kragelund birthe, Schenstrøm Sgine, Panse Vikram, Hartmann-Petersen Rasmus (2016), DSS1/Sem1, a Multifunctional and Intrinsically Disordered Protein., in Trends Biochem Sci.
, 41(5), 446-459.
Greber Basil, Gerhardy Stefan, Leitner Alexander, Leibundgut Marc, Salem Michele, Boehringer Daniel, Leillloit Nicolas, Aebersold Rudolf, Panse Vikram, Ban Nenad (2016), Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation., in Cell
, 164(1-2), 91-102.
Panse vikram, Fischer Ute, Schütz Sabina, ALtvater Martin, Faza Marius Boulos (2015), A non-canonical pathway for Crm1-export complex assembly., in Elife
, 10.7554(eLife.0347), 1-16.
Ban Nenad, Beckmann Roland, Cate Jamie H D, Dinman Jonathan D, Dragon François, Ellis Steven R, Lafontaine Denis L J, Lindahl Lasse, Liljas Anders, Lipton Jeffrey M, McAlear Michael A, Moore Peter B, Noller Harry F, Ortega Joaquin, Panse Vikram Govind, Ramakrishnan V, Spahn Christian M T, Steitz Thomas A, Tchorzewski Marek, Tollervey David, Warren Alan J, Williamson James R, Wilson Daniel, Yonath Ada, Yusupov Marat (2014), A new system for naming ribosomal proteins., in Current opinion in structural biology
, 24, 165-9.
Schütz Sabina, Fischer Ute, Altvater Martin, Nerurkar Purnima, Peña Cohue, Gerber Michaela, Chang Yiming, Caesar Stefanie, Schubert Olga T, Schlenstedt Gabriel, Panse Vikram G (2014), A RanGTP-independent mechanism allows ribosomal protein nuclear import for ribosome assembly., in eLife
, 3, 03473-03473.
Gerhardy Stefan, Menet Anna Maria, Peña Cohue, Petkowski Janusz Jurand, Panse Vikram Govind (2014), Assembly and nuclear export of pre-ribosomal particles in budding yeast., in Chromosoma
, 123(4), 327-44.
Altvater Martin, Schütz Sabina, Chang Yiming, Panse Vikram Govind (2014), Dissecting ribosome assembly and transport in budding yeast., in Methods in cell biology
, 122, 437-61.
Nerurkar Purnima, Altvater Martin, Gerhardy Stefan, Schütz Sabina, Fischer Ute, Weirich Christine, Panse Vikram, Eukaryotic ribosome assembly and nuclear export., in International review of Cell and Molecular Biology
, NA(NA), 1-25.
Panse Vikram, Weirich Christine, Ribosome assembly and export., in Encyclopedia of Cell Biology
, NA(NA), 1-25.
Eukaryotic ribosome assembly is a spectacular example of a highly dynamic and regulated process that occurs in different cellular territories: the nucleus, nucleoplasm and the cytoplasm. This poorly understood process, which begins in the nucleolus, requires >350 conserved transiently associating assembly factors, whose site(s) of action and function(s) on maturing pre-ribosomal particles remain to be discovered. Further, the eukaryotic ribosome biogenesis is intimately linked with the nucleaocytoplasmic transport machinery: the nuclear import machinery ensures safe delivery of ribosomal proteins to evolving pre-ribosomal particles in the nucleolus, the site of biogenesis, and the nuclear export machinery facilitates transport of pre-ribosomal particles through nuclear pore complexes into the cytoplasm, the site of function.By exploiting approaches amenable in the model organism budding yeast in combination with in vitro biochemistry, targeted proteomics and structural approaches, we will uncover:(1) how the cellular transport machinery interfaces with the ribosome assembly pathway. (2) molecular environment of assembly factors on pre-ribosomal particles.Together, we will reveal principles that govern the construction and transport of this universal translating machine, and potentially related macromolecular assemblies.