Heck Angela, Milnik Annette, Vukojevic Vanja, Petrovska Jana, Egli Tobias, Singer Jochen, Escobar Pablo, Sengstag Thierry, Coynel David, Freytag Virginie, Fastenrath Matthias, Demougin Philippe, Loos Eva, Hartmann Francina, Schicktanz Nathalie, Delarue Bizzini Bernardo, Vogler Christian, Kolassa Iris-Tatjana, Wilker Sarah, Elbert Thomas, Schwede Torsten, Beisel Christian, Beerenwinkel Niko, de Quervain Dominique J.-F., et al. (2017), Exome sequencing of healthy phenotypic extremes links TROVE2 to emotional memory and PTSD, in Nature Human Behaviour
, 1(4), 0081-0081.
Freytag Virginie, Carrillo-Roa Tania, Milnik Annette, Sämann Philipp G., Vukojevic Vanja, Coynel David, Demougin Philippe, Egli Tobias, Gschwind Leo, Jessen Frank, Loos Eva, Maier Wolfgang, Riedel-Heller Steffi G., Scherer Martin, Vogler Christian, Wagner Michael, Binder Elisabeth B., de Quervain Dominique J. -F., Papassotiropoulos Andreas (2017), A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory, in Nature Communications
, 8(1), 15193-15193.
Post-traumatic stress disorder (PTSD) is a chronic pathological response to a traumatic event. Aversive memories of such an event are thought to play an important role in the pathogenesis and symptomatology of the disorder. We have previously shown that glucocorticoids play a critical role in regulating aversive memories with potentially important implications for PTSD. Furthermore, we have shown that an epigenetic modification of the glucocorticoid receptor gene promoter is linked to aversive memories and PTSD risk in survivors of the Rwandan genocide. In the current application we propose to extend our previous work by studying epigenetic modifications in genes related to glucocorticoid signalling using gene-set based methods on whole-genome methylation data in survivors of the Rwandan genocide. In addition, we will have the possibility to further explore the findings, in a healthy population with existing genome-wide methylation data regarding aversive memory processing and its underlying neural correlates. The findings of the proposed study will add to the understanding of the mechanisms related to increased PTSD risk after traumatic events.