Project

Back to overview

Interplay of classical and atypical chemokine receptors in immune cell trafficking and dynamic microarchitecture of the secondary lymphoid organs

English title Interplay of classical and atypical chemokine receptors in immune cell trafficking and dynamic microarchitecture of the secondary lymphoid organs
Applicant Thelen Marcus
Number 160719
Funding scheme Sinergia
Research institution Istituto di ricerca in biomedicina (IRB) Facoltà di scienze biomedice
Institution of higher education Università della Svizzera italiana - USI
Main discipline Immunology, Immunopathology
Start/End 01.11.2015 - 30.06.2019
Approved amount 1'679'133.00
Show all

All Disciplines (6)

Discipline
Immunology, Immunopathology
Cardiovascular Diseases
Molecular Biology
Infectious Diseases
Cellular Biology, Cytology
Biochemistry

Keywords (8)

Atpycal-chemokine-receptor; scavenger; leukocytes; immunity; lymphoid-organ; signaling; trafficking; chemokine

Lay Summary (German)

Lead
Atypische Chemokinrezeptoren (ACKR), die im Gegensatz zu den klassischen (typischen) Chemokinrezeptoren keine Zellwanderung auslösen, eliminieren Chemokine durch Internalisierung. Forschung der letzten Jahre hat gezeigt, dass die ACKRs eine Schlüsselfunktion in der Regulation des Chemokinsystems einnehmen. In diesem Projekt sollen Gemeinsamkeiten und Unterschiede der Funktion von drei atypischen Rezeptoren, (ACKR1, ACKR3 und ACKR4) erarbeitet werden.
Lay summary

Die Gruppe der atypischen Chemokinrezeptoren (ACKR1-4) wurde kürzlich auf der Basis definiert, dass die Rezeptoren zwar strukturell verwandt sind aber nicht dem klassischen Schema der G-Protein gekoppelten Rezeptoren folgen und mittels G-Proteinen Zellmigration stimulieren. Dennoch können ACKRs durch ihre Eigenschaft als effiziente Eliminatoren von Chemokinen zur Bildung von Gradienten beitragen. Francis Crick folgerte bereits in den 70er Jahren, dass einer Quelle unbedingt ein Ablauf gegenüber gestellt sein muss, um biologisch wirksame Gradienten zu bilden. Derartige Chemokingradienten sind unabdingbar für die angeborene und eine adaptive Immunantwort.

Ziel des Projektes ist, Chemokin-Gradienten in lymphatischem Gewebe nachzuweisen und dabei die Funktion der ACKR herauszuarbeiten. Das Konsortium erwartet, mit seinen Ergebnissen neue Erkenntnisse über Regulierung der Immunantwort zu erhalten, die sowohl für die Bekämpfung von Pathogenen als auch bei der Autoimmunität von Bedeutung sein können.

Das Projekt befasst sich mit Grundlagenforschung. Um ein besseres Gesamtverständnis der Komplexität des Immunsystems zu erhalten, ist es notwendig mit geeigneten Modellen die Funktion einzelner Rezeptoren zu erforschen.

Direct link to Lay Summary Last update: 16.09.2015

Responsible applicant and co-applicants

Employees

Publications

Publication
Lymphatic endothelial-cell expressed ACKR3 is dispensable for postnatal lymphangiogenesis and lymphatic drainage function in mice
Sigmund Elena C., Baur Lilian, Schineis Philipp, Arasa Jorge, Collado-Diaz Victor, Vranova Martina, Stahl Rolf A. K., Thelen Marcus, Halin Cornelia (2021), Lymphatic endothelial-cell expressed ACKR3 is dispensable for postnatal lymphangiogenesis and lymphatic drainage function in mice, in PLOS ONE, 16(4), e0249068-e0249068.
Editorial: Atypical Functions of Leukocyte Chemoattractant Receptors
Rodríguez-Fernández José Luis, Mellado Mario, Thelen Marcus, Murphy Philip M. (2020), Editorial: Atypical Functions of Leukocyte Chemoattractant Receptors, in Frontiers in Immunology, 11, 596902.
Marginal Zone Formation Requires ACKR3 Expression on B Cells
Radice Egle, Ameti Rafet, Melgrati Serena, Foglierini Mathilde, Antonello Paola, Stahl Rolf A.K., Thelen Sylvia, Jarrossay David, Thelen Marcus (2020), Marginal Zone Formation Requires ACKR3 Expression on B Cells, in Cell Reports, 32(5), 107951-107951.
CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4
Matti Christoph, D'Uonnolo Giulia, Artinger Marc, Melgrati Serena, Salnikov Angela, Thelen Sylvia, Purvanov Vladimir, Strobel Tobias D., Spannagel Lisa, Thelen Marcus, Legler Daniel F. (2020), CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4, in Journal of Leukocyte Biology, 107(6), 1137-1154.
ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins
Matti Christoph, Salnikov Angela, Artinger Marc, D'Agostino Gianluca, Kindinger Ilona, Uguccioni Mariagrazia, Thelen Marcus, Legler Daniel F. (2020), ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins, in Frontiers in Immunology, 11, 720.
Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis
Girbl Tamara, Lenn Tchern, Perez Lorena, Rolas Loïc, Barkaway Anna, Thiriot Aude, del Fresno Carlos, Lynam Eleanor, Hub Elin, Thelen Marcus, Graham Gerard, Alon Ronen, Sancho David, von Andrian Ulrich H., Voisin Mathieu-Benoit, Rot Antal, Nourshargh Sussan (2018), Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis, in Immunity, 30433.
Membrane lipid environment: Potential modulation of chemokine receptor function
Thelen Marcus, Legler Daniel F. (2018), Membrane lipid environment: Potential modulation of chemokine receptor function, in Cytokine, 109, 72-75.
The Atypical Receptor CCRL2 (C-C Chemokine Receptor-Like 2) Does Not Act As a Decoy Receptor in Endothelial Cells
Mazzotti Chiara, Gagliostro Vincenzo, Bosisio Daniela, Del Prete Annalisa, Tiberio Laura, Thelen Marcus, Sozzani Silvano (2017), The Atypical Receptor CCRL2 (C-C Chemokine Receptor-Like 2) Does Not Act As a Decoy Receptor in Endothelial Cells, in Frontiers in Immunology, 8, 1233.
Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis
Duchene Johan, Novitzky-Basso Igor, Thiriot Aude, Casanova-Acebes Maria, Bianchini Mariaelvy, Etheridge S Leah, Hub Elin, Nitz Katrin, Artinger Katharina, Eller Kathrin, Caamaño Jorge, Rülicke Thomas, Moss Paul, Megens Remco T A, von Andrian Ulrich H, Hidalgo Andres, Weber Christian, Rot Antal (2017), Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis, in Nature Immunology, 18(7), 753-761.
Modulation of Chemokine Receptor Function by Cholesterol: New Prospects for Pharmacological Intervention
Legler Daniel F., Matti Christoph, Laufer Julia M., Jakobs Barbara D., Purvanov Vladimir, Uetz-von Allmen Edith, Thelen Marcus (2017), Modulation of Chemokine Receptor Function by Cholesterol: New Prospects for Pharmacological Intervention, in Molecular Pharmacology, 91(4), 331-338.
Chemokines: Chemistry, Biochemistry and Biological Function.
Legler DF, Thelen M (2016), Chemokines: Chemistry, Biochemistry and Biological Function., in Chimia, 70(12), 856-859.

Datasets

microarray data set

Author Duchene, Johan; Novitzky-Basso, Igor; Thiriot, Aude; Casanova-Acebes, Maria; Bianchini, Mariaelvy; Etheridge, S Leah; Hub, Elin; Nitz, Katrin; Artinger, Katharina; Eller, Kathrin; Caamaño, Jorge; Rülicke, Thomas; Moss, Paul; Megens, Remco T A; von Andrian, Ulrich H; Hidalgo, Andres; Weber, Christian; Rot, Antal
Publication date 29.07.2017
Persistent Identifier (PID) GSE86349
Repository Gene Expression Omnibus (GEO)


Collaboration

Group / person Country
Types of collaboration
Onur Boymann / University of Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Michael Sixt / IST Austria (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Burkhard Ludewig / Kantonsspital Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Reinhold Foerster / University of Hannover Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Tatiana Petrova / University of Lausanne Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Michael Detmar / ETHZ Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Sussan Nourshargh / Queen Mary University of London Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Andreas Pauli / Klinikum Konstanz Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Jens Stein / University of Bern Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Dr Kai-Michael Toellner / University of Birmingham Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Gerry Graham / University of Glasgow Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Ulrich H. von Andrian / Harward Medical School United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
Friedemann Kiefer / Max Planck Institute Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
3rd European cell migration conference ECMC2019 Talk given at a conference Function of the membrane microdomain protein flotillin-2 in dendritic cell migration 28.06.2019 Salamanca, Spain Legler Daniel; Hub Elin; Thelen Marcus; Rot Antal;
University of Basel - invited talk Individual talk The Atypical Chemokine Receptor 3 (ACKR3) expression and function 06.05.2019 Basel, Switzerland Thelen Marcus;
BITg Seminar - Progress Report Individual talk Regulation of ACKR4 functions 29.03.2019 Kreuzlingen, Switzerland Matti Christoph;
IRB, Bellinzona Individual talk How do cells migration persistently despite receptor desensitization? 11.02.2019 Bellinzona, Switzerland Legler Daniel;
Department of Biology, University of Konstanz, Germany Individual talk How do cells migration persistently? 13.12.2018 Konstanz, Germany Legler Daniel;
University of Brescia Individual talk The chemokine system: orchestration of cell migration and positioning 12.12.2018 Brescia, Italy Thelen Marcus;
University of Padua Individual talk Chemokines orchestrate cell migration and more 23.11.2018 Padova, Italy Thelen Marcus;
University of Padua Individual talk The chemokine system in cancer 22.11.2018 Padova, Italy Thelen Marcus;
2nd Swiss Vascular Research Symposium - Poster Poster Elucidating the Role of ACKR3 for Lymphatic Vessel Function and Immune Cell Migration Towards Draining Lymph Nodes 25.10.2018 Locarno, Switzerland Sigmund Elena Caroline;
International Bladder Cancer Netwrok annual conference Talk given at a conference The chemokine system in cancer spreading 11.10.2018 Rotterdam, Netherlands Thelen Marcus;
ITN ONCORNET meeting Talk given at a conference The role of ACKR3 in health and disease 30.08.2018 Amsterdam, Netherlands Thelen Marcus;
11th Life Science Zurich Graduate School- PhD Program in Microbiology and Immunology (MIM) - retreat Poster Elucidating the Role of ACKR3 for Lymphatic Vessel Function and Immune Cell Migration Towards Draining Lymph Nodes 23.08.2018 Visp, Switzerland Sigmund Elena Caroline;
Gordon research conference on chemotactic cytokines Talk given at a conference Chemokines in effector T cell function and positioning / Chemotactic cytokines 05.06.2018 Newry, United States of America Thelen Marcus; Rot Antal; Legler Daniel;
Gordon Research Conference on Chemotactic Cytokines - Poster Poster Elucidating the role of ACKR3 for lymphatic vessel function and immune cell migration towards draining lymph nodes 03.06.2018 Newry, United States of America Sigmund Elena Caroline;
SFB1192 Retreat Individual talk ACKR3 (CXCR7) and the Hamburg connection 16.05.2018 Imperia, Italy Thelen Marcus;
BITg Seminar - Progress Report Individual talk Molecular aspects of ACKR4 functions 27.04.2018 Kreuzlingen, Switzerland Matti Christoph;
University of Lausanne Individual talk The Atypical Chemokine Receptor 3 (ACKR3) expression and function 14.02.2018 Lausanne, Switzerland Thelen Marcus;
University of Padua Individual talk the Chemokine System in Cancer 24.11.2017 Padova, Italy Thelen Marcus;
University of Padua Individual talk Chemokines orchestrate cell migration and more 23.11.2017 Padova, Italy Thelen Marcus;
18. Unionstagung der Schweizerischen Gesellschaft für Gefässkrankheiten Talk given at a conference ACKR4 is expressed by afferent lymphatic collectors and affects T cell migration to draining lymph nodes 02.11.2017 Montreux, Switzerland Halin Cornelia;
First Swiss Vascular Research Symposium - Poster Poster Elucidating the role of ACKR3 for lymphatic vessel function and immune cell migration towards draining lymph nodes 02.11.2017 Montreux, Switzerland Sigmund Elena Caroline;
First Swiss Vascular Research Symposium Poster Elucidating the role of ACKR3 for lymphatic vessel function and immune cell migration towards draining lymph nodes 02.11.2017 Montreux, Switzerland Sigmund Elena Caroline;
EADV meeting Talk given at a conference The atypical chemokine receptor ACKR3 in B cell lymphoma 26.10.2017 Bellinzona, Switzerland Thelen Marcus;
Institute of Microbiology, ETH Zurich, Cutting edge topics in immunology and infection biology Individual talk Versatile regulation of chemokine receptor signaling in controling leukocyte migration 03.10.2017 Zurich, Switzerland Legler Daniel;
Invited seminar: Kennedy Institute of Rheumatology, University of Oxford Individual talk New Biology of the Atypical Chemokine Receptor 1 26.09.2017 Oxford, Great Britain and Northern Ireland Rot Antal;
IUPACs International Symposium on Bioorganic Chemistry Poster The role of ACKR4 trafficking and signaling in chemokine gradient formation 25.09.2017 Konstanz, Germany Matti Christoph;
2nd European Cell Migration Conference ECMC2017 Individual talk Session Chair 06.09.2017 Cardiff, Great Britain and Northern Ireland Thelen Marcus; Rot Antal;
2nd European Cell Migration Conference Talk given at a conference ZAP70 expression enhances chemokine-driven chronic lymphatic leukemia cell adhesion and migration 06.09.2017 Cardiff, Great Britain and Northern Ireland Legler Daniel;
2nd European Cell Migration Conference Talk given at a conference Vice Chair 06.09.2017 Cardiff, Great Britain and Northern Ireland Thelen Marcus;
Molecular Life Sciences Graduate School Zurich Poster The role of ACKR4 trafficking and signaling in chemokine gradient formation 31.08.2017 Zurich, Switzerland Matti Christoph;
10th MIM retreat Talk given at a conference Investigating the Role of ACKR4 on Leukocyte Trafficking Within Lymphatic Vessels and on Lymphatic Vessel Biology 26.08.2017 Locarno, Switzerland Halin Cornelia;
STIMM Individual talk The Atypical Chemokine Receptor ACKR3 05.07.2017 Zurich, Switzerland Thelen Marcus;
4th Summer Symposium on Leukocyte Trafficking of the SFB914, LMU, Munich Individual talk ACKRs in Leukocyte Trafficking 26.06.2017 Munich, Germany Rot Antal;
Annual Meeting of the Swiss Society of Allergology and Immunology Poster Role of ACKR3 in leukocyte migration and the microarchitecture of secondary lymphoid organs 01.06.2017 St Gallen, Switzerland Thelen Marcus;
2nd European Cell Migration Conference Poster Role of ACKR3 in leukocyte migration and the microarchitecture of secondary lymphoid organs 01.06.2017 Cardiff, Great Britain and Northern Ireland Ameti Rafet;
2nd Joint Meeting of the European Society for Microcirculation (ESM) and European Vascular Biology Organisation Poster Elucidating the role of ACKR3 for lymphatic vessel function and immune cell migration towards draining lymph nodes 29.05.2017 Geneva, Switzerland Sigmund Elena Caroline;
Joint Meeting for the European Society for Microcirculation and European Vascular Biology Organisation ESM-EVBO 2017 Poster Investigating the Role of ACKR4 on Leukocyte Trafficking Within Lymphatic Vessels and on Lymphatic Vessel Biology 29.05.2017 Geneva, Switzerland Halin Cornelia;
2nd Joint Meeting of the European Society for Microcirculation (ESM) and European Vascular Biology Organization - Poster Poster Elucidating the role of ACKR3 for lymphatic vessel function and immune cell migration towards draining lymph nodes 29.05.2017 Geneva, Switzerland Sigmund Elena Caroline;
Invited talk - Department of Pharmacology and Toxicology, University of Lausanne Individual talk G-protein-dependent and –independent signaling controlling cell migration 03.05.2017 Lausanne, Switzerland Legler Daniel;
Invited talk St Gallen Individual talk Atypical Chemokine Receptors 28.04.2017 St Gallen, Switzerland Thelen Marcus;
Invited talk - CMU University Geneva Individual talk Versatile regulation of chemokine receptor signaling in controlling leukocyte migration 24.03.2017 Geneva, Switzerland Legler Daniel;
Invited Talk - Cardiff University Hospital Individual talk CCR7-mediated signaling controlling leukocyte migration 05.03.2017 Cardiff, Great Britain and Northern Ireland Legler Daniel;
26th Cytomeet Individual talk The role of the atypical chemokinereceptor ACKR3 in leukocytes 24.01.2017 Bern, Switzerland Thelen Marcus;
8th EADV meeting Talk given at a conference The atypical chemokine receptor ACKR3 in immune responses 01.12.2016 Bellinzona, Switzerland Thelen Marcus;
Invited lectures Individual talk The chemokine system in cancer 25.11.2016 Padova, Italy Thelen Marcus;
Invited seminar - University College London Individual talk New Role of the Atypical Chemokine Receptor 1 in Haematopoiesis 17.11.2016 London, Great Britain and Northern Ireland Rot Antal;
Institute for Pharmacology and Toxicology, Friedrich-Schiller University Jena Individual talk Control of leukocyte migration by distinct signaling complexes 09.11.2016 Jena, Germany Legler Daniel;
20th joint meeting Signal transduction: receptors, mediators and genes Talk given at a conference Control of leukocyte migration by distinct signaling complexes 08.11.2016 Weimar, Germany Legler Daniel;
4th ProDoc Cell migration retreat Individual talk CCR7-mediated signaling controlling leukocyte migration 27.10.2016 Gunten, Switzerland Legler Daniel;
ProDoc Cell migration retreat Talk given at a conference ACKR3 in the B cell compartment and its contribution for a long lasting humoral response 07.10.2016 Gunten, Switzerland Radice Egle;
ProDoc Cell migration retreat Poster Role of ACKR3 in leukocyte migration and the microarchitecture of secondary lymphoid organs 07.10.2016 Gunten, Switzerland Ameti Rafet;
Seminar in Zurich Individual talk Cell Migration is Controlled by Typical and Atypical Chemokine Receptors 28.09.2016 Zurich, Switzerland Thelen Marcus;
Seminar, Institute of Science and Technology (IST) Individual talk CCR7-mediated signaling controlling leukocyte migration along chemokine gradients 12.07.2016 Klosterneuburg, Austria Legler Daniel;
13th International Innate Immunity Conference Talk given at a conference Invited speaker 23.06.2016 Rhodes, Greece Rot Antal;
American Transplant Congress Talk given at a conference Invited Speaker 11.06.2016 Boston, United States of America Rot Antal;
Gordon Research Conference Chemotactic Cytokines Talk given at a conference Role of ACKR3 in leukocyte migration and the microarchitecture of secondary lymphoid organs 29.05.2016 Girona, Spain Rot Antal; Ameti Rafet;
Gordon Research Conference Chemotactic Cytokines Talk given at a conference CCR7-mediated signaling controlling leukocyte 29.05.2016 Girona, Spain Legler Daniel;
Gordon Research Conference Chemotactic Cytokines Talk given at a conference ACKR3: a marker for B cell populations 29.05.2016 Girona, Spain Thelen Marcus;
Gordon Research Conference Chemotactic Cytokines Poster Functional ACKR3 expression in the B cell compartment 29.05.2016 Girona, Spain Radice Egle;
Gordon Research Seminar Chemotactic Cytokines Talk given at a conference Functional ACKR3 expression in the B cell compartment 08.05.2016 Girona, Spain Radice Egle;
Doctoral student retreat Konstanz Research School Chemical Biology Poster Role of ACKR4 trafficking and signaling in chemokine gradient formation 03.05.2016 Rastatt, Germany Matti Christoph;
Seminar Institute of Cell Biology, University of Bern Individual talk Control of adaptive immune cell migration by inflammatory signals 25.04.2016 Bern, Switzerland Legler Daniel;
IRB student retreat Talk given at a conference Functional ACKR3 expression in the B cell compartment 07.04.2016 Engelberg, Switzerland Radice Egle;
IRB student retreat Poster Role of ACKR3 in leukocyte migration and the microarchitecture of secondary lymphoid organs 07.04.2016 Engelberg, Switzerland Ameti Rafet;
Joint lab Meeting of Detmar & Halin groups, ETH Zurich Individual talk Contribution of ACKR3 to immune cell migration into lymphatic vessels (LVs) and LV biology 29.03.2016 Zurich, Switzerland Sigmund Elena Caroline;
Monday Discussion Talk given at a conference The atypical chemokine receptor ACKR3 04.03.2016 Bellinzona, Switzerland Thelen Marcus;
Graduate School Cellular and Biomedical Sciences Symposium Bern Poster Functional ACKR3 expression in the B cell compartment 04.02.2016 Bern, Switzerland Radice Egle;
Life Science Zurich Graduate School- PhD Program in Microbiology and Immunology (MIM) - short talk Individual talk Contribution of ACKR3 to immune cell migration into lymphatic vessels (LVs) and LV biology 14.01.2016 Zurich, Switzerland Sigmund Elena Caroline;
Life Science Zurich Graduate School- PhD Program in Microbiology and Immunology (MIM) Program: Introductory course – Short talk Individual talk Contribution of ACKR3 to immune cell migration into lymphatic vessels (LVs) and LV biology 14.01.2016 Zurich, Switzerland Sigmund Elena Caroline;
Seminar University of Padova Individual talk Chemokines and cancer 27.11.2015 Padova, Italy Thelen Marcus;
7th EADV Dermatological Meeting in Ticino - From the Bench to the Clinic Talk given at a conference ACKR3 expression on B cells 26.11.2015 Bellinzona, Switzerland Thelen Marcus;


Self-organised

Title Date Place
Sinergia Progress Meeting 01.04.2019 London, Great Britain and Northern Ireland
28th Cytomeet 22.01.2019 Bern, Switzerland
Workshop co-steering committee 29.10.2018 Bellinzona, Switzerland
Annual PI meeting Sinergia 22.05.2018 Kreuzlingen, Switzerland
27th Cytomeet 23.01.2018 Bern, Switzerland
Monday Discussion - Rafet Ameti 13.11.2017 Bellinzona, Switzerland
Sinergia Progress Meeting 23.10.2017 Bellinzona, Switzerland
Cell migration workshop 02.09.2017 Bellinzona, Switzerland
Workshop costeering committee 17.05.2017 Zurich, Switzerland
Student Retreat 2017 08.05.2017 Weggis, Switzerland
Monday Discussion - Egele Radice 20.03.2017 Bellinzona, Switzerland
Annual meeting Sinergia 23.11.2016 bellinzona, Switzerland
Annual PI meeting Sinergia 29.05.2016 Barcelona, Spain
Student retreat of the IRB 06.04.2016 Engelberg, Switzerland
Kick off meeting Sinergia, ETHZ 08.12.2015 Zurich, Switzerland

Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
Print of Science Talk 16.05.2018 London, Switzerland Rot Antal;


Communication with the public

Communication Title Media Place Year
Talks/events/exhibitions - 20-jähriges Jubiläum Biotechnologie Institut Thurgau, VIP Anlass German-speaking Switzerland 2019
Talks/events/exhibitions - Tag der offenen Labortüren: Einblick in die biomedizinische Forschung German-speaking Switzerland Western Switzerland 2019
Talks/events/exhibitions 50 anni di scienza e gioventù Italian-speaking Switzerland 2017
Media relations: print media, online media How ancestry shapes our immune cells ZME Science International 2017
Print (books, brochures, leaflets) Messenger "DARC is about ACKR1"; ISBN-10: 1910367966 International 2017
Print (books, brochures, leaflets) Messenger "Translation"; ISBN-13: 978-1910367964 International 2017
Talks/events/exhibitions Settimana tecnologica Liceo Bellinzona Italian-speaking Switzerland 2017
New media (web, blogs, podcasts, news feeds etc.) web page for the Sinergia project web International 2015

Awards

Title Year
Wellcome Trust Senior Investigator Award 2017
Fritz Hartmann Lecture and Award 2016

Associated projects

Number Title Start Funding scheme
160612 First European Chemokine and Cell Migration Conference (ECMC2015) 01.06.2015 Scientific Conferences
140704 Conventional and atypical chemokine receptors: different mechanisms of function and common responses 01.06.2012 Project funding
163336 The Atypical Chemokine Receptor ACKR3: Function in vivo in Immune Responses and Coupling to Signal Transduction Pathways 01.10.2015 Project funding
182727 Function of ACKR3 in immune cell trafficking in lymphoid organs 01.10.2018 Project funding
169936 Elucidating distinct spatio-temporal CCR7 signaling complexes in controlling immune cell migration 01.10.2016 Project funding

Abstract

Efficient leukocyte trafficking depends largely on the generation and maintenance of locally confined functional chemokine patterns. Atypical chemokine receptors (ACKRs) recently emerged as powerful regulators of chemokine availability and key contributors to shaping chemokine gradients. The innovative aim of the proposed project is to find similarities and discrepancies in functions of three out of four known ACKRs, ACKR1, ACKR3 and ACKR4, as expressed in most salient immunological microenvironments, in which these ACKRs determine the fate and function of chemokines. Our plan is to elucidate the molecular and cellular mechanisms of actions of these ACKRs as expressed in different cells and tissues and to uncover their yet unknown contributions to the formation or abolishment of chemokine gradients, chemokine transport as well as transmitting signals directly to the cells. All these activities should impact on the outcomes of cellular migratory pathways in immunity and through them on the immune function in general.To achieve this goal, the consortium is called to combine and integrate expertise from three leading Swiss and one foreign laboratory working on different aspect of leukocyte migration. The individual research aims in the proposal are conceived based largely on the completely new, unpublished discoveries by the members of the consortium, including unexpected detection of ACKR3 and ACKR4 expression on a key immune cell, the GC B-cell or by the endothelial cells of afferent lymphatic vessels; the expression of ACKR4 marking a previously unrecognized compartment in the spleen; or new signaling interactions downstream of the ACKRs.Members of the consortium bring together their unique individual insights and know-how on biochemistry, cell biology, in vitro and in vivo physiology and disease pathomechanisms as applied to chemokine biology. The project consists of four individual subprojects focused around four different facets of ACKR activities and led by one partner with most relevant core expertise, but propelled forward by the group effort of all members. Collective effort, combined with the complementary know-how and matrix nature of partner interactions within the individual subprojects, should bring about a completely new level of molecular and cellular understanding on how ACKRs function within different immunological pathways, which never could be achieved by the individual groups working separately. Therefore we believe that, in the true spirit of Synergia program, our efforts will bring more than just the sum of the individual results.
-