Left ventricular function; Gender; Heart failure; Cardiac imaging; Sympathetic nervous system; Sex hormones; Age; Myocardial infarction
Haider Ahmed, Bengs Susan, Schade Katharina, Wijnen Winandus J., Portmann Angela, Etter Dominik, Fröhlich Sandro, Warnock Geoffrey I., Treyer Valerie, Burger Irene A., Fiechter Michael, Kudura Ken, Fuchs Tobias A., Pazhenkottil Aju P., Buechel Ronny R., Kaufmann Philipp A., Meisel Alexander, Stolzmann Paul, Gebhard Catherine (2020), Myocardial 18F-FDG Uptake Pattern for Cardiovascular Risk Stratification in Patients Undergoing Oncologic PET/CT, in
Journal of Clinical Medicine, 9(7), 2279-2279.
Weigel Katharina S, Kubik-Huch Rahel A, Gebhard Catherine (2020), Women in radiology: why is the pipeline still leaking and how can we plug it?, in
Acta Radiologica, 61(6), 743-748.
Ahmed Hazem, Haider Ahmed, Gisler Livio, Schibli Roger, Gebhard Catherine, Ametamey Simon M. (2020), [ 18 F]Flurpiridaz: Facile and Improved Precursor Synthesis for this Next‐Generation Cardiac Positron Emission Tomography Imaging Agent, in
ChemMedChem, 15(12), 1040-1043.
Maredziak Monika, Bengs Susan, Portmann Angela, Haider Ahmed, Wijnen Winandus J., Warnock Geoffrey I., Etter Dominik, Froehlich Sandro, Fiechter Michael, Meisel Alexander, Treyer Valerie, Fuchs Tobias A., Pazhenkottil Aju P., Buechel Ronny R., Kaufmann Philipp A., Gebhard Catherine (2020), Microvascular dysfunction and sympathetic hyperactivity in women with supra-normal left ventricular ejection fraction (snLVEF), in
European Journal of Nuclear Medicine and Molecular Imaging, 1.
Haider Ahmed, Bengs Susan, Gebhard Catherine (2020), Imaging inflammation in atherosclerosis: Exploring all avenues, in
Journal of Nuclear Cardiology, 1.
Gebhard Catherine, Maredziak Monika, Messerli Michael, Buechel Ronny R, Lin Fay, Gransar Heidi, Achenbach Stephan, Al-Mallah Mouaz H, Andreini Daniele, Bax Jeroen J, Berman Daniel S, Budoff Matthew J, Cademartiri Filippo, Callister Tracy Q, Chang Hyuk-Jae, Chinnaiyan Kavitha, Chow Benjamin J W, Cury Ricardo C, DeLago Augustin, Feuchtner Gudrun, Hadamitzky Martin, Hausleiter Joerg, Kim Yong-Jin, Leipsic Jonathon, et al. (2020), Increased long-term mortality in women with high left ventricular ejection fraction: data from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) long-term registry, in
European Heart Journal - Cardiovascular Imaging, 1.
Haider Ahmed, Bengs Susan, Luu Judy, Osto Elena, Siller-Matula Jolanta M, Muka Taulant, Gebhard Catherine (2019), Sex and gender in cardiovascular medicine: presentation and outcomes of acute coronary syndrome, in
European Heart Journal, 1.
Fiechter Michael, Haider Ahmed, Bengs Susan, Marędziak Monika, Burger Irene A., Roggo Andrea, Portmann Angela, Schade Katharina, Warnock Geoffrey I., Treyer Valerie, Messerli Michael, Fuchs Tobias A., Pazhenkottil Aju P., Buechel Ronny R., Kaufmann Philipp A., Gebhard Catherine (2019), Sex-dependent association between inflammation, neural stress responses, and impaired myocardial function, in
European Journal of Nuclear Medicine and Molecular Imaging, 1.
Fiechter Michael, Roggo Andrea, Haider Ahmed, Bengs Susan, Burger Irene A., Marędziak Monika, Portmann Angela, Treyer Valerie, Becker Anton S., Messerli Michael, Mühlematter Urs J., Kudura Ken, von Felten Elia, Benz Dominik C., Fuchs Tobias A., Gräni Christoph, Pazhenkottil Aju P., Buechel Ronny R., Kaufmann Philipp A., Gebhard Catherine (2019), Metabolic Activity in Central Neural Structures of Patients With Myocardial Injury, in
Journal of the American Heart Association, 8(19), 1.
Fiechter Michael, Bengs Susan, Roggo Andrea, Haider Ahmed, Marędziak Monika, Portmann Angela, Treyer Valerie, Burger Irene A., Messerli Michael, Patriki Dimitri, von Felten Elia, Benz Dominik C., Fuchs Tobias A., Gräni Christoph, Pazhenkottil Aju P., Buechel Ronny R., Kaufmann Philipp A., Gebhard Catherine (2019), Association between vertebral bone mineral density, myocardial perfusion, and long-term cardiovascular outcomes: A sex-specific analysis, in
Journal of Nuclear Cardiology, 1.
Gebhard Caroline E., Marędziak Monika, Portmann Angela, Bengs Susan, Haider Ahmed, Fiechter Michael, Herzog Bernhard A., Messerli Michael, Treyer Valerie, Kudura Ken, von Felten Elia, Benz Dominik C., Fuchs Tobias A., Gräni Christoph, Pazhenkottil Aju P., Buechel Ronny R., Kaufmann Philipp A., Gebhard Catherine (2019), Heart rate reserve is a long-term risk predictor in women undergoing myocardial perfusion imaging, in
European Journal of Nuclear Medicine and Molecular Imaging, 1.
Fiechter Michael, Haider Ahmed, Bengs Susan, Marȩdziak Monika, Burger Irene A., Roggo Andrea, Portmann Angela, Warnock Geoffrey I., Schade Katharina, Treyer Valerie, Becker Anton S., Messerli Michael, Felten Elia von, Benz Dominik C., Fuchs Tobias A., Gräni Christoph, Pazhenkottil Aju P., Buechel Ronny R., Kaufmann Philipp A., Gebhard Catherine (2019), Sex Differences in the Association between Inflammation and Ischemic Heart Disease, in
Thrombosis and Haemostasis, 1.
Haider Ahmed, Bengs Susan, Maredziak Monika, Messerli Michael, Fiechter Michael, Giannopoulos Andreas A., Treyer Valerie, Schwyzer Moritz, Kamani Christel Hermann, Patriki Dimitri, von Felten Elia, Benz Dominik C., Fuchs Tobias A., Gräni Christoph, Pazhenkottil Aju P., Kaufmann Philipp A., Buechel Ronny R., Gebhard Catherine (2019), Heart rate reserve during pharmacological stress is a significant negative predictor of impaired coronary flow reserve in women, in
European Journal of Nuclear Medicine and Molecular Imaging, 46(6), 1257-1267.
Buch Thorsten, Moos Katharina, Ferreira Filipa M., Fröhlich Holger, Gebhard Catherine, Tresch Achim (2019), Benefits of a factorial design focusing on inclusion of female and male animals in one experiment, in
Journal of Molecular Medicine, 97(6), 871-877.
Fiechter Michael, Roggo Andrea, Burger Irene A, Bengs Susan, Treyer Valerie, Becker Anton, Marȩdziak Monika, Haider Ahmed, Portmann Angela, Messerli Michael, Patriki Dimitri, Mühlematter Urs J, von Felten Elia, Benz Dominik C, Fuchs Tobias A, Gräni Christoph, Pazhenkottil Aju P, Buechel Ronny R, Kaufmann Philipp A, Gebhard Catherine (2019), Association between resting amygdalar activity and abnormal cardiac function in women and men: a retrospective cohort study, in
European Heart Journal - Cardiovascular Imaging, 20(6), 625-632.
Messerli Michael, Maredziak Monika, Bengs Susan, Haider Ahmed, Giannopoulos Andreas A., Schwyzer Moritz, Benz Dominik C., von Felten Elia, Kudura Ken, Treyer Valerie, Fiechter Michael, Gräni Christoph, Fuchs Tobias A., Pazhenkottil Aju P., Buechel Ronny R., Kaufmann Philipp A., Gebhard Catherine (2019), Association between beta-adrenoceptor antagonist-induced sympathicolysis and severity of coronary artery disease as assessed by coronary computed tomography angiography (CCTA), in
The International Journal of Cardiovascular Imaging, 35(5), 927-936.
Messerli Michael, Panadero Anne-Laurène, Giannopoulos Andreas A., Schwyzer Moritz, Benz Dominik C., Gräni Christoph, Bauer Ralf W., Pazhenkottil Aju P., Gaemperli Oliver, Buechel Ronny R., Kaufmann Philipp A., Gebhard Cathérine (2019), Enhanced radiation exposure associated with anterior–posterior X-ray tube position in young women undergoing cardiac computed tomography, in
American Heart Journal, 1.
Haider Ahmed, Possner Mathias, Messerli Michael, Bengs Susan, Osto Elena, Maredziak Monika, Portmann Angela, Fiechter Michael, Giannopoulos Andreas A., Treyer Valerie, Gaisl Thomas, von Felten Elia, Patriki Dimitri, Benz Dominik C., Fuchs Tobias A., Gräni Christoph, Pazhenkottil Aju P., Buechel Ronny R., Kaufmann Philipp A., Gebhard Catherine (2019), Quantification of intrathoracic fat adds prognostic value in women undergoing myocardial perfusion imaging, in
International Journal of Cardiology, 1.
Gebhard Catherine (2018), Age- and sex-dependent changes in sympathetic activity of the left ventricular apex assessed by 18F-DOPA PET imaging, in
Plos One, 1.
Toma Aurel, Stähli Barbara E., Gick Michael, Ferenc Miroslaw, Mashayekhi Kambis, Buettner Heinz Joachim, Neumann Franz-Josef, Gebhard Catherine (2018), Temporal changes in outcomes of women and men undergoing percutaneous coronary intervention for chronic total occlusion: 2005–2013, in
Clinical Research in Cardiology, 107(6), 449-459.
Gebhard Catherine, Fiechter Michael, Herzog Bernhard A., Lohmann Christine, Bengs Susan, Treyer Valerie, Messerli Michael, Benz Dominik C., Giannopoulos Andreas A., Gräni Christoph, Pazhenkottil Aju P., Buechel Ronny R., Kaufmann Philipp A. (2018), Sex differences in the long-term prognostic value of 13N-ammonia myocardial perfusion positron emission tomography, in
European Journal of Nuclear Medicine and Molecular Imaging, 1.
Liberale Luca, Carbone Federico, Montecucco Fabrizio, Gebhard Cathérine, Lüscher Thomas F., Wegener Susanne, Camici Giovanni G. (2018), Ischemic stroke across sexes: What is the status quo?, in
Frontiers in Neuroendocrinology, 1.
Gebhard Catherine, Messerli Michael, Lohmann Christine, Treyer Valerie, Bengs Susan, Benz Dominik C., Giannopoulos Andreas A., Kudura Ken, von Felten Elia, Schwyzer Moritz, Gaemperli Oliver, Gräni Christoph, Pazhenkottil Aju P., Buechel Ronny R., Kaufmann Philipp A. (2018), Sex and age differences in the association of heart rate responses to adenosine and myocardial ischemia in patients undergoing myocardial perfusion imaging, in
Journal of Nuclear Cardiology, 1.
Gebhard Catherine (2017), Women and acute coronary syndromes: still up to no good, in
European Heart Journal, 38(14), 1066-1068.
Gebhard Catherine (2017), Imaging of cardiac sympathetic activity in heart failure: Not out of the woods yet, in
Journal of Nuclear Cardiology, 1.
Background: Clinical outcomes from acute coronary syndrome (ACS) and heart failure are consistently worse for women than men. The gender-specific environmental, molecular, and cellular variables that contribute to cardiovascular disease are largely unknown; patients are treated the same regardless of sex. There are significant sex- and age-specific differences in baseline left ventricular ejection fraction (LVEF), with a strong age-dependent increase in LVEF observed in healthy women but not in men. Given the prognostic importance of LVEF and its routine use in clinical decision making, understanding the variables that modulate myocardial contractility and vulnerability to cardiac injury in postmenopausal females and older males is of paramount importance so that personalized age- and gender-based therapies can be developed. We therefore intend to elucidate the impact of pathophysiological factors as well as gender specific behavior on left ventricular (LV) function in the aged heart. Our aims will be to characterize (1) the role of sex hormones and their receptors on age dependent LV remodeling, (2) gender and age differences in LV tolerance and adaption to ischemic myocardial injury, and (3) gender and age differences in the impact of adrenergic signaling on cardiac contractility in a murine experimental model. Moreover, we will assess (4) the impact of gender-specific behavior on LV remodeling with age in a prospective, multi-center cardiovascular magnetic resonance imaging (CMR) study in humans.Methods: We will study the extent to which sex- and age-related differences in cardiac function can be attributed to the direct myocardial influence of testosterone, estrogen, or relaxin in an in vivo model of gonadal hormone withdrawal and replacement. Myocardial contractility will be evaluated in vivo by serial CMR imaging, and LV tissue will be assessed using high-throughput and phenotypic assays to identify sex- and age-specific mediators. Subgroups of mice will be subjected to myocardial infarction (MI) at different ages to determine how age and sex influence responses to ischemic myocardial injury. The relationship between sympathetic innervation, sex hormones, and contractile function in aged female and male hearts under normal conditions and stress will be assessed by 11C-meta Hydroxyephedrine (mHED) positron emission tomography (PET) in mice. In a complementary epidemiological study, the impact of gender-specific behaviors on LV remodeling will be evaluated in a multi-ethnic cohort of nearly 10,000 healthy participants.Conclusion: Given the increasing proportion of women dying from cardiovascular disease, particularly in the aging population, it is imperative that we develop our knowledge of the aged female cardiovascular phenotype and its vulnerability to cardiovascular disease. This study will establish the pathophysiological basis of sex- and age-related differences in LV function and the impact of gender-based behavior on LVEF in a large-scale clinical trial. This work lays the foundation for age- and gender-specific individualized cardiac care and identifies new targets for intervention in future clinical trials.