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Dynamics of facilitation and interference during speech production in healthy speakers and in speakers with aphasia: behavioral and ERP investigation

English title Dynamics of facilitation and interference during speech production in healthy speakers and in speakers with aphasia: behavioral and ERP investigation
Applicant Laganaro Marina
Number 146113
Funding scheme Project funding (Div. I-III)
Research institution FPSE Université de Genève
Institution of higher education University of Geneva - GE
Main discipline Psychology
Start/End 01.09.2013 - 28.02.2017
Approved amount 596'376.00
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All Disciplines (3)

Discipline
Psychology
Romance languages and literature
Neurology, Psychiatry

Keywords (4)

dynamics; interference; language production; aphasia

Lay Summary (French)

Lead
Parler est une activité hautement automatique et nous nous rendons compte de la complexité cognitive impliquée dans la planification du message seulement lorsque la production devient difficile. Tous les locuteurs ont fait l’expérience que certaines conditions externes (par exemple parler en faisant autre chose comme conduire une voiture) ou linguistiques (produire un vire-langue) interfèrent avec la planification de la parole et la rendent moins fluente.
Lay summary

Les conditions mentionnées ci-dessus interfèrent de manière amplifiée chez des personnes qui présentent des troubles du langage suite à une lésion cérébrale (une aphasie).Celles-ci se plaignent en effet souvent d’une augmentation des difficultés à parler lorsqu’ils exécutent une autre activité ou simplement avec du bruit environnant. Il y a par contre des conditions qui facilitent la planification et production de la parole qui sont largement exploitées en rééducation.

Le but de ce projet est de comprendre les mécanismes par lesquels des conditions contextuelles et linguistiques spécifiques interfèrent ou au contraire facilitent la production chez les locuteurs adultes sans et avec lésion cérébrale. Pour cela, nous analysons au moyen des potentiels évoqués électriques (électroencéphalogramme) quels processus de planification du langage sont modulés par ces conditions interférentes ou facilitatrices chez des adultes non-cérébrolésés et chez des personnes avec une aphasie.

La compréhension des mécanismes liés à l’interférence et à la facilitation dans la planification et la production du langage permettra de formuler des nouvelles hypothèses sur des approches thérapeutiques facilitatrices ou visant à réduire la sensibilité aux interférences et à optimiser le transfert des progrès de la situation de rééducation à la vie quotidienne où les interférences sont particulièrement présentes.

Direct link to Lay Summary Last update: 06.06.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Neural dynamics of the production of newly acquired words relative to well-known words
Fargier Raphaël, Laganaro Marina (2020), Neural dynamics of the production of newly acquired words relative to well-known words, in Brain Research, 1727, 146557-146557.
Word form encoding is under attentional demand: Evidence from dual-task interference in aphasia
Laganaro Marina, Bonnans Caroline, Fargier Raphael (2019), Word form encoding is under attentional demand: Evidence from dual-task interference in aphasia, in Cognitive Neuropsychology, 36(1-2), 18-30.
The involvement of left inferior frontal and middle temporal cortices in word production unveiled by greater facilitation effects following brain damage. Neuropsychologia
Python Grégoire, Glize Bertrand, Laganaro Marina (2018), The involvement of left inferior frontal and middle temporal cortices in word production unveiled by greater facilitation effects following brain damage. Neuropsychologia, in Neuropsychologia, 121, 122-134.
When wine and apple both help the production of grapes: ERP evidence for post-lexical semantic facilitation in picture naming
Python Grégoire, Fargier Raphael, Laganaro Marina (2018), When wine and apple both help the production of grapes: ERP evidence for post-lexical semantic facilitation in picture naming, in Frontiers in Human Neuroscience, 12, 136.
ERP evidence of distinct processes underlying semantic facilitation and interference in word production
Python Grégoire, Fargier Raphaël, Laganaro Marina (2018), ERP evidence of distinct processes underlying semantic facilitation and interference in word production, in Cortex, 99, 1-12.
The lexical or sub-lexical locus of facilitation by phonemic cueing in aphasic speakers: the effect of onset cohort size
Pellet Pauline, Glize Bertrand, Laganaro Marina (2018), The lexical or sub-lexical locus of facilitation by phonemic cueing in aphasic speakers: the effect of onset cohort size, in Aphasiology, 32(12), 1468-1489.
Does facilitation by phonological cuing in picture naming depend on the modality of the cue?
Pellet Cheneval Pauline, Laganaro Marina (2018), Does facilitation by phonological cuing in picture naming depend on the modality of the cue?, in Aphasiology, 32(2), 204-232.
ERP evidence of distinct processes underlying semantic facilitation and interference in word production
Python Grégoire, Fargier Raphael, Laganaro Marina (2017), ERP evidence of distinct processes underlying semantic facilitation and interference in word production, in Cortex, 99, 1-12.
Spatio-temporal dynamics of referential and inferential naming: different brain and cognitive operations to lexical selection
Fargier Raphael, Laganaro Marina (2017), Spatio-temporal dynamics of referential and inferential naming: different brain and cognitive operations to lexical selection, in Brain Topography, 30, 182-197.
Contextual phonological errors and omission of obligatory liaison as a window into a reduced span of phonological encoding
Michel Lange Violaine, Pellet Pauline, Python Grégoire, Laganaro Marina (2017), Contextual phonological errors and omission of obligatory liaison as a window into a reduced span of phonological encoding, in Aphasiology, 31(3), 201.
Facilitation and interference of phoneme repetition and phoneme similarity in speech production
Monaco Elisa, Pellet Pauline, Laganaro Marina (2017), Facilitation and interference of phoneme repetition and phoneme similarity in speech production, in Language, Cognition and Neuroscience, 32 (5), 650-660.
Neurophysiological Modulations of Non-Verbal and Verbal Dual-Tasks Interference during Word Planning.
Fargier Raphael, Laganaro Marina (2016), Neurophysiological Modulations of Non-Verbal and Verbal Dual-Tasks Interference during Word Planning., in PLos ONE, 11(12), e.0168358.
Impact of concurrent auditory tasks on picture naming in aphasia
Bonnans Caroline, Fargier Raphael, Laganaro Marina (2016), Impact of concurrent auditory tasks on picture naming in aphasia, in 17 th International Science of Aphasia Conference, Stem - , Spraak - en Taalpathologie, http://sstp.nl/index.
Impact of the modality of the phonological cue in healthy and aphasic speakers
Pellet Cheneval Pauline, Python Grégoire, Blosch Laurène, Laganaro Marina (2016), Impact of the modality of the phonological cue in healthy and aphasic speakers, in 16th International Science of Aphasia Conference, Stem-, Spraak- en Taalpathologie, Groningen University Press.
Is facilitation by phonological cues modulated by the size of the activated lexical cohort?
Pellet Pauline, Villain Marie, Glize Bernanrd, Laganaro Marina (2016), Is facilitation by phonological cues modulated by the size of the activated lexical cohort?, in 1 7 th International Science of Aphasia Conference, Stem - , Spraak - en Taalpathologie, http://sstp.nl/.
Semantic facilitation vs interference in picture naming in a group of fluent aphasic speakers
Python Grégoire, Glize Bertrand, Jeulin Mélissa, Laganaro Marina (2016), Semantic facilitation vs interference in picture naming in a group of fluent aphasic speakers, in 17 th International Science of Aphasia Conference, Stem - , Spraak - en Taalpathologie, http://sstp.nl.
How do categorical & associative primes affect picture naming in aphasia?
Python Grégoire, Pellet Cheneval Pauline, Fargier Rapahel, Gay Anne-Carine, Laganaro Marina (2015), How do categorical & associative primes affect picture naming in aphasia?, in 16th International Science of Aphasia Conference, Stem-, Spraak- en Taalpathologie, University Groeningen.
Neural dynamics of object noun, action verb and action noun production in picture naming
Fargier Raphael, Laganaro Marina (2015), Neural dynamics of object noun, action verb and action noun production in picture naming, in Brain and Language, 150, 129-142.
Interference in speaking while hearing and vice versa.
Fargier Raphael, Laganaro Marina, Interference in speaking while hearing and vice versa., in Scientific Report.

Collaboration

Group / person Country
Types of collaboration
Service de Neuropsychologie et de Neuroréhabilitation, CHUV Switzerland (Europe)
- Publication
- Research Infrastructure
- Exchange of personnel
Physical and Rehabilitation Medicine Unit, EA4136, CHU Bordeaux, University of Bordeaux, France France (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Science of Aphasia 2016 Poster Does size of the lexical cohort activated by phonological cue in picture naming affect faciliator effect in aphasic and healthy speakers? 24.09.2016 Venise, Ospedale San Camillo, Italy Pauline Pellet; Laganaro Marina;
Science of Aphasia 2016 Talk given at a conference Facilitation and interference in word production in aphasia 24.09.2016 Venice, Italy Laganaro Marina;
Science of Aphasia 2016 Poster Semantic facilitation vs interference in picture naming in a group of fluent aphasic speakers 24.09.2016 Venise, Ospedale San Camillo, Italy Python Grégoire; Laganaro Marina;
Science of Aphasia 2016 Poster Impact of concurrent auditory tasks on picture naming in aphasia 24.09.2016 Venise, Ospedale San Camillo, Italy Fargier Raphaël; Bonnans Caroline; Laganaro Marina;
International workshop on language production 2016 Poster ERP contrast of semantic facilitation vs interference in picture naming. 25.07.2016 San Diego, United States of America Laganaro Marina; Python Grégoire;
Society for the Neurobiology of Language Poster Dynamics of speech encoding processes under increased attentional demand : an ERP study on dual-tasks interference 15.10.2015 Chicago, United States of America Laganaro Marina; Fargier Raphaël;
Society for the Neurobiology of Language Poster How do categorical & associative primes affect picture naming in aphasia? 15.10.2015 Chicago, United States of America Python Grégoire; Laganaro Marina; Fargier Raphaël;
Science of Aphasia 2015 Poster Impact of the modality of the phonological cue in healthy and aphasic speakers 18.09.2015 Aveiro (P), Portugal Pauline Pellet; Laganaro Marina; Python Grégoire;
Science of Aphasia 2015 Poster How do categorical & associative primes affect picture naming in aphasia? 18.09.2015 Aveiro (P), Portugal Pauline Pellet; Python Grégoire; Laganaro Marina; Fargier Raphaël;
Society for the Neurobiology of Language Poster Neural dynamics of lexico-semantic processes during word production: Action verbs, action nouns and object nouns 27.08.2014 Amsterdam, Netherlands Python Grégoire;
Internationalé Workshop on Language Production 2016 Poster Modulations of word planning processes by dual-tasks: an ERP study with different SOAs 25.07.2014 San Diego, United States of America Laganaro Marina; Fargier Raphaël;
International Workshop on Language Production 2014 Poster Neural dynamics of lexical-semantic processes during word production: Action verbs, action nouns and object nouns 16.07.2014 Genève, Switzerland Laganaro Marina; Fargier Raphaël;
International Workshop on Language Production 2014 Poster Bi-modal vs uni-modal phonological cueing in picture naming: preliminary study with healthy speakers 16.07.2014 Genève, Switzerland Laganaro Marina; Pauline Pellet;
International Workshop on Language Production 2014 Poster What causes older adults’ difficulty in word form retrieval? 16.07.2014 Genève, Switzerland Laganaro Marina; Valente Andrea;


Self-organised

Title Date Place
International Workshop on Language Production 2014 16.07.2014 Genève, Switzerland

Associated projects

Number Title Start Funding scheme
108284 Encodage phonologique: modélisation psycholinguistique, méchanismes corticaux et évaluation et réhabilitation aphasiologique 01.05.2005 Project funding (Div. I-III)
140796 Variability in advance planning and timing of phonological encoding in speech production: an integration of psycholinguistic, neurolinguistic and functional neuroimaging approaches 01.08.2012 SNSF Professorships

Abstract

Every speaker has experienced that language production usually proceeds effortless, but that some conditions interfere with fluent speech planning. For instance, speaking while doing another task demanding some attentional control (eg. driving) or producing a tongue twister (eg. “Six sick hicks nick six slick bricks with picks and sticks”) represent typical contextual and linguistic conditions that enhance the difficulty of speech planning and production. These interfering conditions have a particular detrimental effect on speech production in brain-damaged language impaired (aphasic) speakers, who very often complain that their performance gets worse with co-occurring cognitive tasks or simply with environmental noise. By contrast, specific facilitation conditions are extensively used in speech and language therapy to restore language production in aphasic patients. However, facilitating strategies and contexts do not influence all aphasic patients in the same way and all aphasic speakers are not equally affected by interference. In the present project we seek to understand how some specific linguistic and contextual conditions facilitate or interfere with language production in healthy speakers and in brain-damaged aphasic speakers. To get insight into the dynamics of interference and facilitation in healthy adult speakers, in sub-project A we will run a series of event-related potential (ERP) studies analyzing which speech planning processes are modulated by specific interfering or facilitating conditions. In sub-project B we will then run the same studies with aphasic patients to investigate which behavioral and electrophysiological patterns underlie inter-individual differences in the sensitivity to interference and to facilitation. Understanding the mechanisms underlying facilitation and interference during speech planning and execution in normal conditions and in aphasia should enable to formulate new hypotheses on approaches to aphasia therapy aimed at reducing sensitivity to interference and at optimizing transfer of improvements from clinical settings to real life situations where interference is much more present.
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