Project

Back to overview

SupraMedChem@Balkans.Net: Biomedical Dimension of Supramolecular Chemistry in the training and research in the Balkans area

English title SupraMedChem@Balkans.Net: Biomedical Dimension of Supramolecular Chemistry in the training and research in the Balkans area
Applicant Fromm Katharina M.
Number 160515
Funding scheme SCOPES
Research institution Département de Chimie Université de Fribourg
Institution of higher education University of Fribourg - FR
Main discipline Organic Chemistry
Start/End 01.07.2015 - 30.11.2018
Approved amount 195'000.00
Show all

All Disciplines (4)

Discipline
Organic Chemistry
Physical Chemistry
Pharmacology, Pharmacy
Inorganic Chemistry

Keywords (6)

tautomeric signalling; metal-organic complexes; spectroscopy; molecular design; bioactive compounds; supramolecular chemistry

Lay Summary (German)

Lead
Die Chemiedepartemente der Universitäten Freiburg, Schweiz, und Kragujevac, Serbien, das Adolphe Merkle Institut (AMI) der Universität Freiburg und das Institut für Organische Chemie der Bulgarischen Akademie der Wissenschaften in Sofia arbeiten zusammen an einem Ausbildungsprogramm für die biomedizinische Dimension der Supramolekulaen Chemie, um die Lehre und Forschung in diesem Bereich auf dem Balkan zu stärken.
Lay summary

Auf dem Konzept der supramolekularen Chemie basiert die informations-kontrollierte, programmierte Assoziation von Molekülen zu selbst-organisierenden Systemen. Sie stellt einen orginellen Zugang zu den Nanowissenschaften dar und kann als Alternative zur Nanofabrikation und - manipulation, sowie zum "Drug Delivery" eingesetzt werden. Dies alles illustriert den inter- und multidisziplinären Aspekt der supramolekularen Chemie und das grosse Potential, welches in ihr steckt. Es macht auch deutlich, warum eine gute Lehre basierend auf ihren Prinzipien eine wichtige Rolle in der Ausbildung des Nachwuchses in den Naturwissenschaften spielen sollte.

Das Team um Katharina M. Fromm vom Chemiedepartement der Universität Fribourg (und Alke Fink vom Adolphe Merkle Institute der Universität Fribourg), zusammen mit Liudmil Antonov von der Bulgarischen Akademie der Wissenschaften und Milos Djuran vom Chemiedepartement der Universität von Kragujevac, Serbien werden gemeinsam Sommer- und Winterschulen, Seminare und Workshops zum Thema der biomedizinischen Dimension der supramolekularen Chemie in allen drei Ländern anbieten. 
Direct link to Lay Summary Last update: 23.03.2015

Lay Summary (English)

Lead
The chemistry departments of the Universities of Fribourg, Switzerland, and Kragujevac, Serbia, the Adolphe Merkle Institute (AMI) at the University of Fribourg and the Institute of Organic Chemistry of the Bulgarian Academy of Sciences in Sofia join forces to set up an educational program on the Biomedicinal Dimension of Supramolecular Chemistry for training and research in the Balkan area.
Lay summary

Supramolecular chemistry offers the design of molecular information-controlled, "programmed," and functional
self-organizing systems, and provides an original approach to nanoscience, as well as a powerful
alternative/complement to nanofabrication, nanomanipulation and drug delivery. All this makes supramolecular
chemistry a truly multidisciplinary research subject with great potential for the future development and logically
brings the need for suitable teaching. This training at the level of young researchers and students cannot
possibly encompass all biomedical aspects of the supramolecular idea, but will concentrate on the
achievements reached with synthetic ligands interacting with biological systems. For the young people, this will make visible the unlimited possibilities of using intermolecular interactions in living systems and to inspire them.

The team around Katharina M. Fromm from the Chemistry Department of the University of Fribourg and Alke Fink from the Adolphe Merkle Institute of the University of Fribourg, as well as Liudmil Antonov from the Bulgarian Academy of Sciences and Milos Djuran from the Chemistry Department of Kragujevac, Serbia will join forces to set up summer or winter schools, seminars and workshops in all three countries to educate and train young BSc, MSc, PhD students and postdocs in biomedical aspects of supramolecular chemistry. Besides the teaching, we will also enable the Balkan partners to set up teaching courses and training conditions for a sustainable teaching and research environment.

Direct link to Lay Summary Last update: 23.03.2015

Responsible applicant and co-applicants

Publications

Publication
7-OH quinoline Schiff bases: are they the long awaited tautomeric bistable switches?
Georgiev Anton, Yordanov Dancho, Ivanova Nikoleta, Deneva Vera, Vassilev Nikolay, Kamounah Fadhil S., Pittelkow Michael, Crochet Aurelien, Fromm Katharina M., Antonov Liudmil (2021), 7-OH quinoline Schiff bases: are they the long awaited tautomeric bistable switches?, in Dyes and Pigments, 195, 109739-109739.
Indirect solvent assisted tautomerism in 4-substituted phthalimide 2-hydroxy-Schiff bases
Yordanov Dancho, Deneva Vera, Georgiev Anton, Crochet Aurelien, Fromm Katharina M., Antonov Liudmil (2020), Indirect solvent assisted tautomerism in 4-substituted phthalimide 2-hydroxy-Schiff bases, in Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 237, 118416-118416.
OH Group Effect in the Stator of β-Diketones Arylhydrazone Rotary Switches
Hristova Silvia, Kamounah Fadhil S., Crochet Aurelien, Vassilev Nikolay, Fromm Katharina M., Antonov Liudmil (2020), OH Group Effect in the Stator of β-Diketones Arylhydrazone Rotary Switches, in Chemistry, 2(2), 374-389.
Tautomerism and Self-Association in the Solution of New Pinene-Bipyridine and Pinene-Phenanthroline Derivatives
Solea Atena B., Cornu Ivan, Deneva Vera, Crochet Aurelien, Fromm Katharina M., Antonov Liudmil, Allemann Christophe, Mamula Olimpia (2020), Tautomerism and Self-Association in the Solution of New Pinene-Bipyridine and Pinene-Phenanthroline Derivatives, in Molecules, 25(2), 298-298.
(Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons
Tzvetkov Nikolay T., Stammler Hans-Georg, Hristova Silvia, Atanasov Atanas G., Antonov Liudmil (2019), (Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons, in European Journal of Medicinal Chemistry, 162, 793-809.
Betti Bases from 4‐(3‐Pyridazo)‐1‐naphthol: Synthesis, Coordination Behaviour and Unusual Substitution Reactions
Kurteva Vanya B., Lubenov Lubomir A., Shivachev Boris L., Nikolova Rositsa P., Fromm Katharina M. (2018), Betti Bases from 4‐(3‐Pyridazo)‐1‐naphthol: Synthesis, Coordination Behaviour and Unusual Substitution Reactions, in ChemistrySelect, 3(43), 12017-12021.
Synthesis, cytotoxic activity and DNA interaction studies of new dinuclear platinum( ii ) complexes with an aromatic 1,5-naphthyridine bridging ligand: DNA binding mode of polynuclear platinum( ii ) complexes in relation to the complex structure
Konovalov Bata, Živković Marija D., Milovanović Jelena Z., Djordjević Dragana B., Arsenijević Aleksandar N., Vasić Ivana R., Janjić Goran V., Franich Andjela, Manojlović Dragan, Skrivanj Sandra, Milovanović Marija Z., Djuran Miloš I., Rajković Snežana (2018), Synthesis, cytotoxic activity and DNA interaction studies of new dinuclear platinum( ii ) complexes with an aromatic 1,5-naphthyridine bridging ligand: DNA binding mode of polynuclear platinum( ii ) complexes in relation to the complex structure, in Dalton Transactions, 47(42), 15091-15102.
A concept for stimulated proton transfer in 1-(phenyldiazenyl)naphthalen-2-ols
Hristova S., Deneva V., Pittelkow M., Crochet A., Kamounah F.S., Fromm K.M., Hansen P.E., Antonov L. (2018), A concept for stimulated proton transfer in 1-(phenyldiazenyl)naphthalen-2-ols, in Dyes and Pigments, 156, 91-99.
Mononuclear silver(I) complexes with 1,7-phenanthroline as potent inhibitors of Candida growth
Savić Nada D., Vojnovic Sandra, Glišić Biljana Đ., Crochet Aurélien, Pavic Aleksandar, Janjić Goran V., Pekmezović Marina, Opsenica Igor M., Fromm Katharina M., Nikodinovic-Runic Jasmina, Djuran Miloš I. (2018), Mononuclear silver(I) complexes with 1,7-phenanthroline as potent inhibitors of Candida growth, in European Journal of Medicinal Chemistry, 156, 760-773.
Synthesis, cytotoxic activity and DNA-binding properties of copper(II) complexes with terpyridine
Glišić Biljana Đ., Nikodinovic-Runic Jasmina, Ilic-Tomic Tatjana, Wadepohl Hubert, Veselinović Aleksandar, Opsenica Igor M., Djuran Miloš I. (2018), Synthesis, cytotoxic activity and DNA-binding properties of copper(II) complexes with terpyridine, in Polyhedron, 139, 313-322.
Chemical profiling of Bulgarian rose absolute (Rosa damascena Mill.) using gas chromatography–mass spectrometry and trimethylsilyl derivatives
Nedeltcheva-Antonova Daniela, Stoicheva Petya, Antonov Liudmil (2017), Chemical profiling of Bulgarian rose absolute (Rosa damascena Mill.) using gas chromatography–mass spectrometry and trimethylsilyl derivatives, in Industrial Crops and Products, 108, 36-43.
Tautomerism of N -(3,4-dichlorophenyl)-1 H -indazole-5-carboxamide – A new selective, highly potent and reversible MAO-B inhibitor
Tzvetkov Nikolay T., Stammler Hans-Georg, Antonov Liudmil (2017), Tautomerism of N -(3,4-dichlorophenyl)-1 H -indazole-5-carboxamide – A new selective, highly potent and reversible MAO-B inhibitor, in Journal of Molecular Structure, 1149, 273-281.
Mononuclear gold(III) complexes with phenanthroline ligands as efficient inhibitors of angiogenesis: A comparative study with auranofin and sunitinib
Pavic Aleksandar, Glišić Biljana Đ., Vojnovic Sandra, Warżajtis Beata, Savić Nada D., Antić Marija, Radenković Slavko, Janjić Goran V., Nikodinovic-Runic Jasmina, Rychlewska Urszula, Djuran Miloš I. (2017), Mononuclear gold(III) complexes with phenanthroline ligands as efficient inhibitors of angiogenesis: A comparative study with auranofin and sunitinib, in Journal of Inorganic Biochemistry, 174, 156-168.
Hydrolysis of the amide bond in histidine- and methionine-containing dipeptides promoted by pyrazine and pyridazine palladium(II)-aqua dimers: Comparative study with platinum(II) analogues
Živković Marija D., Rajković Snežana, Glišić Biljana Đ., Drašković Nenad S., Djuran Miloš I. (2017), Hydrolysis of the amide bond in histidine- and methionine-containing dipeptides promoted by pyrazine and pyridazine palladium(II)-aqua dimers: Comparative study with platinum(II) analogues, in Bioorganic Chemistry, 72, 190-198.
Crystal structures, binding interactions, and ADME evaluation of brain penetrant N -substituted indazole-5-carboxamides as subnanomolar, selective monoamine oxidase B and dual MAO-A/B inhibitors
Tzvetkov Nikolay T., Stammler Hans-Georg, Neumann Beate, Hristova Silvia, Antonov Liudmil, Gastreich Marcus (2017), Crystal structures, binding interactions, and ADME evaluation of brain penetrant N -substituted indazole-5-carboxamides as subnanomolar, selective monoamine oxidase B and dual MAO-A/B inhibitors, in European Journal of Medicinal Chemistry, 127, 470-492.
Subnanomolar indazole-5-carboxamide inhibitors of monoamine oxidase B (MAO-B) continued: indications of iron binding, experimental evidence for optimised solubility and brain penetration
Tzvetkov Nikolay T., Antonov Liudmil (2017), Subnanomolar indazole-5-carboxamide inhibitors of monoamine oxidase B (MAO-B) continued: indications of iron binding, experimental evidence for optimised solubility and brain penetration, in Journal of Enzyme Inhibition and Medicinal Chemistry, 32(1), 960-967.
4-Carboxyl-2,6-dinitrophenylazohydroxynaphthalenes tautomerism theoretically re-explained
Manolova Y., Nedeltcheva D., Antonov L. (2017), 4-Carboxyl-2,6-dinitrophenylazohydroxynaphthalenes tautomerism theoretically re-explained, in Dyes and Pigments, 136, 663-668.
Dynamics of excited state proton transfer in nitro substituted 10-hydroxybenzo[h]quinolines
Marciniak H., Hristova S., Deneva V., Kamounah F. S., Hansen P. E., Lochbrunner S., Antonov L. (2017), Dynamics of excited state proton transfer in nitro substituted 10-hydroxybenzo[h]quinolines, in Phys. Chem. Chem. Phys., 19(39), 26621-26629.
Solvent control of intramolecular proton transfer: is 4-hydroxy-3-(piperidin-1-ylmethyl)-1- naphthaldehyde a proton crane?
Manolova Y., Marciniak H., Tschierlei S., Fennel F., Kamounah F.S., Lochbrunner S., Antonov L. (2017), Solvent control of intramolecular proton transfer: is 4-hydroxy-3-(piperidin-1-ylmethyl)-1- naphthaldehyde a proton crane?, in Physical Chemistry Chemical Physics, 19, 7316-7325.
A simple approach to multifunctionalized N1-alkylated 7-amino-6-azaoxindole derivatives using their in situ stabilized tautomer form
Tzvetkov Nikolay T., Neumann Beate, Stammler Hans-Georg, Antonov Liudmil (2016), A simple approach to multifunctionalized N1-alkylated 7-amino-6-azaoxindole derivatives using their in situ stabilized tautomer form, in Tetrahedron , 72, 6455-6466.
Controlled Tautomerism: Is It Possible?
Nedeltcheva Daniela, Antonov Liudmil (2016), Controlled Tautomerism: Is It Possible?, in Antonov Liudmil (ed.), Wiley-VCH, Weinheim, 273-294.
10-Hydroxybenzo[h]quinoline: switching between single- and double-well proton transfer through structural modifications
Hristova S., Dobrikov G., Kamounah F.S., Kawauchi S., Hansen P.E., Deneva V., Nedeltcheva D., Antonov L. (2015), 10-Hydroxybenzo[h]quinoline: switching between single- and double-well proton transfer through structural modifications, in RSC Advances, 5, 102495-102507.

Collaboration

Group / person Country
Types of collaboration
University of Kragujevac Serbien (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
- Exchange of personnel
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences Bulgaria (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
- Exchange of personnel

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
International Meeting on Supramolecular Chemistry in Medicine and in Technology Poster SYNTHESIS, STRUCTURAL CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SILVER(I) COMPLEXES WITH 1-BENZYL-1H-TETRAZOLES 30.08.2018 Albena (Varna), Bulgaria Djuran Miloš;
International Meeting on Supramolecular Chemistry in Medicine and in Technology Poster HYDRAZONE-BASED MOLECULAR SWITCHES: UNDERSTANDING STRUCTURE AND SWITCHING MECHANISM 30.08.2018 Albena (Varna), Bulgaria Antonov Liudmil;
International Meeting on Supramolecular Chemistry in Medicine and in Technology Poster IMPROVEMENT OF ANTIFUNGAL POTENTIAL OF ITRACONAZOLE DRUG AFTER ITS COORDINATION TO SILVER(I) 30.08.2018 Albena (Varna), Bulgaria Djuran Miloš;
International Meeting on Supramolecular Chemistry in Medicine and in Technology Poster DESIGN OF NEW TAUTOMERIC MOLECULAR SENSORS 30.08.2018 Albena (Varna), Bulgaria Antonov Liudmil;
International Meeting on Supramolecular Chemistry in Medicine and in Technology Talk given at a conference Structuring effect of metal ions on peptides 30.08.2018 Varna, Bulgaria Fromm Katharina M.;
International Meeting on Supramolecular Chemistry in Medicine and in Technology Poster Functional metal-organic materials of anthracene 30.08.2018 Albena (Varna), Bulgaria Fromm Katharina M.;
International Meeting on Supramolecular Chemistry in Medicine and in Technology Poster INTERACTIONS OF BENZODIAZINE-BRIDGED DINUCLEAR PALLADIUM(II) COMPLEXES WITH DNA AND BOVINE SERUM ALBUMIN 30.08.2018 Albena (Varna), Bulgaria Djuran Miloš;
International Meeting on Supramolecular Chemistry in Medicine and in Technology Poster (β-Ala)2 derivatives – Synthesis, Characterization & Self-Assembly (SCS) 30.08.2018 Albena (Varna), Bulgaria Fromm Katharina M.;
International Meeting on Supramolecular Chemistry in Medicine and in Technology Poster REACTIONS OF DINUCLEAR PLATINUM(II) COMPLEXES WITH BIOMOLECULES CONTAINING NITROGEN AND SULFUR DONOR ATOMS 30.08.2018 Albena (Varna), Bulgaria Djuran Miloš;
International Meeting on Supramolecular Chemistry in Medicine and in Technology Poster IMPROVEMENT OF ANTIFUNGAL POTENTIAL OF ITRACONAZOLE DRUG AFTER ITS COORDINATION TO SILVER(I) 30.08.2018 Albena (Varna), Bulgaria Djuran Miloš;
International Meeting on Supramolecular Chemistry in Medicine and in Technology Poster A CONCEPT FOR STIMULATED PROTON TRANSFER IN 1-(PHENYLDIAZENYL) NAPHTHALEN-2-OLS 30.08.2018 Albena (Varna), Bulgaria Antonov Liudmil;
International Meeting on Supramolecular Chemistry in Medicine and in Technology Poster ANTIFUNGAL SILVER(I) COMPLEXES WITH 1,7-PHENANTHROLINE: POSSIBLE MECHANISM OF ACTION 30.08.2018 Albena (Varna), Bulgaria Djuran Miloš;
55 th Meeting of the Serbian Chemical Society Poster Polynuclear silver (I) complexes with 1,5 -napthyridine as efficient antifungal agents 08.06.2018 Novi Sad, Serbien Djuran Miloš;
54 th Meeting of the Serbian Chemical Society. 5th Conference of Young Chemists of Serbia Poster Silver (I) complexes with phenanthrolines: the influence of ligand and silver (I)salt on the complex nuclearity 29.09.2017 Beograd, Serbien Djuran Miloš; Fromm Katharina M.;
International Meeting on Medicinal and Bio(in)organic Chemistry Talk given at a conference A CONCEPT FOR STIMULATED PROTON TRANSFER IN 1-(PHENYLDIAZENYL)NAPHTHALEN-2-OLS 26.08.2017 Vrnjačka Banja, Serbien Antonov Liudmil;
International Meeting on Medicinal and Bio(in)organic Chemistry Talk given at a conference MODEL PEPTIDE STUDIES OF Ag+ BINDING SITES FROM THE SILVER RESISTANCE PROTEIN SilE 26.08.2017 Vrnjačka Banja, Serbien Fromm Katharina M.;
International Meeting on Medicinal and Bio(in)organic Chemistry Talk given at a conference COMBINED STUDIES TOWARDS THE AGGREGATION OF TRIMETHINE CYANINE DYES 26.08.2017 Vrnjačka Banja, Serbien Antonov Liudmil;
International Meeting on Medicinal and Bio(in)organic Chemistry Talk given at a conference VINYL ENONES - EXCELLENT PRECURSORS FOR SYNTHESIS OF PYRAZOLOPYRAZOLONES 26.08.2017 Vrnjačka Banja, Serbien Djuran Miloš;
International Meeting on Medicinal and Bio(in)organic Chemistry Talk given at a conference MINERAL RESPIRATION IN BACTERIA: ON THE BIOSYNTHESIS OF SILVER NANOPARTICLES 26.08.2017 Vrnjačka Banja, Serbien Fromm Katharina M.;
International Meeting on Medicinal and Bio(in)organic Chemistry Talk given at a conference MOLECULAR ROTORS BASED ON TAUTOMERIC PROCESSES 26.08.2017 Vrnjačka Banja, Serbien Antonov Liudmil;
International Meeting on Medicinal and Bio(in)organic Chemistry Talk given at a conference POLYMORPHISM, WHAT IT IS AND HOW TO IDENTIFY IT 26.08.2017 Vrnjačka Banja, Serbien Fromm Katharina M.;
International Meeting on Medicinal and Bio(in)organic Chemistry Talk given at a conference GOLD(III) COMPLEXES AS EFFECTIVE ANGIOGENESIS INHIBITORS 26.08.2017 Vrnjačka Banja, Serbien Djuran Miloš;
International Meeting on Medicinal and Bio(in)organic Chemistry Talk given at a conference NANO-BIO-SILVER 26.08.2017 Vrnjačka Banja, Serbien Fromm Katharina M.;
International Meeting on Medicinal and Bio(in)organic Chemistry Talk given at a conference METAL COMPLEXES AS A BASE FOR NEW ANTIFUNGAL DRUGS 26.08.2017 Vrnjačka Banja, Serbien Djuran Miloš;
"Supramolecular chemistry - methods, concepts and applications" Poster 1-(PHENYLDIAZENYL)-3-(PIPERIDIN-1-YLMETHYL)NAPHTHALEN-2-OL - A CONCEPT FOR STIMULATED PROTON TRANSFER 19.04.2017 Plovdiv, Bulgaria Antonov Liudmil;
"Supramolecular chemistry - methods, concepts and applications" Poster 4-HYDROXY-3-(PIPERIDIN-1-YLMETHYL)-1-NAPHTHALDEHYDE - A POTENTIAL CANDIDATE FOR MOLECULAR SWITCH 19.04.2017 Plovdiv, Bulgaria Fromm Katharina M.; Antonov Liudmil;
"Supramolecular chemistry - methods, concepts and applications" Poster SYNTHESIS AND CHARACTERIZATION OF 2,2-diMe-1,3-pdta-Ni(II) COMPLEX: THE INFLUENCE OF SUBSTITUENTS IN THE 1,3-PROPANEDIAMINE RING ON THE COMPLEX STRUCTURE 19.04.2017 Plovdiv, Bulgaria Djuran Miloš;
"Supramolecular chemistry - methods, concepts and applications" Poster A HYDRAZONE-BASED MOLECULAR SWITCH: THEORETICAL STUDY OF THE ROTARY ACTION IN NEUTRAL AND PROTONATED STATE 19.04.2017 Plovdiv, Bulgaria Antonov Liudmil;
"Supramolecular chemistry - methods, concepts and applications" Poster SILVER(I) COMPLEXES WITH PHENANTHROLINE LIGANDS: STRUCTURAL CHARACTERIZATION AND BIOLOGICAL EVALUATION 19.04.2017 Plovdiv, Bulgaria Djuran Miloš; Fromm Katharina M.;
"Supramolecular chemistry - methods, concepts and applications" Talk given at a conference Supramolecular heterometallic coordination compounds: synthesis, structure and applications 19.04.2017 Plovdiv, Bulgaria Fromm Katharina M.;
"Supramolecular chemistry - methods, concepts and applications" Poster THE POSSIBLE TAUTOMERISM OF THE ROTARY SWITCH 2-(2-(2-HYDROXY-4-NITROPHENYL)HYDRAZONO)-1-PHENYLBUTANE-1,3-DIONE 19.04.2017 Plovdiv, Bulgaria Antonov Liudmil;
Xth Conference in Chemistry Poster 2-(2-(2-hydroxy-4-nitrophenyl)-hydrazono)-1-phenylbutane-1,3-dione: a potential rotory switch 09.11.2016 Plovdiv, Bulgaria Antonov Liudmil;
Fourth Conference of Young Chemists of Serbia Poster Synthesis and characterization of silver(I) complexes with aromatic N-heterocycles 05.10.2016 Belgrade, Serbien Djuran Miloš; Fromm Katharina M.;
VI-th National Crystallographic Symposium NCS2016 Poster First example of three stable desmotropes 05.10.2016 Sofia, Bulgaria Antonov Liudmil;
VI-th National Crystallographic Symposium NCS2016 Talk given at a conference From mixed-metal coordination compounds towards nanomaterials 05.10.2016 Sofia, Bulgaria Fromm Katharina M.;
VI-th National Crystallographic Symposium NCS2016 Poster Molecular wires: Design of new tautomeric ligands 05.10.2016 Sofia, Bulgaria Antonov Liudmil; Fromm Katharina M.;
18th Central and Eastern European NMR Symposium & Bruker User’s Meeting Poster Tuneable by the side chain tautomerism in azonaphthol dyes 18.09.2016 Sofia, Bulgaria Antonov Liudmil; Fromm Katharina M.;
30th European Crystallographic Meeting Poster Crystal structures of novel polydentate N,O-ligands 28.08.2016 Basel, Switzerland Fromm Katharina M.;
"Supramolecular Chemistry: Ideas, Design and Methods for Investigations" Talk given at a conference Metal complexes in medicine: Gold(III) complexes as potential antitumor and antimicrobial agents 16.06.2016 Borovets, near Sofia, Bulgaria Djuran Miloš;
"Supramolecular Chemistry: Ideas, Design and Methods for Investigations" Poster SYNTHESIS AND BIOLOGICAL EVALUATION OF DINUCLEAR GOLD(III) COMPLEXES WITH AROMATIC NITROGEN-CONTAINING HETEROCYCLES 16.06.2016 Borovets, near Sofia, Bulgaria Djuran Miloš;
"Supramolecular Chemistry: Ideas, Design and Methods for Investigations" Poster BACTERIAL RESISTANCE TO SILVER: THE ROLE OF SilE PROTEIN 16.06.2016 Borovets, near Sofia, Bulgaria Fromm Katharina M.;
"Supramolecular Chemistry: Ideas, Design and Methods for Investigations" Poster MULTITOPIC PRECURSORS FOR OXIDE MATERIALS’ SYNTHESIS 16.06.2016 Borovets, near Sofia, Bulgaria Fromm Katharina M.;
"Supramolecular Chemistry: Ideas, Design and Methods for Investigations" Poster FERROCENE DERIVATIVES: NEW MECHANOPHORES FOR STIMULI-RESPONSIVE MATERIALS 16.06.2016 Borovets, near Sofia, Bulgaria Fromm Katharina M.;
"Supramolecular Chemistry: Ideas, Design and Methods for Investigations" Poster 10-HYDROXYBENZO[H]QUINOLINE: SWITCHING BETWEEN SINGLE- AND DOUBLE-WELL PROTON TRANSFER THROUGH STRUCTURAL MODIFICATIONS 16.06.2016 Borovets, near Sofia, Bulgaria Antonov Liudmil;
Meeting "Supramolecular Chemistry: Ideas, Design and Methods for Investigations" Talk given at a conference UV-Vis spectroscopy, binding constants, chemometrics 16.06.2016 Borovets, near Sofia, Bulgaria Antonov Liudmil;
"Supramolecular Chemistry: Ideas, Design and Methods for Investigations" Poster SYNERGISTIC ANTIMICROBIAL EFFECT OF SILVER AND OTHER METALS IN BIMETALLIC COMPLEXES 16.06.2016 Borovets, near Sofia, Bulgaria Fromm Katharina M.;
"Supramolecular Chemistry: Ideas, Design and Methods for Investigations" Poster DESIGN OF LUMINESCENT METAL–ORGANIC FRAMEWORKS (MOFs) OF Zn(II) AND Cd(II) WITH ANTHRACENE–BASED LIGANDS 16.06.2016 Borovets, near Sofia, Bulgaria Fromm Katharina M.;
"Supramolecular Chemistry: Ideas, Design and Methods for Investigations" Poster 4-HYDROXY-1-NAPHTHALDEHYDES: THE DECEPTIVE TAUTOMERISM 16.06.2016 Borovets, near Sofia, Bulgaria Fromm Katharina M.; Antonov Liudmil;
"Supramolecular Chemistry: Ideas, Design and Methods for Investigations" Poster TAUTOMERIC MOLECULAR ROTORS 16.06.2016 Borovets, near Sofia, Bulgaria Antonov Liudmil;
"Supramolecular Chemistry: Ideas, Design and Methods for Investigations" Poster DINUCLEAR PALLADIUM(II) COMPLEXES AS A CATALYTIC REAGENTS FOR THE HYDROLYSIS OF METHIONINE- AND HISTIDINE-CONTAINING DIPEPTIDES 16.06.2016 Borovets, near Sofia, Bulgaria Djuran Miloš;
Scientific Colloquium of Faculty of Chemistry, University of Plovdiv, Bulgaria Individual talk From Analytical Chemistry to Molecular Electronics 18.02.2016 Plovdiv, Bulgaria Antonov Liudmil;


Self-organised

Title Date Place
International Meeting on Supramolecular Chemistry in Medicine and in Technology 30.08.2018 Albena (Varna), Bulgaria
International Meeting on Medicinal and Bio(in)organic Chemistry 26.08.2017 Vrnjačka Banja, Serbien

Awards

Title Year
Bulgarian Grand Prize for PhD thesis Award to Dr. Silvia Hristova 2021
Grand National Pythagoras Prize 2021 (=Bulgarian Nobel Prize) 2021
One of the three national nominees for The National Annual Prize for Advanced Research in Natural Sciences Pitagor 2016 http://www.mon.bg/?h=downloadFile&fileId=9524 2016
Second prize for Best BSc/MSc Thesis in Chemistry (Annual national competition of The Union of Bulgarian Chemists) for Silvia Hristova (BSc thesis under supervision of Liudmil Antonov) 2016

Abstract

Supramolecular chemistry offers the design of molecular information-controlled, "programmed," and functional self-organizing systems, and provides an original approach to nanoscience, as well as a powerful alternative/complement to nanofabrication, nanomanipulation and drug delivery. All this makes supramolecular chemistry a truly multidisciplinary research subject with great potential for the future development -and logically brings the need for suitable teaching. This training at the level of young researchers and students cannot possibly encompass all biomedical aspects of the supramolecular idea, but must concentrate on the achievements reached with synthetic ligands interacting with biological systems. Following this concept it is clear that the teaching cannot give illustration of all aspects of non-covalent assemblies in the biomedical field. And there is no need to do that! It is enough to make visible, for the young people, the unlimited possibilities of using intermolecular interactions in living systems and to inspire them. The inspiration is the building stone of the current proposal. In this Institutional Partnership we unite the efforts of the Department of Chemistry and the Adolphe Merkle Institute (AMI) (University of Fribourg), the Faculty of Science (University of Kragujevac) and the Institute of Organic Chemistry (Bulgarian Academy of Sciences) in creating of suitable educational background for teaching in supramolecular chemistry and its biomedical applications in the Balkan area. This geographic area, for long time a synonym of violence and instability, is now in a process of transition, success of which crucially depends on the availability of well-educated, motivated, beyond geographical borders minded young people. With SupraMedChem@Balkans.Net we plan to create a solid background in the modern teaching in supramolecular chemistry and to implement the best Swiss educational and research standards. This will be achieved by a three layers approach:- Teaching activities (basic layer), which aim to develop new curricula for teaching in supramolecular chemistry and to provide conditions for training in the general concepts of supramolecular chemistry by organizing Summer/Winter schools;- Training initiatives (upgrade layer), which are directed to increase the capacity of the staff of the partner institutions to do research and education in biomedical supramolecular chemistry through personnel exchange and organizing workshops;- Strengthening the research and renewal of the infrastructure (sustainable development layer) in order to strengthen the training and research capacity of the participating Balkan institutions.Number of important outcomes is expected in respect of the institutional capacity building, but the most substantial benefits are expected for the young people (high school and university students, PhD students and young researchers). This IP provides a unique opportunity to build up an educational profile and research career. We will provide basic (Summer schools) and advanced (Workshops and exchange scheme) teaching by using the complementary expertise (solid state - solution - gas phase; theory - experimental studies) of the partner groups. Through the exchange schemes the trainees will have the opportunity to work in different scientific and cultural environment, to establish new contacts and friendships and to acquire new skills in the research and management. The proposal unites 3 successful research teams, working actively in experimental supramolecular chemistry, and gives a clear perspective for strengthening their research and teaching by creating condition for expansion in the biomedical direction and for collaborative networking in future.
-