Cortical microelectronic implants; Wireless cortical implants; Bio-electronic interfaces
M. Shoaran H. Afshari A. Schmid (2014), A Novel Compressive Sensing Architecture for High-Density Biological Signal Recording, in IEEE 2014 Biomedical Circuits and Systems Conference
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G. Yilmaz C. Dehollain (2014), An Implantable System for Intracranial Neural Recording Applications, in IEEE Biomedical Circuits and Systems Conference (BioCAS) 2014
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M. Shoaran M. H. Kamal C. Pollo P. Vandergheynst A. Schmid (2014), Compact Low-Power Cortical Recording Architecture for Compressive Multichannel Data Acquisition, in IEEE TBioCAS
Shoaran Yilmaz Periasamy Seiler Di Santo Pollo SchindlerWidmer Dehollain Schmid (2014), In-Vivo Validation of a Compact Inductively-Powered Neural Recording Interface, in IEEE 2014 Biomedical Circuits and Systems Conference
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O. Kazanc G. Yilmaz F. Maloberti and C. Dehollain (2014), Remote Powering Platform for Implantable Sensor Systems at 2.45 GHz, in IEEE EMBC 2014
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Mahsa Shoaran Alexandre Schmid (2014), System and Circuit Design for High-Density iEEG Recording and Epileptic Seizure Detection
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G. Yilmaz C. Dehollain (2014), Wireless Communication and Power Transfer System for Intracranial Neural Recording Applications, in IEEE New Circuits and Systems Conference (NEWCAS) 2014
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M. Shoaran C. Pollo K. Schindler and A. Schmid, A Fully-Integrated IC with 0.85-W/Channel Consumption for Epileptic iEEG Detection, in IEEE Transactions on Circuits and Systems II
G.Yilmaz C. Dehollain, Single frequency wireless power transfer and full-duplex communication system for intracranial epilepsy monitoring, in Elsevier Microelectronics Journal
Monitoring epileptogenic cortical areas in-vivo has been carried out in clinical environment within the context of epilepsy treatment consisting in detecting and subsequently resecting incriminated areas. A portable and autonomous system in charge of the focus detection forms a significant advance in this area where the monitoring time of patient can not be predicted, and thus, the prescription of a heavy clinical monitoring phase represents costs and risks that are difficult to balance with respect to potential therapeutic benefits. In addition, epilepsy research has recently acknowledged high-density acquisition of ECoG as a promising domain susceptible to offer new perspectives and understanding of the eplilepsy onset and seizure episode, from the perspective of the electrical activity of individual or small groups of neural cells. This project is proposed as an extension to the SNSF-funded project No. 200021_130166 “Implantable Bio-Electronics for Wireless and High-Resolution Monitoring of Epilepsy in-vivo,” formally extending over the period of December 2010 through November 2013. Significant progresses have been made as the result of collaborative results between the three involved research groups, notably in the development of low-power, low-noise high-density microelectronic analog front-end with embedded multichannel compressed sensing capability, conformal packaging of the device including electrodes on a flexible substrate, wireless transmission of data and power, and system-level specifications.This extension of the initial research proposes to achieve the following scientific goals:• 64-channel analog front-end with SAR-ADC at 20 MS/s, and data compression;• packaging technology for the analog front-end using a flexible substrate, and microfabricated high-density electrodes;• 2Mb/s data and power wireless transmission system;• co-integration of the three aforementioned blocks, packaging into one system;• animal experiments studying the effectiveness of high-density readout electrodes, and study of epileptical signal capture using the proposed system.The project extension aims at gathering the theoretical and development parts into one comprehensive system and methodology, that is applied to epilepsy study in-vivo. The research is conducted with the researchers and the supervisors involved in the earlier part of the project. The research is proposed as an extension of demonstrated successful research, which significantly mitigates any risk. This research project is presented as part of long-term goals of the research groups, which have been active and have collaborated in the domain for several years.