Project

Back to overview

Micro Computer-Tomographie für in-vivo Bildgebung

English title Micro Computed-Tomography for in-vivo Imaging
Applicant Boss Andreas
Number 139258
Funding scheme R'EQUIP
Research institution Institut für Diagnostische Radiologie Departement Medizinische Radiologie Universitätsspital Zürich
Institution of higher education University of Zurich - ZH
Main discipline Biomedical Engineering
Start/End 01.01.2012 - 31.12.2012
Approved amount 188'000.00
Show all

All Disciplines (4)

Discipline
Biomedical Engineering
Embryology, Developmental Biology
Surgery
Biophysics

Keywords (3)

Computer-Tomographie; Magnetresonanz-Tomographie; Lungentransplantation

Lay Summary (German)

Lead
Lay summary

 

Das MicroCT wird genutzt werden, um immunologische Effekte auf Lungentransplantation gemeinsam mit der Magnetresonanztomographie zu beurteilen,  Lungengewebe mit unterschiedlichen Methoden der Computer-Tomographie darzustellen, die Mrophologie von atherosklerotischen Plaques zu untersuchen, den Uebergang von Knorpel zu Knochengewebe im Vergleich zur Magnetresonanztomographie aufzuzeigen und Gewebe mit niedrigem Wassergehalt zu visualisieren. Die erwarteten Ergebnisse sollen medizinische Fortschritte auf dem Gebiet der Lungenerkrankungen (insbesondere Lungentransplantation), der Alterung des Knorpels und der Gewebe mit niedrigem Wassergehalt bringen.

Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Publications

Publication
Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification.
Vanlandewijck Michael, Lebouvier Thibaud, Andaloussi Mäe Maarja, Nahar Khayrun, Hornemann Simone, Kenkel David, Cunha Sara I, Lennartsson Johan, Boss Andreas, Heldin Carl-Henrik, Keller Annika, Betsholtz Christer (2015), Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification., in PloS one, 10(11), 0143407-0143407.
Assessing lung transplantation ischemia-reperfusion injury by microcomputed tomography and ultrashort echo-time magnetic resonance imaging in a mouse model.
Wurnig Moritz C, Tsushima Yukio, Weiger Markus, Jungraithmayr Wolfgang, Boss Andreas (2014), Assessing lung transplantation ischemia-reperfusion injury by microcomputed tomography and ultrashort echo-time magnetic resonance imaging in a mouse model., in Investigative radiology, 49(1), 23-8.
Characterization of trabecular bone density with ultra-short echo-time MRI at 1.5, 3.0 and 7.0 T--comparison with micro-computed tomography.
Wurnig Moritz C, Calcagni Maurizio, Kenkel David, Vich Magdalena, Weiger Markus, Andreisek Gustav, Wehrli Felix W, Boss Andreas (2014), Characterization of trabecular bone density with ultra-short echo-time MRI at 1.5, 3.0 and 7.0 T--comparison with micro-computed tomography., in NMR in biomedicine, 27(10), 1159-66.
Mastering mouse lung transplantation from scratch--a track record.
Tsushima Yukio, Jang Jae-Hwi, Wurnig Moritz C, Boss Andreas, Suzuki Kenji, Weder Walter, Jungraithmayr Wolfgang (2013), Mastering mouse lung transplantation from scratch--a track record., in The Journal of surgical research, 185(1), 426-32.
Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice
Keller Annika, Westenberger Ana, Sobrido Maria J, García-Murias Maria, Domingo Aloysius, Sears Renee L, Lemos Roberta R, Ordoñez-Ugalde Andres, Nicolas Gael, da Cunha José E Gomes, Rushing Elisabeth J, Hugelshofer Michael, Wurnig Moritz C, Kaech Andres, Reimann Regina, Lohmann Katja, Dobričić Valerija, Carracedo Angel, Petrović Igor, Miyasaki Janis M, Abakumova Irina, Mäe Maarja Andaloussi, Raschperger Elisabeth, Zatz Mayana, et al. (2013), Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice, in Nature Genetics, 45(9), 1077-1082.
MR imaging by using very short echo-time sequences after syngeneic lung transplantation in mice.
Boss Andreas (2012), MR imaging by using very short echo-time sequences after syngeneic lung transplantation in mice., in Radiology, 265(3), 753-761.

Collaboration

Group / person Country
Types of collaboration
Prof. Prüssmann, Prof. Bösiger, ETH Zürich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Prof. Christian Münz, Institut für Experimentelle Immunologie, Universität Zürich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Prof. Frank Rühli, Zentrum für Evolutionäre Medizin, Universität Zürich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure

Associated projects

Number Title Start Funding scheme
170791 Dedicated Breast Computer Tomography 01.05.2017 R'EQUIP
144075 Magnetic resonance imaging for the detection of chronic lung allograft rejection in mouse lung transplantation 01.04.2013 Project funding
130824 The role of CD26/DPP IV and SDF-1 in pulmonary ischemic injury in a mouse lung transplantation model 01.09.2010 Project funding

Abstract

The Institute of Diagnostic and Interventional Radiology (DIR) intends to purchase a device for in-vivo micro computed-tomography (microCT) for radiological research projects. A collaboration of six research groups is formed, which will share the available measurement time on the new device, thus guaranteeing on optimal degree of capacity utilization. Most of the intended research projects specified in the research plan require the microCT as a state-of-the-art reference technique allowing for a comparison to other imaging modalities. In addition to the microCT, a 4.7 Tesla Bruker BioSpec small animal magnetic resonance (MR) imager is already installed in the University Hospital of Zürich. This state-of-the-art MR device provides newly developed imaging sequences (so-called ultra-short echo time sequences), which are capable to detect MR signal of tissue, which cannot be visualized with conventional techniques due to fast signal decay (such as tissue with low water content or lung tissue). The visualization of the anatomical or pathological structure of these tissues has so far been the domain of computed tomography showing the need for microCT as a reference technique. In one research project (plaque imaging, PD Stolzmann), the microCT will be used as primary imaging modality compared to histology and in one project (PD Frauenfelder) correlation to phase-contrast CT will be investigated. The majority of research projects will be performed in-vivo with mice, therefore requiring the microCT device to be equipped with an integrated physiology monitoring unit, a powerful X-ray tube for fast scanning and state-of-the-art detector technology to keep radiation exposure to the animals as low as possible. Furthermore, the system should provide spatial resolution below 10 µm in all 3 dimensions. The microCT has to be installed in close proximity to the already installed small animal MR device (within walking range). There are several important reasons for this requirement: First, due to hygienic reasons of veterinary medicine, the animals cannot be scanned in other institutions keeping mice as the import of an infectious disease would endanger the complete mouse population at the University Hospital. Therefore, the cooperation with other research institutions keeping mice is excluded. Second, long transportation distances and periods are not amenable with the in-vivo mice after surgical intervention. Third, for daily practicability the microCT should be installed within the University Hospital as the majority of researchers in this collaboration are implemented in a clinical work environment. The DIR will provide 50% of acquisition costs of the microCT according to the funding regulations; furthermore the DIR will cover costs of maintenance and operating expenses.
-