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Regulation of translation initiation in the yeast Saccharomyces cerevisiae

English title Regulation of translation initiation in the yeast Saccharomyces cerevisiae
Applicant Altmann Michael
Number 146722
Funding scheme Project funding (Div. I-III)
Research institution Institut für Biochemie und Molekulare Medizin Universität Bern
Institution of higher education University of Berne - BE
Main discipline Molecular Biology
Start/End 01.06.2013 - 31.01.2018
Approved amount 262'960.00
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Keywords (4)

Modulators of translation; Cap binding complex; Saccharomyces cerevisiae; Translation initiation

Lay Summary (German)

Lead
Die Regulation der Proteinsynthese in eukaryotischen Zellen
Lay summary
eIF4E aus Säugetierzellen ist ein wichtiges Onkogen, dass in verschiedenen Krebsformen (zB. Prostata- und Brustkrebs) überproduziert wird.
In diesem Projekt wird die Interaktion von eIF4E, dem Initiationsfaktor der eukaryotischen Proteinsynthese, der an die cap-Struktur von mRNAs bindet, mit anderen Proteinen, die dessen Aktivität regulieren, studiert. Als Modellsystem wird die Bäckerhefe gewählt.
Die aus diesem Projekt gewonnen Erkenntnisse können auch für die Regulation der Proteinsynthese in Säugetierzellen von Bedeutung sein.
Direct link to Lay Summary Last update: 24.04.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Properties of the ternary complex formed by yeast eIF4E, p20 and mRNA
Arndt Nick, Ross-Kaschitza Daniela, Kojukhov Artyom, Komar Anton A., Altmann Michael (2018), Properties of the ternary complex formed by yeast eIF4E, p20 and mRNA, in Scientific Reports, 0001.
The Benefits of Saccharomyces cerevisiae
Altmann Michael (2018), The Benefits of Saccharomyces cerevisiae, in Abdulkhair Waleed (ed.), InTechOpen, Croatia, 03-10.
A fast protocol for purification of translating mRNAs
Ross Daniela, Altmann Michael (2016), A fast protocol for purification of translating mRNAs, in Methods, 107 (Sep 1;107), 57-62.
eIF4Es and Their Interactors from Yeast Species
Ross Daniela, Altmann Michael (2016), eIF4Es and Their Interactors from Yeast Species, in Hernandez Greco & Jagus Rosemary (ed.), Springer Nature, Switzerland, 143-164.
Translation Elongation and Termination: Are They Conserved Processes?
Eltschinger Sandra, Bütikofer Peter, Altmann Michael (2016), Translation Elongation and Termination: Are They Conserved Processes?, in Hernandez Greco & Jagus Rosemary (ed.), 277-309.

Associated projects

Number Title Start Funding scheme
119996 Regulation of translation initiation in the yeast Saccharomyces cerevisia 01.09.2008 Project funding (Div. I-III)

Abstract

We propose to study the mechanism and regulation of translation in Saccharomyces cerevisiae by investigating the physiological significance of posttranslational modifications on eIF4E, the cap binding protein and on p20, a modulator of translation that interacts with eIF4E.
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