Project

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The developing of research infrastructure and approaches to optical point-of-care medical diagnostics

English title The developing of research infrastructure and approaches to optical point-of-care medical diagnostics
Applicant Wolf Martin
Number 137423
Funding scheme SCOPES
Research institution Klinik für Neonatologie UniversitätsSpital Zürich
Institution of higher education University of Zurich - ZH
Main discipline Biophysics
Start/End 01.08.2011 - 28.02.2015
Approved amount 210'000.00
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All Disciplines (5)

Discipline
Biophysics
Electrical Engineering
Other disciplines of Physics
Other disciplines of Engineering Sciences
Biomedical Engineering

Lay Summary (English)

Lead
Lay summary

A potentially catastrophic ecological situation has developed in Uzbekistan, provoked by a drought. This leads to a proliferation of many diseases especially in the Aral Sea region. Therefore an urgent task is to prevent these diseases and their spreading from rural regions to other rural regions and highly populated areas. Thanks to donor countries and government health care programs after the independence, Uzbekistan was able to acquire much needed medical equipment for diagnostics and treatment. However, the educational and research infrastructure in Uzbekistan is not yet able to provide qualified and experienced personnel to operate, support, and modify the modern medical devices. Currently there is no specialized research and educational center, which could stimulate research and educate professionals to operate these medical devices based on light. Biophotonics, which is the field of employing light to diagnose and treat diseases, is a field of rapid development with tremendous prospects for the future in particular for Uzbekistan, because there is a firm physical background present and the technology is generally inexpensive.

The main objective of the present project is to develop a core research and education institution for engineers and physicists and to train personnel for research and service in the field of Biophotonics. This objective will promoted by an institutional partnership with the University Hospital Zurich and Saratov State University. To reach this objective we will address these three main tasks:

Task 1 is to develop a new Laboratory of Biophotonics (LB) situated at the Institute of Electronics of the Uzbek Academy of Science. LB will study the interaction of light and biological tissue, develop new diagnostic methods based on light to study human cells and tissues, and train engineers and physicists. To promote this development a long term international partnership with the University Hospital Zurich and Saratov State University, which have expertise in Biophotonics, will be established.

Task 2 is to establish a collaboration between LB and local medical and technical universities in Tashkent to develop a new course in “Medical Photonics”.

Task 3 is to promote biophotonic medical devices at hospitals, diagnostic centers etc. and to strongly enhance medical diagnostics.

In conclusion the proposed institutional partnership will start and establish a self-sustained research and educational institution, the Laboratory of Biophotonics.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Method of white light interference in thin film for analysis morphology of red blood cells. [Метод интерференции белого света в тонких пленках для анализа морфологии эритроцитов].
Dyachenko A. A., Paiziev A. A, Ryabukho V. P., Malinova L. I. (2016), Method of white light interference in thin film for analysis morphology of red blood cells. [Метод интерференции белого света в тонких пленках для анализа морфологии эритроцитов]., in Russian Physics Journal, 58(11-3), 116-119.
The Application of Bioresonance Diagnostics Using Electrical Stimulation of Meridian Systems in the Preparation of Wrestlers
Payzieva Shaira, Djmaniyazov Davon, Curby David G. (2016), The Application of Bioresonance Diagnostics Using Electrical Stimulation of Meridian Systems in the Preparation of Wrestlers, in International Journal of Wrestling Science, 6(1), 58-61.
Application of NIRS technology in sport science
Paiziev A.A. (2014), Application of NIRS technology in sport science, in Int. Conf. Med. Rehabilitation and Sport Science, Samarkand Unknown, Samarkand.
Dermal component based optical modeling of the skin translucency: impact on the skin color
Meglinski I., Doronin A., Bashkatov AN, Genina E.A., Tuchin V.V. (2014), Dermal component based optical modeling of the skin translucency: impact on the skin color, in Querleux B. (ed.), CRC Press, Taylor & Francis Group, London, 25-61.
In vivo optical flow cytometry and cell imaging
Tuchin V. V. (2014), In vivo optical flow cytometry and cell imaging, in RIVISTA DEL NUOVO CIMENTO, 37(7), 375-416.
In vivo optical flow cytometry and cell imaging, edited by
Tuchin V.V. (2014), In vivo optical flow cytometry and cell imaging, edited by, in Pavone F. S. (ed.), Italian Physical Society, Bologna, 1-45.
Light-Tissue Interactions
Tuchin V.V. (2014), Light-Tissue Interactions, in Vo-Dinh Tuan (ed.), CRC Press, Taylor and Francis Books, 123 -168.
Morphological Features of a Cervical Cancer Cells Membrane Under Reflected Light Microscope
Paiziev A. (2014), Morphological Features of a Cervical Cancer Cells Membrane Under Reflected Light Microscope, in GRF Davos Planet@Risk, 2(4), 217-220.
Multiresolution analysis of pathological changes in cerebral venous dynamics in newborn mice with intracranial hemorrhage: adrenorelated vasorelaxation.
Pavlov A N, Semyachkina-Glushkovskaya O V, Zhang Y, Bibikova O A, Pavlova O N, Huang Q, Zhu D, Li P, Tuchin V V, Luo Q (2014), Multiresolution analysis of pathological changes in cerebral venous dynamics in newborn mice with intracranial hemorrhage: adrenorelated vasorelaxation., in Physiological measurement, 35(10), 1983-99.
NEAR INFRA-RED SPECTROSCOPY AND SKELETAL MUSCLES PHYSIOLOGY OF ATHLETES
Paiziev A. (2014), NEAR INFRA-RED SPECTROSCOPY AND SKELETAL MUSCLES PHYSIOLOGY OF ATHLETES, in Unknown (ed.), Fan, Tashkent, 233-239.
NIRS instruments to monitor athletes muscle performances during and after exercise
Paiziev A., Kerimov F. (2014), NIRS instruments to monitor athletes muscle performances during and after exercise, in Unknown (ed.), Fan, Tashkent, 203-206.
Optical Properties of Tissues
Mobley J., Vo-Dinh T., Tuchin V.V. (2014), Optical Properties of Tissues, in Vo-Dinh Tuan (ed.), CRC Press, Taylor & Francis Group, 23-122.
Paiziev A. (2014) Vascular occlusion test of sportsmen in rest and exercise
Kerimov F., Paiziev A. (2014), Paiziev A. (2014) Vascular occlusion test of sportsmen in rest and exercise, in Unknown (ed.), Fan, Tashkent, 23-26.
VASCULAR OCCLUSION TEST OF SPORTSMAN’S UPPER AND LOWER EXTREMITIES AND NIRS TECHNOLOGY
Paiziev A., Payziyeva Sh. (2014), VASCULAR OCCLUSION TEST OF SPORTSMAN’S UPPER AND LOWER EXTREMITIES AND NIRS TECHNOLOGY, in Unknown (ed.), Fan, Tashkent, 455-460.
Advanced Biophotonics
Ruikang K. Wang, Valery V Tuchin (2013), Advanced Biophotonics, CRC Press, Tylor and Francis Book.
Blood optical clearing studied by optical coherence tomography.
Zhernovaya Olga, Tuchin Valery V, Leahy Martin J (2013), Blood optical clearing studied by optical coherence tomography., in Journal of biomedical optics, 18(2), 26014-26014.
Cancer laser therapy using gold nanoparticles
Terentyuk G.S., Maksimova I.L., Dikht N.I., Terentyuk A.G., Khlebtsov B.N., Tuchin V.V. (2013), Cancer laser therapy using gold nanoparticles, in Jelinkova Helena (ed.), Woodhead Pub Limited, Woodhead, 659-703.
Change dynamics of RBC morphology after injection glucose for diabetes by diffraction phase microscope
Talaykova N. A., Kalyanov A. L., Lychagov V. V., Ryabukho V. P., Malinova L. I. (2013), Change dynamics of RBC morphology after injection glucose for diabetes by diffraction phase microscope, in BIOPHOTONICS - RIGA 2013, 9032, 90320F -90320F.
COHERENT-DOMAIN OPTICAL METHODS, chapters 4, 5, 13, 16
Tuchin Valery (2013), COHERENT-DOMAIN OPTICAL METHODS, chapters 4, 5, 13, 16, Springer, Berlin.
Color Contrast of Red Blood Cells on Solid Substrate
Paiziev Adkham A. (2013), Color Contrast of Red Blood Cells on Solid Substrate, in Proceedings SPIE , 8699 , 869908.
Enhanced photoinactivation of Staphylococcus aureus with nanocomposites containing plasmonic particles and hematoporphyrin.
Khlebtsov Boris N, Tuchina Elena S, Khanadeev Vitaly A, Panfilova Elizaveta V, Petrov Pavel O, Tuchin Valery V, Khlebtsov Nikolai G (2013), Enhanced photoinactivation of Staphylococcus aureus with nanocomposites containing plasmonic particles and hematoporphyrin., in Journal of biophotonics, 6(4), 338-51.
OPTICAL COHERENCE TOMOGRAPHY OF ADIPOSE TISSUE AT PHOTODYNAMIC/PHOTOTHERMAL TREATMENT IN VITRO
Yanina Irina Yu., Trunina Natalia A., Tuchin Valery V. (2013), OPTICAL COHERENCE TOMOGRAPHY OF ADIPOSE TISSUE AT PHOTODYNAMIC/PHOTOTHERMAL TREATMENT IN VITRO, in JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES, 6(2), 1350010-1--1350010-1-.
OPTICAL MEASUREMENTS OF RAT MUSCLE SAMPLES UNDER TREATMENT WITH ETHYLENE GLYCOL AND GLUCOSE
Oliveira Luis, Carvalho Maria Ines, Nogueira Elisabete, Tuchin Valery V. (2013), OPTICAL MEASUREMENTS OF RAT MUSCLE SAMPLES UNDER TREATMENT WITH ETHYLENE GLYCOL AND GLUCOSE, in JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES, 6(2), 1350012-1--1350012-1-.
Photoinduced cell morphology alterations quantified within adipose tissues by spectral optical coherence tomography.
Yanina Irina Yu, Trunina Natalia A, Tuchin Valery V (2013), Photoinduced cell morphology alterations quantified within adipose tissues by spectral optical coherence tomography., in Journal of biomedical optics, 18(11), 111407-111407.
PHOTONIC CRYSTAL WAVEGUIDE BIOSENSOR
Zanishevskaya A. A., Malinin A. V., Tuchin V. V., Skibina Yu. S., Silokhin I. Yu. (2013), PHOTONIC CRYSTAL WAVEGUIDE BIOSENSOR, in JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES, 6(2), 1350008-1--1350008-1-.
Photonic Crystal Waveguide Sensing
Skibina J.S., MalininA.V., Zanishevskaya A.A., Tuchin V.V. (2013), Photonic Crystal Waveguide Sensing, in Nikolelis Dimitrios P. Varzakas Theodoros Erdem Arzum Nikoleli Georgia-Paraskevi (ed.), CRC Press, CRC Press, 1-32.
Portable point-of-care optical device to detect brain injury
Paiziev A. A. (2013), Portable point-of-care optical device to detect brain injury, in NATO Science for Peace and Security. Series B: Physics and Biophysics (ed.), Springer Science, Berlin, Heidelberg, N.Y., 193.
Portable point-of-care optical device to detect brain injury
Paiziev Adkham A. (2013), Portable point-of-care optical device to detect brain injury, in NATO Science for Peace and Security Series B: Physics and Biophysics, 193-202.
Recent progress in tissue optical clearing.
Zhu Dan, Larin Kirill V, Luo Qingming, Tuchin Valery V (2013), Recent progress in tissue optical clearing., in Laser & photonics reviews, 7(5), 732-757.
The response of tissue to laser light
Douplik, Saiko G, Schelkanova I, Tuchin Valery V. (2013), The response of tissue to laser light, in Jelinkova Helena (ed.), Woodhead Pub Limited, Woodhead, 47-109.
Visible and near-infrared spectroscopy for distinguishing malignant tumor tissue from benign tumor and normal breast tissues in vitro.
Zhang Yang, Chen Yongjun, Yu Yuan, Xue Xingbo, Tuchin Valery V, Zhu Dan (2013), Visible and near-infrared spectroscopy for distinguishing malignant tumor tissue from benign tumor and normal breast tissues in vitro., in Journal of biomedical optics, 18(7), 077003-077003.
Morphological Defects of Cotton Fibers. In book:. “Fiber Research for Tomorrow’s Applications
Paiziev A., Abdullaev Sh., Khalilov S. (2012), Morphological Defects of Cotton Fibers. In book:. “Fiber Research for Tomorrow’s Applications, in The Fiber Society Spring 2012 Conference Proceedings , Curran Associates, Red Hook, NY, USA.
Dictionary of Biomedical Optics and Biophotonics
Tuchin Valery (2012), Dictionary of Biomedical Optics and Biophotonics, SPIE Press, Bellingham, WA, USA.
Diffusing Wave Spectroscopy: Application for Blood Diagnostics
Meglinski Igor, Tuchin Valery V. (2012), Diffusing Wave Spectroscopy: Application for Blood Diagnostics, in Tuchin V.V. (ed.), Springer-Verlag, Berlin, Heidelberg, N.Y, 149-166.
Laser Doppler and Speckle Techniques
Fedosov Ivan V., Tuchin Valery V. (2012), Laser Doppler and Speckle Techniques, in Tuchin Valery V. (ed.), Springer-Verlag, Berlin, Heidelberg, N.Y., 487-564.
Laser Speckle Imaging of Cerebral Blood Flow
Luo Qingming, Jiang Chao, Li Pengcheng, Cheng Haiying, Wang Zhen, Tuchin Valery V. (2012), Laser Speckle Imaging of Cerebral Blood Flow, in Tuchin Valery V. (ed.), Springer-Verlag, Berlin, Heidelberg, N.Y., 167-212.
Morphological Defects of Cotton Fibers
Paiziev A., Abdullaev Sh., Khalilov S. (2012), Morphological Defects of Cotton Fibers, in The Fiber Society Spring 2012 Conference Proceedings, St. GallenThe Fiber Society Spring 2012 Conference Proceedings , Unknown.
Numerical Reconstruction of 3D Image in Fourier Domain Confocal Optical Coherence Microscopy
Grebenyuk A. A., Ryabukho V. P. (2012), Numerical Reconstruction of 3D Image in Fourier Domain Confocal Optical Coherence Microscopy, in Proceedings of Advanced Laser Technologies‘12, Thun, September 2-6 2012Bern Open Publishing, Bern.
Optical Coherence Tomography: Light Scattering and Imaging Enhancement
Wang Ruikang K., Tuchin Valery V. (2012), Optical Coherence Tomography: Light Scattering and Imaging Enhancement, in Tuchin Valery V. (ed.), Springer-Verlag, Berlin, Heidelberg, N.Y., 665-742.
Optics of Biological Tissues: Methods of Light Scattering in Medical Diagnosis
Tuchin Valery (2012), Optics of Biological Tissues: Methods of Light Scattering in Medical Diagnosis, Fizmatlit, Moscow.
The Fourier Transformed MIR Microspectroscopy to Reveal a Morphological and Spectral Markers of a Cervical Cancer Cells
Paiziev A (2012), The Fourier Transformed MIR Microspectroscopy to Reveal a Morphological and Spectral Markers of a Cervical Cancer Cells, in NATO Advanced Research Workshop on Detection of Explosives and CBRN (Using Terahertz), 103-108.
White-light full-field OCT resolution improvement by image sensor colour balance adjustment: numerical simulation
Kalyanov A. L., Lychagov V. V., Ryabukho V. P., Smirnov I. V. (2012), White-light full-field OCT resolution improvement by image sensor colour balance adjustment: numerical simulation, in J. Opt., 14, 125708-5.
Dorsiflexor muscle oxygenation during low, moderate and maximal sustained isometric contraction
2. Paiziev A., Kerimov F., Wolf M., Dorsiflexor muscle oxygenation during low, moderate and maximal sustained isometric contraction, in Adv Exp Med Biol.
Современное состояние исследований по применению спектроскопии ближнего инфракрасного диапазона для функциональной диагностики в неонатологии
Wolf M., Paiziev A.A., Современное состояние исследований по применению спектроскопии ближнего инфракрасного диапазона для функциональной диагностики в неонатологии, in Uzb.Phys. Journal , 15, 112-118.

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
12th International Conference on Photonics and Imaging in Biology and Medicine Talk given at a conference Tissue optics and innovations in tissue optical clearing 14.06.2014 Wuhan, China Tuchin Valery;
The 13th Conference of the International Society of Optics within Life Sciences Talk given at a conference Tissue optics and in vivo optical clearing technologies 10.06.2014 Ningbo, China Tuchin Valery;
Saratov Fall Meeting 2013 Talk given at a conference Imaging Deep Tissue in Three Dimensions by Near Infrared Imaging 24.09.2013 Saratov, Russia Wolf Martin; Tuchin Valery;
Biophotonics - Riga Talk given at a conference Change Dynamics of RBC Morphology after Injection Glucose for Diabetes by Diffraction Phase Microscope 25.08.2013 Riga, Latvia Tuchin Valery;
IV International Symposium, TOPICAL PROBLEMS OF BIOPHOTONICS – 2013 Talk given at a conference Fundamentals and advances of tissue optical clearing 21.07.2013 Nizhny Novgorod, Russia Tuchin Valery;
11th International Conference on Photonics and Imaging in Biology and Medicine Talk given at a conference Tissue optical clearing: pathology, mechanics, and light impact 26.05.2013 Wuhan, China Tuchin Valery;
NATO Advanced Research Workshop on Detection of Explosives and CBRN (Using Terahertz) TERA-MIR 2012 Poster The Fourier Transformed MIR Microspectroscopy to Reveal a Morphological and Spectral Markers of a Cervical Cancer Cells 03.11.2012 Izmir, Turkey Paiziev Adkhamjon;
fNIRS Conference Poster A Wireless Self-Calibrating Sensor for fNIRS Studies in Preterm Infants 26.10.2012 London, Great Britain and Northern Ireland Wolf Martin; Pastewski Marcin;
Saratov Fall Meeting 2012 Poster Color contrast of red blood cells on solid surface 25.09.2012 Saratov, Russia Pastewski Marcin; Tuchin Valery; Paiziev Adkhamjon;
Saratov Fall Meeting 2012 Poster Spectral analysis of R-450 cytochrom isoforms under IR radiation of microsoms, extracted from animals liver with toxic hepatitis 25.09.2012 Saratov, Russia Pastewski Marcin; Paiziev Adkhamjon; Tuchin Valery;
Saratov Fall Meeting Talk given at a conference A Novel, Integrated, Self-Calibrating Sensor to Monitor the Cerebral Tissue Oxygen Saturation (StO2) of the Critically Ill Preterm Infants 25.09.2012 Saratov, Russia Pastewski Marcin;
Saratov Fall Meeting 2012 Poster Biophoton emission from plant cells 25.09.2012 Saratov, Russia Paiziev Adkhamjon; Pastewski Marcin; Tuchin Valery;
Saratov Fall Meeting 2012 Talk given at a conference Diffraction phase module for commercial 25.09.2012 Saratov, Russia Tuchin Valery; Pastewski Marcin;
Advanced Laser Technologies‘12, Thun, September 2-6, 2012 Talk given at a conference Colour Sensor White Balance Influence on White-Light Interferometer Resolution, 02.09.2012 Thun , Switzerland Wolf Martin; Tuchin Valery;
European Summit for Clinical Nanomedicine Poster Morphological Markers of Cancer Cells from Uterine Neck Smears 07.05.2012 Basel, Switzerland Paiziev Adkhamjon;


Self-organised

Title Date Place
Progress in Research 27.08.2014 Zürich, Switzerland
Biophotonics in Medicine, Seminat at the Academy of Medical Sciences 30.03.2012 Tahskent, Uzbekistan
Opening Cerimony of Laboratory of Biophotonics in Tashkent 26.03.2012 Tashkent,, Uzbekistan

Abstract

A potentially catastrophic ecological situation has developed in Uzbekistan, provoked by a drought. This leads to a broad spread of many diseases especially in the Aral Sea region. Therefore an urgent task is to prevent these diseases and their spreading rural regions to other rural regions and regions with a high population density. Thanks to donor countries and government health care programs after the independence, Uzbekistan was able to acquire much needed medical equipment for diagnostics and treatment. However, the educational and research infrastructure in Uzbekistan is not yet able to provide qualified and experienced personnel to operate, support, and modify the modern medical devices, which are based on comprehensive physical and biophysical principles. Currently there is no specialized research and educational center, which could stimulate research and educate professionals in the field of “point-of-care” medical devices based on photonics. Biophotonics is a field of rapid development with tremendous prospects for the future in medical diagnostics and treatment. This field is particularly promising for Uzbekistan, because there is a firm physical background present and the technology is generally inexpensive.The main objective of the present project is to develop a core research and education structure for engineers and physicists based on Institute of Electronics of the Uzbek Academy of Science, which is promoted by an institutional partnership with the University Hospital Zurich and Saratov State University. The aim is to train personnel for research and service in the field of biophotonics. To reach this objective we need to address these three main tasks:1.To develop a new biophotonics academic core structure, which will be called the Laboratory of Biophotonics (LB) and situated at the Institute of Electronics Uzbek Academy of Science. LB will study photon-biological matter interaction, elaborate new diagnostic methods based on photon probing of human cells and tissues, and train engineers and physicists. To promote this development a long term international partnership with the University Hospital Zurich and Saratov State University, which have expertise in Biophotonics, will be established.2.To establish a collaboration between LB and local educational universities in Tashkent such as Tashkent State Medical Academy (TSMA) to develop the new educational course “Medical Photonics”. 3.To promote biophotonic “point-of-care” medical devices at hospitals, diagnostic centers etc. to strongly enhance medical diagnostics. In conclusion the proposed institutional partnership will start and establish a self-sustained research and educational institution at end of project.
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