two-photon microscope; cell trafficking; immune responses
Stein Jens V., F. Gonzalez Santiago (2017), Dynamic intravital imaging of cell-cell interactions in the lymph node, in Journal of Allergy and Clinical Immunology
, 139(1), 12-20.
Chatziandreou Nikolaos, Farsakoglu Yagmur, Palomino-Segura Miguel, D’Antuono Rocco, Pizzagalli Diego Ulisse, Sallusto Federica, Lukacs-Kornek Veronika, Uguccioni Mariagrazia, Corti Davide, Turley Shannon J., Lanzavecchia Antonio, Carroll Michael C., Gonzalez Santiago F. (2017), Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node, in Cell Reports
, 18(10), 2427-2440.
With the present proposal the Institute for Research in Biomedicine (IRB) requests co-funding for the acquisition of a Two-Photon Microscope by the Swiss National Science Foundation. This proposal contains five independent research projects for which such state-of-the-art equipment would be essential. The initiative underlines the leading position of the IRB in life science research and will provide support for other institutions interested in the new technique. The proposed users of the microscope are internationally recognized experts in their respective subspecialties. As outlined in the individual project descriptions, future multiphoton intravital work by these investigators is likely to shed new light on diverse aspects of immune system regulation and function. These activities and those of other future users have the potential to make important contributions to our understanding and therapeutic capabilities in many important diseases.