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NCCR RNA & disease: Understanding the role of RNA biology in disease mechanisms (phase I)

English title NCCR RNA & disease: Understanding the role of RNA biology in disease mechanisms
Applicant Mühlemann Oliver
Number 141735
Funding scheme National Centres of Competence in Research (NCCRs)
Research institution Departement für Chemie, Biochemie und Pharmazie Universität Bern
Institution of higher education University of Berne - BE
Main discipline Molecular Biology
Start/End 01.05.2014 - 30.04.2018
Approved amount 16'751'666.00
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All Disciplines (5)

Molecular Biology
Cellular Biology, Cytology

Keywords (15)

molecular life science; RNA processing; RNA metabolism; noncoding RNA; disease mechanism; translation; ribosome; RNA interference; miRNA; gene regulation; mRNA; tRNA; rRNA; lncRNA; nucleic acid

Responsible applicant and co-applicants

Associated projects

Number Title Start Funding scheme
166565 Ribosome synthesis in mammalian cells 01.04.2016 Project funding (Div. I-III)
170808 Acquisition of a Talos Arctica transmission electron microscope for single particle analysis and cryo-tomography 01.05.2017 R'EQUIP
162986 Quality control of gene expression: towards understanding mechanism and physiological role of nonsense-mediated mRNA decay (NMD) 01.10.2015 Project funding (Div. I-III)
163478 Bonus of Excellence - Structural studies of complexes involved in ribosome assembly and translation initiation in yeast 01.11.2015 Project funding (Div. I-III)
166527 Stress-mediated effects on ribosome functions and translation control 01.07.2016 Project funding (Div. I-III)
164092 Upgrade of a Titan Krios electron cryo-microscope for single particle analysis and tomography 01.12.2015 R'EQUIP
166772 Stem cell biotechnology and microfluidics for transcriptome and proteome analysis of motor neuron axons and somas in health and ALS 01.03.2016 International short research visits
169612 Chemical Approaches to Functionalize Human microRNAs 01.10.2016 Project funding (Div. I-III)
179190 Molecular mechanisms and physiological signals underlying daily rhythms in translation 01.07.2018 Project funding (Div. I-III)
152832 Genetics of miRNA action and biogenesis-II 01.08.2014 Project funding (Div. I-III)
156940 Mitochondrial biogenesis in the unicellular parasite Trypanosoma brucei 01.01.2015 Project funding (Div. I-III)
189063 Cell type-specific expression of 3’ untranslated region isoforms: quantification, modeling, and prediction of functional impact 01.01.2020 Project funding (Div. I-III)
170130 NMR structure determination of protein-RNA complexes involved in pre-mRNA splicing and translation regulation 01.10.2016 Project funding (Div. I-III)
184947 The role of tRNA modifications in vertebrates 01.01.2020 Project funding (Div. I-III)
170976 Role of Disordered Regions in RNA-Binding Proteins for Function and Pathology 01.01.2017 Sinergia
182880 NCCR RNA & disease: The role of RNA biology in disease mechanisms (phase II) 01.05.2018 National Centres of Competence in Research (NCCRs)