molecular evolution; Americas; population genomics; ancient DNA; Polynesia
Cruz-Dávalos Diana I., Nieves-Colón María A., Sockell Alexandra, Poznik G. David, Schroeder Hannes, Stone Anne C., Bustamante Carlos D., Malaspinas Anna-Sapfo, Ávila-Arcos María C. (2018), In-solution Y-chromosome capture-enrichment on ancient DNA libraries, in
BMC Genomics, 19(1), 608-608.
Cruz-Dávalos Diana I., Nieves-Colón María A., Sockell Alexandra, Poznik G. David, Schroeder Hannes, Stone Anne C., Bustamante Carlos D., Malaspinas Anna-Sapfo, Ávila-Arcos María C. (2018), In-solution Y-chromosome capture-enrichment on ancient DNA libraries, in
BMC Genomics, 19(1), 608-608.
McColl Hugh, Racimo Fernando, Vinner Lasse, Demeter Fabrice, Gakuhari Takashi, Moreno-Mayar J. Víctor, van Driem George, Gram Wilken Uffe, Seguin-Orlando Andaine, de la Fuente Castro Constanza, Wasef Sally, Shoocongdej Rasmi, Souksavatdy Viengkeo, Sayavongkhamdy Thongsa, Saidin Mohd Mokhtar, Allentoft Morten E., Sato Takehiro, Malaspinas Anna-Sapfo, Aghakhanian Farhang A., Korneliussen Thorfinn, Prohaska Ana, Margaryan Ashot, de Barros Damgaard Peter, Kaewsutthi Supannee, et al. (2018), The prehistoric peopling of Southeast Asia, in
Science, 361(6397), 88-92.
de la Fuente Constanza, Ávila-Arcos María C., Galimany Jacqueline, Carpenter Meredith L., Homburger Julian R., Blanco Alejandro, Contreras Paloma, Cruz Dávalos Diana, Reyes Omar, San Roman Manuel, Moreno-Estrada Andrés, Campos Paula F., Eng Celeste, Huntsman Scott, Burchard Esteban G., Malaspinas Anna-Sapfo, Bustamante Carlos D., Willerslev Eske, Llop Elena, Verdugo Ricardo A., Moraga Mauricio (2018), Genomic insights into the origin and diversification of late maritime hunter-gatherers from the Chilean Patagonia, in
Proceedings of the National Academy of Sciences, 115(17), E4006-E4012.
de la Fuente Constanza, Ávila-Arcos María C., Galimany Jacqueline, Carpenter Meredith L., Homburger Julian R., Blanco Alejandro, Contreras Paloma, Cruz Dávalos Diana, Reyes Omar, San Roman Manuel, Moreno-Estrada Andrés, Campos Paula F., Eng Celeste, Huntsman Scott, Burchard Esteban G., Malaspinas Anna-Sapfo, Bustamante Carlos D., Willerslev Eske, Llop Elena, Verdugo Ricardo A., Moraga Mauricio (2018), Genomic insights into the origin and diversification of late maritime hunter-gatherers from the Chilean Patagonia, in
Proceedings of the National Academy of Sciences, 115(17), E4006-E4012.
Ponce de León Marcia S., Koesbardiati Toetik, Weissmann John David, Milella Marco, Reyna-Blanco Carlos S., Suwa Gen, Kondo Osamu, Malaspinas Anna-Sapfo, White Tim D., Zollikofer Christoph P. E. (2018), Human bony labyrinth is an indicator of population history and dispersal from Africa, in
Proceedings of the National Academy of Sciences, 115(16), 4128-4133.
Ponce de León Marcia S., Koesbardiati Toetik, Weissmann John David, Milella Marco, Reyna-Blanco Carlos S., Suwa Gen, Kondo Osamu, Malaspinas Anna-Sapfo, White Tim D., Zollikofer Christoph P. E. (2018), Human bony labyrinth is an indicator of population history and dispersal from Africa, in
Proceedings of the National Academy of Sciences, 115(16), 4128-4133.
Wutke Saskia, Sandoval-Castellanos Edson, Benecke Norbert, Döhle Hans-Jürgen, Friederich Susanne, Gonzalez Javier, Hofreiter Michael, Lõugas Lembi, Magnell Ola, Malaspinas Anna-Sapfo, Morales-Muñiz Arturo, Orlando Ludovic, Reissmann Monika, Trinks Alexandra, Ludwig Arne (2018), Decline of genetic diversity in ancient domestic stallions in Europe, in
Science Advances, 4(4), eaap9691-eaap9691.
Moreno-Mayar J. Víctor, Potter Ben A., Vinner Lasse, Steinrücken Matthias, Rasmussen Simon, Terhorst Jonathan, Kamm John A., Albrechtsen Anders, Malaspinas Anna-Sapfo, Sikora Martin, Reuther Joshua D., Irish Joel D., Malhi Ripan S., Orlando Ludovic, Song Yun S., Nielsen Rasmus, Meltzer David J., Willerslev Eske (2018), Terminal Pleistocene Alaskan genome reveals first founding population of Native Americans, in
Nature, 553(7687), 203-207.
Dortch Joe, Malaspinas Anna-Sapfo (2017), Madjedbebe and genomic histories of Aboriginal Australia, in
Australian Archaeology, 83(3), 174-177.
Malaspinas Anna-Sapfo, Westaway Michael C., Muller Craig, Sousa Vitor C., Lao Oscar, Alves Isabel, Bergström Anders, Athanasiadis Georgios, Cheng Jade Y., Crawford Jacob E., Heupink Tim H., Macholdt Enrico, Peischl Stephan, Rasmussen Simon, Schiffels Stephan, Subramanian Sankar, Wright Joanne L., Albrechtsen Anders, Barbieri Chiara, Dupanloup Isabelle, Eriksson Anders, Margaryan Ashot, Moltke Ida, Pugach Irina, et al. (2016), A genomic history of Aboriginal Australia, in
Nature, 538(7624), 207-214.
Malaspinas Anna-Sapfo (2016), Methods to characterize selective sweeps using time serial samples: an ancient DNA perspective, in
Molecular Ecology, 25(1), 24-41.
Ávila-Arcos María C., Sandoval-Velasco Marcela, Schroeder Hannes, Carpenter Meredith L., Malaspinas Anna-Sapfo, Wales Nathan, Peñaloza Fernando, Bustamante Carlos D., Gilbert M. Thomas P. (2015), Comparative performance of two whole-genome capture methodologies on ancient DNA Illumina libraries, in
Methods in Ecology and Evolution, 6(6), 725-734.
Schroeder Hannes, Ávila-Arcos María C., Malaspinas Anna-Sapfo, Poznik G. David, Sandoval-Velasco Marcela, Carpenter Meredith L., Moreno-Mayar José Víctor, Sikora Martin, Johnson Philip L. F., Allentoft Morten Erik, Samaniego José Alfredo, Haviser Jay B., Dee Michael W., Stafford Thomas W., Salas Antonio, Orlando Ludovic, Willerslev Eske, Bustamante Carlos D., Gilbert M. Thomas P. (2015), Genome-wide ancestry of 17th-century enslaved Africans from the Caribbean, in
Proceedings of the National Academy of Sciences, 201421784-201421784.
Raghavan Maanasa, Steinrücken Matthias, Harris Kelley, Schiffels Stephan, Rasmussen Simon, DeGiorgio Michael, Albrechtsen Anders, Valdiosera Cristina, Ávila-Arcos María C., Malaspinas Anna-Sapfo, Eriksson Anders, Moltke Ida, Metspalu Mait, Homburger Julian R., Wall Jeff, Cornejo Omar E., Moreno-Mayar J. Víctor, Korneliussen Thorfinn S., Pierre Tracey, Rasmussen Morten, Campos Paula F., Damgaard Peter de Barros, Allentoft Morten E., Lindo John, Metspalu Ene (2015), Genomic evidence for the Pleistocene and recent population history of Native Americans, in
Science, 349(6250), 3884-3884.
Allentoft Morten E., Sikora Martin, Sjögren Karl-Göran, Rasmussen Simon, Rasmussen Morten, Stenderup Jesper, Damgaard Peter B., Schroeder Hannes, Ahlström Torbjörn, Vinner Lasse, Malaspinas Anna-Sapfo, Margaryan Ashot, Higham Tom, Chivall David, Lynnerup Niels, Harvig Lise, Baron Justyna, Casa Philippe Della, Dąbrowski Paweł, Duffy Paul R., Ebel Alexander V., Epimakhov Andrey, Frei Karin, Furmanek Mirosław, Gralak Tomasz (2015), Population genomics of Bronze Age Eurasia, in
Nature, 522(7555), 167-172.
BACKGROUND: The mode and tempo of the colonization of the Americas before it was discovered by Europeans remains unresolved. After more than a century of study the majority of available genetic, archaeological and linguistic evidence supports one or more pre-Columbian migration event(s) from Siberia to North America around 15-30 thousand years before present, followed by an expansion into South America. Prehistoric or historic connections between South America and Southeast Asia/Oceania have been noted including similarities in culture, human skull morphology and domestic breeds, but so far no genetic evidence from humans has been found to support such contact. We recently found that skeletal remains from Brazil belonging to two indigenous Botocudos presented a combination of mitochondrial DNA variants common in present day Oceanian populations. AIMS: I propose to investigate the question of a Polynesian-South American contact with genomic data. Specifically, we aim to (I) infer the colonization of Polynesia using genetic data from present-day Polynesians, (II) infer the structure of the indigenous Botocudo of Brazil, (III) characterize the Polynesian-South American contact considering ancient and modern data jointly. The main questions I seek to answer are: (I) What was the mode and tempo of the colonization of Polynesia? Does the genetic data fit the archeological data? Which Polynesian populations exhibit a Native American signal? (II) What is the structure within the Botocudo population? How do they relate to other Native American populations? Is there more than two individuals with a Polynesian signal? How strong is the Polynesian signal? (III) When did the Polynesian and South American populations first began admixing? Was it before or after European contact with South America/Polynesia? What was the direction of the gene flow? RELEVANCE: The results will contribute to deepen our understanding of the peopling of the world, ultimately having relevance to enduring questions such as: Where do we all come from? Who are our ancestors? The statistical methods will be applicable to any migration/admixture event across the tree of life. They will also benefit the growing field of ancient genomics and other fields where data are collected at several time points, such as experimental evolution and epidemiology. The generated data will be of general interest to investigate other population genetics aspect, including related human migration events and the impact of a range expansion in terms of genetic load. Finally, by the end of the project, we should have all the pieces necessary to solve the decades-old puzzle concerning the colonization of the Americas.