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Carnitine Palmitoyl-Transferase 1C (CPT1C) as Novel Key regulator of Cancer Metabolism and Carcinogenesis: Deciphering Mechanisms and Signaling Pathways

English title Carnitine Palmitoyl-Transferase 1C (CPT1C) as Novel Key regulator of Cancer Metabolism and Carcinogenesis: Deciphering Mechanisms and Signaling Pathways
Applicant Zaugg Kathrin
Number 144061
Funding scheme Project funding
Research institution Klinik und Poliklinik für Radio-Onkologie Inselspital
Institution of higher education University of Zurich - ZH
Main discipline Molecular Biology
Start/End 01.11.2012 - 31.12.2016
Approved amount 385'000.00
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All Disciplines (3)

Discipline
Molecular Biology
Experimental Cancer Research
Cellular Biology, Cytology

Keywords (6)

Cancer; Hypoxia; Metabolism; p53; Carnitine Palmitoyltransferase 1C; Mitochondria

Responsible applicant and co-applicants

Name Institute

Employees

Publications

Publication
Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model.
Sanchez-Macedo N, Feng J, Faubert B, Chang N, Elia A, Rushing E J, Tsuchihara K, Bungard D, Berger S L, Jones R G, Mak T W, Zaugg K (2013), Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model., in Cell death and differentiation, 20(4), 659-68.

Collaboration

Group / person Country
Types of collaboration
Cardiovascular Anesthesia Research Laboratory Canada (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Institute of Veterinary Physiology Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Functional Genomic Center Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
SASRO/SSRMP annual meeting 2016 Talk given at a conference Regulation of the Oncogene Carnitine Palmitoyltransferase 1C under hypoxia involves HIF1 alpha and p53 25.08.2016 Sursee, Switzerland Zaugg Kathrin;
14th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology 2015 Poster Investigating the role of CPT1C, a novel p53 target in carcinogenesis 22.06.2015 Ermatingen, Switzerland Feng Jianhua; Zaugg Kathrin;
SASRO Talk given at a conference Cpt1c acts as an oncogene in metabolic transformation 27.03.2014 Lugano, Switzerland Zaugg Kathrin;
5th Cancer Network Retreat Poster Cpt1c protects from tumor growth in a mouse tumor model 11.04.2013 Grindelwald, Switzerland Zaugg Kathrin;


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