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Beyond individual brain activity: Assessing inter-personal brain coupling using functional near-infrared imaging (fNIRI) hyperscanning

English title Beyond individual brain activity: Assessing inter-personal brain coupling using functional near-infrared imaging (fNIRI) hyperscanning
Applicant Wolf Martin
Number 159490
Funding scheme Project funding (Div. I-III)
Research institution Klinik für Neonatologie UniversitätsSpital Zürich
Institution of higher education University of Zurich - ZH
Main discipline Neurophysiology and Brain Research
Start/End 01.01.2016 - 31.12.2019
Approved amount 429'543.00
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All Disciplines (7)

Discipline
Neurophysiology and Brain Research
Biophysics
Other disciplines of Engineering Sciences
Other disciplines of Physics
Rehabilitation
Biomedical Engineering
Psychology

Keywords (7)

multimodal imaging; neuroscience; near infrared imaging; cerebal oxygenation; resting state; hyperconnectivity; hyperscanning

Lay Summary (German)

Lead
Wenn zwei Personen zusammenarbeiten, synchronisieren sich auch verschiedene Aktivitätsmuster der beiden Gehirne. Wie dies genau vor sich geht und welche Sinne dabei eine Rolle spielen, ist bisher wenig untersucht. Um dies zu verstehen, soll in diesem Forschungsprojekt die Gehirnaktivität mittels Nahinfrarotimaging (NIRI) untersucht werden.
Lay summary

Inhalt und Ziele des Forschungsprojekts

Gehirnaktivität begleitet unser tägliches Leben und wird hervorgerufen durch Sinnesreize, Handlungen und geistige Prozesse. Dabei spielt auch die Zusammenarbeit zwischen Menschen eine Rolle, denn die Gehirnaktivität der verschiedenen Gehirne synchronisiert sich dabei. Bisher wurde hier vor allem elektrische Aktivität untersucht. Die Stoffwechselprozesse wurden bisher kaum untersucht, weil es dafür bisher keine guten Methoden gab. In diesem Projekt werden mit NIRI die Durchblutungsänderungen im Gehirn mit Licht auf harmlose, nicht-invasive Art gemessen. NIRI Geräte sind klein, die Sensoren bequem und darum kann die Zusammenarbeit von Personen in alltäglichen Situationen ausgezeichnet untersucht werden. In einem ersten wichtigen Schritt in dieser Forschung soll die Wichtigkeit verschiedener Sinne (Seh-, Hör- und/oder Geruchsinn) für die Zusammenarbeit bestimmt werden.

Wissenschaftlicher und gesellschaftlicher Kontext des Forschungsprojekts

Der Mensch unterscheidet sich von den Tieren durch seine geistigen Fähigkeiten. Dabei spielt das Gehirn eine wichtige Rolle. Allerdings sind die geistige Funktion des Gehirns und auch die Rolle des Gehirns bei der Zusammenarbeit zwischen Menschen noch sehr wenig verstanden. Dies Projekt soll neuropsychologische Grundlagen erarbeiten. Ein besseres Verständnis der menschlichen Zusammenarbeit ermöglicht auch diese zu verbessern, was gesellschaftlich relevant ist.

Direct link to Lay Summary Last update: 26.10.2015

Responsible applicant and co-applicants

Employees

Publications

Publication
Impact of Skull Thickness on Cerebral NIRS Oximetry in Neonates: An in silico Study
Ostojic D., Jiang J., Isler H., Kleiser S., Karen T., Wolf M., Scholkmann F. (2020), Impact of Skull Thickness on Cerebral NIRS Oximetry in Neonates: An in silico Study, in Ryu Pan Dong, LaManna Joseph C., Harrison David K, Lee Sang-Suk (ed.), Springer International Publishing, Cham, 33-38.
Reducing False Alarm Rates in Neonatal Intensive Care: A New Machine Learning Approach
Ostojic D., Guglielmini S., Moser V., Fauchère J. C., Bucher H. U., Bassler D., Wolf M., Kleiser S., Scholkmann F., Karen T. (2020), Reducing False Alarm Rates in Neonatal Intensive Care: A New Machine Learning Approach, in LaManna Joseph C, Lee Sang-Suk, Ryu Pan Dong, Harrison David K (ed.), Springer International Publishing, Cham, 285-290.
Time-Resolved NIROT ‘Pioneer’ System for Imaging Oxygenation of the Preterm Brain: Preliminary Result
Di Costanzo-Mata A., Jiang J., Lindner S., Ahnen L., Zhang C., Sánchez-Majos S., Wolf M., Charbon E., Kalyanov A. (2020), Time-Resolved NIROT ‘Pioneer’ System for Imaging Oxygenation of the Preterm Brain: Preliminary Result, in Harrison David K, Lee Sang-Suk, Ryu Pan Dong, LaManna Joseph C (ed.), Springer International Publishing, Cham, 347-354.
Validation and Comparison of Monte Carlo and Finite Element Method in Forward Modeling for Near Infrared Optical Tomography
Jiang Jingjing, Ren Wuwei, Isler Helene, Kalyanov Alexander, Lindner Scott, Aldo Di Costanzo Mata, Rudin Markus, Wolf Martin (2020), Validation and Comparison of Monte Carlo and Finite Element Method in Forward Modeling for Near Infrared Optical Tomography, in Lee Sang-Su, Harrison David K, Ryu Pan Dong, LaManna Joseph C. (ed.), Springer International Publishing, Cham, 307-313.
Absorption spectra of early stool from preterm infants need to be considered in abdominal NIRS oximetry
Isler Helene, Schenk Daniel, Bernhard Jérôme, Kleiser Stefan, Scholkmann Felix, Ostojic Daniel, Kalyanov Alexander, Ahnen Linda, Wolf Martin, Karen Tanja (2019), Absorption spectra of early stool from preterm infants need to be considered in abdominal NIRS oximetry, in Biomedical Optics Express, 10(6), 2784-2784.
Characterization of the optical properties of color pastes for the design of optical phantoms mimicking biological tissue
Tomm Natasha, Ahnen Linda, Isler Helene, Kleiser Stefan, Karen Tanja, Ostojic Daniel, Wolf Martin, Scholkmann Felix (2018), Characterization of the optical properties of color pastes for the design of optical phantoms mimicking biological tissue, in Journal of Biophotonics, 12(4), e201800300-e201800300.
Comparison of tissue oximeters on a liquid phantom with adjustable optical properties: an extension
Kleiser S., Ostojic D., Andresen B., Nasseri N., Isler H., Scholkmann F., Karen T., Greisen G., Wolf M. (2018), Comparison of tissue oximeters on a liquid phantom with adjustable optical properties: an extension, in Biomedical Optics Express, 9(1), 86-86.
In Vitro Comparisons of Near-Infrared Spectroscopy Oximeters: Impact of Slow Changes in Scattering of Liquid Phantoms
Ostojic Daniel, Kleiser Stefan, Nasseri Nassim, Isler Helene, Andresen Bjørn, Wabnitz Heidrun, Karen Tanja, Scholkmann Felix, Wolf Martin (2018), In Vitro Comparisons of Near-Infrared Spectroscopy Oximeters: Impact of Slow Changes in Scattering of Liquid Phantoms, in Thews Oliver, Harrison David K., Lamanna Joseph C. (ed.), Springer International Publishing, Cham, 375-379.
Liquid Blood Phantoms to Validate NIRS Oximeters: Yeast Versus Nitrogen for Deoxygenation
Isler Helene, Kleiser Stefan, Ostojic Daniel, Scholkmann Felix, Karen Tanja, Wolf Martin (2018), Liquid Blood Phantoms to Validate NIRS Oximeters: Yeast Versus Nitrogen for Deoxygenation, in Harrison David K., Lamanna Joseph C., Thews Oliver (ed.), Springer International Publishing, Cham, 381-385.
Synchronized Oscillations of Arterial Oxygen Saturation, Cerebral Tissue Oxygenation and Heart Rate in Preterm Neonates: Investigation of Long-Term Measurements with Multiple Einstein’s Cross Wavelet
Scholkmann Felix, Herrera Graciela Velasco, Karen Tanja, Isler Helene, Ostojic Daniel, Herrera Victor Manuel Velasco, Wolf Ursula, Wolf Martin (2018), Synchronized Oscillations of Arterial Oxygen Saturation, Cerebral Tissue Oxygenation and Heart Rate in Preterm Neonates: Investigation of Long-Term Measurements with Multiple Einstein’s Cross Wavelet, in Lamanna Joseph C., Thews Oliver, Harrison David K. (ed.), Springer International Publishing, Cham, 157-161.
In vivo precision assessment of a near-infrared spectroscopy-based tissue oximeter (OxyPrem v1.3) in neonates considering systemic hemodynamic fluctuations
Kleiser Stefan, Ostojic Daniel, Nasseri Nassim (2018), In vivo precision assessment of a near-infrared spectroscopy-based tissue oximeter (OxyPrem v1.3) in neonates considering systemic hemodynamic fluctuations, in Journal of Biomedical Optics, 23(06), 1-1.
Hemoglobin spectra affect measurement of tissue oxygen saturation
Raghavachari Ramesh, Liang Rongguang, Pfefer T. Joshua (ed.) (2018), Hemoglobin spectra affect measurement of tissue oxygen saturation, SPIE, Bellingham, Washington 10486.
Development and Validation of a Sensor Prototype for Near-Infrared Imaging of the Newborn Brain
Ahnen Linda, Stachel Helene, Kleiser Stefan, Hagmann Cornelia, Jiang Jingjing, Kalyanov Alexander, Lindner Scott, Wolf Martin, Sanchez Salvador (2017), Development and Validation of a Sensor Prototype for Near-Infrared Imaging of the Newborn Brain, in Harrison David K., Epel Boris, LaManna Joseph C, Halpern Howard (ed.), Springer International Publishing, Cham, 163-168.

Collaboration

Group / person Country
Types of collaboration
Biomedical Engineering/ETHZ Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Exchange of personnel
University Hospital of Psychiatry Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Biomedical Signal Analysis, KU Leuven Belgium (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel
Physiology/University of Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Neurosurgery/University Hospital Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Conference of the International Society on Oxygen Transport to Tissue Talk given at a conference In-phantom Validation of Time-Resolved Near-Infrared Optical Tomograph Pioneer for Imaging Brain Hypoxia and Hemorrhage 27.07.2019 Albuquerque, United States of America Wolf Martin; Kalyanov Alexander;
Biomedical Photonics Network annual conference Talk given at a conference Time domain near-infrared optical tomography with time-of-flight SPAD camera: the new generation 11.12.2018 Bern, Switzerland Wolf Martin; Kalyanov Alexander;
Biomedical Photonics Network annual conference Talk given at a conference TR NIR0T system 'Pioneer' for preterm brain imaging: in-phantom tests 11.12.2018 St. Gallen, Switzerland Wolf Martin; Kalyanov Alexander;
Biomedical Photonics Network annual conference Poster Synchronizations of brain and body activity of interacting subjects: preliminary results of the world's first study employing systemic physiology augmented functional near-infrared spectroscopy (SPA-fNIRS) hyperscanning 11.12.2018 St. Gallen, Switzerland Wolf Martin; Guglielmini Sabino;
Conference of the International Society on Oxygen Transport to Tissue Talk given at a conference In silico accuracy assessment of cerebral oximetry by near-infrared spectroscopy: Impact of skull thickness in term and preterm neonates 01.07.2018 Seoul, Korean Republic (South Korea) Wolf Martin;
Conference of the International Society on Oxygen Transport to Tissue Talk given at a conference Reducing false alarm rates in neonatal intensive care monitoring: A multimodal machine learning approach 01.07.2018 Seoul, Korean Republic (South Korea) Kalyanov Alexander; Guglielmini Sabino; Wolf Martin;
Biomedical Photonics Network annual conference Talk given at a conference A high-speed time-resolved image sensor for near-infrared optical tomography: challenges and opportunities 11.12.2017 Bern, Switzerland Kalyanov Alexander; Wolf Martin; Ahnen Linda;
Conference of the International Society on Oxygen Transport to Tissue Talk given at a conference Multispectral near-infrared optical tomography for cancer hypoxia study in mice 19.08.2017 Halle, Germany Kalyanov Alexander; Wolf Martin;
Conference of the International Society on Oxygen Transport to Tissue Talk given at a conference Measuring tissue oxygenation by near-infrared light: Achievements, challenges and possible solutions 19.08.2017 Halle, Germany Wolf Martin;
Conference of the International Society on Oxygen Transport to Tissue Talk given at a conference Comparison of NIRS oximeters on a liquid phantom with adjustable oxygenation 10.07.2016 Chicago, United States of America Wolf Martin;
Conference of the International Society on Oxygen Transport to Tissue Poster Development and Validation of a Sensor Prototype for Near-Infrared Imaging of the Newborn Brain 10.07.2016 Chicago, United States of America Ahnen Linda; Wolf Martin;


Awards

Title Year
Britton Chance Award of the International Society on Oxyten Transport to Tissue 2019
Duane F. Bruley Travel Award of the International Society on Oxygen Transport to Tissue 2017
Britton Chance Award of the International Society on Oxyten Transport to Tissue 2016

Abstract

TThe main aim of this project is to shed new light on the neurobiological correlates of inter-personal interactions, i.e. the brain-to-brain coupling, using a novel methodological approach: functional near-infrared imaging (fNIRI) hyperscanning. fNIRI is an optical neuroimaging method that is able to non-invasively measure changes in cerebral oxygenation and haemodynamics in humans while having the advantages of being easily applicable in “real world” situations and enabling the measurement of physiological signals that cannot be derived by the classical neuroimaging methods such as functional magnetic resonance imaging (fMRI) or electroencephalography (EEG).Our aims are to advance fNIRI hyperscanning by (i) developing an fNIRI device specifically for hyperscanning, (ii) assessing task-evoked brain-to-brain coupling for a button press and neurodidactic tasks, (iii) determining the importance of different communication channels. We will achieve these aims by a novel setup, which enables multimodal fNIRI hyperscanning.The results obtained by the proposed research study will have a significant impact on fNIRI hyperscanning methodology and will lead to important insights into the neurobiology of interaction between subjects. Our studies will pave the way for a whole new scope of clinical applications.
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