Project

Back to overview

Gene-environment interactions in the etiology, symptomatology and treatment of posttraumatic stress disorder

English title Gene-environment interactions in the etiology, symptomatology and treatment of posttraumatic stress disorder
Applicant De Quervain Dominique
Number 147570
Funding scheme Project funding
Research institution Kognitive Neurowissenschaften Universität Basel
Institution of higher education University of Basel - BS
Main discipline Neurology, Psychiatry
Start/End 01.07.2013 - 31.12.2017
Approved amount 483'075.00
Show all

All Disciplines (2)

Discipline
Neurology, Psychiatry
Genetics

Keywords (2)

Posttraumatische Belastungsstörung; Genetik

Lay Summary (German)

Lead
Ziel dieses Projektes ist die systematische Untersuchung der Genetik der Posttraumatischen Belastungsstörung mittels genomweiter Scans.
Lay summary

Genetische Faktoren beeinflussen das Risiko der Entwicklung einer Posttraumatischen Belastungsstörung (PTBS) nach einem traumatischen Ereignis. Ein besseres Verständnis der genetischen Grundlagen der PTBS könnte wertvolle Hinweise für die Entwicklung neuer Medikamente zur Prävention und Therapie von PTBS liefern. Die Entwicklung kosteneffizienter Genotypisierungs-Chips erlaubt die Durchführung hochauflösender genomweiter Assoziationsstudien. Ziel dieses Projektes ist die systematische Untersuchung der Genetik der PTBS mittels genomweiter Scans an einer großen Stichprobe von Individuen aus afrikanischen Konfliktregionen. Die Ergebnisse dieser Studie dienen einem besseren Verständnis genetischer Risikofaktoren für die Entstehung der PTBS, und ihrer Relevanz für die Therapie dieser Störung.

Direct link to Lay Summary Last update: 29.06.2013

Responsible applicant and co-applicants

Publications

Publication
Does trauma event type matter in the assessment of traumatic load?
Conrad Daniela, Wilker Sarah, Pfeiffer Anett, Lingenfelder Birke, Ebalu Tracie, Lanzinger Hartmut, Elbert Thomas, Kolassa Iris-Tatjana, Kolassa Stephan (2017), Does trauma event type matter in the assessment of traumatic load?, in European journal of psychotraumatology, 8(1), 1344079-1344079.
How to quantify exposure to traumatic stress? Reliability and predictive validity of measures for cumulative trauma exposure in a post-conflict population.
Wilker Sarah, Pfeiffer Anett, Kolassa Stephan, Koslowski Daniela, Elbert Thomas, Kolassa Iris-Tatjana (2015), How to quantify exposure to traumatic stress? Reliability and predictive validity of measures for cumulative trauma exposure in a post-conflict population., in European journal of psychotraumatology, 6, 28306-28306.
The downside of strong emotional memories: how human memory-related genes influence the risk for posttraumatic stress disorder--a selective review.
Wilker Sarah, Elbert Thomas, Kolassa Iris-Tatjana (2014), The downside of strong emotional memories: how human memory-related genes influence the risk for posttraumatic stress disorder--a selective review., in Neurobiology of learning and memory, 112, 75-86.
The role of FKBP5 genotype in moderating long-term effectiveness of exposure-based psychotherapy for posttraumatic stress disorder.
Wilker S, Pfeiffer A, Kolassa S, Elbert T, Lingenfelder B, Ovuga E, Papassotiropoulos A, de Quervain D, Kolassa I-T (2014), The role of FKBP5 genotype in moderating long-term effectiveness of exposure-based psychotherapy for posttraumatic stress disorder., in Translational psychiatry, 4, 403-403.

Associated projects

Number Title Start Funding scheme
159740 The role of epigenetic modification of glucocorticoid-related genes in aversive memory and post-traumatic stress disorder 01.04.2015 Project funding

Abstract

Genetic risk factors contribute to the susceptibility of developing Posttraumatic Stress Disorder (PTSD) after exposure to traumatic events. A comprehensive characterization of the genetics of PTSD could contribute to a better understanding of the underlying molecular mechanisms and provide important insights for the development of drugs to prevent and treat PTSD. Furthermore, PTSD is uniquely suited for the study of gene × environment interactions since trauma exposure constitutes a necessary factor for the disorder to manifest. Likewise, in contrast to other disorders, the relevant environmental risk factor can be quantified and included in the analyses, which makes PTSD uniquely suited for etiological research on individual vulnerability factors. The recent development of cost-effective genotyping platforms allows high-resolution genome-wide association studies for the unbiased identification of novel genes related to PTSD. This project aims at systematically investigating the genetics of PTSD, by using genome-wide scans in a large sample of individuals from conflict regions in Africa. More specifically, we plan to investigate gene × environment interactions in the etiology and symptomatology of PTSD. The identified genetic risk factors will be validated in an independent sample and their influence on the response to trauma-focused therapeutic treatment will be analyzed. The results of this project will contribute to a deeper understanding of genetic risk factors involved in PTSD etiology and their role in trauma-focused therapy.
-