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Influence of Caffeine Consumption on the Human Circadian System: Neurobehavioral, Hormonal and Cerebral Mechanisms

English title Influence of Caffeine Consumption on the Human Circadian System: Neurobehavioral, Hormonal and Cerebral Mechanisms
Applicant Cajochen Christian
Number 163058
Funding scheme Project funding (Div. I-III)
Research institution Abteilung Chronobiologie Universitäre Psychiatrische Kliniken Basel
Institution of higher education University of Basel - BS
Main discipline Neurophysiology and Brain Research
Start/End 01.02.2016 - 31.01.2019
Approved amount 377'111.70
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All Disciplines (2)

Discipline
Neurophysiology and Brain Research
Physiology : other topics

Keywords (3)

caffeine; sleep; circadian

Lay Summary (German)

Lead
Neuste Studien belegen, dass 85% der Erwachsenenpopulation täglich Koffein konsumiert. Die psychotrope Substanz beeinflusst die homöostatischen Schlafprozesse durch Hemmung des Schlaffaktors Adenosin. Ob und wie Koffein zusätzlich die zirkadiane Regulation von Schlaf und Wachheit beeinflusst, ist weitgehend unerforscht. Das Projekt leistet dazu einen Beitrag.
Lay summary

Die Dauer, Qualität und der Zeitpunkt von Schlaf und Wachheit werden durch das Zusammenwirken eines schlaf-homeostatischen und eines zirkadianen Prozesses bestimmt. Es ist bekannt, dass Koffeinkonsum eine optimale Wirkweise schlaf-homeostatischer Mechanismen verhindert durch ein Blockieren sogenannter Adenosinrezeptoren. Weitgehend ungeklärt ist jedoch, inwiefern auch zirkadiane Prozesse durch Koffein beeinflusst werden.

Das Ziel dieses Projekts ist die Untersuchung des Einflusses von regelmässigem Koffeinkonsum und dessen Beendigung auf die zirkadiane Regulation von Schlaf und Wachheit, die zirkadiane Variation von Hormonen, das Wohlbefinden, die neurobehaviorale Leistungsfähigkeit und auf die damit verbundenen zerebralen Mechanismen. Wir werden junge, gesunde Koffeinkonsumenten mittels funktioneller Magnetresonanztomographie (fMRT) sowie Elektroenzephalographie (EEG) während des Koffeinkonsums, und des Koffeinentzugs untersuchen und mit einer Kontrollbedingung (Placebo) vergleichen. Die Resultate sollen zu einem besseren Verständnis des Einflusses von Koffeinkonsum auf das Schlaf-Wach-Regulationssystem beitragen. Abhängig von den Resultaten, kann unser Projekt wichtige Einblicke in neuste soziale Veränderungen im Schlaf-Wach-Verhalten (wie z.B. eine Verspätung und Verkürzung von Schlafzeiten) und die damit verbundene Zunahme von Schlafproblemen liefern.

 

Direct link to Lay Summary Last update: 13.05.2016

Responsible applicant and co-applicants

Employees

Publications

Publication
The impact of daily caffeine intake on nighttime sleep in young adult men
Weibel Janine, Lin Yu-Shiuan, Landolt Hans-Peter, Kistler Joshua, Rehm Sophia, Rentsch Katharina M., Slawik Helen, Borgwardt Stefan, Cajochen Christian, Reichert Carolin F. (2021), The impact of daily caffeine intake on nighttime sleep in young adult men, in Scientific Reports, 11(1), 4668-4668.
Regular Caffeine Intake Delays REM Sleep Promotion and Attenuates Sleep Quality in Healthy Men
Weibel Janine, Lin Yu-Shiuan, Landolt Hans-Peter, Berthomier Christian, Brandewinder Marie, Kistler Joshua, Rehm Sophia, Rentsch Katharina M., Meyer Martin, Borgwardt Stefan, Cajochen Christian, Reichert Carolin F. (2021), Regular Caffeine Intake Delays REM Sleep Promotion and Attenuates Sleep Quality in Healthy Men, in Journal of Biological Rhythms, 0748730421-0748730421.
Daily Caffeine Intake Induces Concentration-Dependent Medial Temporal Plasticity in Humans: A Multimodal Double-Blind Randomized Controlled Trial
Lin Yu-Shiuan, Weibel Janine, Landolt Hans-Peter, Santini Francesco, Meyer Martin, Brunmair Julia, Meier-Menches Samuel M, Gerner Christopher, Borgwardt Stefan, Cajochen Christian, Reichert Carolin (2021), Daily Caffeine Intake Induces Concentration-Dependent Medial Temporal Plasticity in Humans: A Multimodal Double-Blind Randomized Controlled Trial, in Cerebral Cortex, 31(6), 3096-3106.
Caffeine-dependent changes of sleep-wake regulation: Evidence for adaptation after repeated intake
Weibel Janine, Lin Yu-Shiuan, Landolt Hans-Peter, Garbazza Corrado, Kolodyazhniy Vitaliy, Kistler Joshua, Rehm Sophia, Rentsch Katharina, Borgwardt Stefan, Cajochen Christian, Reichert Carolin Franziska (2020), Caffeine-dependent changes of sleep-wake regulation: Evidence for adaptation after repeated intake, in Progress in Neuro-Psychopharmacology and Biological Psychiatry, 99, 109851-109851.
Effects of chronic caffeine consumption and caffeine withdrawal on human waking performance, sleep and brain structure
ReichertCarolin (2018), Effects of chronic caffeine consumption and caffeine withdrawal on human waking performance, sleep and brain structure, John Wiley & Sons Ltd, Oxford.
Habitual daily caffeine consumption and its cessation changes human grey matter density independent from the effect of cerebral blood flow: a multimodal study
LinYu-Shiuan (2018), Habitual daily caffeine consumption and its cessation changes human grey matter density independent from the effect of cerebral blood flow: a multimodal study, John Wiley & Sons Ltd, Oxford.
Influence of habitual caffeine intake and its withdrawal on circadian phase and nap sleep in the evening
WeibelJanine (2018), Influence of habitual caffeine intake and its withdrawal on circadian phase and nap sleep in the evening, John Wiley & Sons Ltd, Oxford.
Influence of Long-Term Caffeine Consumption and Its Withdrawal on Subjective Sleepiness, Vigilance, and Melatonin
WeibelJanine (2018), Influence of Long-Term Caffeine Consumption and Its Withdrawal on Subjective Sleepiness, Vigilance, and Melatonin, Oxford University Press, Oxford.

Collaboration

Group / person Country
Types of collaboration
Institute for Pharmacology and Toxicology, University of Zürich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Institute of Analytical Chemistry, University of Vienna Austria (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Clinical Trial Unit, Department of Clinical Research, University Hospital Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Medical Image Analysis Centre, University Hospital Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Department of Radiological Physics, University Hospital Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Cyclotron Research Center University of Liège Belgium (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Congress of European Sleep Research Society Poster Habitual daily caffeine consumption and its cessation changes human grey matter density independent from the effect of cerebral blood flow: a multimodal study 25.09.2018 Basel, Switzerland Weibel Janine; Lin Yu-Shiuan; Cajochen Christian; Borgwardt Stefan;
Congress of European Sleep Research Society Talk given at a conference Effects of chronic caffeine consumption and caffeine withdrawal on human waking performance, sleep and brain structure 25.09.2018 Basel, Switzerland Weibel Janine; Borgwardt Stefan; Cajochen Christian; Lin Yu-Shiuan;
Congress of European Sleep Research Society Talk given at a conference Influence of habitual caffeine intake and its withdrawal on circadian phase and nap sleep in the evening 25.09.2018 Basel, Switzerland Lin Yu-Shiuan; Weibel Janine; Cajochen Christian; Borgwardt Stefan;
Meeting of the Swiss Society for Sleep and Chronobiological Reserach Talk given at a conference Influence of habitual caffeine intake and its withdrawal on circadian phase and nap sleep in the evening 25.09.2018 Basel, Switzerland Borgwardt Stefan; Cajochen Christian; Lin Yu-Shiuan; Weibel Janine;
Meeting of the Swiss Society for Sleep and Chronobiological Reserach Poster Influence of habitual caffeine intake and its withdrawal on circadian phase and nap sleep in the evening 25.09.2018 Basel, Switzerland Cajochen Christian; Borgwardt Stefan; Weibel Janine; Lin Yu-Shiuan;
Congress of the Organization for Human Brain Mapping Poster Habitual Daily Caffeine Consumption and its Cessation Changes Human Grey Matter Density 17.06.2018 Singapore, Singapore Cajochen Christian; Lin Yu-Shiuan; Weibel Janine; Borgwardt Stefan;
SLEEP meeting Poster Influence of Long-Term Caffeine Consumption and Its Withdrawal on Subjective Sleepiness, Vigilance, and Melatonin 02.06.2018 Baltimore, United States of America Cajochen Christian; Weibel Janine; Borgwardt Stefan; Lin Yu-Shiuan;
International Symposium of the CRPP Sleep & Health 2018 Poster Influence of habitual caffeine consumption and its withdrawal on subjective sleepiness, vigilance, caffeine craving, and melatonin 01.02.2018 Zürich, Switzerland Lin Yu-Shiuan; Cajochen Christian; Borgwardt Stefan; Weibel Janine;
International Symposium of the CRPP Sleep & Health 2018 Poster Changes in Human Grey Matter Density during Long-Term Caffeine Consumption and Caffeine Withdrawal 01.02.2018 Zürich, Switzerland Cajochen Christian; Lin Yu-Shiuan; Borgwardt Stefan; Weibel Janine;
Meeting of the Swiss Society for Sleep and Chronobiological Reserach Talk given at a conference Effects of habitual caffeine consumption and its cessation on subjective sleepiness, vigilance performance, and melatonin 11.05.2017 Lugano, Switzerland Cajochen Christian; Borgwardt Stefan; Weibel Janine; Lin Yu-Shiuan;


Communication with the public

Communication Title Media Place Year
Media relations: print media, online media Der Körper passt sich dem Konsum an Basler Zeitung German-speaking Switzerland 2021
Media relations: radio, television Kaffeekonsum lässt die graue Hirnsubstanz schrumpfen SRF German-speaking Switzerland 2021
Media relations: print media, online media Kaffeetrinker bilden sich nur ein, wacher zu sein – warum wir uns trotzdem so fühlen Argauer Zeitung German-speaking Switzerland 2018
Media relations: print media, online media Kein Koffein-Kick bei Dauerkonsum / Boire régulièrement du café réduit son effet Horizonte Western Switzerland German-speaking Switzerland 2018

Awards

Title Year
Award for best oral presentation at Meeting of the Swiss Society for Sleep and Chronobiological Reserach (2018) 2018

Associated projects

Number Title Start Funding scheme
143736 Inter-individual differences underlying circadian and sleep-wake dependent modulations in cognitive performance : an electrophysiological, behavioural and functional neuroimaging approach. 01.04.2013 Project funding (Div. I-III)
171364 Caffeine-induced effects on sleep, cognitive performance, and underlying cerebral correlates during adolescence 01.10.2017 Marie Heim-Voegtlin grants
130689 Cerebral mechanisms underlying the influence of age-related changes in circadian and homeostatic processes on cognition: a functional neuroimaging approach 01.04.2010 Project funding (Div. I-III)
191725 The Influence of Chronic Caffeine Consumption and Sleep Restriction on Adenosine and Brain Morphometry in Humans: A PET-MR Study 01.02.2020 Doc.Mobility

Abstract

BackgroundRecent surveys indicate that 85% of the adult population consume caffeine on a daily basis. Caffeine acts on sleep homeostatic mechanisms by antagonizing the sleep factor adenosine. Whether and how caffeine also impacts on the circadian regulation of sleep and -wakefulness is fairly unexplored. The circadian timing system promotes wakefulness at the end of the biological day (“wake maintenance zone”) and promotes sleep after the onset of the endogenous melatonin secretion (“opening of sleep gate”). There is mounting evidence that circadian and sleep homeostatic mechanisms continuously interact at the neurobehavioral, hormonal and cerebral level. Furthermore, we have recent evidence that the strength of circadian wake-promotion and the timing of circadian rhythmicity differs according to a genetic predisposition in the adenosinergic system. Thus, we assume that the daily consumption of caffeine may substantially impact on both circadian and homeostatic sleep-wake processes at different systemic levels. General AimWe aim at quantifying the influence of regular caffeine intake and its cessation on circadian promotion of sleep and wakefulness, on circadian hormonal markers, well-being, neurobehavioral performance and associated cerebral mechanisms.Specific AimsRegular caffeine intake: We aim at investigating the effects of sleep-wake regulatory adaptations to regular caffeine consumption a) on night-time sleep structure and sleep intensity (electroencephalography, EEG), b) on circadian wake-promotion (nap sleep during the biological day) and circadian timing of hormonal rhythms, and c) on waking quality, as indexed by subjective ratings, objective measures of neurobehavioral performance, and cerebral mechanisms (EEG and functional magnetic resonance imaging [MRI]) (see 1.4). Cessation of regular caffeine intake: To investigate the response of sleep-wake regulatory mechanisms to a sudden change in the adenosinergic system on points a- c (as delineated above). Experimental Design/MethodsYoung healthy regular caffeine consumers will be asked to participate in a double-blind, placebo-controlled within-subjects design with three conditions: Regular caffeine intake, regular placebo intake, and cessation of regular caffeine intake. In the chronobiology laboratory, circadian sleep-wake promotion will be assessed by combining EEG and multimodal MRI techniques. Circadian timing will be assessed by salivary melatonin and cortisol rhythms. Sleep and waking quality will be quantified by continuous polysomnography, waking EEG, subjective ratings (sleepiness, mood, craving, withdrawal symptoms) and cognitive performance (vigilance and working memory). Each of the three laboratory parts will last 40 h under strictly controlled conditions (i.e., dim light, constant ambient temperature etc.). Subsequent to each laboratory condition, actimetry and sleep diaries will serve to assess sleep- and waking patterns in the field under caffeine vs. placebo conditions.Potential ValueThe project will substantially advance our knowledge about the impact of the commonly encountered caffeine consumption on the sleep-wake regulatory system. Circadian mechanisms might be crucially involved in the maintenance of a vicious circle of counteraction of sleepiness by caffeine, leading to impaired sleep, followed by daytime sleepiness. Furthermore, the project will substantially contribute to understand the complex interplay of sleep-wake regulatory mechanisms in response to acute or long-term changes in the adenosinergic system. Depending on the outcome of the results, our project may contribute important insights on recent societal changes in sleep-wake behaviour (e.g., shorter sleep duration and delayed sleep phase) and the related increase in people suffering from sleep problems.
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