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The two faces of neuroplasticity - In vivo study of brain plasticity induced by epileptic seizures and electroconvulsive therapy

English title The two faces of neuroplasticity - In vivo study of brain plasticity induced by epileptic seizures and electroconvulsive therapy
Applicant Draganski Bogdan
Number 159780
Funding scheme Project funding
Research institution Laboratoire de Recherche en Neuroimagerie Departement de Neuroscience Cliniques CHUV
Institution of higher education University of Lausanne - LA
Main discipline Neurophysiology and Brain Research
Start/End 01.04.2016 - 31.03.2019
Approved amount 372'000.00
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All Disciplines (3)

Discipline
Neurophysiology and Brain Research
Neurology, Psychiatry
Pathophysiology

Keywords (7)

Brain; Computational anatomy; functional MRI; MRI; Neuroplasticity; Electroconvulsive therapy; Seizures

Lay Summary (German)

Lead
Modulation der Neurogenese im menschlichen Hippocampus - neurobiologische Folgen und Auswirkungen auf das Verhalten.
Lay summary

Hauptziel unseres Projektes ist die in vivo Untersuchung der Folgen einer Stimulation der Produktion neuer Hirnzellen (Neurogenese) auf die Funktion des menschlichen Gehirns und Verhaltens. Aufbauend auf unsere frühere Arbeiten zum Thema der Training-induzierten Hirnplastizität und anatomischen Veränderungen vom Hippocampus nach elektro-konvulsiven Therapie, wollen wir unseren Verständnis über die Regelmechanismen der Neurogenese im Erwachsenengehirn vertiefen und diese mit individuellem Lernverhalten in Zusammenhang bringen. Die Hypothese hier ist dass die lebenslange Produktion von neuen Hirnzellen dient nicht nur der Ersetzung alter Neuronen, hat aber hauptsächlich eine wichtige Rolle für das Gedächtnis und im weiteren Sinne für das menschliche Verhalten.

Unser Projekt ist auf Beispiele vom klinischen Alltag basiert - die Experimente sind auf die Modulation der Neurogenese durch endogene (gelegentlicher epileptische Anfall bei Temporallappenepilepsie Patienten) oder exogene (induziert durch geplante therapeutische electro-konvulsive Therapie) epileptische Aktivität fokussiert. Darüber hinaus untersuchen wir die Effekte von repetitiver transkraniellen Magnetstimulation unter der Anfallsschwelle in gesunden Probanden.  

Die akkurate in vivo Erfassung der Dynamik der Neurogenese wird uns verhelfen Grundprinzipien der exogenen und endogenen Modulation vom Verhalten zu verstehen und wird damit neue Perspektiven in der Behandlung von kognitiven Defizite bei Hirnerkrankungen öffnen.

Direct link to Lay Summary Last update: 23.06.2019

Responsible applicant and co-applicants

Employees

Publications

Publication
1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans
Sønderby Ida E, van der Meer Dennis, Moreau Clara, Kaufmann Tobias, Walters G Bragi, Ellegaard Maria, Abdellaoui Abdel, Ames David, Amunts Katrin, Andersson Micael, Armstrong Nicola J, Bernard Manon, Blackburn Nicholas B, Blangero John, Boomsma Dorret I, Brodaty Henry, Brouwer Rachel M, Bülow Robin, Bøen Rune, Cahn Wiepke, Calhoun Vince D, Caspers Svenja, Ching Christopher R K, Cichon Sven, Ciufolini Simone, Crespo-Facorro Benedicto, Curran Joanne E, Dale Anders M, Dalvie Shareefa, Dazzan Paola, de Geus Eco J C, de Zubicaray Greig I, de Zwarte Sonja M C, Desrivieres Sylvane, Doherty Joanne L, Donohoe Gary, Draganski Bogdan, Ehrlich Stefan, Eising Else, Espeseth Thomas, Fejgin Kim, Fisher Simon E, Fladby Tormod, Frei Oleksandr, Frouin Vincent, Fukunaga Masaki, Gareau Thomas, Ge Tian, Glahn David C, Grabe Hans J, Groenewold Nynke A, Gústafsson Ómar, Haavik Jan, Haberg Asta K, Hall Jeremy, Hashimoto Ryota, Hehir-Kwa Jayne Y, Hibar Derrek P, Hillegers Manon H J, Hoffmann Per, Holleran Laurena, Holmes Avram J, Homuth Georg, Hottenga Jouke-Jan, Hulshoff Pol Hilleke E, Ikeda Masashi, Jahanshad Neda, Jockwitz Christiane, Johansson Stefan, Jönsson Erik G, Jørgensen Niklas R, Kikuchi Masataka, Knowles Emma E M, Kumar Kuldeep, Le Hellard Stephanie, Leu Costin, Linden David E J, Liu Jingyu, Lundervold Arvid, Lundervold Astri Johansen, Maillard Anne M, Martin Nicholas G, Martin-Brevet Sandra, Mather Karen A, Mathias Samuel R, McMahon Katie L, McRae Allan F, Medland Sarah E, Meyer-Lindenberg Andreas, Moberget Torgeir, Modenato Claudia, Sánchez Jennifer Monereo, Morris Derek W, Mühleisen Thomas W, Murray Robin M, Nielsen Jacob, Nordvik Jan E, Nyberg Lars, Loohuis Loes M Olde, Ophoff Roel A (2021), 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans, in Translational psychiatry, 11(1), 182-182.
Apolipoprotein E4 effects on topological brain network organization in mild cognitive impairment
Sanabria-Diaz Gretel, Melie-Garcia Lester, Draganski Bogdan, Demonet Jean-Francois, Kherif Ferath (2021), Apolipoprotein E4 effects on topological brain network organization in mild cognitive impairment, in Scientific reports, 11(1), 845-845.
Brain plasticity dynamics during tactile Braille learning in sighted subjects: Multi-contrast MRI approach
Matuszewski Jacek, Kossowski Bartosz, Bola Łukasz, Banaszkiewicz Anna, Paplińska Małgorzata, Gyger Lucien, Kherif Ferath, Szwed Marcin, Frackowiak Richard S, Jednoróg Katarzyna, Draganski Bogdan, Marchewka Artur (2021), Brain plasticity dynamics during tactile Braille learning in sighted subjects: Multi-contrast MRI approach, in NeuroImage, 227, 117613-117613.
Brain tissue properties link cardio-vascular risk factors, mood and cognitive performance in the CoLaus|PsyCoLaus epidemiological cohort
Trofimova Olga, Loued-Khenissi Leyla, DiDomenicantonio Giulia, Lutti Antoine, Kliegel Matthias, Stringhini Silvia, Marques-Vidal Pedro, Vollenweider Peter, Waeber Gérard, Preisig Martin, Kherif Ferath, Draganski Bogdan (2021), Brain tissue properties link cardio-vascular risk factors, mood and cognitive performance in the CoLaus|PsyCoLaus epidemiological cohort, in Neurobiology of aging, 102, 50-63.
Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape
Sulc Jonathan, Sonrel Anthony, Mounier Ninon, Auwerx Chiara, Marouli Eirini, Darrous Liza, Draganski Bogdan, Kilpeläinen Tuomas O., Joshi Peter, Loos Ruth J. F., Kutalik Zoltán (2021), Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape, in Communications Biology, 4(1), 1-13.
Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs
Sønderby Ida E, Ching Christopher R K, Thomopoulos Sophia I, van der Meer Dennis, Sun Daqiang, Villalon-Reina Julio E, Agartz Ingrid, Amunts Katrin, Arango Celso, Armstrong Nicola J, Ayesa-Arriola Rosa, Bakker Geor, Bassett Anne S, Boomsma Dorret I, Bülow Robin, Butcher Nancy J, Calhoun Vince D, Caspers Svenja, Chow Eva W C, Cichon Sven, Ciufolini Simone, Craig Michael C, Crespo-Facorro Benedicto, Cunningham Adam C, Dale Anders M, Dazzan Paola, de Zubicaray Greig I, Djurovic Srdjan, Doherty Joanne L, Donohoe Gary, Draganski Bogdan, Durdle Courtney A, Ehrlich Stefan, Emanuel Beverly S, Espeseth Thomas, Fisher Simon E, Ge Tian, Glahn David C, Grabe Hans J, Gur Raquel E, Gutman Boris A, Haavik Jan, Håberg Asta K, Hansen Laura A, Hashimoto Ryota, Hibar Derrek P, Holmes Avram J, Hottenga Jouke-Jan, Hulshoff Pol Hilleke E, Jalbrzikowski Maria, Knowles Emma E M, Kushan Leila, Linden David E J, Liu Jingyu, Lundervold Astri J, Martin-Brevet Sandra, Martínez Kenia, Mather Karen A, Mathias Samuel R, McDonald-McGinn Donna M, McRae Allan F, Medland Sarah E, Moberget Torgeir, Modenato Claudia, Monereo Sánchez Jennifer, Moreau Clara A, Mühleisen Thomas W, Paus Tomas, Pausova Zdenka, Prieto Carlos, Ragothaman Anjanibhargavi, Reinbold Céline S, Reis Marques Tiago, Repetto Gabriela M, Reymond Alexandre, Roalf David R, Rodriguez-Herreros Borja, Rucker James J, Sachdev Perminder S, Schmitt James E, Schofield Peter R, Silva Ana I, Stefansson Hreinn, Stein Dan J, Tamnes Christian K, Tordesillas-Gutiérrez Diana, Ulfarsson Magnus O, Vajdi Ariana, van 't Ent Dennis, van den Bree Marianne B M, Vassos Evangelos, Vázquez-Bourgon Javier, Vila-Rodriguez Fidel, Walters G Bragi, Wen Wei, Westlye Lars T, Wittfeld Katharina, Zackai Elaine H, Stefánsson Kári, Jacquemont Sebastien (2021), Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs, in Human brain mapping, 1-29.
Effects of eight neuropsychiatric copy number variants on human brain structure
Modenato Claudia, Kumar Kuldeep, Moreau Clara, Martin-Brevet Sandra, Huguet Guillaume, Schramm Catherine, Jean-Louis Martineau, Martin Charles-Olivier, Younis Nadine, Tamer Petra, Douard Elise, Thébault-Dagher Fanny, Côté Valérie, Charlebois Audrey-Rose, Deguire Florence, Maillard Anne M, Rodriguez-Herreros Borja, Pain Aurèlie, Richetin Sonia, 16p11.2 European Consortium, Simons Searchlight Consortium, Melie-Garcia Lester, Kushan Leila, Silva Ana I, van den Bree Marianne B M, Linden David E J, Owen Michael J, Hall Jeremy, Lippé Sarah, Chakravarty Mallar, Bzdok Danilo, Bearden Carrie E, Draganski Bogdan, Jacquemont Sébastien (2021), Effects of eight neuropsychiatric copy number variants on human brain structure, in Translational psychiatry, 11(1), 399-399.
Gradient of electro-convulsive therapy's antidepressant effects along the longitudinal hippocampal axis
Gyger Lucien, Regen Francesca, Ramponi Cristina, Marquis Renaud, Mall Jean-Frederic, Swierkosz-Lenart Kevin, von Gunten Armin, Toni Nicolas, Kherif Ferath, Heuser Isabella, Draganski Bogdan (2021), Gradient of electro-convulsive therapy's antidepressant effects along the longitudinal hippocampal axis, in Translational psychiatry, 11(1), 191-191.
Mapping grip force to motor networks
Weitnauer Ladina, Frisch Stefan, Melie-Garcia Lester, Preisig Martin, Schroeter Matthias L., Sajfutdinow Ines, Kherif Ferath, Draganski Bogdan (2021), Mapping grip force to motor networks, in NeuroImage, 229, 117735-117735.
Temporal trajectory of brain tissue property changes induced by electroconvulsive therapy
Gyger L., Ramponi C., Mall J.F., Swierkosz-Lenart K., Stoyanov D., Lutti A., von Gunten A., Kherif F., Draganski B. (2021), Temporal trajectory of brain tissue property changes induced by electroconvulsive therapy, in NeuroImage, 232, 117895-117895.
The Relationship between Life Course Socioeconomic Conditions and Objective and Subjective Memory in Older Age
Künzi Morgane, Joly-Burra Emilie, Zuber Sascha, Haas Maximilian, Tinello Doriana, Da Silva Coelho Chloé, Hering Alexandra, Ihle Andreas, Laera Gianvito, Mikneviciute Greta, Stringhini Silvia, Draganski Bogdan, Kliegel Matthias, Ballhausen Nicola (2021), The Relationship between Life Course Socioeconomic Conditions and Objective and Subjective Memory in Older Age, in Brain sciences, 11(1), 1-16.
Unraveling brain interactions in vision: The example of crowding
Jastrzębowska Maya A, Chicherov Vitaly, Draganski Bogdan, Herzog Michael H (2021), Unraveling brain interactions in vision: The example of crowding, in NeuroImage, 240, 118390-118390.
Converging patterns of aging-associated brain volume loss and tissue microstructure differences
Taubert M., Roggenhofer E., Melie-Garcia L., Muller S., Lehmann N., Preisig M., Vollenweider P., Marques-Vidal P., Lutti A., Kherif F., Draganski B. (2020), Converging patterns of aging-associated brain volume loss and tissue microstructure differences, in Neurobiology of Aging, 108-118.
Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia
Sønderby Ida E, Gústafsson Ómar, Doan Nhat Trung, Hibar Derrek P, Martin-Brevet Sandra, Abdellaoui Abdel, Ames David, Amunts Katrin, Andersson Michael, Armstrong Nicola J, Bernard Manon, Blackburn Nicholas, Blangero John, Boomsma Dorret I, Bralten Janita, Brattbak Hans-Richard, Brodaty Henry, Brouwer Rachel M, Bülow Robin, Calhoun Vince, Caspers Svenja, Cavalleri Gianpiero, Chen Chi-Hua, Cichon Sven, Ciufolini Simone, Corvin Aiden, Crespo-Facorro Benedicto, Curran Joanne E, Dale Anders M, Dalvie Shareefa, Dazzan Paola, de Geus Eco J C, de Zubicaray Greig I, de Zwarte Sonja M C, Delanty Norman, den Braber Anouk, Desrivières Sylvane, Donohoe Gary, Draganski Bogdan, Ehrlich Stefan, Espeseth Thomas, Fisher Simon E, Franke Barbara, Frouin Vincent, Fukunaga Masaki, Gareau Thomas, Glahn David C, Grabe Hans, Groenewold Nynke A, Haavik Jan, Håberg Asta, Hashimoto Ryota, Hehir-Kwa Jayne Y, Heinz Andreas, Hillegers Manon H J, Hoffmann Per, Holleran Laurena, Hottenga Jouke-Jan, Hulshoff Hilleke E, Ikeda Masashi, Jahanshad Neda, Jernigan Terry, Jockwitz Christiane, Johansson Stefan, Jonsdottir Gudrun A, Jönsson Erik G, Kahn Rene, Kaufmann Tobias, Kelly Sinead, Kikuchi Masataka, Knowles Emma E M, Kolskår Knut K, Kwok John B, Hellard Stephanie Le, Leu Costin, Liu Jingyu, Lundervold Astri J, Lundervold Arvid, Martin Nicholas G, Mather Karen, Mathias Samuel R, McCormack Mark, McMahon Katie L, McRae Allan, Milaneschi Yuri, Moreau Clara, Morris Derek, Mothersill David, Mühleisen Thomas W, Murray Robin, Nordvik Jan E, Nyberg Lars, Olde Loohuis Loes M, Ophoff Roel, Paus Tomas, Pausova Zdenka, Penninx Brenda, Peralta Juan M, Pike Bruce, Prieto Carlos (2020), Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia, in Molecular psychiatry, 25(3), 584-602.
A nation-wide initiative for brain imaging and clinical phenotype data federation in Swiss university memory centres
Draganski Bogdan, Kherif Ferath, Damian Daniel, Demonet Jean-Francois (2019), A nation-wide initiative for brain imaging and clinical phenotype data federation in Swiss university memory centres, in Current Opinion in Neurology, 32(4), 557-563.
Example dataset for the hMRI toolbox
Callaghan Martina F., Lutti Antoine, Ashburner John, Balteau Evelyne, Corbin Nadège, Draganski Bogdan, Helms Gunther, Kherif Ferath, Leutritz Tobias, Mohammadi Siawoosh, Phillips Christophe, Reimer Enrico, Ruthotto Lars, Seif Maryam, Tabelow Karsten, Ziegler Gabriel, Weiskopf Nikolaus (2019), Example dataset for the hMRI toolbox, in Data in Brief, 25, 104132-104132.
Dopaminergic modulation of motor network compensatory mechanisms in Parkinson's disease
Jastrzębowska Maya A., Marquis Renaud, Melie‐García Lester, Lutti Antoine, Kherif Ferath, Herzog Michael H., Draganski Bogdan (2019), Dopaminergic modulation of motor network compensatory mechanisms in Parkinson's disease, in Human Brain Mapping, hbm.24710-hbm.24710.
hMRI – A toolbox for quantitative MRI in neuroscience and clinical research
Tabelow Karsten, Balteau Evelyne, Ashburner John, Callaghan Martina F., Draganski Bogdan, Helms Gunther, Kherif Ferath, Leutritz Tobias, Lutti Antoine, Phillips Christophe, Reimer Enrico, Ruthotto Lars, Seif Maryam, Weiskopf Nikolaus, Ziegler Gabriel, Mohammadi Siawoosh (2019), hMRI – A toolbox for quantitative MRI in neuroscience and clinical research, in NeuroImage, 194, 191-210.
Spatial Resolution and Imaging Encoding fMRI Settings for Optimal Cortical and Subcortical Motor Somatotopy in the Human Brain
Marquis Renaud, Muller Sandrine, Lorio Sara, Rodriguez-Herreros Borja, Melie-Garcia Lester, Kherif Ferath, Lutti Antoine, Draganski Bogdan (2019), Spatial Resolution and Imaging Encoding fMRI Settings for Optimal Cortical and Subcortical Motor Somatotopy in the Human Brain, in Frontiers in Neuroscience, 13, 571.
The Combination of DAT-SPECT, Structural and Diffusion MRI Predicts Clinical Progression in Parkinson’s Disease
Lorio Sara, Sambataro Fabio, Bertolino Alessandro, Draganski Bogdan, Dukart Juergen (2019), The Combination of DAT-SPECT, Structural and Diffusion MRI Predicts Clinical Progression in Parkinson’s Disease, in Frontiers in Aging Neuroscience, 11, 57.
Controlling motion artefact levels in MR images by suspending data acquisition during periods of head motionCastella et al.
Castella Rémi, Arn Lionel, Dupuis Estelle, Callaghan Martina F., Draganski Bogdan, Lutti Antoine (2018), Controlling motion artefact levels in MR images by suspending data acquisition during periods of head motionCastella et al., in Magnetic Resonance in Medicine, 80(6), 2415-2426.
Change in Emotional and Theory of Mind Processing in Borderline Personality DisorderA Pilot Study
Kramer Ueli, Kolly Stéphane, Maillard Pauline, Pascual-Leone Antonio, Samson Andrea C., Schmitt Ruth, Bernini Adriano, Allenbach Gilles, Charbon Patrick, de Roten Yves, Conus Philippe, Despland Jean-Nicolas, Draganski Bogdan (2018), Change in Emotional and Theory of Mind Processing in Borderline Personality DisorderA Pilot Study, in The Journal of Nervous and Mental Disease, 206(12), 935-943.
Quantifying the Effects of 16p11.2 Copy Number Variants on Brain Structure: A Multisite Genetic-First Study
Martin-Brevet Sandra, Rodríguez-Herreros Borja, Nielsen Jared A., Moreau Clara, Modenato Claudia, Maillard Anne M., Pain Aurélie, Richetin Sonia, Jønch Aia E., Qureshi Abid Y., Zürcher Nicole R., Conus Philippe, Chung Wendy K., Sherr Elliott H., Spiro John E., Kherif Ferath, Beckmann Jacques S., Hadjikhani Nouchine, Reymond Alexandre, Buckner Randy L., Draganski Bogdan, Jacquemont Sébastien, Addor Marie-Claude, Andrieux Joris, et al. (2018), Quantifying the Effects of 16p11.2 Copy Number Variants on Brain Structure: A Multisite Genetic-First Study, in Biological Psychiatry, 84(4), 253-264.
Simultaneous estimation of population receptive field and hemodynamic parameters from single point BOLD responses using Metropolis-Hastings sampling
Adaszewski Stanisław, Slater David, Melie-Garcia Lester, Draganski Bogdan, Bogorodzki Piotr (2018), Simultaneous estimation of population receptive field and hemodynamic parameters from single point BOLD responses using Metropolis-Hastings sampling, in NeuroImage, 172, 175-193.
Networks of myelin covariance
Melie‐Garcia Lester, Slater David, Ruef Anne, Sanabria‐Diaz Gretel, Preisig Martin, Kherif Ferath, Draganski Bogdan, Lutti Antoine (2018), Networks of myelin covariance, in Human Brain Mapping, 39(4), 1532-1554.
Evolution of white matter tract microstructure across the life span
Slater David A., Melie‐Garcia Lester, Preisig Martin, Kherif Ferath, Lutti Antoine, Draganski Bogdan (2017), Evolution of white matter tract microstructure across the life span, in Human Brain Mapping, 40(7), 2252-2268.
Regional volumetric change in Parkinson's disease with cognitive decline
Gee Myrlene, Dukart Juergen, Draganski Bogdan, Wayne Martin WR, Emery Derek, Camicioli Richard (2017), Regional volumetric change in Parkinson's disease with cognitive decline, in Journal of the Neurological Sciences, 373, 88-94.
The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy
Oltedal Leif, Bartsch Hauke, Sørhaug Ole Johan Evjenth, Kessler Ute, Abbott Christopher, Dols Annemieke, Stek Max L, Ersland Lars, Emsell Louise, van Eijndhoven Philip, Argyelan Miklos, Tendolkar Indira, Nordanskog Pia, Hamilton Paul, Jorgensen Martin Balslev, Sommer Iris E, Heringa Sophie M, Draganski Bogdan, Redlich Ronny, Dannlowski Udo, Kugel Harald, Bouckaert Filip, Sienaert Pascal, Anand Amit, et al. (2017), The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy, in NeuroImage: Clinical, 14, 422-432.
Brain networks modulated by subthalamic nucleus deep brain stimulation
Accolla Ettore A., Herrojo Ruiz Maria, Horn Andreas, Schneider Gerd-Helge, Schmitz-Hübsch Tanja, Draganski Bogdan, Kühn Andrea A. (2016), Brain networks modulated by subthalamic nucleus deep brain stimulation, in Brain, 139(9), 2503-2515.

Collaboration

Group / person Country
Types of collaboration
Neurologie - Fribourg Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Wellcome Trust Centre for Neuroimaging - UCL Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel
Service Neurologie - HUG Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Neuroradiologie Unispital Bern Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Longitudinal MRI workshop Talk given at a conference Brain plasticity - the nature of nurture 19.11.2018 Melbourne, Australia Draganski Bogdan;
2nd GEMRIC workshop Talk given at a conference Voxel-Based Morphometry -useful extensions 17.09.2018 Bergen, Norway Draganski Bogdan;
Brain Meeting - Wellcome Trust Centre for Neuroimaging, UCL Talk given at a conference Neural plasticity – the quest for brain’s green matter 23.03.2018 London, Great Britain and Northern Ireland Draganski Bogdan;
OHBM Talk given at a conference In vivo studies of use-dependant brain tissue property changes 17.06.2017 Vancouver, Canada Draganski Bogdan;
Continuity and discontinuity in brain research Talk given at a conference Brain plasticity – past, presence and future of neuroimgaing 11.03.2017 Padua, Italy Draganski Bogdan;
11th winter conference European Society for Molecular Imaging Talk given at a conference In vivo studies of use-dependent changes in brain tissue properties 19.02.2017 Les Houches, France Draganski Bogdan;
Neuroscientific colloque, Psychology Department, University Salzburg Talk given at a conference In vivo study of brain plasticity 22.06.2016 Salzburg, Austria Draganski Bogdan;


Associated projects

Number Title Start Funding scheme
186239 Swiss Centenarian Study (SWISS100): Vulnerability and Resilience at Age 100 01.01.2020 Sinergia
140332 Imaging large scale neuronal networks in epilepsy 01.05.2012 SPUM
156854 Structural and functional brain plasticity in inhibitory control: towards expertise 01.01.2015 Project funding
135679 Anatomical and functional segregation within cortico-basal ganglia circuits 01.01.2012 Project funding

Abstract

After more than two decades of research into adult neurogenesis the role of newly generated hippocampal neurons remains poorly understood. Motivated by our early work on use-dependent brain plasticity and our recent findings on the impact of electro-convulsive therapy (ECT) on hippocampus anatomy and behaviour, we want to investigate human neurogenesis in detail and to link the findings to memory performance. We propose to use leading-edge technologies we have pioneered and finally to contrast findings in normal subjects with those in diseases associated with aberrant neurogenesis.We will concentrate on the functional relevance of new immature dentate granule cells on memory encoding. We plan to use epileptic seizures and ECT to boost hippocampal neurogenesis at well-defined time-points and to follow the consequences. These clinical perturbations will i) allow us to define in detail the temporal trajectory of neurogenesis-induced structural brain changes locally in hippocampus and on any effects on cortical areas; ii) permit analysis of the impact of changes in local anatomy and connectivity on inter-individual cognitive variability; and iii) facilitate an assessment of the functional relevance of neurogenesis on memory. We will use new magnetic resonance imaging techniques to quantitatively characterise local in vivo anatomical effects produced by seizure- and ECT- induced neurogenesis. To this end we measure local brain tissue properties known to be sensitive to changes in cyto- and myeloarchitecture. Additional technical refinements will capture neurogenesis-related activity changes associated with the anatomical modifications for linkage to memory performance measured behaviourally.
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