polymers; microfabrication; bioelectronics; neuroprosthesis
Kathe Claudia, Michoud Frédéric, Schönle Philipp, Rowald Andreas, Brun Noé, Ravier Jimmy, Furfaro Ivan, Paggi Valentina, Kim Kyungjin, Soloukey Sadaf, Asboth Leonie, Hutson Thomas H., Jelescu Ileana, Philippides Antoine, Alwahab Noaf, Gandar Jérôme, Huber Daniel, De Zeeuw Chris I., Barraud Quentin, Huang Qiuting, Lacour Stéphanie P., Courtine Grégoire (2021), Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice, in Nature Biotechnology
Michoud Frederic, Seehus Corey, Schönle Philipp, Brun Noé, Taub Daniel, Zhang Zihe, Jain Aakanksha, Furfaro Ivan, Akouissi Outman, Moon Rachel, Meier Pascale, Galan Katia, Doyle Benjamin, Tetreault Michael, Talbot Sébastien, Browne Liam E., Huang Qiuting, Woolf Clifford J., Lacour Stephanie P. (2021), Epineural optogenetic activation of nociceptors initiates and amplifies inflammation, in Nature Biotechnology
, 39(2), 179-185.
Shur Michael, Fallegger Florian, Pirondini Elvira, Roux Adrien, Bichat Arnaud, Barraud Quentin, Courtine Grégoire, Lacour Stéphanie P. (2020), Soft Printable Electrode Coating for Neural Interfaces, in ACS Applied Bio Materials
, 3(7), 4388-4397.
Vachicouras Nicolas, Tarabichi Osama, Kanumuri Vivek V., Tringides Christina M., Macron Jennifer, Fallegger Florian, Thenaisie Yohann, Epprecht Lorenz, McInturff Stephen, Qureshi Ahad A., Paggi Valentina, Kuklinski Martin W., Brown M. Christian, Lee Daniel J., Lacour Stéphanie P. (2019), Microstructured thin-film electrode technology enables proof of concept of scalable, soft auditory brainstem implants, in Science Translational Medicine
, 11(514), eaax9487-eaax9487.
Macron Jennifer, Gerratt Aaron P., Lacour Stéphanie P. (2019), Thin Hydrogel–Elastomer Multilayer Encapsulation for Soft Electronics, in Advanced Materials Technologies
, 4(7), 1900331-1900331.
Michoud Frederic, Sottas Loic, Browne L.E., Asboth Leonie, Latremoliere Alban, Courtine Gregoire, Woolf Clifford, Lacour Stephanie P. (2018), Optical cuff for optogenetic control of the peripheral nervous system, in Journal of Neural Engineering
, 15(1), 015002.
SOFT proposes a paradigm shift in our technological offer to neural implants. The next generation of implantable neuroprostheses will be soft and intimately integrated with the neural tissues, three dimensional, capable of distributed and local delivery of multiple inputs e.g. electricity, light, drugs, monitor activity from one or several neurons at a time, and function reliably even in clinically relevant chronic settings.The key objective of this SOFT project is to invent and implement novel technologies for chronic neural implants that are “by design” adapted to the soft and delicate neural tissues, and respond to medical needs and demands. The specific objectives are to (1) develop a new toolbox for long-term bidirectional neural implants based on soft materials, devices and constructs i.e. soft bioelectronics, (2) assess the efficiency of matching the physical tissue/implant interface on preventing foreign body reactions, and (3) deliver and test the novel neurotechnologies in two selected sensorimotor neuroprosthesis: peripheral nerve and deep brain interfaces. The innovative implants and novel technologies resulting from SOFT will enable fundamental new studies of the mechanisms of brain and nerve functions, and start new repair strategies to restore lost neuronal functions. The impact of the proposed research is significant both on scientific and societal grounds. SOFT will not only mobilize the fields of neural engineering and neurorehabilitation but also initiate a transdisciplinary effort in materials science, electrical and mechanical engineering by setting yet a new evolution in microfabricated devices, and uniting electronics and neuroscience.