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Cardiovascular effects of acute alcohol consumption: interaction with festive meals

English title Cardiovascular effects of acute alcohol consumption: interaction with festive meals
Applicant Montani Jean-Pierre
Number 159512
Funding scheme Project funding
Research institution Division de Physiologie Département de Médecine Université de Fribourg
Institution of higher education University of Fribourg - FR
Main discipline Cardiovascular Research
Start/End 01.11.2015 - 31.10.2017
Approved amount 157'105.00
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All Disciplines (2)

Discipline
Cardiovascular Research
Physiology : other topics

Keywords (5)

orthostatic intolerance; elderly; alcohol; postprandial hypotension; water

Lay Summary (French)

Lead
Titre: Les effets cardiovasculaires de la consommation aiguë d'alcool : interaction avec des repas festifsLa combinaison d'un repas avec des boissons alcoolisées peut entraîner, particulièrement chez les personnes âgées, une baisse importante de la pression artérielle, avec des vertiges, malaise voire une syncope. Le projet vise à mieux comprendre l’interaction entre l’alcool et les repas, dans le but d’une prévention des troubles cardio-vasculaires lors d’événements festifs.
Lay summary
Dans la population âgée, l'ingestion d'un repas (sans alcool) est souvent caractérisée par une hypotension postprandiale et dans les cas les plus graves par des épisodes de malaise, voire de syncope. L'ingestion d'alcool en soi est également un facteur de risque connu pour l'hypotension orthostatique. Cependant, bien que l'alcool et les repas tous deux diminuent la résistance vasculaire, l'interaction de l'alcool avec un repas en ce qui concerne la réponse à une provocation orthostatique n'a pas bien été caractérisée. Notre hypothèse de travail est (1) que les propriétés vasodilatatrices de l'alcool sont potentialisées par l'ingestion concomitante d'un repas de fête, en particulier chez les personnes âgées qui sont connues pour être sujettes à de l’hypotension postprandiale, et que cette combinaison favorise l'intolérance orthostatique ; et (2) que l'ingestion d'eau avant un repas peut atténuer l'hypotension postprandiale et améliorer la tolérance orthostatique.  Cette étude permettra de mieux comprendre les mécanismes de dérégulation cardiovasculaire et fournira des indications utiles pour une meilleure prévention de l'hypotension postprandiale et des complications cardio-vasculaires lors d'événements sociaux associant un repas festif et la consommation d'alcool.
Direct link to Lay Summary Last update: 30.09.2015

Responsible applicant and co-applicants

Employees

Publications

Publication
Cardiovascular and Orthostatic Responses to a Festive Meal Associated With Alcohol in Young Men
Sarafian Delphine, Charrière Nathalie, Maufrais Claire, Montani Jean-Pierre (2019), Cardiovascular and Orthostatic Responses to a Festive Meal Associated With Alcohol in Young Men, in Frontiers in Physiology, 10, 1-14.
Early and Late Cardiovascular and Metabolic Responses to Mixed Wine: Effect of Drink Temperature
Sarafian Delphine, Maufrais Claire, Montani Jean-Pierre (2018), Early and Late Cardiovascular and Metabolic Responses to Mixed Wine: Effect of Drink Temperature, in Frontiers in Physiology, 9, 1-14.
Cardiovascular and Cutaneous Responses to the Combination of Alcohol and Soft Drinks: The Way to Orthostatic Intolerance?
Maufrais Claire, Charriere Nathalie, Montani Jean-Pierre (2017), Cardiovascular and Cutaneous Responses to the Combination of Alcohol and Soft Drinks: The Way to Orthostatic Intolerance?, in Frontiers in Physiology, 8, 860.
Orthostatic Intolerance in Older Persons: Etiology and Countermeasures
Goswami Nandu, Blaber Andrew P., Hinghofer-Szalkay Helmut, Montani Jean-Pierre (2017), Orthostatic Intolerance in Older Persons: Etiology and Countermeasures, in Frontiers in Physiology, 8, 803.

Collaboration

Group / person Country
Types of collaboration
Prof. Bruce N. Van Vliet, Memorial University of Newfoundland, St John's Canada (North America)
- in-depth/constructive exchanges on approaches, methods or results

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
IUPS (International Union of Physiological Sciences) 2017 Poster Cardiovascular and Cutaneous Responses to the Combination of Alcohol and Soft Drinks: The Way to Orthostatic Intolerance? 02.08.2017 Rio de Janeiro, Brazil Montani Jean-Pierre; Charrière Nathalie;
IUPS (International Union of Physiological Sciences) 2017 Talk given at a conference Post-prandial orthostatic hypotension in the elderly: precipitating factors and countermeasures 01.08.2017 Rio de Janeiro, Brazil Montani Jean-Pierre;


Associated projects

Number Title Start Funding scheme
122554 Mechanisms of cardiovascular and autonomic dysregulation induced by caffeinated soft drinks in humans 01.03.2009 Project funding

Abstract

Background. The combination of a large festive meal with alcoholic drinks is common in social festive events. In the older population the ingestion of a meal is often characterized by postprandial hypotension and in more severe cases by episodes of cardiovascular dysregulation, malaise and even syncope. Alcohol ingestion per se is also a known risk factor for orthostatic hypotension. However, despite the fact that alcohol and meals both decrease vascular resistance, the interaction of alcohol and meals with respect to systemic vasodilation, autonomic response and, most importantly, in the response to orthostatic challenge, have not been well characterized. Hypothesis and Aims. The purpose of the studies outlined in the current proposal is to evaluate the interaction of alcohol consumption with festive meals in young (control group) and older men. The working hypothesis is that the vasodilatory properties of alcohol and the alcohol-induced autonomic impairment are potentiated by the concomitant ingestion of festive meals, particularly in older people who are known to be prone to postprandial hypotension, and thus that the combination of festive meals with alcohol will increase orthostatic intolerance. An additional working hypothesis is that the ingestion of water prior to the meal can attenuate the meal- and alcohol-induced postprandial hypotension, since ingestion of water per se has been shown to attenuate orthostatic hypotension in older subjects.Project. Interaction of a festive meal with concomitant alcohol ingestion In a randomized crossover design, we will monitor, in young (20-30 year-old) and older (60-70 year-old) healthy men, blood pressure (on a beat-to-beat basis), heart rate, cardiac output, and cutaneous and cerebral blood flow. After a stable baseline, subjects will ingest at noon over 30 min a festive high-fat/sugary meal (~1’000 kcal), accompanied with either (a) red wine (12.5% alcohol per volume) at a dose of 5 mL/kg body weight (~0.5 g ethanol/kg body weight), yielding thus 350 mL of wine for a 70-kg subject; or (b) isocaloric grape juice. Hemodynamic monitoring will continue for another 2 hours. Blood sampling and an orthostatic test (consisting of active standing from the sitting position, during 10 min) will be performed at 1 and 2 hours after ingestion of the meal, to test the propensity to acute (< 3 min) and delayed (up to 10 min) orthostatic hypotension. In older subjects (which are known to be prone to postprandial hypotension), another two arms, as a possible preventive measure, will include the ingestion of water (300 mL) prior to the same meal accompanied with either (c) red wine, or (d) isocaloric grape juice, as described above.Significance. Acute alcohol consumption accompanied by a large meal is a relatively common occurrence in festive events. A study of the interaction between meals (rich in carbohydrates and fat) and alcohol will provide a better understanding of the mechanisms of cardiovascular dysregulation and useful insights for a better prevention of cardiovascular complications during those periods of festive excess. Testing the effects of the ingestion of water prior to the meal will help us establish strategies to attenuate postprandial hypotension after a festive meal and to improve orthostatic tolerance.
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