Project

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New anti-bacterial coatings for implant materials

Applicant Fromm Katharina M.
Number 138122
Funding scheme Project funding (Div. I-III)
Research institution Département de Chimie Université de Fribourg
Institution of higher education University of Fribourg - FR
Main discipline Inorganic Chemistry
Start/End 01.10.2011 - 31.03.2014
Approved amount 205'648.00
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All Disciplines (5)

Discipline
Inorganic Chemistry
Surgery
Cellular Biology, Cytology
Experimental Microbiology
Biochemistry

Lay Summary (English)

Lead
Lay summary

More and more implant materials can be inserted into the human body in order to serve medical and/or aesthetic purposes. Nevertheless, these body-foreign materials do not have a natural defence system as e. g. natural bones do. Therefore, the surfaces of implant materials are prone to bacterial adhesion and biofilm formation, thus bacterial infection. Very often, the infections cannot be eradicated by classical antibiotic therapy, and implants have to be removed and replaced with a long healing period in between.

After having proposed simple silver coordination polymers as coatings for metal implants, we are now investigating the deposition of silver compound in and on polymers used within the body. There are e. g. polyethylenegylcol, PEEK, silicones or polystyrenesulfonates which are being investigated in this respect. We study the incorporation of silver ions into the polymers as well as methods to coat silver coordination polymers to surfaces of polymers. The latter technique requires the functionalisation of the surface. In another approach, we attempt to increase the activity of silver ions by combining the metal ion effect with antibiotics in order to act in a synergic way. All material development approaches are combined with microbiological and biocompatibility tests.

Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Synthesis of new polyether ether ketone derivatives with silver binding site and coordination compounds of their monomers with different silver salts
Girard Jérôme, Joset Nathalie, Tan Milène, Holzheu Anja, Crochet Aurélien, Brunetto Priscilla S., Fromm Katharina M. (2016), Synthesis of new polyether ether ketone derivatives with silver binding site and coordination compounds of their monomers with different silver salts, in Polymers, 8, 208.
Nanorattles or yolk-shell nanoparticles-What are they, How are they made, and What are they good for
Priebe Magdalena, Fromm Katharina M. (2015), Nanorattles or yolk-shell nanoparticles-What are they, How are they made, and What are they good for, in Chem. Eur. J. , 21, 3854-3874.
One-Pot Synthesis and Catalytic Properties of Encapsulated Silver Nanoparticles in Silica Nanocontainers
Priebe Magdalena, Fromm Katharina M. (2014), One-Pot Synthesis and Catalytic Properties of Encapsulated Silver Nanoparticles in Silica Nanocontainers, in Particles & Particle Systems Characterization, 1.
Bioinorganic Chemistry of Silver: Its Interactions with Amino Acids and Peptides
Fromm Katharina M. (2013), Bioinorganic Chemistry of Silver: Its Interactions with Amino Acids and Peptides, in Chimia, 67(12), 851-854.
Development of a polystyrene sulfonate/silver nanocomposite with self-healing properties for biomaterial applications
Girard Jérôme, Brunetto Priscilla S., Braissant Olivier, Rajacic Zarco, Khanna Nina, Landmann Regine, Daniels Alma U. Dan, Fromm Katharina M. (2013), Development of a polystyrene sulfonate/silver nanocomposite with self-healing properties for biomaterial applications, in Comtes Rendus Chimie, 16(6), 550-556.
Nano-Bio-Silver: Its interactions with peptides and bacteria, and its uses in medicine
Eckhardt Sonja, Brunetto Priscilla S., Gagnon Jacinthe, Priebe Magdalena, Giese Bernd, Fromm Katharina M. (2013), Nano-Bio-Silver: Its interactions with peptides and bacteria, and its uses in medicine, in Chem. Rev. , 113(7), 4708-4754.
pH-Dependent coordination of Ag+ by histidine: experiment, theory, and a model for SilE
Mirolo Laurent, Schmidt Tobias, Eckhardt Sonja, Meuwly Markus, Fromm Katharina M. (2013), pH-Dependent coordination of Ag+ by histidine: experiment, theory, and a model for SilE, in Chem. Eur. J. , 19(5), 1754-1761.
Rings, chains and helices: new antimicrobial silver coordination compounds with (iso-)nicotinic acid derivatives
Chevrier Inès, Sagué Jorge, Brunetto Priscilla, Khanna Nina, Rajacic Zarco, Fromm Katharina M. (2013), Rings, chains and helices: new antimicrobial silver coordination compounds with (iso-)nicotinic acid derivatives, in Dalton Trans., 42, 217-231.
Silver Coordination Compounds with Antimicrobial Properties
Fromm Katharina M. (2013), Silver Coordination Compounds with Antimicrobial Properties, in Appl. Organomet. Chem., 27(12), 638-687.
Silver coordination polymers with isonicotinic acid derived short polyethylenegylcol – Synthesis, structures, anion effect and solution behavior
Fromm Katharina M., Sague Jorge L., Robin Adeline Y. (2013), Silver coordination polymers with isonicotinic acid derived short polyethylenegylcol – Synthesis, structures, anion effect and solution behavior, in Inorg. Chim. Acta, 403, 2-8.
Antimicrobial properties of nanoparticles
Hajipour M. J., Fromm K. M., Ashkarran A. A., Abersturi D. J. de, Larramendi I. R. de, Rojo T., Serpooshan V., Parak W. J., Mahmoudi M. (2012), Antimicrobial properties of nanoparticles, in Trends in Biotechnology, 30(10), 499-511.
Single crystal to single crystal polymorphic phase transition of a silver nitrate 24-crown-8 complex and its pseudo-polymorphism
Girard Jerome, Fromm Katharina M. (2012), Single crystal to single crystal polymorphic phase transition of a silver nitrate 24-crown-8 complex and its pseudo-polymorphism, in CrystEngComm, 14, 6487-6491.
Rings, chains and helices: new antimicrobial silver coordination compounds with (iso)-nicotinic acid derivatives
Chevrier Ines, Sagué Jorge L., Brunetto Priscilla S., Khanna Nina, Rajacic Zarko, Fromm Katharina M., Rings, chains and helices: new antimicrobial silver coordination compounds with (iso)-nicotinic acid derivatives, in Dalton Transactions.

Collaboration

Group / person Country
Types of collaboration
Universität Basel, Unispital Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Universität Basel, Dept Chemie Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
International Symposium on Surface and Interface of Biomaterials Poster Biocompatible antimicrobial surfaces based on metal – vancomycin complexes 24.09.2013 Rom, Italy Fromm Katharina M.;
FRiMatDay 2013 Poster Biocompatible antimicrobial surfaces based on metal – vancomycin complexes 04.07.2013 Fribourg, Switzerland Fromm Katharina M.;
Swiss Nano Convention Poster Biocompatible antimicrobial surfaces based on metal – vancomycin complexes 21.05.2013 Basel, Switzerland Fromm Katharina M.;
SupraChem@Balkans Summer School Poster Biocompatible antimicrobial surfaces based on metal – vancomycin complexes 25.03.2013 Plovdiv, Bulgaria Fromm Katharina M.;
1st year graduate student symposium Talk given at a conference Biocompatible antimicrobial surfaces based on metal – vancomycin complexes 09.09.2012 Bern, Switzerland Fromm Katharina M.;


Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
First year PhD student symposium Talk 10.09.2012 Bern, Switzerland Girard Jérôme; Priebe Magdalena;
CUSO Summer School Inorganic Chemistry "Inorganic and organometallic polymers" Poster 13.08.2012 Villars sur Ollon, Switzerland Girard Jérôme; Priebe Magdalena; Fromm Katharina M.;
FriMat Day 2012 Poster 04.07.2012 Fribourg, Switzerland Fromm Katharina M.; Girard Jérôme; Priebe Magdalena;
GECOM CONCOORD 2012 Talk 03.06.2012 Metabief, France Girard Jérôme; Fromm Katharina M.;


Awards

Title Year
Fellow of the American Chemical Society (first person in Europe) 2013

Associated projects

Number Title Start Funding scheme
121813 Neue antibakterielle Oberflächen auf Implantat- Materialien 01.10.2008 Project funding (Div. I-III)
121813 Neue antibakterielle Oberflächen auf Implantat- Materialien 01.10.2008 Project funding (Div. I-III)
114149 Neue antibakterielle Oberflächen auf Implantat- Materialien 01.10.2006 Project funding (Div. I-III)
152777 Coordination Compounds: From Basics towards Applications in Materials and Medicine 01.04.2014 Project funding (Div. I-III)
150731 Laboratory multi-scale nano-CT scanner for 3D visualization and 4D experimentation in Earth and Material Sciences 01.05.2014 R'EQUIP

Abstract

Based on the CDC report “Health, United States, 2009”, the number of implants and devices inserted into humans is steadily growing, e. g. by 30-70% for hip, respectively knee implants over the past 10 years. Medical doctors improve technologies and implant more and more materials and devices into the human body. They have to be biocompatible in order not to have any adverse effects and to fulfill their function in the body properly. On the other hand, implant infection is emerging as an extremely important medical problem. This problem remains a major challenge for material science and requires a broad range of expertise from different disciplines.Our team covers the relevant areas of chemistry, material science, biochemistry, cell biology, microbiology and medicine to tackle the problem of implant infections. So far, we have well established know-how on depositing silver coordination compounds as antimicrobial coatings on model gold, gold alloy and titanium. After showing that these compounds are bactericidal and biocompatible, we now want to cope with other implant materials such as alloys, e. g. Ti6Al4V, CoCr-alloys as well as polymer materials used in implantable devices. Furthermore, we would like to extend our activities to copper compounds as well as combinations of silver, respectively copper with antibiotics, as initiated in the previous project. A further new aspect will be the use of a combination of our silver compounds with antibodies in a “catch-and-kill” approach. Another task of this project is to understand the mechanism of action of our compounds at the cellular level. While the chemists will cope with the synthesis, deposition and thorough material analysis, cell biology will deal with the race of cells and bacteria to the surface, with cell response towards the mechanical properties and subsequent cell proliferation and differentiation on the coated material. Finally, antimicrobial properties against bacteria and fungi and biocompatibility will be investigated by the medical/microbiological team in vitro and in vivo, working towards application.
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