Girard Jérôme, Joset Nathalie, Tan Milène, Holzheu Anja, Crochet Aurélien, Brunetto Priscilla S., Fromm Katharina M. (2016), Synthesis of new polyether ether ketone derivatives with silver binding site and coordination compounds of their monomers with different silver salts, in Polymers
, 8, 208.
Priebe Magdalena, Fromm Katharina M. (2015), Nanorattles or yolk-shell nanoparticles-What are they, How are they made, and What are they good for, in Chem. Eur. J.
, 21, 3854-3874.
Priebe Magdalena, Fromm Katharina M. (2014), One-Pot Synthesis and Catalytic Properties of Encapsulated Silver Nanoparticles in Silica Nanocontainers, in Particles & Particle Systems Characterization
Fromm Katharina M. (2013), Bioinorganic Chemistry of Silver: Its Interactions with Amino Acids and Peptides, in Chimia
, 67(12), 851-854.
Girard Jérôme, Brunetto Priscilla S., Braissant Olivier, Rajacic Zarco, Khanna Nina, Landmann Regine, Daniels Alma U. Dan, Fromm Katharina M. (2013), Development of a polystyrene sulfonate/silver nanocomposite with self-healing properties for biomaterial applications, in Comtes Rendus Chimie
, 16(6), 550-556.
Eckhardt Sonja, Brunetto Priscilla S., Gagnon Jacinthe, Priebe Magdalena, Giese Bernd, Fromm Katharina M. (2013), Nano-Bio-Silver: Its interactions with peptides and bacteria, and its uses in medicine, in Chem. Rev.
, 113(7), 4708-4754.
Mirolo Laurent, Schmidt Tobias, Eckhardt Sonja, Meuwly Markus, Fromm Katharina M. (2013), pH-Dependent coordination of Ag+ by histidine: experiment, theory, and a model for SilE, in Chem. Eur. J.
, 19(5), 1754-1761.
Chevrier Inès, Sagué Jorge, Brunetto Priscilla, Khanna Nina, Rajacic Zarco, Fromm Katharina M. (2013), Rings, chains and helices: new antimicrobial silver coordination compounds with (iso-)nicotinic acid derivatives, in Dalton Trans.
, 42, 217-231.
Fromm Katharina M. (2013), Silver Coordination Compounds with Antimicrobial Properties, in Appl. Organomet. Chem.
, 27(12), 638-687.
Fromm Katharina M., Sague Jorge L., Robin Adeline Y. (2013), Silver coordination polymers with isonicotinic acid derived short polyethylenegylcol – Synthesis, structures, anion effect and solution behavior, in Inorg. Chim. Acta
, 403, 2-8.
Hajipour M. J., Fromm K. M., Ashkarran A. A., Abersturi D. J. de, Larramendi I. R. de, Rojo T., Serpooshan V., Parak W. J., Mahmoudi M. (2012), Antimicrobial properties of nanoparticles, in Trends in Biotechnology
, 30(10), 499-511.
Girard Jerome, Fromm Katharina M. (2012), Single crystal to single crystal polymorphic phase transition of a silver nitrate 24-crown-8 complex and its pseudo-polymorphism, in CrystEngComm
, 14, 6487-6491.
Chevrier Ines, Sagué Jorge L., Brunetto Priscilla S., Khanna Nina, Rajacic Zarko, Fromm Katharina M., Rings, chains and helices: new antimicrobial silver coordination compounds with (iso)-nicotinic acid derivatives, in Dalton Transactions
Based on the CDC report “Health, United States, 2009”, the number of implants and devices inserted into humans is steadily growing, e. g. by 30-70% for hip, respectively knee implants over the past 10 years. Medical doctors improve technologies and implant more and more materials and devices into the human body. They have to be biocompatible in order not to have any adverse effects and to fulfill their function in the body properly. On the other hand, implant infection is emerging as an extremely important medical problem. This problem remains a major challenge for material science and requires a broad range of expertise from different disciplines.Our team covers the relevant areas of chemistry, material science, biochemistry, cell biology, microbiology and medicine to tackle the problem of implant infections. So far, we have well established know-how on depositing silver coordination compounds as antimicrobial coatings on model gold, gold alloy and titanium. After showing that these compounds are bactericidal and biocompatible, we now want to cope with other implant materials such as alloys, e. g. Ti6Al4V, CoCr-alloys as well as polymer materials used in implantable devices. Furthermore, we would like to extend our activities to copper compounds as well as combinations of silver, respectively copper with antibiotics, as initiated in the previous project. A further new aspect will be the use of a combination of our silver compounds with antibodies in a “catch-and-kill” approach. Another task of this project is to understand the mechanism of action of our compounds at the cellular level. While the chemists will cope with the synthesis, deposition and thorough material analysis, cell biology will deal with the race of cells and bacteria to the surface, with cell response towards the mechanical properties and subsequent cell proliferation and differentiation on the coated material. Finally, antimicrobial properties against bacteria and fungi and biocompatibility will be investigated by the medical/microbiological team in vitro and in vivo, working towards application.