Project

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Soft bioelectronics for bidirectional neural implants

English title Soft bioelectronics for bidirectional neural implants
Applicant Lacour Stéphanie
Number 157800
Funding scheme SNSF Consolidator Grants
Research institution
Institution of higher education EPF Lausanne - EPFL
Main discipline Material Sciences
Start/End 01.03.2016 - 31.08.2021
Approved amount 1'999'978.00
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All Disciplines (6)

Discipline
Material Sciences
Mechanical Engineering
Neurophysiology and Brain Research
Microelectronics. Optoelectronics
Biomedical Engineering
Electrical Engineering

Keywords (4)

polymers; microfabrication; bioelectronics; neuroprosthesis

Lay Summary (French)

Lead
Les neuroprothèses implantables sont des systèmes conçus pour restaurer ou substituer une ou des fonctions cognitives ou d’action altérées suite à un traumatisme ou une maladie neurodégénératrice. La neuroprothèse la plus répandue aujourd’hui est l’implant cochléaire qui vise à restaurer un certain niveau d’audition aux personnes atteintes de surdité profonde grâce à un réseau d’électrodes insérées chirurgicalement dans la cochlée et délivrant un train de pulsations électriques aux terminaisons nerveuses de la cochlée. Plus de 100,000 personnes dans le monde bénéficient de cet implant.Cependant, malgré de nombreuses recherches et les applications prometteuses, l'utilisation de neuroprothèses implantables reste limitée. La stabilité et l’intégration de l’implant dans le tissu biologique restent souvent incompatible avec son utilisation fiable prolongée.
Lay summary

Le principal objectif du projet SOFT est de développer une nouvelle génération d’implants neuronaux adaptés à la physiologie du tissu nerveux et permettant une communication efficace et prolongée entre le dispositif synthétique et le tissu biologique.

Nous allons examiner le rôle de l'inadéquation physique et mécanique entre les tissus neuronaux et les interfaces implantables d’aujourd’hui afin de guider la sélection des nouveaux matériaux formant l’implant.  Nous développerons les technologies associées pour concevoir et fabriquer des neuroprothèses « molles » biocompatibles, multimodales et intégrées au tissu nerveux.  Nous implémenterons ces neurotechnologies innouvantes pour traiter ou mieux comprendre certaines conditions cliniquement pertinentes.

Direct link to Lay Summary Last update: 05.02.2016

Responsible applicant and co-applicants

Employees

Publications

Publication
Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice
Kathe Claudia, Michoud Frédéric, Schönle Philipp, Rowald Andreas, Brun Noé, Ravier Jimmy, Furfaro Ivan, Paggi Valentina, Kim Kyungjin, Soloukey Sadaf, Asboth Leonie, Hutson Thomas H., Jelescu Ileana, Philippides Antoine, Alwahab Noaf, Gandar Jérôme, Huber Daniel, De Zeeuw Chris I., Barraud Quentin, Huang Qiuting, Lacour Stéphanie P., Courtine Grégoire (2021), Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice, in Nature Biotechnology, 1-35.
Epineural optogenetic activation of nociceptors initiates and amplifies inflammation
Michoud Frederic, Seehus Corey, Schönle Philipp, Brun Noé, Taub Daniel, Zhang Zihe, Jain Aakanksha, Furfaro Ivan, Akouissi Outman, Moon Rachel, Meier Pascale, Galan Katia, Doyle Benjamin, Tetreault Michael, Talbot Sébastien, Browne Liam E., Huang Qiuting, Woolf Clifford J., Lacour Stephanie P. (2021), Epineural optogenetic activation of nociceptors initiates and amplifies inflammation, in Nature Biotechnology, 39(2), 179-185.
Soft Printable Electrode Coating for Neural Interfaces
Shur Michael, Fallegger Florian, Pirondini Elvira, Roux Adrien, Bichat Arnaud, Barraud Quentin, Courtine Grégoire, Lacour Stéphanie P. (2020), Soft Printable Electrode Coating for Neural Interfaces, in ACS Applied Bio Materials, 3(7), 4388-4397.
Microstructured thin-film electrode technology enables proof of concept of scalable, soft auditory brainstem implants
Vachicouras Nicolas, Tarabichi Osama, Kanumuri Vivek V., Tringides Christina M., Macron Jennifer, Fallegger Florian, Thenaisie Yohann, Epprecht Lorenz, McInturff Stephen, Qureshi Ahad A., Paggi Valentina, Kuklinski Martin W., Brown M. Christian, Lee Daniel J., Lacour Stéphanie P. (2019), Microstructured thin-film electrode technology enables proof of concept of scalable, soft auditory brainstem implants, in Science Translational Medicine, 11(514), eaax9487-eaax9487.
Thin Hydrogel–Elastomer Multilayer Encapsulation for Soft Electronics
Macron Jennifer, Gerratt Aaron P., Lacour Stéphanie P. (2019), Thin Hydrogel–Elastomer Multilayer Encapsulation for Soft Electronics, in Advanced Materials Technologies, 4(7), 1900331-1900331.
Optical cuff for optogenetic control of the peripheral nervous system
Michoud Frederic, Sottas Loic, Browne L.E., Asboth Leonie, Latremoliere Alban, Courtine Gregoire, Woolf Clifford, Lacour Stephanie P. (2018), Optical cuff for optogenetic control of the peripheral nervous system, in Journal of Neural Engineering, 15(1), 015002.

Collaboration

Group / person Country
Types of collaboration
C. Woolf / Harvard Medical School United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
G. Courtine / EPFL Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
D- Lee / MEEI United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Q. Huang / ETHZ Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
10th International IEEE EMBS Conference on Neural Engineering (NER 2021) Poster Development and Proof of Concept of a Soft Auditory Brainstem Implant in Non-Human Primate. Tu1PO-04.1. 04.05.2021 virtual conference, United States of America Lacour Stéphanie; Coen Florent-Valéry;
10th International IEEE EMBS Conference on Neural Engineering (NER 2021) Poster Development of Zwitterionic-Coated Neural Implants for Deep Brain Recording. Paper Tu2PO-05.3. 04.05.2021 virtual conference, United States of America Alwahab Noaf; Lacour Stéphanie;
Association of Research in Otolaryngology MidWinter Meeting (2021) Talk given at a conference Comparison of Dorsal vs Ventral Cochlear Nucleus Responses to Amplitude Modulated Pulse Trains in a Mouse Model of the Auditory Brainstem Implant (ABI). [Abstract #T20] 20.02.2021 Virtual conference, United States of America Lacour Stéphanie; Coen Florent-Valéry;
Association of Research in Otolaryngology MidWinter Meeting (2021) Poster Soft Auditory Brainstem Implant: Proof of Concept in Non-Human Primates. 20.02.2021 virtual conference, United States of America Lacour Stéphanie; Coen Florent-Valéry;
65th IEEE International Electron Devices Meeting (2019) Talk given at a conference Microfabricated bioelectronics systems for prevention, diagnostics and treatment of neurological disorders 12.09.2019 San Francisco, United States of America Lacour Stéphanie;
ASILOMAR 2019 Poster Printable soft electrode coating for bioelectronic interfaces 30.08.2019 San Francisco, United States of America Shur Michael;
EMBC 2019 Talk given at a conference Soft neural implants with light delivery to study the somatosensory system 23.07.2019 Berlin, Germany Michoud Frederic;
IUPAC 2019 Talk given at a conference From Chemistry to Mechanically-Adaptive Assemblies: Soft bioelectronic systems 05.07.2019 Paris, France Lacour Stéphanie;
OptoDBS 2019 Poster A wireless optoelectronic system for unconstrained optogenetic interrogation of neurons in the mouse spinal cord 20.06.2019 Geneva, Switzerland Michoud Frederic;
FENS - Summer School on Neurotechnology (2019) Talk given at a conference Soft neural implants with light delivery to study the somatosensory system 02.06.2019 Bertinoro, Italy Lacour Stéphanie; Alwahab Noaf;
FENS - Summer School on Neurotechnology (2019) Poster A conceptual soft neural probe to investigate deep motor circuits 02.06.2019 Bertinoro, Italy Alwahab Noaf; Lacour Stéphanie;
Spring MRS 2019 Talk given at a conference From Chemistry to Mechanically-Adaptive Assemblies: designs for soft thin film electronics 22.04.2019 Phoenix, United States of America Lacour Stéphanie; Macron Jennifer;
9th International IEEE EMBS Conference on Neural Engineering (NER 2019) Talk given at a conference Soft Implantable Bioelectronic Interfaces 20.03.2019 San Francisco, United States of America Lacour Stéphanie;
GRC on Adhesion (2017) Poster Hydrogel-Elastomer Hybrid Material with Tunable Mechanical Properties for Intracortical Probe 23.07.2017 Mount Holyoke College, United States of America Lacour Stéphanie; Macron Jennifer;
Materials Research Society Spring Meeting (2017) Talk given at a conference Hydrogel-Elastomer Hybrid Material with Tunable Mechanical Properties for Intracortical Probe 17.04.2017 Phoenix, United States of America Lacour Stéphanie; Lee Aaron; Macron Jennifer;
IEEE 38th Annual International Conference of the EMBC (2016) Poster A Wireless System with Stimulation and Recording Capabilities for Interfacing Peripheral Nerves in Rodents 16.08.2016 Orlando, United States of America Michoud Frederic; Lacour Stéphanie;


Awards

Title Year
Shortlisted candidate to the 2020 IET AF Harvey Prize (1 of 4) 2020

Associated projects

Number Title Start Funding scheme
149609 Multifunctional regenerative conduits for peripheral nerve repair 01.10.2013 Interdisciplinary projects
182055 High performance materials and technologies for soft bioelectronics 01.05.2019 Project funding
125773 NCCR Robotics: Intelligent Robots for Improving the Quality of Life (phase I) 01.12.2010 National Centres of Competence in Research (NCCRs)
183519 Neuroprosthetic Platform for Personalized and Implantable Systems: Application to Reverse Paralysis and Restore Hearing 01.05.2019 Sinergia

Abstract

SOFT proposes a paradigm shift in our technological offer to neural implants. The next generation of implantable neuroprostheses will be soft and intimately integrated with the neural tissues, three dimensional, capable of distributed and local delivery of multiple inputs e.g. electricity, light, drugs, monitor activity from one or several neurons at a time, and function reliably even in clinically relevant chronic settings.The key objective of this SOFT project is to invent and implement novel technologies for chronic neural implants that are “by design” adapted to the soft and delicate neural tissues, and respond to medical needs and demands. The specific objectives are to (1) develop a new toolbox for long-term bidirectional neural implants based on soft materials, devices and constructs i.e. soft bioelectronics, (2) assess the efficiency of matching the physical tissue/implant interface on preventing foreign body reactions, and (3) deliver and test the novel neurotechnologies in two selected sensorimotor neuroprosthesis: peripheral nerve and deep brain interfaces. The innovative implants and novel technologies resulting from SOFT will enable fundamental new studies of the mechanisms of brain and nerve functions, and start new repair strategies to restore lost neuronal functions. The impact of the proposed research is significant both on scientific and societal grounds. SOFT will not only mobilize the fields of neural engineering and neurorehabilitation but also initiate a transdisciplinary effort in materials science, electrical and mechanical engineering by setting yet a new evolution in microfabricated devices, and uniting electronics and neuroscience.
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