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The antiviral activity of Mx proteins: Evaluation of the role of the cellular Mx-associated DExD/H-box RNA helicases UAP56 and URH49

English title The antiviral activity of Mx proteins: Evaluation of the role of the cellular Mx-associated DExD/H-box RNA helicases UAP56 and URH49
Applicant Pavlovic Jovan
Number 143834
Funding scheme Project funding
Research institution Institut für Medizinische Virologie Universität Zürich
Institution of higher education University of Zurich - ZH
Main discipline Experimental Microbiology
Start/End 01.11.2012 - 31.03.2016
Approved amount 366'376.00
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Keywords (6)

Interferon type I system; Influenza A virus; Mx proteins ; DExD/H-box helicases; UAP56; antiviral activity

Responsible applicant and co-applicants

Employees

Publications

Publication
Oligomerization and GTP-binding Requirements of MxA for Viral Target Recognition and Antiviral Activity against Influenza A Virus.
Nigg Patricia E, Pavlovic Jovan (2015), Oligomerization and GTP-binding Requirements of MxA for Viral Target Recognition and Antiviral Activity against Influenza A Virus., in The Journal of biological chemistry, 290(50), 29893-906.
Characterization of multi-subunit protein complexes of human MxA using non-denaturing polyacrylamide gel-electrophoresis
Nigg Patricia and Pavlovic Jovan, Characterization of multi-subunit protein complexes of human MxA using non-denaturing polyacrylamide gel-electrophoresis, in Journal of Visualized Experiments.

Collaboration

Group / person Country
Types of collaboration
Prof. Georg Kochs/Universitätsklinikum Albert Ludwigs-Universität Freiburg Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel
Prof. Oliver Daumke/Max Delbrück-Centrum for Molecular Medizine, Berlin Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Prof. Thomas Stamminger/University of Erlangen-Nuremberg, Erlangen, Germany Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Prof Martin Schwemmle/Universitätsklinikum Albert Ludwigs-Universität Freiburg Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel

Associated projects

Number Title Start Funding scheme
116489 Influenza virus: antiviral measures of the type I interferon system and viral countermeasures mediated by the viral polymerase and the matrix protein 1 01.11.2007 Project funding

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