block copolymer vesicles; amphiphilic block copolymers; smart surfaces; controlled encapsulation and release; block copolymer membranes; molecular recognition; self-assembly
Housecroft Catherine, Palivan Cornelia, Gademann Karl, Calame Michel, Meier Wolfgang, Mikhalevich Viktoria, Zhang Xiaoyan, Piel Ellen, Szponarski Mathieu, Wisler Alexandra, Lanzilloto Angelo, Constable Edwin, Fanget Axel, Stoop Ralph (2016), Active surfaces as Possible Functional Systems in Detection and Chemical (Bio) Reactivity, in Chimia
, 6(70), 402-412.
X. Zhang, M. Lomora, T. Einfalt, W. Meier, N. Klein, D. Schneider, C. G. Palivan (2016), Active surfaces engineerd by immobilizing protein-polymer nanoreactors for selectively detecting sugar alcohols, in Biomaterials
, 89, 79-88.
Housecroft C. E., Palivan C. G., Gademann K., Meier W., Calame M., Mikhalevich V., Zhang X., Piel E., Szponarski M., Wiesler A., Lanzilotto A., Constable E. C., Fanget A., Stoop R. (2016), Active surfaces’ as Possible Functional Systems in Detection and Chemical (Bio) Reactivity, in Chimia
, 6, 402.
A. Najer, D. Wu, G. Nussbaumer, G. Schwertz, A. Schwab, M. C. Wischel, A. Schäfer, F. Friedrich, M. Rottmann, C. G. Palivan, H. Beck, W. Meier (2016), An amphiphilic graft copolymer-based nanoparticle platform for reduction-responsive anticancer and antimalarial drug delivery, in Nanoscale
, 8, 14858-14869.
Garni M., Einfalt T., Lomora M, Car A., Meier W., Palivan C. G. (2016), Artificial Organelles: Reactions inside Protein–Polymer Supramolecular Assemblies, in Chimia
, 6, 424.
Vasquez D., Einfalt T., Meier W., Palivan C. G. (2016), Asymmetric triblock copolymer nanocarriers for controlled localization and pH-sensitive release of proteins, in Langmuir
, 32, 10235.
C. G. Palivan, R. Goers, A. Najer, X. Zhang, A. Car, W. Meier (2016), Bioinspired polymer vesicles and membranes for biological and medical applications, in Chem. Soc. Rev.
, 45, 377-411.
A. I. Dinu, J. T. Duskey, A. Car, C. G. Palivan, W. Meier (2016), Engineered non-toxic cationic nanocarriers with photo-triggered slow-release properties, in Polymer Chemistry
, 7, 3451-3464.
Hirschi S., Stauffer M., Harder D., Müller D. J., Meier W., Fotiadis D. (2016), Engineering and Assembly of Protein Modules into Functional Molecular Systems, in Chimia
, 6, 398.
A. Najer, S. Thamboo, H. P. Beck, C. G. Palivan, W. Meier (2016), Giant Host Red Blood Cell Membrane Mimicking Polymersomes Bind Parasite Proteins and Malaria Parasites, in CHIMIA
, 70(4), 288-291.
Cotelle Y., Chuard N., Lascano S., Lebrun V., Wehlauch R., Bohni N., Lorcher S., Postupalenko V., Reddy S., Meier W., Palivan C. G., Gademann K., Ward T. R., Matile S. (2016), Interfacing Functional Systems, in Chimia
, 6, 418.
Konishcheva E., Haeussinger D., Loercher S., Meier W. (2016), Key aspects to yield low dispersity of PEO-b-PCL diblock copolymers and their mesoscale self-assembly, in European Polymer Journal
S. J. Sigg, F. Santini, A. Najer, P. U. Richard, W. Meier, C. G. Palivan (2016), Nanoparticle-based highly sensitive MRI contrast agents with enhanced relaxivity in reductive milieu, in ChemComm
, 52(64), 9937-9940.
S. J. Sigg, V. Postupalenko, J. T. Duskey, C. G. Palivan, W. Meier (2016), Stimuli-Responsive Codelivery of Oligonucleotides and Drugs by Self-Assembled Peptide Nanoparticles, in Biomacromolecules
, 17(3), 935-945.
A. Najer, S. Tamboo, J. T. Duskey, C. G. Palivan, H.-P. Beck, W. Meier (2015), Analysis of Molecular Parameters Determining the Antimalarial Activity of Polymer-Based Nanomimics, in Maxcromol Rapid Commun.
, 36, 1923-1928.
Najer A., Thamboo S., Duskey J. T., Palivan C. G., Beck H. P., Meier W. (2015), Analysis of MolecularParameters Determining the Antimalarial Activity of Polymer-Based Nanomimics, in Macromol. Rapid Commun.
, 36, 1923-1928.
D. Witzigmann, D. Wu, S. H. Schenk, V. Balasubramanian, W. Meier, J. Huwyler (2015), Biocompatible Polymer-Peptide Hybrid-Based DNA Nanoparticles for Gene Delivery, in Appl. Mater. Interfaces
, 7(19), 10446-10456.
F. Itel, A. Najer, C. G. Palivan, W. Meier (2015), Dynamics of Membrane Proteins within Synthetic Polymer Membranes with Large Hydrophobic Mismatch, in Nanoletters
, 15(6), 3871-3878.
J. Kowal, D. Wu, V. Mikhalevich, C. G. Palivan, W. Meier (2015), Hybrid Polymer-Lipid Films as Platforms for Directed Membrane Protein Insertion, in Langmuir
, 31, 4868-4877.
G. Tsiavaliaris, F. Itel, K. Hedfalk, S. Al-Samir, W. Meier, G. Gros, V. Endevaward (2015), Low CO2 permeability of cholesterol-containing liposomes detected by stopped-flow fluorescence spectroscopy, in FASEB Jornal
, 29(5), 1780-1793.
G. Gunkel-Grabole, An. Car, V. V. Naik, L. Marot, G. Ferk, C. Palivan, W. Meier (2015), PEG Brushes on Porous, PDMS-Coated Surfaces and Their Interaction with Carbon Dioxide, in Macromol. Chem. Phys.
, 217, 966-973.
J. Liu, V. Postupalenko, J. Duskey, C. G. Palivan, W. Meier (2015), pH-Triggered Reversible Multiple Protein-Polymer Conjugation Based on Molecular Recognition, in J. Phys. Chem. B
, 119(36), 12066-12073.
G. Gunkel-Grabole, S. Sigg, M. Lamora, S. Lörcher, W. Meier (2015), Polymeric 3D nano-architectures for transport and delivery of therapeutically relevant biomacromolecules, in Biomaterials Science
, 3(1), 25-40.
S. Toughrai, V. Malinova, R. Masciadri, S. Menon, P.Tanner, C. Palivan, N. Bruns, W. Meier (2015), Reduction-Sensitive Amphiphilic Triblock Copolymers Self-Assemble Into Stimuli-Responsive Micelles for Drug Delivery(a), in Macromolecular Bioscience
, 15(4), 481-489.
C. Draghici, J. Kowal, A. Darjan, W.Meier, C.G. Palivan (2014), "Active Surfaces" Formed by Immobilization of Enzymes on Solid-Supported Polymer Membranes, in Langmuir
, 30(39), 11660-11669.
K. Langowska, J. Kowal, C. G. Palivan, W. Meier (2014), A general strategy for creating self-defending surfaces for controlled drug production for long periods of time, in J. Mater. Chem. B
, 2, 4684-4693.
D. Wu, M. Spulber, F. Itel, M. Chami, T. Pfohl, C. G. palivan, W. P. Meier (2014), Effect of Molecular Parameters on the Architecture and Membrane Properties of 3D Assemblies of Amphiphilic Copolymers, in Macromolecules
, 15, 5060-5069.
J. Kowal, D. Wu, C. G. Palivan, H. Stahlberg, W. Meier (2014), Functional surface engineering by nucleotide-modulated potassium channel insertion into polymer membranes attached to solid supports, in Biomaterials
, 35, 7286-7294.
F. Itel, M. Chami, A. Najer, S. Lörcher, D. Wu, W. Meier (2014), Molecular Organization and Dynamics in Polymersome Membranes: A Lateral Diffusion Study, in Macromolecules
, 47, 7588-7596.
A. Najer, D. Wu, A. Bieri, F. Brand, C. G. Palivan, H-P Beck, W. Meier (2014), Nanomimics of Host Cell Membranes Block Invasion and Expose Invasive Malaria Parasites, in ACS Nano
, 8, 12560-12571.
A. Car, P. Baumann, J. T. Duskey, M. Chami, N. Bruns, W. Meier (2014), pH-Responsive PDMS-b-PDMAEMA Micelles for Intracellular Anticancer Drug Delivery, in Biomacromolecules
, 15 (9), 3235-3245.
J. Kowal, X. Zhang, I. A. Dinu, C. G. Palivan, W. Meier (2014), Planar Biomimetic Membranes Based on Amphiphilic Block Copolymers, in ACS Macro Lett.
, 3, 59-63.
J. Liu, M. Spulber, D. Wu, R. Talom, C. Palivan, W. Meier (2014), Poly(N-isopropylacrylamide-co-tris-nitrilotriacetic acid acrylamide) for a Combined Study of Molecular Recognition and Spatial Constraints in Protein Binding and Interactions, in J. Am. Soc.
, 136(36), 12607-12614.
M. Spulber, P. Baumann, S. Saxer, U. Pieles, W. Meier, N. Bruns (2014), Poly(N-vinylpyrrolidone)-Poly(dimethylsiloxane)-Based Polymersome Nanoreactors for Laccase-Catalyzed Biotransformations, in Biomacromolecules
, 15, 1469-1475.
A.I. Dinu, C. Edlinger, E. Konishcheva, C. G. Palivan, W. Meier (2014), Polymer Vesicles
, Springer-Verlag, Berlin.
Schuster T., Nussbaumer M., Baumann P., Bruns N., Meier W., Car A. (2014), Polymeric Particulates for Subunit Vaccine Delivery, in Subunit Vaccine Delivery - Advances in Delivery Science and Technology
L. G. Tulli, N. Moridi, W. Wang, K. Helttunen, M. Neuburger, D. Vaknin, W. Meier, T. A. Jung, P. Shahgaldin (2014), Polymorphism control of an active pharmaceutical ingredient beneath calixarene-based Langmuir monolayers, in Chem. Commun.
, 50(30), 3938-3940.
de Bruyn Ouboter D., Schuster T. B., Sigg S. J., Meier W. (2013), Self-assembled peptide beads used as a template for ordered gold nanoparticle superstructures, in Colloids and Surfaces B: Biointerfaces
, 112, 542.
Development of new systems able to rapidly, selectively, and sensitively identify molecules, to provide stable and multifunctional membranes, and to engineer devices at the nanometer scale is a key focus today in various domains, including medicine, environmental science, catalysis, electronics, and food science. The self-assembly of amphiphilic block copolymers in aqueous media is a powerful tool for the hierarchical generation of supramolecular assemblies with specific desired properties and functionality. Chemical tuning of the architecture and properties of supramolecular assemblies can be used to combine the assemblies with bioactive compounds, such as proteins and enzymes. This results in new soft, hybrid materials that benefit from the robustness of polymers and the functionality of biomolecules.We propose to synthesize new amphiphilic diblock and triblock copolymers containing one stimuli-responsive block. Structural changes of the self-assembled superstructures induced by the presence of external stimuli (pH, light irradiation) will enable “on demand” release of bioactive compounds encapsulated in or entrapped on the synthetic assemblies. Both 3D supramolecular assemblies in solution (vesicles, micelles), and polymer mono- and bilayers on solid supports will be combined with bioactive molecules, and their potential for triggered release will be evaluated. By functionalising the block copolymers with specific molecules (metal-NTA, metal-tris-NTA), the membrane surface will be equipped with a density of binding sites that can support targeting approaches and immobilization on solid support. Functionalised membranes could find interest as tools in structural biology for membrane protein characterization, as nanocarriers of bioactive compounds, or as new devices for biosensing. The combination of polymers with lipids in a variety of ratios and conditions will provide an extended approach to modulate the structure and properties of mono- and bilayers on solid support. The phase separation that induces rich domains of lipids and polymers will serve to introduce an inhomogeneity at the surface level, in order to provide local conditions supporting combination with bioactive molecules to create “smart surfaces”. A second approach to produce synthetic planar membranes with tuned properties will be based on expanding polymer membranes on pore-containing solid supports. The approach will generate domains of planar membranes with different flexibility and accessibility whose tuning will support the simultaneous insertion of different types of membrane proteins for the development of multifunctional membranes.