Nanomedicine; Computational chemistry; Cancer; Imaging; PET/MRI; Radiochemistry; Metal complexes; Fluorine; Synthesis; Oncogenic signaling; Coordination chemistry; Ligand
Guillou Amaury, Earley Daniel, Holland Jason P. (2020), Light‐Activated Protein Conjugation and 89 Zr‐Radiolabelling with Water‐Soluble Desferrioxamine Derivatives, in
Chemistry - A European Journal.
Klingler Simon, Fay Rachael, Holland Jason P. (2020), Light-induced radiosynthesis of 89ZrDFO-azepin-onartuzumab for imaging the hepatocyte growth factor receptor, in
The Journal of Nuclear Medicine.
Holland Jason P., Gut Melanie, Klingler Simon, Fay Rachael, Guillou Amaury (2020), Photochemical Reactions in the Synthesis of Protein–Drug Conjugates, in
Chemistry {\textendash} A European Journal, 26(1), 33-48.
Fay Rachael, Linden Anthony, Holland Jason P. (2020), PhotoTag: Photoactivatable Fluorophores for Protein Labeling, in
Organic Letters.
Holland Jason P. (2020), Predicting the Thermodynamic Stability of Zirconium Radiotracers, in
Inorganic Chemistry, 59, 2070-2082.
Varlow Cassis, Murrell Emily, Holland Jason P., Kassenbrock Alina, Shannon Whitney, Liang Steven H., Vasdev Neil, Stephenson Nickeisha (2020), Revisiting the Radiosynthesis of [
18F]FPEB and Preliminary PET Imaging in a Mouse Model of Alzheimer’s Disease, in
Molecules, 25(4), 982-982.
Patra Malay, Klingler Simon, Eichenberger Larissa S., Holland Jason P. (2019), Simultaneous Photoradiochemical Labeling of Antibodies for Immuno-Positron Emission Tomography, in
iScience, 13, 416-431.
Brown Christopher J. M., Gotsbacher Michael P., Holland Jason P., Codd Rachel (2019), endo-Hydroxamic Acid Monomers for the Assembly of a Suite of Non-native Dimeric Macrocyclic Siderophores Using Metal-Templated Synthesis, in
Inorganic Chemistry, 58, 13591-13603.
Patra Malay, Eichenberger Larissa S., Fischer Gregor, Holland Jason P. (2019), Frontispiece: Photochemical Conjugation and One-Pot Radiolabelling of Antibodies for Immuno-PET, in
Angewandte Chemie International Edition, 58, 1928-1933.
Patra Malay, Eichenberger Larissa S., Fischer Gregor, Holland Jason P. (2019), Frontispiz: Photochemische Konjugation und Eintopfradiomarkierung von Antikörpern für Immun-PET, in
Angewandte Chemie, 131, 1946-1951.
Lamb Jennifer, Fischer Eliane, Rosillo-Lopez Martin, Salzmann Christoph G., Holland Jason P. (2019), Multi-functionalised graphene nanoflakes as tumour-targeting theranostic drug-delivery vehicles, in
Chemical Science, 10, 8880-8888.
Eichenberger Larissa S., Patra Malay, Holland Jason P. (2019), Photoactive chelates for radiolabelling proteins, in
Chemical Communications, 55, 2257-2260.
Patra Malay, Eichenberger Larissa S., Fischer Gregor, Holland Jason P. (2019), Photochemical Conjugation and One-Pot Radiolabelling of Antibodies for Immuno-PET, in
Angewandte Chemie International Edition, 58, 1928-1933.
Patra Malay, Eichenberger Larissa S., Fischer Gregor, Holland Jason P. (2019), Photochemische Konjugation und Eintopfradiomarkierung von Antikörpern für Immun-PET, in
Angewandte Chemie, 131, 1946-1951.
Fay Rachael, Gut Melanie, Holland Jason P. (2019), Photoradiosynthesis of 68Ga-Labeled HBED-CC-Azepin-MetMAb for Immuno-PET of c-MET Receptors, in
Bioconjugate Chemistry, 30, 1814-1820.
Holland Jason P. (2019), Radiochemistry of Seldom-used Radionuclides in Nuclear Medicine, in Zeglis Brian M., Lewis Jason S., Windhorst Albert (ed.), Springer, New York, 1-651.
Gut Melanie, Holland Jason P. (2019), Synthesis and Photochemical Studies on Gallium and Indium Complexes of DTPA-PEG3-ArN3 for Radiolabeling Antibodies, in
Inorganic Chemistry, 58(18), 12302-12310.
Frei Angelo, Fischer Eliane, Childs Bradley Covington, Holland Jason P., Alberto Roger (2019), Two is better than one: difunctional high-affinity PSMA probes based on a [CpM(CO)3] (M = Re/99mTc) scaffold, in
Dalton Transactions, 48, 14600-14605.
Weinmann Christian, Holland Jason P., Läppchen Tilman, Scherer Harald, Maus Stephan, Stemler Tobias, Bohnenberger Hendrik, Ezziddin Samer, Kurz Philipp, Bartholomä Mark D. (2018), Optimized synthesis and indium complex formation with the bifunctional chelator NODIA-Me, in
Organic & Biomolecular Chemistry, 16(40), 7503-7512.
Lamb Jennifer, Holland Jason P. (2018), Advanced methods for radiolabelling multi-modality nanomedicines for SPECT/MRI and PET/MRI, in
Journal of Nuclear Medicine, 59, 382-389.
Holland Jason P. (2018), Antibody-based radiopharmaceuticals for imaging and therapy, in
Journal of Labelled Compounds and Radiopharmaceuticals, 61, 610-610.
Boros Eszter, Holland Jason P. (2018), Chemical aspects of metal ion chelation in the synthesis and application antibody-based radiotracers, in
Journal of Labelled Compounds and Radiopharmaceuticals, 61, 652-671.
Boros Eszter, Holland Jason P. (2018), Chemical aspects of metal ion chelation in the synthesis and application antibody‐based radiotracers, in
Journal of Labelled Compounds and Radiopharmaceuticals, 1-20.
Holland Jason P. (2018), Chemical Kinetics of Radiolabelling Reactions, in
Chemistry - A European Journal, 24, 16472-16483.
Holland Jason P. (2018), Frontispiece: Chemical Kinetics of Radiolabelling Reactions, in
Chemistry - A European Journal, 24, 16472-16483.
Läppchen Tilman, Kiefer Yvonne, Holland Jason P., Bartholomä Mark (2018), In vitro and in vivo evaluation of the bifunctional chelator NODIA-Me in combination with a prostate specific membrane antigen targeting vector, in
Nuclear Medicine and Biology, 60, 45-54.
Läppchen Tilman, Kiefer Yvonne, Holland Jason P., Bartholomä Mark (2018), Preparation and preclinical evaluation of a 68Ga-labelled c(RGDfK) conjugate comprising the bifunctional chelator NODIA-Me, in
European Journal of Nuclear Medicine and Molecular Imaging: Radiopharmacy and Chemistry, 3(6), 1-11.
Collier Thomas L., Dahl Kenneth, Stephenson Nickeisha A., Holland Jason P., Riley Adam, Liang Steven H., Vasdev Neil (2018), Recent applications of a single quadrupole mass spectrometer in PET radiochemistry, in
Journal of Fluorine Chemistry, 210, 46-55.
Schmidtke Alexander, Läppchen Tilman, Weinmann Christian, Bier-Schorr Lorenz, Keller Manfred, Kiefer Yvonne, Holland Jason P., Bartholomä Mark D. (2017), Gallium complexation, stability and bioconjugation of TACN derived chelators with azaheterocyclic arms, in
Inorganic Chemistry, 56(15), 9097-9110.
Gourni Eleni, Del Pozzo Luigi, Bartholomä Mark, Kiefer Yvonne, Meyer Philipp T., Maecke Helmut R., Holland Jason P. (2017), Radiochemistry and PET imaging of 68Ga-desferrioxamine radiotracers targeting prostate-specific membrane, in
Molecular Imaging, 16, 1-11.
Holland Jason P. (2016), The role of molecular imaging in personalised healthcare, in
Chimia, 70(11), 787-795.
FayRachael, HollandJason, The impact of emerging bioconjugation chemistries on radiopharmaceuticals, in
Journal of Nuclear Medicine.
Nanomedicine is the medical application of nanotechnology to diagnose or treat disease. Increased availability of clinical Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) scanners means there is now an urgent need to develop new molecular imaging (MI) agents that can simultaneously take advantage of the functional and anatomic information available from hybrid imaging. Nanoparticles offer a unique opportunity for designing novel multi-modal MI agents. However, at present there are no general methods available for rapid, facile and versatile radiolabelling of nanoparticles using a variety of different nuclides. This SNSF Professorship will address this critical need by i) identifying and characterising new radiolabelling methods, and ii) exploring the potential of multi-modal imaging to measure dynamic biochemical changes in various cancer signaling pathways in response to chemotherapy.