Project

Back to overview

Regulation of antigen presentation and antigen presenting cell function

English title Regulation of antigen presentation and antigen presenting cell function
Applicant Reith Walter
Number 144085
Funding scheme Project funding
Research institution Département de Pathologie et Immunologie Faculté de Médecine / CMU Université de Genève
Institution of higher education University of Geneva - GE
Main discipline Immunology, Immunopathology
Start/End 01.01.2013 - 31.03.2016
Approved amount 843'600.00
Show all

All Disciplines (4)

Discipline
Immunology, Immunopathology
Genetics
Molecular Biology
Cellular Biology, Cytology

Keywords (10)

molecular immunology; Major Histocompatibility Complex class II; antigen presentation; antigen presenting cells; regulation of gene expression; transcription; knockout and transgenic mouse models; medullary thymic epihelial cells; thymic development and function; BTN proteins

Responsible applicant and co-applicants

Employees

Publications

Publication
Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes.
Sarter Kerstin, Leimgruber Elisa, Gobet Florian, Agrawal Vishal, Dunand-Sauthier Isabelle, Barras Emmanuèle, Mastelic-Gavillet Béatris, Kamath Arun, Fontannaz Paola, Guéry Leslie, Duraes Fernanda do Valle, Lippens Carla, Ravn Ulla, Santiago-Raber Marie-Laure, Magistrelli Giovanni, Fischer Nicolas, Siegrist Claire-Anne, Hugues Stéphanie, Reith Walter (2016), Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes., in The Journal of experimental medicine, 213(2), 177-87.
Major Histocompatibility Complex Class II Deficiency
(2016), Major Histocompatibility Complex Class II Deficiency, in -, (ed.), Elsevier, - , ---.
Regulation of Immunity by Butyrophilins.
Rhodes David A, Reith Walter, Trowsdale John (2016), Regulation of Immunity by Butyrophilins., in Annual review of immunology, 34, 151-72.
T Cell Priming by Activated Nlrc5-Deficient Dendritic Cells Is Unaffected despite Partially Reduced MHC Class I Levels.
Rota Giorgia, Ludigs Kristina, Siegert Stefanie, Tardivel Aubry, Morgado Leonor, Reith Walter, De Gassart Aude, Guarda Greta (2016), T Cell Priming by Activated Nlrc5-Deficient Dendritic Cells Is Unaffected despite Partially Reduced MHC Class I Levels., in Journal of immunology (Baltimore, Md. : 1950), 196(7), 2939-46.
Absence of nonhematopoietic MHC class II expression protects mice from experimental autoimmune myocarditis.
Thelemann Christoph, Haller Sergio, Blyszczuk Przemyslaw, Kania Gabriela, Rosa Muriel, Eriksson Urs, Rotman Samuel, Reith Walter, Acha-Orbea Hans (2015), Absence of nonhematopoietic MHC class II expression protects mice from experimental autoimmune myocarditis., in European journal of immunology, 46(3), 656-64.
Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells.
Hepworth Matthew R, Fung Thomas C, Masur Samuel H, Kelsen Judith R, McConnell Fiona M, Dubrot Juan, Withers David R, Hugues Stephanie, Farrar Michael A, Reith Walter, Eberl Gérard, Baldassano Robert N, Laufer Terri M, Elson Charles O, Sonnenberg Gregory F (2015), Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells., in Science (New York, N.Y.), 348(6238), 1031-5.
NLRC5 exclusively transactivates MHC class I and related genes through a distinctive SXY module.
Ludigs Kristina, Seguín-Estévez Queralt, Lemeille Sylvain, Ferrero Isabel, Rota Giorgia, Chelbi Sonia, Mattmann Chantal, MacDonald H Robson, Reith Walter, Guarda Greta (2015), NLRC5 exclusively transactivates MHC class I and related genes through a distinctive SXY module., in PLoS genetics, 11(3), 1005088-1005088.
TLR3-Mediated CD8+ Dendritic Cell Activation Is Coupled with Establishment of a Cell-Intrinsic Antiviral State.
Széles Lajos, Meissner Felix, Dunand-Sauthier Isabelle, Thelemann Christoph, Hersch Micha, Singovski Simon, Haller Sergio, Gobet Florian, Fuertes Marraco Silvia A, Mann Matthias, Garcin Dominique, Acha-Orbea Hans, Reith Walter (2015), TLR3-Mediated CD8+ Dendritic Cell Activation Is Coupled with Establishment of a Cell-Intrinsic Antiviral State., in Journal of immunology (Baltimore, Md. : 1950), 195(3), 1025-33.
Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression.
Guéry Leslie, Dubrot Juan, Lippens Carla, Brighouse Dale, Malinge Pauline, Irla Magali, Pot Caroline, Reith Walter, Waldburger Jean-Marc, Hugues Stéphanie (2014), Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression., in Cancer research, 74(22), 6430-40.
Extensive remodeling of DC function by rapid maturation-induced transcriptional silencing.
Seguín-Estévez Queralt, Dunand-Sauthier Isabelle, Lemeille Sylvain, Iseli Christian, Ibberson Mark, Ioannidis Vassilios, Schmid Christoph D, Rousseau Philippe, Barras Emmanuèle, Geinoz Antoine, Xenarios Ioannis, Acha-Orbea Hans, Reith Walter (2014), Extensive remodeling of DC function by rapid maturation-induced transcriptional silencing., in Nucleic acids research, 42(15), 9641-55.
Interferon-γ induces expression of MHC class II on intestinal epithelial cells and protects mice from colitis.
Thelemann Christoph, Eren Remzi Onur, Coutaz Manuel, Brasseit Jennifer, Bouzourene Hanifa, Rosa Muriel, Duval Anais, Lavanchy Christine, Mack Vanessa, Mueller Christoph, Reith Walter, Acha-Orbea Hans (2014), Interferon-γ induces expression of MHC class II on intestinal epithelial cells and protects mice from colitis., in PloS one, 9(1), 86844-86844.
Lymph node stromal cells acquire peptide-MHCII complexes from dendritic cells and induce antigen-specific CD4⁺ T cell tolerance.
Dubrot Juan, Duraes Fernanda V, Potin Lambert, Capotosti Francesca, Brighouse Dale, Suter Tobias, LeibundGut-Landmann Salomé, Garbi Natalio, Reith Walter, Swartz Melody A, Hugues Stéphanie (2014), Lymph node stromal cells acquire peptide-MHCII complexes from dendritic cells and induce antigen-specific CD4⁺ T cell tolerance., in The Journal of experimental medicine, 211(6), 1153-66.
MHC class II transactivator is an in vivo regulator of osteoclast differentiation and bone homeostasis co-opted from adaptive immunity.
Benasciutti Elisa, Mariani Elisabetta, Oliva Laura, Scolari Maria, Perilli Egon, Barras Emmanuele, Milan Enrico, Orfanelli Ugo, Fazzalari Nicola L, Campana Lara, Capobianco Annalisa, Otten Luc, Particelli Francesca, Acha-Orbea Hans, Baruffaldi Fabio, Faccio Roberta, Sitia Roberto, Reith Walter, Cenci Simone (2014), MHC class II transactivator is an in vivo regulator of osteoclast differentiation and bone homeostasis co-opted from adaptive immunity., in Journal of bone and mineral research : the official journal of the American Society for Bone and Min, 29(2), 290-303.
MHC Class II-restricted antigen presentation by plasmacytoid dendritic cells drives proatherogenic T cell immunity.
Sage Andrew P, Murphy Deirdre, Maffia Pasquale, Masters Leanne M, Sabir Suleman R, Baker Lauren L, Cambrook Helen, Finigan Alison J, Ait-Oufella Hafid, Grassia Gianluca, Harrison James E, Ludewig Burkhard, Reith Walter, Hansson Göran K, Reizis Boris, Hugues Stéphanie, Mallat Ziad (2014), MHC Class II-restricted antigen presentation by plasmacytoid dendritic cells drives proatherogenic T cell immunity., in Circulation, 130(16), 1363-73.
Molecular basis of major histocompatibility complex class II deficiency
Reith Walter, Piccard Capucine, Fischer Alain (2014), Molecular basis of major histocompatibility complex class II deficiency, in Ochs Hans , Smith C. I. Edvard , Puck Jennifer M. (ed.), Oxford University Press, New York, ---.
Repression of arginase-2 expression in dendritic cells by microRNA-155 is critical for promoting T cell proliferation.
Dunand-Sauthier Isabelle, Irla Magali, Carnesecchi Stéphanie, Seguín-Estévez Queralt, Vejnar Charles E, Zdobnov Evgeny M, Santiago-Raber Marie-Laure, Reith Walter (2014), Repression of arginase-2 expression in dendritic cells by microRNA-155 is critical for promoting T cell proliferation., in Journal of immunology (Baltimore, Md. : 1950), 193(4), 1690-700.
Role of major histocompatibility complex class II expression by non-hematopoietic cells in autoimmune and inflammatory disorders: facts and fiction.
Duraes F V, Thelemann C, Sarter K, Acha-Orbea H, Hugues S, Reith W (2013), Role of major histocompatibility complex class II expression by non-hematopoietic cells in autoimmune and inflammatory disorders: facts and fiction., in Tissue antigens, 82(1), 1-15.
Three-dimensional visualization of the mouse thymus organization in health and immunodeficiency.
Irla Magali, Guenot Jeanne, Sealy Gregg, Reith Walter, Imhof Beat A, Sergé Arnauld (2013), Three-dimensional visualization of the mouse thymus organization in health and immunodeficiency., in Journal of immunology (Baltimore, Md. : 1950), 190(2), 586-96.
Thymic epithelial cell expansion through matricellular protein CYR61 boosts progenitor homing and T-cell output.
Emre Yalin, Irla Magali, Dunand-Sauthier Isabelle, Ballet Romain, Meguenani Mehdi, Jemelin Stephane, Vesin Christian, Reith Walter, Imhof Beat A (2013), Thymic epithelial cell expansion through matricellular protein CYR61 boosts progenitor homing and T-cell output., in Nature communications, 4, 2842-2842.

Collaboration

Group / person Country
Types of collaboration
Adriano Fontana, Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Simone Cenci, Milan Italy (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Ioannis Xenarios, Geneva/Lausanne Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Christoph Schmidt, Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Bénédicte Durand, Lyon France (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Georg Hollander, Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
NovImmune SA, Geneva Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Genomics core facilty, Geneva Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Hans Acha-Orbea, Lausanne Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel
Mathias Mann, Munich Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Ed Palmer, Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Proteomics core facility, Geneva Switzerland (Europe)
- Research Infrastructure

Associated projects

Number Title Start Funding scheme
127255 Regulation of MHC class II expression and antigen presenting cell function 01.01.2010 Project funding
130444 Synergic signals for cytokine production in dendritic cells 01.04.2010 Sinergia
166371 Expression, function and mechanism of action of BTN2A2, a new costimulatory molecule coregulated with MHC class II expression 01.04.2016 Project funding
121418 Ultra High Throughput sequencing platform for functional genome analysis 01.08.2008 R'EQUIP

-