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Med-XPhase - Phase contrast X-ray imaging as a new diagnostic tool

English title Med-XPhase - Phase contrast X-ray imaging as a new diagnostic tool
Applicant Stampanoni Marco
Number 154472
Funding scheme Sinergia
Research institution Institut für Biomedizinische Technik Universität Zürich und ETHZ
Institution of higher education ETH Zurich - ETHZ
Main discipline Other disciplines of Physics
Start/End 01.01.2015 - 31.12.2018
Approved amount 1'555'005.00
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All Disciplines (3)

Discipline
Other disciplines of Physics
Biomedical Engineering
Cancer

Keywords (4)

mammography; phase contrast X-ray imaging; breast cancer; gratings interferometry

Lay Summary (German)

Lead
Konventionelle, absorption-basierte Screening-Mammographie wird durch zwei große Hindernisse erschwert: ein dramatischer Rückgang der Sensitivität bei Patienten mit dichtem Brustgewebe und die hohe Zahl der falsch-positive abnormale Mammographie-Befunde, was zu unnötigen Schaden für die Patienten und erhöhten Kosten im Gesundheitswesen führt. Unser Projekt zielt darauf ab, Weichteilkontrast und Klassifizierung von Mikroverkalkungen zu verbessern, ohne die Strahlenbelastung signifikant zu erhöhen.
Lay summary

Ziele und Hypothesen 

Physikalisch wird der Bildkontrast aus Brechung und Beugung statt Absorption erzeugt. Klinisch ist diese Technologie noch nicht ausgereift und das ist genau das Ziel des Projektes: wir möchten die sogenannte Phasenkontrast-Röntgen-Mammographie in der klinischen Routine einführen und wollen dessen Nutzen im Vergleich zu herkömmlichen Mammographie untersuchen.

Wir werden ein in-vivo Prototyp für Phasenkontrast-Mammographie entwickeln und zum ersten Mal am Patienten betreiben. Bei der gleichen Dosis erwarten wir Mammographien von besseren Qualität und Schärfe, wo Läsionen-Abgrenzung und Mikroverkalkungen viel besser beurteilt werden sollten. Unsere Hypothesen sind:

(1) Erhöhung der Empfindlichkeit der Phasenkontrast Mammographie zur Detektion von Brustkrebs-Anomalien.
(2) Eine Abnahme falsch positiver Befunde.
(3) Untersuchungen zu stabilen Strahlenbelastung.

Wissenschaftlichen und gesellschaftlichen Kontext der Forschung

Es gibt eine allgemeine Übereinstimmung, dass bei Frauen im Alter von 50 Jahren oder älter das Mammographie-Screening die Todesrate von Brustkrebs reduziert. Unser Projekt pflegt die Synergie zwischen Grundlagenforschung und klinischen Partnern mit dem Ziel, dank einer bahnbrechenden Technologie, der Patientinnen eine verbesserte Diagnosewerkzeug anzubieten.  

 

 

Direct link to Lay Summary Last update: 17.12.2014

Responsible applicant and co-applicants

Employees

Publications

Publication
Microbubbles as a contrast agent in grating interferometry mammography: an ex vivo proof-of-mechanism study
Lång Kristina, Arboleda Carolina, Forte Serafino, Wang Zhentian, Prevrhal Sven, Koehler Thomas, Kuhn Norbert, David Bernd, Jefimovs Konstantins, Kubik-Huch Rahel A., Stampanoni Marco (2019), Microbubbles as a contrast agent in grating interferometry mammography: an ex vivo proof-of-mechanism study, in European Radiology Experimental, 3(1), 19-19.
Fabrication of Au gratings by seedless electroplating for X-ray grating interferometry
Kagias Matias, Wang Zhentian, Guzenko Vitaliy A., David Christian, Stampanoni Marco, Jefimovs Konstantins (2019), Fabrication of Au gratings by seedless electroplating for X-ray grating interferometry, in Materials Science in Semiconductor Processing, 92, 73-79.
Accuracy of Ex Vivo Semiautomatic Segmentation of Urinary Stone Size in Computed Tomography Compared With Manual Size Estimation in Radiographic Correlation
Niemann T., Jerjen I., Hefermehl L, Wang Z, Stampanoni M, Lehmann K, Kubik-Huch RA (2019), Accuracy of Ex Vivo Semiautomatic Segmentation of Urinary Stone Size in Computed Tomography Compared With Manual Size Estimation in Radiographic Correlation, in Urology, 123, 75-75.
Model-free classification of X-ray scattering signals applied to image segmentation
Lutz-Bueno V., Arboleda C., Leu L., Blunt M. J., Busch A., Georgiadis A., Bertier P., Schmatz J., Varga Z., Villanueva-Perez P., Wang Z., Lebugle M., David C., Stampanoni M., Diaz A., Guizar-Sicairos M., Menzel A. (2018), Model-free classification of X-ray scattering signals applied to image segmentation, in Journal of Applied Crystallography, 51(5), 1378-1386.
Towards sub-micrometer high aspect ratio X-ray gratings by atomic layer deposition of iridium
Vila-Comamala Joan, Romano Lucia, Guzenko Vitaliy, Kagias Matias, Stampanoni Marco, Jefimovs Konstantins (2018), Towards sub-micrometer high aspect ratio X-ray gratings by atomic layer deposition of iridium, in Microelectronic Engineering, 192, 19-24.
Hot embossing of Au- and Pb-based alloys for x-ray grating fabrication
Romano Lucia, Vila-Comamala Joan, Schift Helmut, Stampanoni Marco, Jefimovs Konstantins (2017), Hot embossing of Au- and Pb-based alloys for x-ray grating fabrication, in Journal of Vacuum Science & Technology B, Nanotechnology and Microelectronics: Materials, Processing, 35(6), 06G302-06G302.
Effect of isopropanol on gold assisted chemical etching of silicon microstructures
Romano L., Vila-Comamala J., Jefimovs K., Stampanoni M. (2017), Effect of isopropanol on gold assisted chemical etching of silicon microstructures, in Microelectronic Engineering, 177, 59-65.
High aspect ratio metal microcasting by hot embossing for X-ray optics fabrication
Romano L., Vila-Comamala J., Kagias M., Vogelsang K., Schift H., Stampanoni M., Jefimovs K. (2017), High aspect ratio metal microcasting by hot embossing for X-ray optics fabrication, in Microelectronic Engineering, 176, 6-10.
High-aspect ratio silicon structures by displacement Talbot lithography and Bosch etching
Jefimovs Konstantins, Romano Lucia, Vila-Comamala Joan, Kagias Matias, Wang Zhentian, Wang Li, Dais Christian, Solak Harun, Stampanoni Marco (2017), High-aspect ratio silicon structures by displacement Talbot lithography and Bosch etching, in SPIE Advanced Lithography, San Jose, California, United StatesSPIE , San Jose.
Sensitivity-based optimization for the design of a grating interferometer for clinical X-ray phase contrast mammography
Arboleda Carolina, Wang Zhentian, Koehler Thomas, Martens Gerhard, Van Stevendaal Udo, Bartels Matthias, Villanueva-Perez Pablo, Roessl Ewald, Stampanoni Marco (2017), Sensitivity-based optimization for the design of a grating interferometer for clinical X-ray phase contrast mammography, in Optics Express, 25(6), 6349-6349.
Dual phase grating interferometer for tunable dark-field sensitivity
Kagias Matias, Wang Zhentian, Jefimovs Konstantins, Stampanoni Marco (2017), Dual phase grating interferometer for tunable dark-field sensitivity, in Applied Physics Letters, 110(1), 014105-014105.
Investigation of suitable biopsy markers for grating-based phase contrast mammography
Arboleda C., Wang Z., Forte S., Kubik-Huch R.A., Stampanoni M. (2017), Investigation of suitable biopsy markers for grating-based phase contrast mammography, in Journal of Instrumentation, 12(01), T01007-T01007.
A generalized quantitative interpretation of dark-field contrast for highly concentrated microsphere suspensions
Gkoumas Spyridon, Villanueva-Perez Pablo, Wang Zhentian, Romano Lucia, Abis Matteo, Stampanoni Marco (2016), A generalized quantitative interpretation of dark-field contrast for highly concentrated microsphere suspensions, in Scientific Reports, 6(1), 35259-35259.
Correspondence: Reply to ‘Quantitative evaluation of X-ray dark-field images for microcalcification analysis in mammography’
Wang Zhentian, Hauser Nik, Singer Gad, Trippel Mafalda, Kubik-Huch Rahel A., Schneider Christof W., Stampanoni Marco (2016), Correspondence: Reply to ‘Quantitative evaluation of X-ray dark-field images for microcalcification analysis in mammography’, in Nature Communications, 7(1), 10868-10868.
Joint absorption and phase retrieval in grating-based x-ray radiography
Nilchian Masih, Bostan Emrah, Wang Zhentian, Nilchiyan Mohammad Reza, Stampanoni Marco, Unser Michael (2016), Joint absorption and phase retrieval in grating-based x-ray radiography, in Optics Express, 24(7), 7253-7253.
Grating-based interferometry and hybrid photon counting detectors: Towards a new era in X-ray medical imaging
Gkoumas Spyridon, Wang Zhentian, Abis Matteo, Arboleda Carolina, Tudosie George, Donath Tilman, Brönnimann Christian, Schulze-Briese Clemens, Stampanoni Marco (2016), Grating-based interferometry and hybrid photon counting detectors: Towards a new era in X-ray medical imaging, in Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detector, 809, 23-30.
2D-Omnidirectional Hard-X-Ray Scattering Sensitivity in a Single Shot
Kagias Matias, Wang Zhentian, Villanueva-Perez Pablo, Jefimovs Konstantins, Stampanoni Marco (2016), 2D-Omnidirectional Hard-X-Ray Scattering Sensitivity in a Single Shot, in Physical Review Letters, 116(9), 093902.
Micrometer-resolution imaging using MoNCH: towards G(2)-less grating interferometry
Cartier S., Kagias M., Bergamaschi A., Wang Z. T., Dinapoli R., Mozzanica A., Ramilli M., Schmitt B., Bruckner M., Frojdh E., Greiffenberg D., Mayilyan D., Mezza D., Redford S., Ruder C., Schadler L., Shi X. T., Thattil D., Tinti G., Zhang J. G., Stampanoni M. (2016), Micrometer-resolution imaging using MoNCH: towards G(2)-less grating interferometry, in Journal of Synchrotron Radiation, 23, 1462-1473.
Quantitative evaluation of X-ray dark-field images for microcalcification analysis in mammography
Wang Z. T., Hauser N., Singer G., Trippel M., Kubik-Huch R. A., Schneider C. W., Stampanoni M. (2016), Quantitative evaluation of X-ray dark-field images for microcalcification analysis in mammography, in Nature Communications, 7, 010.
Self-assembly nanostructured gold for high aspect ratio silicon microstructures by metal assisted chemical etching
Romano L., Kagias M., Jefimovs K., Stampanoni M. (2016), Self-assembly nanostructured gold for high aspect ratio silicon microstructures by metal assisted chemical etching, in RSC Advances, 6(19), 16025-16029.
Single shot x-ray phase contrast imaging using a direct conversion microstrip detector with single photon sensitivity
Kagias M., Cartier S., Wang Z., Bergamaschi A., Dinapoli R., Mozzanica A., Schmitt B., Stampanoni M. (2016), Single shot x-ray phase contrast imaging using a direct conversion microstrip detector with single photon sensitivity, in Applied Physics Letters, 108, 0100.
Quantitative volumetric breast density estimation using phase contrast mammography
Wang Zhentian, Hauser Nik, Kubik-Huch Rahel A, D’Isidoro Fabio, Stampanoni Marco (2015), Quantitative volumetric breast density estimation using phase contrast mammography, in Physics in Medicine and Biology, 60(10), 4123-4135.
Spline based iterative phase retrieval algorithm for X-ray differential phase contrast radiography
Nilchian Masih, Wang Zhentian, Thuering Thomas, Unser Michael, Stampanoni Marco (2015), Spline based iterative phase retrieval algorithm for X-ray differential phase contrast radiography, in Optics Express, 23(8), 10631-10631.
Quantitative volumetric breast density estimation using phase contrast mammography.
Wang Zhentian, Hauser Nik, Kubik-Huch Rahel A, D'Isidoro Fabio, Stampanoni Marco (2015), Quantitative volumetric breast density estimation using phase contrast mammography., in Physics in medicine and biology, 60(10), 4123-35.
Spline based iterative phase retrieval algorithm for X-ray differential phase contrast radiography.
Nilchian Masih, Wang Zhentian, Thuering Thomas, Unser Michael, Stampanoni Marco (2015), Spline based iterative phase retrieval algorithm for X-ray differential phase contrast radiography., in Optics express, 23(8), 10631-42.

Collaboration

Group / person Country
Types of collaboration
Philips Technologie GmbH Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Industry/business/other use-inspired collaboration

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
SPIE Medical imaging Talk given at a conference Design of a sensitive grating-based phase contrast mammography prototype 02.02.2017 Orlando, United States of America Arboleda Clavijo Carolina; Stampanoni Marco; Wang Zhentian;
Annual meeting of Radiological Society of North America (RSNA) Talk given at a conference Characterization of urinary calculi by dark-field X-ray imaging 30.11.2016 Chicago, United States of America Stampanoni Marco; Kubik-Huch Rahel A.; Wang Zhentian; Jerjen Iwan;
EMPA Topical day : Imaging and Image Analysis VIII Talk given at a conference Multi-contrast X-ray imaging with grating interferometry 03.04.2016 Dübendorf, Switzerland Wang Zhentian; Stampanoni Marco; Arboleda Clavijo Carolina;
X-ray and neutron phase imaging with gratings (XNPIG) Talk given at a conference X-ray and neutron phase imaging with gratings (XNPIG) 05.09.2015 Bethesda, United States of America Stampanoni Marco; Wang Zhentian; Kubik-Huch Rahel A.; Jerjen Iwan;
X-ray and neutron phase imaging with gratings (XNPIG) Talk given at a conference Sensitivity-based optimization for the design of a grating interferometer for in-vivo phase contrast mammography 01.09.2015 Bethesda, United States of America Stampanoni Marco; Arboleda Clavijo Carolina; Wang Zhentian;


Self-organised

Title Date Place
XNPIG 2019 12.09.2017 Zürich, Switzerland

Use-inspired outputs


Start-ups

Name Year

Associated projects

Number Title Start Funding scheme
177036 Displacement Talbot Lithography for micro and nanopatterning 01.01.2018 R'EQUIP
159263 X-ray phase-contrast micro computed tomography for improved pathology 01.10.2015 Interdisciplinary projects
183568 GI-BCT - Clinical Grating Interferometry Breast Computed Tomography 01.01.2019 Sinergia
170791 Dedicated Breast Computer Tomography 01.05.2017 R'EQUIP
170743 An ultra-high resolution scanning electron microscope (SEM) for low-energy imaging and analysis 01.02.2017 R'EQUIP

Abstract

There is a general agreement that screening X-ray mammography reduces the rate of death from breast cancer in women who are of the age of 50 years or older. However, conventional absorption-based screening mammography is hampered by two major obstacles: A dramatic drop of sensitivity in patients with dense breasts and the high number of false-positive abnormal mammographic findings resulting in unnecessary harm to patients and increased health care costs. The Med-XPhase project addresses this fundamental issue: how to increase soft-tissue contrast and improve the distinction between microcalcification subtypes while keeping dose under control?Physically, we will generate image contrast exploiting refraction and diffraction, rather than absorption. Clinically, this technology is not yet mature and this is exactly the aim of the project: bringing phase contrast X-ray mammography into clinical routine and evaluate its benefit compared to conventional mammography. We aim at developing an in-vivo prototype for phase-contrast mammography to be installed and operated for the first time on patients. For the same dose, we expect mammograms of superior quality and sharpness, where lesions’ delineation, spiculations and microcalcifications will be much better assessed.
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