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Systems epidemiology of human schistosomiasis and livestock fascioliasis in sub-Saharan Africa

English title Systems epidemiology of human schistosomiasis and livestock fascioliasis in sub-Saharan Africa
Applicant Utzinger Jürg
Number 141246
Funding scheme Project funding (Div. I-III)
Research institution Department of Epidemiology and Public Health Swiss Tropical and Public Health Institute Universität Basel
Institution of higher education University of Basel - BS
Main discipline Methods of Epidemiology and Preventive Medicine
Start/End 01.08.2012 - 31.07.2015
Approved amount 510'017.00
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All Disciplines (6)

Discipline
Methods of Epidemiology and Preventive Medicine
Infectious Diseases
Human Ecology
Tropical Medicine
Veterinary Medicine
Medical Statistics

Keywords (13)

One health; Cattle; Transdisciplinarity; Land use; Epidemiology; Geographical information system; Fasciola spp.; Parasitology; Schistosoma spp.; Hydrology; Risk profiling; Human; Social-ecological systems

Lay Summary (German)

Lead
Die hier vorgestellte Forschung verfolgt einen neuen systemischen Ansatz um die Epidemiologie der Bilharziose beim Mensch und der Fasciolose beim Nutztier umfassender zu verstehen. Detaillierte Feld- und Laboruntersuchungen in zwei verschiedenen Kontexten in Westafrika werden lokal-spezifische Ansatzpunkte identifizieren für eine verbesserte Kontrolle dieser chronisch-parasitären Erkrankungen.
Lay summary

Hintergrund:  Die Gesundheit von Mensch und Nutztier steht in engem Zusammenhang mit ihrer sozial-ökologischen Umwelt. Wollen wir zur langfristigen Verbesserung der Gesundheit von Mensch und Tier in einer bestimmten Region beitragen, so bedingt dies ein grundlegendes Verständnis des Zusammenspiels von Verhalten, Kultur, Demographie, Klima, Ökologie und weiteren sozio-kulturellen und biologischen Faktoren. Dies ist ein komplexes Unterfangen welches nach systemischem Denken verlangt.

Das Ziel:  Das Ziel dieses Projekt ist es, die Epidemiologie der Bilharziose des Menschen und der Fasciolose beim Nutztier in zwei unterschiedlichen Gegenden mit verschiedenen sozial-ökologischen Umweltbedingungen in Westafrika zu untersuchen und universelle Ansatzpunkte für Interventionen zur Verbesserung der Situation zu identifizieren. Dies soll mit einem innovativen System-epidemiologischen Ansatz erreicht werden.

Die Bedeutung: Die epidemiologische Situation der Bilharziose des Menschen und der Fasciolose beim Nutztier werden in der Tschadsee Region im Südwesten des Tschads und in der Korhogo Region im nördlichen Côte d’Ivoire mittels harmonisierten Protokollen beurteilt werden. Daten über die saisonale Dynamik der regionalen Wassersysteme und der Umwelt (z.B. Niederschlag, Lufttemperatur und Landnutzungsmuster) werden von hochauflösenden Satellitenbildern gewonnen. In beiden Studienregionen werden demographische Daten zu Mensch und Vieh erhoben und der sozio-ökonomische Status wird durch einen Haushalt-basierten Ansatz bestimmt werden. Die räumlich-zeitliche Dynamik der Bilharziose und der Fasciolose wird zwischen Tschad und Côte d’Ivoire verglichen werden und die regional vorherrschenden, spezifischen Risikofaktoren werden bestimmt. Mit einem partizipativen Ansatz der Dorfschaften, Ministerien und Forscher zusammen bringt werden lokal angepasste und akzeptiere Interventions-Massnahmen entwickelt. Das Projekt wird (i) zu einem besseren Verständnis der Rolle von sozial-ökologischen Systemen bei bestimmten parasitären Erkrankungen von Mensch und Tier beitragen, (ii) einen integrativen Ansatz zur Identifikation von Risikofaktoren von menschlichen und tierischen Parasitosen erarbeiten und testen, und (iii) mittels Einbezug aller beteiligter Gruppen, den Gemeinden, Ministerien und Forschern, zur Entwicklung von lokalen, an die sozial-ökologischen Bedingungen angepassten und akzeptierten Interventionen im Tschad und in Côte d’Ivoire beitragen.

Direct link to Lay Summary Last update: 29.11.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Validation of a point-of-care circulating cathodic antigen urine cassette test for Schistosoma mansoni diagnosis in the Sahel, and potential cross-reaction in pregnancy
Greter H, Krauth SJ, Ngandolo BN, Alfaroukh IO, Zinsstag J, Utzinger J (2016), Validation of a point-of-care circulating cathodic antigen urine cassette test for Schistosoma mansoni diagnosis in the Sahel, and potential cross-reaction in pregnancy, in American Journal of Tropical Medicine and Hygiene, 94(2), 361-364.
Access to, and use of, water by populations living in a schistosomiasis and fascioliasis co-endemic area of northern Côte d'Ivoire
Krauth SJ, Musard C, Traoré SI, Zinsstag J, Achi LY, N'Goran EK, Utzinger J (2015), Access to, and use of, water by populations living in a schistosomiasis and fascioliasis co-endemic area of northern Côte d'Ivoire, in Acta Tropica, 149, 179-185.
All that is blood is not schistosomiasis: experiences with reagent strip testing for urogenital schistosomiasis with special consideration to very-low prevalence settings
Krauth SJ, Greter H, Stete K, Coulibaly JT, Traoré SI, Ngandolo BN, Achi LY, Zinsstag J, N'Goran EK, Utzinger J (2015), All that is blood is not schistosomiasis: experiences with reagent strip testing for urogenital schistosomiasis with special consideration to very-low prevalence settings, in Parasites & Vectors, 8, 584.
Prevalence of Fasciola gigantica infection in slaughtered animals in south-eastern Lake Chad area in relation to husbandry practices and seasonal water levels
Jean-Richard V, Crump L, Abicho AA, Naré NB, Greter H, Hattendorf J, Schelling E, Zinsstag J (2014), Prevalence of Fasciola gigantica infection in slaughtered animals in south-eastern Lake Chad area in relation to husbandry practices and seasonal water levels, in BMC Veterinary Research, 10, 81.
The benefits of 'One Health' for pastoralists in Africa
Greter H, Jean-Richard V, Crump L, Béchir M, Alfaroukh IO, Schelling E, Bonfoh B, Zinsstag J (2014), The benefits of 'One Health' for pastoralists in Africa, in Onderstepoort Journal of Veterinary Research, 81(2), E1-E3.
The spatial and seasonal distribution of Bulinus truncatus, Bulinus forskalii and Biomphalaria pfeifferi, the intermediate host snails of schistosomiasis, in N'Djamena, Chad
Moser W, Greter H, Schindler C, Allan F, Ngandolo BN, Moto DD, Utzinger J, Zinsstag J (2014), The spatial and seasonal distribution of Bulinus truncatus, Bulinus forskalii and Biomphalaria pfeifferi, the intermediate host snails of schistosomiasis, in N'Djamena, Chad, in Geospatial Health, 9(1), 109-118.
Treatment of human and livestock helminth infections in a mobile pastoralist setting at Lake Chad: attitudes to health and analysis of active pharmaceutical ingredients of locally available...
Greter H, Cowan N, Ngandolo BN, Kessely H, Alfaroukh IO, Utzinger J, Keiser J, Zinsstag J, Treatment of human and livestock helminth infections in a mobile pastoralist setting at Lake Chad: attitudes to health and analysis of active pharmaceutical ingredients of locally available..., in Acta Tropica.

Collaboration

Group / person Country
Types of collaboration
Prof. Dr. Bassirou Bonfoh, Centre Suisse de Recherches Scientifiques (CSRS), Abidjan Ivory Coast (Africa)
- in-depth/constructive exchanges on approaches, methods or results
- Exchange of personnel
Dr. Louise Achie, Ecole de Spécialisation en Elevage et Métiers de la Viande de Bingerville Ivory Coast (Africa)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
Laboratoire de Recherches Vétérinaires et Zootechniques de Farcha (LRVZ), N'Djaména Chad (Africa)
- Exchange of personnel
Prof. Dr. Eliézer K. N'Goran, Université de Cocody, Abidjan Ivory Coast (Africa)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
Dr. D. M. Daugla, Centre de Support en Santé Internationale, N'Djaména Chad (Africa)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
PD Dr. Penelope Vounatsou, Swiss TPH, Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
9th European Congress on Tropical Medicine and International Health Poster Trematode epidemiology at Lake Chad: schistosomiasis and fascioliasis in a mobile pastoralist setting 06.09.2015 Basel, Switzerland Utzinger Jürg; Krauth Stefanie Jennifer; Zinsstag Jakob; Greter Helena;
9th European Congress on Tropical Medicine and International Health Poster A systemic approach to understand neglected diseases at the human-animal-ecology interface 06.09.2015 Basel, Switzerland Greter Helena; Krauth Stefanie Jennifer; Utzinger Jürg; Zinsstag Jakob;
9th European Congress on Tropical Medicine and International Health Poster Treatment of human and animal helminth infections at Lake Chad: awareness, access, common practice and content of active ingredient in drugs 06.09.2015 Basel, Switzerland Zinsstag Jakob; Greter Helena; Utzinger Jürg; Krauth Stefanie Jennifer;
9th European Congress on Tropical Medicine and International Health Talk given at a conference Human and animal trematode infections at Lake Chad: a One Health approach 06.09.2015 Basel, Switzerland Greter Helena; Utzinger Jürg; Zinsstag Jakob; Krauth Stefanie Jennifer;
9th International Symposium on Geospatial Health Talk given at a conference Geospatial co-occurrence of Schistosoma haematobium and Schistosoma bovis in the Lake Chad area in Chad 05.09.2015 Basel, Switzerland Greter Helena; Utzinger Jürg; Krauth Stefanie Jennifer; Zinsstag Jakob;
3rd International One Health Congress Talk given at a conference A systemic approach to understand neglected diseases at the human-animal-ecology interface 15.03.2015 Amsterdam, Netherlands Krauth Stefanie Jennifer; Utzinger Jürg;
3rd International One Health Congress Poster Trematode epidemiology at Lake Chad: a One Health approach – schistosomiasis and fascioliasis in a mobile pastoralist setting 15.03.2015 Amsterdam, Netherlands Greter Helena; Zinsstag Jakob;
Paratrop 2014 Talk given at a conference A One Health approach to schistosomiasis and fascioliasis at Lake Chad 16.07.2014 Zurich, Switzerland Greter Helena;
Symposium of Biology Students in Europe (SymBioSE) Talk given at a conference The life cycles of schistosomiasis and fascioliasis 18.07.2013 Sheffield, Great Britain and Northern Ireland Krauth Stefanie Jennifer;


Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
Atelier de restitution des résultats et planification des activités futures en milieu pastoral du Lac Tchad Workshop 16.03.2013 N'Djamena, Chad Zinsstag Jakob; Greter Helena;


Awards

Title Year
Oral presentation at the 3rd International One Health Congress that took place in Amsterdam from 15-18 March 2015: Award for best oral presentation 2015
Poster presentation at the 3rd International One Health Congress, held in Amsterdam from 15-18 March 2015: Award for best poster 2015

Associated projects

Number Title Start Funding scheme
123185 Morbidity patterns and transmission dynamics of neglected tropical diseases in semi-arid and humid Africa 01.11.2008 ProDoc
170113 Transmission dynamics and hybridization of human and animal trematodes in sub-Saharan Africa 01.01.2017 Project funding (Div. I-III)

Abstract

Background: Faced with complex issues of global change, the inextricable interconnection of humans, pet animals, livestock and wildlife is evident and requires integrated approaches to maintain and further improve human and animal health. In 1984, Calvin Schwabe reintroduced the concept of “one medicine”, which has its conceptual roots two centuries ago. “One medicine” recognizes that there is no difference of paradigm between human and veterinary medicine and both disciplines can contribute to the development of each other. The close interdependence of humans and animals in their social and ecological context relates to the concept of “human-environmental systems”, more recently phrased “social-ecological systems”. A systemic approach to health in social-ecological systems requires inter- and transdisciplinary inquiry to further our understanding of complex interactions in health-related fields. Ecosystems and the services they provide are threatened by demographic, environmental and social transformations and economic activities. In turn, disrupted and depleted ecosystem services may negatively affect human and animal health. We enter thus into a negotiation on the trade-off between health, socio-economic wellbeing and the maintenance of ecosystem services. This requires a deeper understanding than heretofore of the dynamics of environmental and social systems and their intimate connection with human and animal health and wellbeing.Goal and specific objectives: The goal of this project is to deepen our understanding of a selected human disease (i.e. schistosomiasis) and livestock disease (i.e. fascioliasis) in their social-ecological systems, and to assess the mutual interdependence of human and animal health as a quantitative and qualitative interaction and outcome process in given social-ecological contexts. Specifically, we will (i) determine the frequency and transmission dynamics of human schistosomiasis and livestock fascioliasis; (ii) employ an integrated risk profiling approach to identify behavioural, demographic, environmental and socio-economic determinants of disease risk and reinfection patterns; and (iii) engage communities and other stakeholders to develop disease control interventions that are tailored to the prevailing social-ecological systems.Methods: Human schistosomiasis and livestock fascioliasis will be assessed in their systemic interaction with demographic, environmental and social systems in the Lake Chad area (western Chad) and the Korhogo region (northern Côte d’Ivoire). The dynamics of the hydrological systems (seasonal extend of water surface) and environmental data (e.g. land surface temperature, vegetation indices and land use patterns) will be obtained by readily available high-resolution remote sensing sources. Social systems assessments will include demographic composition of humans and their livestock, whereas socio-economic status will be determined by a household-based asset approach. The spatio-temporal dynamics of schistosomiasis and fascioliasis will be compared between western Chad and northern Côte d’Ivoire aiming at identifying generic and specific trends and interactions. Specifically the mutual predictive potential of schistosomiasis prevalence in humans for fascioliasis in animals and vice versa will be examined. Such an in-depth understanding will serve as the basis for the planning of setting-specific interventions. Interventions will be developed as part of a participatory transdisciplinary process involving local communities and other stakeholders.Expected outcome and innovations: Research proposed here will result in (i) a deeper understanding of social-ecological systems that govern selected human and animal parasitic diseases; (ii) an integrated approach for risk profiling of human and animal diseases, which might have mutual predictive potential; and (iii) community- and other stakeholder-led interventions that are tailored to the prevailing social-ecological systems to improve health of humans and animals, alleviating poverty and maintaining ecosystem services.
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