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Brain Connectivity and Sleep in Preschool Children

English title Brain Connectivity and Sleep in Preschool Children
Applicant Kurth Salomé
Number 147180
Funding scheme Fellowships for prospective researchers
Research institution
Institution of higher education Institution abroad - IACH
Main discipline Neurophysiology and Brain Research
Start/End 01.02.2013 - 31.07.2013
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All Disciplines (2)

Discipline
Neurophysiology and Brain Research
Embryology, Developmental Biology

Keywords (4)

brain maturation; sleep; myelin; children

Lay Summary (German)

Lead
Welche Rolle der Schlaf für die Entwicklung des Gehirns im Kleinkindesalter spielt, ist noch weitgehend ungeklärt. Neuste Studien zeigen, dass besonders die Hirnaktivität im Tiefschlaf ein "Fenster" darstellt, um die Reifungsprozesse im jungen Gehirn zu beobachten.
Lay summary

Neuste Methoden ermöglichen, zusätzlich zur Messung von Veränderungen der Hirnoberfläche, auch die Reifung von tieferliegenden Hirnfasern zu verfolgen. Diese Faserreifung erfährt im Kleinkindesalter grösste Entwicklungssprünge, v.a. durch den Aufbau von Myelin, und es wird weitgehend angenommen, dass das Erlernen verschiedener Fähigkeiten wie Motorik, Sprache, Kognition grösstenteils auf diese Faserreifung zurückzuführen ist, indem die Aktivität zwischen auseinanderliegenden Hirnregionen besser synchronisiert wird.

Obwohl angenommen wird, dass die Hirnwellen im Tiefschlaf eine entscheidende Rolle für die Hirnentwicklung spielen, gibt es riesige Lücken in der Forschung auf diesem Themengebiet. Insbesondere ist unklar, wie der Schlaf mit der Faserreifung und dem Lernen auf Verhaltensebene zusammenhängt. 

Zudem entstehen Entwicklungsstörungen oftmals im Kleinkindesalter und verlässliche Methoden um solche zu identifizieren sind heute ungenügend. Das laufende Projekt widmet sich der Aufgabe, mit neusten Methoden das Verhältnis von Schlaf-Verhalten-Hirnstruktur bei Kleinkindern intensiv zu untersuchen. 


Direct link to Lay Summary Last update: 06.09.2013

Responsible applicant and co-applicants

Publications

Publication
A simple sleep EEG marker in childhood predicts brain myelin 3.5 years later
LeBourgeois Monique K., Dean Douglas C., Deoni Sean C.L., Kohler Malcolm, Kurth Salome (2019), A simple sleep EEG marker in childhood predicts brain myelin 3.5 years later, in NeuroImage, xxxx.
Traveling Slow Oscillations During Sleep: A Marker of Brain Connectivity in Childhood
Kurth Salome, Riedner Brady, Dean Douglas, O'Muircheartaigh Jonathan, Huber Reto, Jenni Oskar, Deoni Sean, LeBourgeois Monique (2017), Traveling Slow Oscillations During Sleep: A Marker of Brain Connectivity in Childhood, in SLEEP, zsx121.
Sleep moderates the association between response inhibition and self-regulation in early childhood
Schumacher Allyson, Miller Allison, Watamura Sarah, Kurth Salome, Lassonde Jonathan, LeBourgeois Monique (2017), Sleep moderates the association between response inhibition and self-regulation in early childhood, in Journal of Child and Adolescent Psychology, 46(2), 222-235.
Acute sleep restriction increases dietary intake in preschool-age children
Mullins Elsa, Miller Alison, Cherian Sherin, Lumeng Julie, Wright Kenneth, Kurth Salome, LeBourgeois Monique (2017), Acute sleep restriction increases dietary intake in preschool-age children, in Journal of Sleep Research, 26(1), 48-54.
Development of nap neurophysiology: preliminary insights into sleep regulation in early childhood.
Kurth Salome, Lassonde Jonathan M, Pierpoint Lauren A, Rusterholz Thomas, Jenni Oskar G, McClain Ian J, Achermann Peter, LeBourgeois Monique K (2016), Development of nap neurophysiology: preliminary insights into sleep regulation in early childhood., in Journal of sleep research, 25(6), 646-654.
Increased sleep depth in developing neural networks: new insights from sleep restriction in children
Kurth Salome, Dean Douglas, Achermann Peter, O'Muircheartaigh Jonathan, Huber Reto, Deoni Sean, LeBourgeois Monique (2016), Increased sleep depth in developing neural networks: new insights from sleep restriction in children, in Frontiers in Human Neuroscience, 10, 456.
Developmental Changes in Sleep Spindle Characteristics and Sigma Power across Early Childhood.
McClain Ian J, Lustenberger Caroline, Achermann Peter, Lassonde Jonathan M, Kurth Salome, LeBourgeois Monique K (2016), Developmental Changes in Sleep Spindle Characteristics and Sigma Power across Early Childhood., in Neural plasticity, 2016, 3670951-3670951.
Sleep physiology in toddlers: effects of missing a nap on subsequent night sleep
Lassonde Jonathan, Rusterholz Thomas, Kurth Salome, Schumacher Allyson, Achermann Peter, LeBourgeois Monique (2016), Sleep physiology in toddlers: effects of missing a nap on subsequent night sleep, in Neurobiology of Sleep and Circadian Rhythms, 1(1), 19-26.
Caffeine Consuming Children and Adolescents Show Altered Sleep Behavior and Deep Sleep
Aepli Andrina, Kurth Salome, Tesler Noemi, Jenni Oskar, Huber Reto (2015), Caffeine Consuming Children and Adolescents Show Altered Sleep Behavior and Deep Sleep, in Brain Sciences, 5(4), 441-455.
Myelination Is Associated with Processing Speed in Early Childhood: Preliminary Insights.
Chevalier Nicolas, Kurth Salome, Doucette Margaret Rae, Wiseheart Melody, Deoni Sean C L, Dean Douglas C, O'Muircheartaigh Jonathan, Blackwell Katharine A, Munakata Yuko, LeBourgeois Monique K (2015), Myelination Is Associated with Processing Speed in Early Childhood: Preliminary Insights., in PloS one, 10(10), 0139897-0139897.
Sleep and early cortical development
Kurth Salome, Olini Nadja, Huber Reto, LeBourgeois Monique (2015), Sleep and early cortical development, in Current Sleep Medicine Reports, 1(1), 64.
Topography of Slow Sigma Power during Sleep is Associated with Processing Speed in Preschool Children.
Doucette Margaret R, Kurth Salome, Chevalier Nicolas, Munakata Yuko, LeBourgeois Monique K (2015), Topography of Slow Sigma Power during Sleep is Associated with Processing Speed in Preschool Children., in Brain sciences, 5(4), 494-508.
Development of brain EEG connectivity across early childhood – does sleep play a role?
Kurth Salome, Achermann Peter, Rusterholz Thomas, LeBourgeois Monique (2013), Development of brain EEG connectivity across early childhood – does sleep play a role?, in Brain Sciences, 3(4), 1445-1460.
The sleep EEG topography in children and adolescents shows sex differences in language areas
Kurth Salome, Ringli Maya, Huber Reto, Jenni Oskar (2013), The sleep EEG topography in children and adolescents shows sex differences in language areas, in International Journal of Psychophysiology, 241.

Collaboration

Group / person Country
Types of collaboration
Sean Deoni, Brown University United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
Nicolas Chevalier, University of Edinburgh Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel
Reto Huber, Oskar Jenni, Kinderspital Zuerich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Yuko Munakata, Institute of Cognitive Sciences, CU Boulder, CO United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
Jonathan O'Muircheartaigh, Kings College, London Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel
Sean Deoni, Anschutz Medical Campus United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel
Douglas Dean, Waisman Center, University of Wisconsin-Madison United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel
Brady Riedner, University of Wisconsin, Madison United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Peter Achermann, Universitaet Zuerich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
SLEEP 2015 APSS Annual Meeting Talk given at a conference Symposium Chair: "Brain Plasticity and Network Dynamics in Sleep: Moving the Field Forward with Novel Quantitative Tools - Neural network dynamics" Talk innerhalb des Symposiums: "What can we learn from children’s sleep?" 06.06.2015 Seattle, United States of America Kurth Salomé;
SLEEP 2015 APSS Annual Meeting Poster THE DEVELOPMENT OF SLEEP SPINDLES ACROSS EARLY CHILDHOOD 06.06.2015 Seattle, United States of America Kurth Salomé;
SLEEP 2015 APSS Annual Meeting Talk given at a conference TRAVELLING SLEEP SLOW OSCILLATIONS AND MYELINATION IN PRESCHOOL CHILDREN 06.06.2015 Seattle, United States of America Kurth Salomé;
SLEEP 2015 APSS Annual Meeting Poster SLEEP HOMEOSTASIS IN TODDLERS: EEG REGIONAL ASPECTS IN RESPONSE TO A MISSED NAP 06.06.2015 Seattle, United States of America Kurth Salomé;
SLEEP 2015 APSS Annual Meeting Talk given at a conference SLEEP IN PRESCHOOL CHILDREN: ASSOCIATIONS BETWEEN SLOW SPINDLE ACTIVITY AND PROCESSING SPEED 06.06.2015 Seattle, United States of America Kurth Salomé;
Psychoneuroimmunology Research Society (PNIRS), Annual Meeting 2015 Talk given at a conference Region-specific response to shortened sleep in childhood: Associations with performance and myelination 03.06.2015 Seattle, United States of America Kurth Salomé;
PNIRS 2015 Poster Region-specific response to shortened sleep in childhood: Associations with performance and myelination 03.06.2015 Seattle, United States of America Kurth Salomé;
Second Annual Colorado Sleep and Circadian Research Symposium Talk given at a conference Travelling sleep slow oscillations and myelination in children 01.06.2015 Boulder, United States of America Kurth Salomé;
SRCD 2015 Biennial Meeting Poster Region-specific response to shortened sleep in childhood: Associations with performance and myelination 19.03.2015 Philadelphia, United States of America Kurth Salomé;
ESRS 2014, Biennial Meeting Talk given at a conference Young Investigator Award: "Region-specific response to sleep restriction in children: Associations with performance and myelination" 17.09.2014 Tallinn, Estonia Kurth Salomé;
Colorado Sleep and Circadian Research Symposia Talk given at a conference Sleep & Brain Development 10.06.2014 Boulder, United States of America Kurth Salomé;
SLEEP 2014 APSS Annual Meeting Poster ACUTE SLEEP RESTRICTION IN CHILDREN: REGIONAL EFFECTS ON SLEEP EEG BRAIN ACTIVITY 31.05.2014 Minneapolis, United States of America Kurth Salomé;
Sleep Regulation and Function Gordon Research Conference (GRC), 2014 Poster The developing brain is vulnerable to sleep restriction in a region-specific manner 16.03.2014 Austin, Texas, United States of America Kurth Salomé;
SLEEP 2013 APSS Annual Meeting Talk given at a conference Late Breaking Abstract: "Quantifying Myelin Patterns and High Density Sleep EEG in Preschool Children: Investigations of Brain Maturation and Function" 01.06.2013 Baltimore, MD, USA, United States of America Kurth Salomé;
SLEEP 2013 APSS Annual Meeting Talk given at a conference Early developmental changes and across-night dynamics in sleep EEG coherence 01.06.2013 Baltimore, United States of America Kurth Salomé;
The Rocky Mountain Regional Neuroscience Group (RMRNG), Annual Meeting 2013 Poster The Relationship between Sleep Slow Wave Activity Topography and Speed of Processing in Preschoolers 16.05.2013 Denver, CO, USA, United States of America Kurth Salomé;


Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
Boulder Creek Festival Performances, exhibitions (e.g. for education institutions) 25.05.2013 Boulder, CO, USA, United States of America Kurth Salomé;


Self-organised

Title Date Place
Schulbesuche, Hirn & Schlaf 02.04.2013 Boulder, CO, USA, United States of America

Communication with the public

Communication Title Media Place Year
Media relations: print media, online media Der Tiefschlaf als Spiegel der Hirnreifung NZZ German-speaking Switzerland 2015
Media relations: radio, television Beta Test: Another reason why kids need sleep Colorado Public Radio International 2013
Media relations: print media, online media Connections in the brains of young children strengthen during sleep, CU-Boulder study finds Press Release: University of Colorado Boulder International 2013
Talks/events/exhibitions School visits, "Learning about the brain" International 2013

Awards

Title Year
Merit Award, Sleep Regulation and Function Gordon Research Conference (GRC) 2014
Travel Award from the European Sleep Research Society (ESRS) 2014
Young Scientist Award at the Congress of the European Sleep Research Society (ESRS) 2014
Jacobs Foundation Young Investigator Research Grant (to Sean Deoni) 2013
Late Breaking Abstract at "SLEEP 2013" 2013
Outreach Award 2013
Sleep Research Society Honorable Mention Award 2013

Associated projects

Number Title Start Funding scheme
138801 Brain Connectivity and Sleep in Preschool Children 01.02.2012 Fellowships for prospective researchers

Abstract

The brain undergoes massive changes in synaptic remodeling and brain function during the first two decades of life. Exciting new findings indicate that the deep sleep EEG (slow waves, 1-4.5 Hz) reflects plastic changes of the cortex and contributes to alterations in synaptic strength. Although sleep is hypothesized to play a significant role in brain development, huge gaps exist in research addressing this relationship. Moreover, neurodevelopmental disorders often emerge in childhood, and reliable tools to identify and better understand the cortical underpinnings of such disorders are lacking. The primary goal of our current research project is to examine sleep-structure-function relationships in the healthy developing human brain. This proposal is a 6-month continuation of the project “Brain Connectivity and Sleep in Preschool Children” (PBZHP3-128801).
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