherine;
16th Day of Clinical Research, University Hospital Zurich Individual talk Wissenschaftliches Hauptreferat: Gender in Cardiovascular Disease: Back to Basics 09.02.2017 University Hospital Zurich, Switzerland Gebhard Catherine;


Self-organised

Title Date Place

Knowledge transfer events

Communication with the public

Communication Title Media Place Year
Media relations: radio, television Blick in die Feuilletons SRF2 German-speaking Switzerland 2020
Media relations: print media, online media Covid-19: Warum es Männer härter trifft. Apotheken-Umschau International 2020
Media relations: print media, online media Der Lockdown war männlich. Work Zeitung German-speaking Switzerland 2020
New media (web, blogs, podcasts, news feeds etc.) Der medizinische Prototyp war lange Zeit der Mann USZ Newsroom German-speaking Switzerland 2020
Media relations: print media, online media Frauenherzen ticken anders Vitagate.ch German-speaking Switzerland 2020
Media relations: radio, television Gendermedizin: Studiengang in der Schweiz entsteht SWR2 International 2020
New media (web, blogs, podcasts, news feeds etc.) Mit Herz und Hirn. USZ Newsletter German-speaking Switzerland 2020
Media relations: radio, television Schweiz plant Studiengang Gendermedizin Bayerischer Rundfunk International 2020
Media relations: print media, online media Warum eine geschlechtsspezifische Medizin wichtig ist Der Tagesspiegel German-speaking Switzerland 2020
Media relations: print media, online media Why more women than men have gotten Covid-19 during lockdown. Swissinfo International 2020
Media relations: print media, online media Wie der Lockdown den Gender Gap verschärft Tagesanzeiger German-speaking Switzerland 2020
Media relations: print media, online media Frauen zu wenig berücksichtigt und zu schlecht behandelt. Tages-Anzeiger German-speaking Switzerland 2019
Media relations: print media, online media Grosse Ignoranz beim kleinen Unterschied Beobachter.ch German-speaking Switzerland 2019
Print (books, brochures, leaflets) Infobroschüre der Schweizerischen Herzstiftung: Frauenherzen schlagen anders. German-speaking Switzerland Western Switzerland 2019
Media relations: print media, online media Vernachlässigte Frauenherzen. Sonntagszeitung.ch German-speaking Switzerland 2019
Media relations: print media, online media Von Megatrends und Wendepunkten: Sex und Gender in der Medizin Schweizerische Ärztezeitung German-speaking Switzerland 2019
Media relations: print media, online media Frauen sind anders krank als Männer – Die Medizin wendet sich den Frauen zu St. Galler Tagblatt German-speaking Switzerland 2018
Media relations: print media, online media Spezialistin für Gender-Medizin: «Frauen sind anders krank als Männer. Aargauer Zeitung German-speaking Switzerland 2018
Media relations: print media, online media Auch in der Medizin sind Frauen und Männer nicht gleich MediXblog German-speaking Switzerland 2017
Media relations: print media, online media Stimmt es, dass…..es männliche und weibliche Krankheiten gibt? University of Zurich Journal. 2017 German-speaking Switzerland 2017
Media relations: print media, online media Frauenherzen schlagen anders USZ Blog German-speaking Switzerland 2016

Awards

Title Year
Forschungskredit Postdoc, University of Zurich 2019
Kenneth Brown Award for Best Editorial, American Society of Nuclear Cardiology 2019

Associated projects

Number Title Start Funding scheme
189776 SAFIR - From the Prototype to the Full-Scale Scanner 01.09.2020 R'EQUIP
190074 Gender-Differences in Heart-Brain-Crosstalk: Role of Inflammation, Sympathetic Pathways, and Psychosocial Complexity 01.06.2020 SNSF Professorships

Abstract

Background: Clinical outcomes from acute coronary syndrome (ACS) and heart failure are consistently worse for women than men. The gender-specific environmental, molecular, and cellular variables that contribute to cardiovascular disease are largely unknown; patients are treated the same regardless of sex. There are significant sex- and age-specific differences in baseline left ventricular ejection fraction (LVEF), with a strong age-dependent increase in LVEF observed in healthy women but not in men. Given the prognostic importance of LVEF and its routine use in clinical decision making, understanding the variables that modulate myocardial contractility and vulnerability to cardiac injury in postmenopausal females and older males is of paramount importance so that personalized age- and gender-based therapies can be developed. We therefore intend to elucidate the impact of pathophysiological factors as well as gender specific behavior on left ventricular (LV) function in the aged heart. Our aims will be to characterize (1) the role of sex hormones and their receptors on age dependent LV remodeling, (2) gender and age differences in LV tolerance and adaption to ischemic myocardial injury, and (3) gender and age differences in the impact of adrenergic signaling on cardiac contractility in a murine experimental model. Moreover, we will assess (4) the impact of gender-specific behavior on LV remodeling with age in a prospective, multi-center cardiovascular magnetic resonance imaging (CMR) study in humans.Methods: We will study the extent to which sex- and age-related differences in cardiac function can be attributed to the direct myocardial influence of testosterone, estrogen, or relaxin in an in vivo model of gonadal hormone withdrawal and replacement. Myocardial contractility will be evaluated in vivo by serial CMR imaging, and LV tissue will be assessed using high-throughput and phenotypic assays to identify sex- and age-specific mediators. Subgroups of mice will be subjected to myocardial infarction (MI) at different ages to determine how age and sex influence responses to ischemic myocardial injury. The relationship between sympathetic innervation, sex hormones, and contractile function in aged female and male hearts under normal conditions and stress will be assessed by 11C-meta Hydroxyephedrine (mHED) positron emission tomography (PET) in mice. In a complementary epidemiological study, the impact of gender-specific behaviors on LV remodeling will be evaluated in a multi-ethnic cohort of nearly 10,000 healthy participants.Conclusion: Given the increasing proportion of women dying from cardiovascular disease, particularly in the aging population, it is imperative that we develop our knowledge of the aged female cardiovascular phenotype and its vulnerability to cardiovascular disease. This study will establish the pathophysiological basis of sex- and age-related differences in LV function and the impact of gender-based behavior on LVEF in a large-scale clinical trial. This work lays the foundation for age- and gender-specific individualized cardiac care and identifies new targets for intervention in future clinical trials.
-