Computer-Tomographie; Magnetresonanz-Tomographie; Lungentransplantation
Vanlandewijck Michael, Lebouvier Thibaud, Andaloussi Mäe Maarja, Nahar Khayrun, Hornemann Simone, Kenkel David, Cunha Sara I, Lennartsson Johan, Boss Andreas, Heldin Carl-Henrik, Keller Annika, Betsholtz Christer (2015), Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification., in
PloS one, 10(11), 0143407-0143407.
Wurnig Moritz C, Tsushima Yukio, Weiger Markus, Jungraithmayr Wolfgang, Boss Andreas (2014), Assessing lung transplantation ischemia-reperfusion injury by microcomputed tomography and ultrashort echo-time magnetic resonance imaging in a mouse model., in
Investigative radiology, 49(1), 23-8.
Wurnig Moritz C, Calcagni Maurizio, Kenkel David, Vich Magdalena, Weiger Markus, Andreisek Gustav, Wehrli Felix W, Boss Andreas (2014), Characterization of trabecular bone density with ultra-short echo-time MRI at 1.5, 3.0 and 7.0 T--comparison with micro-computed tomography., in
NMR in biomedicine, 27(10), 1159-66.
Tsushima Yukio, Jang Jae-Hwi, Wurnig Moritz C, Boss Andreas, Suzuki Kenji, Weder Walter, Jungraithmayr Wolfgang (2013), Mastering mouse lung transplantation from scratch--a track record., in
The Journal of surgical research, 185(1), 426-32.
Keller Annika, Westenberger Ana, Sobrido Maria J, García-Murias Maria, Domingo Aloysius, Sears Renee L, Lemos Roberta R, Ordoñez-Ugalde Andres, Nicolas Gael, da Cunha José E Gomes, Rushing Elisabeth J, Hugelshofer Michael, Wurnig Moritz C, Kaech Andres, Reimann Regina, Lohmann Katja, Dobričić Valerija, Carracedo Angel, Petrović Igor, Miyasaki Janis M, Abakumova Irina, Mäe Maarja Andaloussi, Raschperger Elisabeth, Zatz Mayana, et al. (2013), Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice, in
Nature Genetics, 45(9), 1077-1082.
Boss Andreas (2012), MR imaging by using very short echo-time sequences after syngeneic lung transplantation in mice., in
Radiology, 265(3), 753-761.
The Institute of Diagnostic and Interventional Radiology (DIR) intends to purchase a device for in-vivo micro computed-tomography (microCT) for radiological research projects. A collaboration of six research groups is formed, which will share the available measurement time on the new device, thus guaranteeing on optimal degree of capacity utilization. Most of the intended research projects specified in the research plan require the microCT as a state-of-the-art reference technique allowing for a comparison to other imaging modalities. In addition to the microCT, a 4.7 Tesla Bruker BioSpec small animal magnetic resonance (MR) imager is already installed in the University Hospital of Zürich. This state-of-the-art MR device provides newly developed imaging sequences (so-called ultra-short echo time sequences), which are capable to detect MR signal of tissue, which cannot be visualized with conventional techniques due to fast signal decay (such as tissue with low water content or lung tissue). The visualization of the anatomical or pathological structure of these tissues has so far been the domain of computed tomography showing the need for microCT as a reference technique. In one research project (plaque imaging, PD Stolzmann), the microCT will be used as primary imaging modality compared to histology and in one project (PD Frauenfelder) correlation to phase-contrast CT will be investigated. The majority of research projects will be performed in-vivo with mice, therefore requiring the microCT device to be equipped with an integrated physiology monitoring unit, a powerful X-ray tube for fast scanning and state-of-the-art detector technology to keep radiation exposure to the animals as low as possible. Furthermore, the system should provide spatial resolution below 10 µm in all 3 dimensions. The microCT has to be installed in close proximity to the already installed small animal MR device (within walking range). There are several important reasons for this requirement: First, due to hygienic reasons of veterinary medicine, the animals cannot be scanned in other institutions keeping mice as the import of an infectious disease would endanger the complete mouse population at the University Hospital. Therefore, the cooperation with other research institutions keeping mice is excluded. Second, long transportation distances and periods are not amenable with the in-vivo mice after surgical intervention. Third, for daily practicability the microCT should be installed within the University Hospital as the majority of researchers in this collaboration are implemented in a clinical work environment. The DIR will provide 50% of acquisition costs of the microCT according to the funding regulations; furthermore the DIR will cover costs of maintenance and operating expenses.