fluorescence microscopy; animals and plants; live cells, tissue, organisms; 3-D microscopy; imaging platform
Felker Anastasia, Nieuwenhuize Susan, Dolbois Aymeric, Blazkova Kristyna, Hess Christopher, Low Larry W L, Burger Sibylle, Samson Natasha, Carney Tom J, Bartunek Petr, Nevado Cristina, Mosimann Christian (2016), In Vivo Performance and Properties of Tamoxifen Metabolites for CreERT2 Control., in PloS one
, 11(4), 0152989-0152989.
Burger Alexa, Lindsay Helen, Felker Anastasia, Hess Christopher, Anders Carolin, Chiavacci Elena, Zaugg Jonas, Weber Lukas M, Catena Raul, Jinek Martin, Robinson Mark D, Mosimann Christian (2016), Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes., in Development (Cambridge, England)
, 143(11), 2025-37.
Caviglia Sara, Brankatschk Marko, Fischer Elisabeth J, Eaton Suzanne, Luschnig Stefan (2016), Staccato/Unc-13-4 controls secretory lysosome-mediated lumen fusion during epithelial tube anastomosis., in Nature cell biology
, 18(7), 727-39.
Life science research and teaching at the University of Zurich (UZH) covers a large range from physical and molecular cell biology to developmental and organismic biology. Imaging techniques are key for the quest to understand how things work the way we observe them. During the last years, the development of selective plane illumination microscopy (SPIM) or lightsheet microscopy has given deep insights into biological processes and structures in cells, tissues and organisms. With this proposal, the University of Zurich aims to establish lightsheet microscopy for the life science community. We propose to install and administer a lightsheet microscope in the Center for Microscopy and Image Analysis (ZMB). With this setup, we strive to provide maximal support and accessibility of lightsheet microscopy for the life science community.