Essaidi-Laziosi Manel, Geiser Johan, Huang Song, Constant Samuel, Kaiser Laurent, Tapparel Caroline (2020), Interferon-Dependent and Respiratory Virus-Specific Interference in Dual Infections of Airway Epithelia, in Scientific Reports
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Manel Essaidi-Laziosi, Francisco Brito, Sacha Benaoudia, Léna Royston, Valeria Cagno, Mélanie Fernandes-Rocha, Isabelle Piuz, Evgeny Zdobnov, Song Huang, Samuel Constant, Marc-Olivier Boldi, Laurent Kaiser, Caroline Tappare (2017), Propagation of respiratory viruses in human airway epithelia reveals persistent virus-specific signatures, in JACI
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Essaidi-Laziosi Manel, Lyon Matthieu, Mamin Aline, Fernandes Rocha Mélanie, Kaiser Laurent, Tapparel Caroline (2016), A new real-time RT-qPCR assay for the detection, subtyping and quantification of human respiratory syncytial viruses positive- and negative-sense RNAs., in Journal of virological methods
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Lena Royston, Manel Essaidi-Laziosi, Francisco J. Pérez-Rodríguez, Isabelle Piuz, Johan Geiser, Karl-Heinz Krause, Song Huang, Samuel Constant, Laurent Kaiser, Dominique Garcin, Caroline Tapparel, Viral chimeras decrypt the role of enterovirus capsid proteins in viral tropism, acid sensitivity and optimal growth temperature, in PPAT
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Rhinoviruses (RVs) are the most frequent cause of the common cold and can be associated with disease of enhanced severity and infection of the lower respiratory tract. Rhinoviruses co-circulate with many other respiratory viruses in human populations but how they cross-interact is poorly understood. In this project, we intend to study RV replication and pathogenesis in the context of co- and successive infections with other human pathogens like influenza virus, respiratory syncytial virus and coronavirus. The interplay with cellular innate immune response will also be investigated. Infections will be performed in reconstituted human airway epithelia, a relevant model system widely used by my host laboratory to study RV biology. This study will extend the understanding of the pathogenesis of these highly common respiratory viruses as well as their pathogenesis in the context of multiple infections. This will improve patients handling in hospital settings and may avoid the misuse of medicines/antivirals.