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Application of Synchrotron-based Fourier Transform Infrared Microspectroscopy

English title Application of Synchrotron-based Fourier Transform Infrared Microspectroscopy
Applicant Forro Laszlo
Number 156981
Funding scheme Project funding
Research institution Institut de physique de la matière condensée EPFL - SB - ICMP
Institution of higher education EPF Lausanne - EPFL
Main discipline Condensed Matter Physics
Start/End 01.03.2015 - 29.02.2016
Approved amount 64'546.00
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Keywords (3)

spéctroscopie infrarouge de balayage; toxicité de nanostructures; toxicité de nouveaux matériaux

Lay Summary (French)

Lead
Les nouvelles technologies prévoient l’utilisation des matériaux (nanotubes, nanofils, graphene, cages organométalliques, composé de plomb) avec un grand espoir qu’ils vont améliorer notre vie quotidienne. La production de masse de ces nanomatériaux progresse rapidement. Il est vraisemblable que dans un proche avenir, lerisque d’exposition aux êtres humains s’accélère soit par des procédés intentionnels ou non intentionnels. Il est primordial d’étudier leurs effets sur la matière vivante. Le programme de travail de ce projet consiste de suivre les conséquences biochimiques d’exposition sur les cellules vivantes.
Lay summary

Grâce au développement de sources infrarouges ultra-brillantes à rayonnement synchrotron, les spectro-microscopes infrarouge de nouvelle génération offrent la réalisation des cartographies vibrationnelles/biochimique au sein des cellules et tissus biologiques. Ces cartographies biochimiques contiennent une information quantitative de chaque composé moléculaire, voire chaque groupement chimique dans un même échantillon aussi complexe qu’il soit.  

Ce projet est un suivi du projet soumis auparavant pour l’étude de i) les maladies neuro-dégénératives, et ii) les effets cytotoxiques de nanostructures (l’amiante, nitrures de bore et des cages métallo-organiques), où les précurseurs biochimiques/moléculaires de la toxicité et leurs conséquences seront adressés. Dans la continuation elle étudiera également les effets cytotoxiques des iodides de plomb methyl-ammonium, un matériau nouvellement introduit dans la scène de la recherche pour de potentielles applications photovoltaïques.

Direct link to Lay Summary Last update: 25.10.2014

Responsible applicant and co-applicants

Employees

Name Institute

Publications

Publication
Health hazard of the photovoltaic perovskite CH3NH3PbI3
Iness R. Benmessaoud Anne-Laure Mahul Mellier Endre Horvath Bohumil Maco Massimo Spina Hilal A. (2016), Health hazard of the photovoltaic perovskite CH3NH3PbI3, in Toxicology Research, 5, 407 - 419.

Collaboration

Group / person Country
Types of collaboration
University of Amsterdam Netherlands (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
EPFL, School of Life Sciences Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Uni Fribourg, Dept of Medicine Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
1st International conference on Perovsskite Solar Cells and Optoelectronics Poster Health hazard of the photovoltaic perovskite CH3NH3PbI3 27.09.2015 Lausanne, Switzerland Benmessasoud Iness;
Conference of the Hungarian Biophysical Society Talk given at a conference Scanning Infrared Micro Spectroscopy in neurodegenerative diseases 25.08.2015 Budapest, Hungary Forro Laszlo;
Infrared Beamline Workshop Talk given at a conference Scanning Infrared Microscope Spectroscopy in neurodegenerative diseases 10.04.2015 Zürich, Switzerland Benmessasoud Iness;


Associated projects

Number Title Start Funding scheme
138306 Application of Synchrotron-based Fourier Transform Infrared Microspectroscopy 01.02.2012 Project funding
125299 Toxicity study of nanostructures 01.04.2009 Project funding

Abstract

Infrared spectroscopy is a powerful technique in the study of condensed matter since the energy of electronic excitations and lattice vibrations fall in its range. The lattice vibrations are especially useful in soft condensed matter where the change is phonon modes signal conformational changes, oxidative stress or other bio-chemical processes in the living matter. Since the development of very bright infrared sources based on synchrotron radiation, the scanning infrared spectro-microscopy (SIRMS) enables the creation of a vibrational map of tissues, cells with a spatial resolution of few microns. This allows the localization of regions where structural/biochemical changes have happened. These maps carry quantitative information of the sample in contrast to simple fluorescence imaging.This is a follow-up of the proposal which was granted to study i) neurodegenerative diseases and ii) the toxicity effect of nanostructures, where the biochemical precursors and consequences of cell death could be addressed. One PhD student was granted by SNF, Miss Iness Benmessaoud, whose task is the toxicity effect of novel materials and nanostructures. In the first period of the project she was studying asbestos, boron nitride and metal organic frameworks. For the completion of her PhD work she will address the toxicity study of methyl ammonium lead iodide, a recently launched material for photovoltaic applications.One part of the measurements will be carried out at the National Synchrotron Light Source at Brookhaven National Laboratory, and for the rest beam-time at SOLEIL synchrotron facility at Paris (GIF-sur-Yvette).
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