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Nanostructured Polymers

English title Nanostructured Polymers
Applicant Meier Wolfgang
Number 150059
Funding scheme Project funding
Research institution Physikalische Chemie Departement Chemie Universität Basel
Institution of higher education University of Basel - BS
Main discipline Physical Chemistry
Start/End 01.10.2013 - 30.09.2016
Approved amount 700'000.00
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Keywords (7)

block copolymer vesicles; amphiphilic block copolymers; smart surfaces; controlled encapsulation and release; block copolymer membranes; molecular recognition; self-assembly

Lay Summary (German)

Lead
Wir planen die Herstellunhg neuer, amphiphiler Blockcopolymere. In Abhängigkeit derer Zusammensetzung können sie gezielt zu funktionelle Mizellen, Vesikel und Membranen aggregieren. Die Selbstorganisation der Polymere wird charakterisiert, sowie zur Einlagerung und/oder Freisetzung funktioneller Moleküle oder Proteine ausgenützt. Durch Kombination von Polymeren mit Lipiden werden neuartige, synthetische Membranen hergestellt. Dies sollte den gezielten Einbau funktioneller Moleküle erlauben.
Lay summary

Inhalt und Ziel des Forschungsprojekts

Die Selbstorganisation von Polymeren, die aus wasserlöslichen und wasserunlöslichen Blöcken aufgebaut sind, wird detailliert untersucht.  Als Folge davon erwarten wir, dass solche Polymere in wässriger Lösung ganz gezielt 1-, 2- oder 3-dimensionale Ueberstrukturen bilden, die zur Verkapselung oder Einlagerung funktioneller Substanzen verwendet werden können. Beispielsweise, durch Aenderung der Umgebungseigenschaften (z.B. Lichtintensität, pH,…) können verkapselte Substanzen wieder freigesetzt werden.  Darüber hinaus werden wir die Einlagerung funktioneller Moleküle in künstliche Polymermembranen genauer untersuchen. Erste Experimente zeigten auch, dass (biologische) Lipide und (synthetische) Polymere nicht vollständig mischbar sind. Hier wollen wir herausfinden unter welchen Voraussetzungen funktionelle Proteine gezielt

Wissenschaftlicher und gesellschaftlicher Kontext des Forschungsprojekts

Die geplanten Experimente liefern neue Informationen zur Selbstorganisation von Polymeren in wässrigen Medien und der gezielten Bildung künstlicher, zellartiger Membranen aus Lipiden und Polymeren. Dies ermöglicht neue Systeme zur gezielten Verkapselung und/oder Freisetzung funktioneller Moleküle, sowie der Ausnützung funktioneller, biologischer Moleküle, die in Polymeren gegen Umwelteinflüsse geschützt sind.

Direct link to Lay Summary Last update: 27.09.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Active surfaces as Possible Functional Systems in Detection and Chemical (Bio) Reactivity
Housecroft Catherine, Palivan Cornelia, Gademann Karl, Calame Michel, Meier Wolfgang, Mikhalevich Viktoria, Zhang Xiaoyan, Piel Ellen, Szponarski Mathieu, Wisler Alexandra, Lanzilloto Angelo, Constable Edwin, Fanget Axel, Stoop Ralph (2016), Active surfaces as Possible Functional Systems in Detection and Chemical (Bio) Reactivity, in Chimia, 6(70), 402-412.
Active surfaces engineerd by immobilizing protein-polymer nanoreactors for selectively detecting sugar alcohols
X. Zhang, M. Lomora, T. Einfalt, W. Meier, N. Klein, D. Schneider, C. G. Palivan (2016), Active surfaces engineerd by immobilizing protein-polymer nanoreactors for selectively detecting sugar alcohols, in Biomaterials, 89, 79-88.
Active surfaces’ as Possible Functional Systems in Detection and Chemical (Bio) Reactivity
Housecroft C. E., Palivan C. G., Gademann K., Meier W., Calame M., Mikhalevich V., Zhang X., Piel E., Szponarski M., Wiesler A., Lanzilotto A., Constable E. C., Fanget A., Stoop R. (2016), Active surfaces’ as Possible Functional Systems in Detection and Chemical (Bio) Reactivity, in Chimia, 6, 402.
An amphiphilic graft copolymer-based nanoparticle platform for reduction-responsive anticancer and antimalarial drug delivery
A. Najer, D. Wu, G. Nussbaumer, G. Schwertz, A. Schwab, M. C. Wischel, A. Schäfer, F. Friedrich, M. Rottmann, C. G. Palivan, H. Beck, W. Meier (2016), An amphiphilic graft copolymer-based nanoparticle platform for reduction-responsive anticancer and antimalarial drug delivery, in Nanoscale, 8, 14858-14869.
Artificial Organelles: Reactions inside Protein–Polymer Supramolecular Assemblies
Garni M., Einfalt T., Lomora M, Car A., Meier W., Palivan C. G. (2016), Artificial Organelles: Reactions inside Protein–Polymer Supramolecular Assemblies, in Chimia, 6, 424.
Asymmetric triblock copolymer nanocarriers for controlled localization and pH-sensitive release of proteins
Vasquez D., Einfalt T., Meier W., Palivan C. G. (2016), Asymmetric triblock copolymer nanocarriers for controlled localization and pH-sensitive release of proteins, in Langmuir, 32, 10235.
Bioinspired polymer vesicles and membranes for biological and medical applications
C. G. Palivan, R. Goers, A. Najer, X. Zhang, A. Car, W. Meier (2016), Bioinspired polymer vesicles and membranes for biological and medical applications, in Chem. Soc. Rev., 45, 377-411.
Engineered non-toxic cationic nanocarriers with photo-triggered slow-release properties
A. I. Dinu, J. T. Duskey, A. Car, C. G. Palivan, W. Meier (2016), Engineered non-toxic cationic nanocarriers with photo-triggered slow-release properties, in Polymer Chemistry, 7, 3451-3464.
Engineering and Assembly of Protein Modules into Functional Molecular Systems
Hirschi S., Stauffer M., Harder D., Müller D. J., Meier W., Fotiadis D. (2016), Engineering and Assembly of Protein Modules into Functional Molecular Systems, in Chimia, 6, 398.
Giant Host Red Blood Cell Membrane Mimicking Polymersomes Bind Parasite Proteins and Malaria Parasites
A. Najer, S. Thamboo, H. P. Beck, C. G. Palivan, W. Meier (2016), Giant Host Red Blood Cell Membrane Mimicking Polymersomes Bind Parasite Proteins and Malaria Parasites, in CHIMIA, 70(4), 288-291.
Interfacing Functional Systems
Cotelle Y., Chuard N., Lascano S., Lebrun V., Wehlauch R., Bohni N., Lorcher S., Postupalenko V., Reddy S., Meier W., Palivan C. G., Gademann K., Ward T. R., Matile S. (2016), Interfacing Functional Systems, in Chimia, 6, 418.
Key aspects to yield low dispersity of PEO-b-PCL diblock copolymers and their mesoscale self-assembly
Konishcheva E., Haeussinger D., Loercher S., Meier W. (2016), Key aspects to yield low dispersity of PEO-b-PCL diblock copolymers and their mesoscale self-assembly, in European Polymer Journal, 83.
Nanoparticle-based highly sensitive MRI contrast agents with enhanced relaxivity in reductive milieu
S. J. Sigg, F. Santini, A. Najer, P. U. Richard, W. Meier, C. G. Palivan (2016), Nanoparticle-based highly sensitive MRI contrast agents with enhanced relaxivity in reductive milieu, in ChemComm, 52(64), 9937-9940.
Stimuli-Responsive Codelivery of Oligonucleotides and Drugs by Self-Assembled Peptide Nanoparticles
S. J. Sigg, V. Postupalenko, J. T. Duskey, C. G. Palivan, W. Meier (2016), Stimuli-Responsive Codelivery of Oligonucleotides and Drugs by Self-Assembled Peptide Nanoparticles, in Biomacromolecules, 17(3), 935-945.
Analysis of Molecular Parameters Determining the Antimalarial Activity of Polymer-Based Nanomimics
A. Najer, S. Tamboo, J. T. Duskey, C. G. Palivan, H.-P. Beck, W. Meier (2015), Analysis of Molecular Parameters Determining the Antimalarial Activity of Polymer-Based Nanomimics, in Maxcromol Rapid Commun., 36, 1923-1928.
Analysis of MolecularParameters Determining the Antimalarial Activity of Polymer-Based Nanomimics
Najer A., Thamboo S., Duskey J. T., Palivan C. G., Beck H. P., Meier W. (2015), Analysis of MolecularParameters Determining the Antimalarial Activity of Polymer-Based Nanomimics, in Macromol. Rapid Commun. , 36, 1923-1928.
Biocompatible Polymer-Peptide Hybrid-Based DNA Nanoparticles for Gene Delivery
D. Witzigmann, D. Wu, S. H. Schenk, V. Balasubramanian, W. Meier, J. Huwyler (2015), Biocompatible Polymer-Peptide Hybrid-Based DNA Nanoparticles for Gene Delivery, in Appl. Mater. Interfaces, 7(19), 10446-10456.
Dynamics of Membrane Proteins within Synthetic Polymer Membranes with Large Hydrophobic Mismatch
F. Itel, A. Najer, C. G. Palivan, W. Meier (2015), Dynamics of Membrane Proteins within Synthetic Polymer Membranes with Large Hydrophobic Mismatch, in Nanoletters, 15(6), 3871-3878.
Hybrid Polymer-Lipid Films as Platforms for Directed Membrane Protein Insertion
J. Kowal, D. Wu, V. Mikhalevich, C. G. Palivan, W. Meier (2015), Hybrid Polymer-Lipid Films as Platforms for Directed Membrane Protein Insertion, in Langmuir, 31, 4868-4877.
Low CO2 permeability of cholesterol-containing liposomes detected by stopped-flow fluorescence spectroscopy
G. Tsiavaliaris, F. Itel, K. Hedfalk, S. Al-Samir, W. Meier, G. Gros, V. Endevaward (2015), Low CO2 permeability of cholesterol-containing liposomes detected by stopped-flow fluorescence spectroscopy, in FASEB Jornal, 29(5), 1780-1793.
PEG Brushes on Porous, PDMS-Coated Surfaces and Their Interaction with Carbon Dioxide
G. Gunkel-Grabole, An. Car, V. V. Naik, L. Marot, G. Ferk, C. Palivan, W. Meier (2015), PEG Brushes on Porous, PDMS-Coated Surfaces and Their Interaction with Carbon Dioxide, in Macromol. Chem. Phys., 217, 966-973.
pH-Triggered Reversible Multiple Protein-Polymer Conjugation Based on Molecular Recognition
J. Liu, V. Postupalenko, J. Duskey, C. G. Palivan, W. Meier (2015), pH-Triggered Reversible Multiple Protein-Polymer Conjugation Based on Molecular Recognition, in J. Phys. Chem. B, 119(36), 12066-12073.
Polymeric 3D nano-architectures for transport and delivery of therapeutically relevant biomacromolecules
G. Gunkel-Grabole, S. Sigg, M. Lamora, S. Lörcher, W. Meier (2015), Polymeric 3D nano-architectures for transport and delivery of therapeutically relevant biomacromolecules, in Biomaterials Science, 3(1), 25-40.
Reduction-Sensitive Amphiphilic Triblock Copolymers Self-Assemble Into Stimuli-Responsive Micelles for Drug Delivery(a)
S. Toughrai, V. Malinova, R. Masciadri, S. Menon, P.Tanner, C. Palivan, N. Bruns, W. Meier (2015), Reduction-Sensitive Amphiphilic Triblock Copolymers Self-Assemble Into Stimuli-Responsive Micelles for Drug Delivery(a), in Macromolecular Bioscience, 15(4), 481-489.
"Active Surfaces" Formed by Immobilization of Enzymes on Solid-Supported Polymer Membranes
C. Draghici, J. Kowal, A. Darjan, W.Meier, C.G. Palivan (2014), "Active Surfaces" Formed by Immobilization of Enzymes on Solid-Supported Polymer Membranes, in Langmuir, 30(39), 11660-11669.
A general strategy for creating self-defending surfaces for controlled drug production for long periods of time
K. Langowska, J. Kowal, C. G. Palivan, W. Meier (2014), A general strategy for creating self-defending surfaces for controlled drug production for long periods of time, in J. Mater. Chem. B, 2, 4684-4693.
Effect of Molecular Parameters on the Architecture and Membrane Properties of 3D Assemblies of Amphiphilic Copolymers
D. Wu, M. Spulber, F. Itel, M. Chami, T. Pfohl, C. G. palivan, W. P. Meier (2014), Effect of Molecular Parameters on the Architecture and Membrane Properties of 3D Assemblies of Amphiphilic Copolymers, in Macromolecules, 15, 5060-5069.
Functional surface engineering by nucleotide-modulated potassium channel insertion into polymer membranes attached to solid supports
J. Kowal, D. Wu, C. G. Palivan, H. Stahlberg, W. Meier (2014), Functional surface engineering by nucleotide-modulated potassium channel insertion into polymer membranes attached to solid supports, in Biomaterials, 35, 7286-7294.
Molecular Organization and Dynamics in Polymersome Membranes: A Lateral Diffusion Study
F. Itel, M. Chami, A. Najer, S. Lörcher, D. Wu, W. Meier (2014), Molecular Organization and Dynamics in Polymersome Membranes: A Lateral Diffusion Study, in Macromolecules, 47, 7588-7596.
Nanomimics of Host Cell Membranes Block Invasion and Expose Invasive Malaria Parasites
A. Najer, D. Wu, A. Bieri, F. Brand, C. G. Palivan, H-P Beck, W. Meier (2014), Nanomimics of Host Cell Membranes Block Invasion and Expose Invasive Malaria Parasites, in ACS Nano, 8, 12560-12571.
pH-Responsive PDMS-b-PDMAEMA Micelles for Intracellular Anticancer Drug Delivery
A. Car, P. Baumann, J. T. Duskey, M. Chami, N. Bruns, W. Meier (2014), pH-Responsive PDMS-b-PDMAEMA Micelles for Intracellular Anticancer Drug Delivery, in Biomacromolecules, 15 (9), 3235-3245.
Planar Biomimetic Membranes Based on Amphiphilic Block Copolymers
J. Kowal, X. Zhang, I. A. Dinu, C. G. Palivan, W. Meier (2014), Planar Biomimetic Membranes Based on Amphiphilic Block Copolymers, in ACS Macro Lett., 3, 59-63.
Poly(N-isopropylacrylamide-co-tris-nitrilotriacetic acid acrylamide) for a Combined Study of Molecular Recognition and Spatial Constraints in Protein Binding and Interactions
J. Liu, M. Spulber, D. Wu, R. Talom, C. Palivan, W. Meier (2014), Poly(N-isopropylacrylamide-co-tris-nitrilotriacetic acid acrylamide) for a Combined Study of Molecular Recognition and Spatial Constraints in Protein Binding and Interactions, in J. Am. Soc., 136(36), 12607-12614.
Poly(N-vinylpyrrolidone)-Poly(dimethylsiloxane)-Based Polymersome Nanoreactors for Laccase-Catalyzed Biotransformations
M. Spulber, P. Baumann, S. Saxer, U. Pieles, W. Meier, N. Bruns (2014), Poly(N-vinylpyrrolidone)-Poly(dimethylsiloxane)-Based Polymersome Nanoreactors for Laccase-Catalyzed Biotransformations, in Biomacromolecules, 15, 1469-1475.
Polymer Vesicles
A.I. Dinu, C. Edlinger, E. Konishcheva, C. G. Palivan, W. Meier (2014), Polymer Vesicles, Springer-Verlag, Berlin.
Polymeric Particulates for Subunit Vaccine Delivery
Schuster T., Nussbaumer M., Baumann P., Bruns N., Meier W., Car A. (2014), Polymeric Particulates for Subunit Vaccine Delivery, in Subunit Vaccine Delivery - Advances in Delivery Science and Technology, 181.
Polymorphism control of an active pharmaceutical ingredient beneath calixarene-based Langmuir monolayers
L. G. Tulli, N. Moridi, W. Wang, K. Helttunen, M. Neuburger, D. Vaknin, W. Meier, T. A. Jung, P. Shahgaldin (2014), Polymorphism control of an active pharmaceutical ingredient beneath calixarene-based Langmuir monolayers, in Chem. Commun., 50(30), 3938-3940.
Self-assembled peptide beads used as a template for ordered gold nanoparticle superstructures
de Bruyn Ouboter D., Schuster T. B., Sigg S. J., Meier W. (2013), Self-assembled peptide beads used as a template for ordered gold nanoparticle superstructures, in Colloids and Surfaces B: Biointerfaces , 112, 542.

Collaboration

Group / person Country
Types of collaboration
Prof. P Beck, Switzerland (Europe)
- Publication
- Research Infrastructure
Cornelia Palivan /Uni Basel Chemistry Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Jörg Huwiler / Uni Basel Pharmacy Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
SICS'16 - 1st Swiss Industrial Chemistry Symposium Poster Cosolvent fractionation of PMOXA-PDMDS-PMOXA: a bulk separation method of triblocks from multiblocks 28.10.2016 Basel, Switzerland Meier Wolfgang; Lörcher Samuel;
SCS fall meeting Poster Self-organisation of polymeric nano-compartments or polymersome-origami 15.09.2016 Zürich, Switzerland Meier Wolfgang; Lörcher Samuel;
Liposomes, Exosomes and Virosomes: From Modeling Complex Membrane Processes to Mecical Diagnostics and Drug Delivery Individual talk Biomimetic Block Copolymer Membranes 12.09.2016 Monte Verita/Ascona , Switzerland Meier Wolfgang;
TNT2016 Individual talk Functional Polymer-Lipid Membranes 07.09.2016 Fribourg, Switzerland Meier Wolfgang;
Swiss Soft Day Talk given at a conference Active Surfaces Engineered by Immobilizing Protein-polymer Nanoreactors for Selectively Detecting Sugar Alcohols 02.09.2016 Basel, Switzerland Zhang Xiaoyan; Meier Wolfgang;
ACS-Meeting (Symposium on Poly(2-oxazoline and Polypeptides) Individual talk Amphiphilic Polymers with Hydrophilic PMOXA-Blocks 23.08.2016 Brugg, Switzerland Meier Wolfgang;
Basel Postdoc Network Retreat Talk given at a conference Active Surfaces Engineered by Immobilizing Protein-polymer Nanoreactors for Selectively Detecting Sugar Alcohols 23.08.2016 Saas Fee, Switzerland Zhang Xiaoyan; Meier Wolfgang;
Biointerfaces International Poster Active Surfaces Engineerd by Immobilizing Protein-polymer Nanoreactors for Selectively Detecting Sugar Alcohols 23.08.2016 Zürich, Switzerland Meier Wolfgang; Zhang Xiaoyan;
ACS-Meeting(Symposium Materials Genome, Approach of Structure&Function) Talk given at a conference Functional Polymer-Lipid Membranes 22.08.2016 Philadelphia, United States of America Meier Wolfgang;
252nd ACS National Meeting and Exposition. 3rd symopsium on poly(2-oxaline)s and polypeptoids Talk given at a conference Novel PEG-b-PCL-b-PMOXA amphiphilic triblock copolymers: towards polymersomes with asymetric membrane 21.08.2016 Philadelphia, United States of America Meier Wolfgang; Konishcheva Evgeniia V.;
International Nanoscience Student Conference Talk given at a conference Sugar Alcohol Biosensors based on Polymer-Protein Self-assembled Nanoreactors 05.08.2016 Baarlo, Netherlands Meier Wolfgang; Zhang Xiaoyan;
SoMas: Synthetic and Biological Membranes Talk given at a conference Behavior of Polymer Membranes 04.07.2016 Mittelwihr, France Meier Wolfgang;
Evaluation of NCCR-MSE Talk given at a conference Development of Molecular Factories 22.06.2016 Basel, Switzerland Meier Wolfgang;
NCCR_MSE Site Visit Poster DNA-mediated self-organization of polymeric nano-compartments leads to interconnected artificial organelles 22.06.2016 Basel, Switzerland Meier Wolfgang; Lörcher Samuel;
LPP-World Congress on Living Polimerisations and Polymers Talk given at a conference New insight yields biocompatible block copolymers with narrow molecular weight distributions 02.06.2016 Budapest, Hungary Meier Wolfgang; Lörcher Samuel;
Industry Meeting of SNI Talk given at a conference ‚Polymer Membranes’ 01.03.2016 Basel, Switzerland Meier Wolfgang;
2nd International Conference on Infectious Diseases and Nanomedicine-2015 (ICIDN-2015) Talk given at a conference Trick malaria parasites using nanomimics of host red blood cell membranes? 15.12.2015 Kathmandu, Nepal Najer Adrian; Meier Wolfgang;
Euromembrane Conference Talk given at a conference Biomimetic block copolymer membranes 09.11.2015 Aachen, Germany Meier Wolfgang;
2nd Technology Apero of the NCCR Molecular Systems Engineering Poster Photo-Labile Nanocarriers based on Amphiphilic Diblock Copolymers for the Delivery of Small Molecules 29.10.2015 Lausanne, Switzerland Dinu Ionel Adrian; Meier Wolfgang;
Kick-off meeting for SSSTC project Talk given at a conference "Self-defending" polymer surfaces: A new strategy to protect medical devices against infection 25.10.2015 Beijing, China Zhang Xiaoyan; Meier Wolfgang;
IUPAC 11th International Conference on Advanced Polymers via Macromolecular Engineering Talk given at a conference PEG-PCL-PMOXA triblock copolymers: from synthesis to self-assembled structures 19.10.2015 Yokohama, Japan Meier Wolfgang; Konishcheva Evgeniia V.;
13th International Nanomedicine & Drug Delivery Symposium (NanoDDS) Talk given at a conference Host cell surface-mimicking polymersomes (nanomimicks) to trap and expose malaria parasites 16.09.2015 Seattle, United States of America Najer Adrian; Meier Wolfgang;
SCS Fall Meeting Poster Transport of Calcium Ions through Thick Biomimetic Polymer Membranes 04.09.2015 Lausanne, Switzerland Meier Wolfgang; Dinu Ionel Adrian;
SCS Fall Meeting Poster Synthetic Biocompartments with Selective Membrane Permeability towards Protons and Monovalent Cations 04.09.2015 Lausanne, Switzerland Dinu Ionel Adrian; Meier Wolfgang;
SCS Fall Meeting Talk given at a conference Photo-Sensitive Cationic Nanocarriers for non-Toxic Delivery of Small Molecules 04.09.2015 Lausanne, Switzerland Meier Wolfgang; Dinu Ionel Adrian;
Swiss Chemical Society Fall Meeting Talk given at a conference Functionalized polymersomes inhibit malaria parasite invasion into host red blood cells 04.09.2015 Lausanne, Switzerland Najer Adrian; Meier Wolfgang;
IUPAC-2015, 45th World Chemistry Congress Poster Selective Ion Permeability of Biomimetic Membranes Induced by Insertion of Biopores 09.08.2015 Bexco, Korean Republic (South Korea) Dinu Ionel Adrian; Meier Wolfgang;
80th Prague Meeting on Macromoleules. Self-assembling in the world of polymers Poster PEG-PCL diblock copolymers: optimization of the synthesis towards low PDI for targeted self-assembled structures 11.07.2015 Prague, Czech Republic Meier Wolfgang; Konishcheva Evgeniia V.;
FBPS'15 The 11th International Symposium on Frontiers in Biomedical Polymers Poster Self-Assembled Nanocarriers Based on Amphiphilic Diblock Copolymers Containing Photo-Labile Moieties 08.07.2015 Riva del Garda, Italy Dinu Ionel Adrian; Meier Wolfgang;
FBPS'15 The 11th International Symposium on Frontiers in Biomedical Polymers Talk given at a conference Biomimetic Nano-Compartments with Ion-Selective Membrane Permeability 08.07.2015 Riva del Garda, Italy Meier Wolfgang; Dinu Ionel Adrian;
Annual Meeting of the Division of Polymers, Colloids and Interfaces (PolyColl) Poster Malaria Parasite Invasion Inhibited by Red Blood Cell Mimicking Polymersomes 03.07.2015 Fribourg, Switzerland Najer Adrian;
FU-Berlin Individual talk Molecular factories based on amphiphilic block copolymers 16.06.2015 Berlin, Germany Meier Wolfgang;
NCCR-MSE Meeting Talk given at a conference Molecular Systems Engineering 04.06.2015 Basel, Switzerland Meier Wolfgang;
Polymer Science Conference Talk given at a conference Biomimetic block copolymer membranes 21.05.2015 Garda See, Switzerland Meier Wolfgang;
Challenges in Science and Technology of Polymer Materials Talk given at a conference Biomimetic nanostructures based on amphiphilic block copolymers 19.05.2015 Bansko, Bulgaria Meier Wolfgang; Dinu Ionel Adrian;
EMBL Conference BioMalPar XI: Biology and Pathology of the Malaria Parasite Talk given at a conference Simle nanomimics of host cell membranes interrupt malaria blood-stage cicle 11.05.2015 Heidelberg, Germany Najer Adrian; Meier Wolfgang;
Swiss Soft Days, SSD16 Talk given at a conference Photo-Sensitive Cationic Polymers for Non-toxic Stimulated Release and Delivery of Small Molecules 04.05.2015 Villingen, Switzerland Meier Wolfgang; Dinu Ionel Adrian;
NCCR-MSE Retreat Talk given at a conference A basis for molecular factories 15.04.2015 Riederalp, Switzerland Meier Wolfgang;
NCCR 1st Fellow Retreat Poster Amphiphilic Block Copolymers - Tools for Molecular Factories 15.04.2015 Riederalp, Switzerland Meier Wolfgang; Dinu Ionel Adrian;
Advanced Functional Polymers for Medicine (AFPM) Talk given at a conference Trap and expose Invasive Pathogenes Using Nanomimics of Host Cell Membranes 23.03.2015 Galway, Ireland Najer Adrian; Meier Wolfgang;
NRP 62 "Smart Materials" Poster Functional Surfaces through Immobilization of Nanoreactors and Biomimetic Block Copolymer Membranes 19.03.2015 Bern, Switzerland Zhang Xiaoyan; Meier Wolfgang;
BASF Workshop Talk given at a conference Transport of energy across polymer membranes 09.03.2015 Ludwigshafen, Germany Meier Wolfgang;
Macromolecular Colloquium Talk given at a conference Conquering Infections using Polymer-based Nanomimics of Host Cell Membranes 26.02.2015 Freiburg, Germany Meier Wolfgang; Najer Adrian;
SSS Swiss Snow Sympoium Poster PEG-PCL block copolymers: new insights into the well-known synthesis 23.01.2015 Saas-Fee, Switzerland Konishcheva Evgeniia V.; Meier Wolfgang;
2nd International Conference on Bioinspired and Biobased Chemistry & Materials Talk given at a conference Photo-triggerable nanocarriers based on amphiphilic block copolymer 15.10.2014 Nice, France Dinu Ionel Adrian; Meier Wolfgang;
The 12th International School of Biophysics - Biomacromolecular Complexes Poster FRET Triangulation of OMPF in Polymersomes06.10.2014 06.10.2014 Primosten, Croatia Lörcher Samuel; Meier Wolfgang;
Eröffnung NCCR – Molecular Systems Engineering Talk given at a conference Molecular Systems Engineering 29.09.2014 Basel, Switzerland Meier Wolfgang;
Invited lecture at Marburg University Individual talk Biomimetic Block Copolymer Membranes 25.09.2014 Universität Marburg, Germany Meier Wolfgang;
SCS Swiss Chemical Society fall Meeting Talk given at a conference Effect of hydrophobicity on Nanoparticle formation: a case of ABC asymetric triblock copolymers 11.09.2014 Zürich, Switzerland Meier Wolfgang; Konishcheva Evgeniia V.;
Novartis Individual talk Molecular Systems Engineering 11.07.2014 Boston, United States of America Meier Wolfgang;
Gordon Research Conference Talk given at a conference Biomimetic Block Copolymer Membranes 10.07.2014 Boston, United States of America Meier Wolfgang;
PolyColl, Annual meeting of the Division of polymers, Colloids and Interfaces Talk given at a conference Amphiphilic Block Copolymers: From Sythesis to Biomedical Applications 20.06.2014 Dübendorf, Switzerland Dinu Ionel Adrian; Meier Wolfgang;
Swiss Soft days, 14th Edition Poster pH and Photo-Responsive Polymers: Toward gene Delivery Platform 06.06.2014 Basel, Switzerland Dinu Ionel Adrian; Meier Wolfgang;
Swiss Soft Days Poster Long-Term stable Immobilization of Nanoparticles on the Surfaces 06.06.2014 Basel, Switzerland Dinu Ionel Adrian; Meier Wolfgang;
Swiss Soft Days Poster ABC Amphiphilic Triblock Copolymers: Effect of Hydrophobicity on Nanoparticle Formation 06.06.2014 Basel, Switzerland Konishcheva Evgeniia V.; Meier Wolfgang;
DPG spring meeting Talk given at a conference Biomimetic Solid-supported Polymer Bilayer Incorporated with Membrane Proteins 05.06.2014 Dresden, Germany Meier Wolfgang; Zhang Xiaoyan;
MPI Individual talk Molecular Systems Engineering 29.05.2014 München, Germany Meier Wolfgang;
Swiss NanoConvention Individual talk New NCCR: Molecular Systems Engineering 21.05.2014 Brugg, Switzerland Meier Wolfgang;
6th International Symposium on Polymer Chemistry Talk given at a conference Biomimetic Block Copolymer Membranes and Immobilized Nanoreactors for Medical Applications 03.04.2014 Shanghai, China Meier Wolfgang; Zhang Xiaoyan;
1st Annual Conference of the COST Action MP1302 Nanospectroscopy (Optical Nanospectroscopy1) Poster Nanoreactors, Nanomimics, and Artificial Organelles for Medicine: Analysis by Fluorescence Correlation Spectroscopy (FCS) 23.03.2014 Tübingen, Germany Meier Wolfgang; Najer Adrian;
Makrokolloq 2014 Talk given at a conference Immobilized Nanoreactors and Biomimetic Block Copolymer Membranes 26.02.2014 Freiburg, Germany Meier Wolfgang;
NCCR Meeting Talk given at a conference Amphiphilic Block Copolymers 04.02.2014 Basel, Switzerland Meier Wolfgang;
SSSTC Workshop "Bioinspires Surfaces & Materials: recent developments, technical breakthroughs and translation to application" Talk given at a conference Polymer membranes decorated with proteins as functional bionanosystems and biofunctional surfaces 01.02.2014 Zürich, Switzerland Meier Wolfgang; Zhang Xiaoyan;
University of Bern Talk given at a conference Biomimetic Block Copolymer Vesicles and Membranes 31.10.2013 Bern, Switzerland Meier Wolfgang;


Associated projects

Number Title Start Funding scheme
131884 Nanostructured Polymers 01.10.2010 Project funding
169189 Nanostructured Polymers 01.10.2016 Project funding
126099 Functional surfaces through immobilization of nanoreactors and biomimetic block copolymer membranes 01.01.2010 NRP 62 Smart Materials

Abstract

Development of new systems able to rapidly, selectively, and sensitively identify molecules, to provide stable and multifunctional membranes, and to engineer devices at the nanometer scale is a key focus today in various domains, including medicine, environmental science, catalysis, electronics, and food science. The self-assembly of amphiphilic block copolymers in aqueous media is a powerful tool for the hierarchical generation of supramolecular assemblies with specific desired properties and functionality. Chemical tuning of the architecture and properties of supramolecular assemblies can be used to combine the assemblies with bioactive compounds, such as proteins and enzymes. This results in new soft, hybrid materials that benefit from the robustness of polymers and the functionality of biomolecules.We propose to synthesize new amphiphilic diblock and triblock copolymers containing one stimuli-responsive block. Structural changes of the self-assembled superstructures induced by the presence of external stimuli (pH, light irradiation) will enable “on demand” release of bioactive compounds encapsulated in or entrapped on the synthetic assemblies. Both 3D supramolecular assemblies in solution (vesicles, micelles), and polymer mono- and bilayers on solid supports will be combined with bioactive molecules, and their potential for triggered release will be evaluated. By functionalising the block copolymers with specific molecules (metal-NTA, metal-tris-NTA), the membrane surface will be equipped with a density of binding sites that can support targeting approaches and immobilization on solid support. Functionalised membranes could find interest as tools in structural biology for membrane protein characterization, as nanocarriers of bioactive compounds, or as new devices for biosensing. The combination of polymers with lipids in a variety of ratios and conditions will provide an extended approach to modulate the structure and properties of mono- and bilayers on solid support. The phase separation that induces rich domains of lipids and polymers will serve to introduce an inhomogeneity at the surface level, in order to provide local conditions supporting combination with bioactive molecules to create “smart surfaces”. A second approach to produce synthetic planar membranes with tuned properties will be based on expanding polymer membranes on pore-containing solid supports. The approach will generate domains of planar membranes with different flexibility and accessibility whose tuning will support the simultaneous insertion of different types of membrane proteins for the development of multifunctional membranes.
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