Bulk metallic glasses constitute one example of a class of materials generally referred to as amorphous solids. An amorphous solid is special since it is not regarded as an equilibrium phase of matter, as defined by thermodynamics, but rather as a meta-stable structure with a characteristic time-scale which is usually well beyond that of a typical experiment or appropriate material application. Such glassy materials are made by rapid quenching from the melt, a multi-component metallic alloy, to the glass transition temperature where the viscosity rapidly increases and the atomic mobility rapidly decreases many orders of magnitude. Well below the glass transition temperature is the regime of the amorphous solid, a material exhibiting exceptional structural and mechanical properties such as an enhanced elastic deformation regime and a considerably high yield strength whilst being extremely brittle. The underlying deformation mechanism remains a subject of intense international research and the present project investigates those atomic-scale structural transformations that lead to emergent macroscopic material failure, using both static and dynamic atomistic simulation techniques. In particular, energy-landscape exploration algorithms will be used to traverse the structural energy landscape to identify transition pathways, involving collective atomic activity, that allow the system to exit its current structural state. This will be done as a function of both model system type and applied stress.