Project

Back to overview

The Metabolic Basis of Disease

English title The Metabolic Basis of Disease
Applicant Krek Wilhelm
Number 137143
Funding scheme ProDoc
Research institution Institut für Zellbiologie ETH Zürich
Institution of higher education ETH Zurich - ETHZ
Main discipline Physiology : other topics
Start/End 01.01.2012 - 31.12.2015
Approved amount 179'164.00
Show all

All Disciplines (5)

Discipline
Physiology : other topics
Pathophysiology
Biochemistry
Molecular Biology
Experimental Cancer Research

Keywords (6)

Metabolism; Metabolic Diseases; Diabetes; Inflammation; Cancer; PhD Program

Lay Summary (English)

Lead
Lay summary

The new ProDoc Educational Program ‘The Metabolic Basis of Disease’ is a 3-4 year Ph.D. program offered jointly by the University Hospital Zurich and the ETH Zurich. It focuses on the education of young scientists iwho wish to pursue a scientific career in the biomedical and health sciences. A group of leading scientists in this field provide their expertise for this new teaching program and propose several integrated research modules to introduce students to contemporary approaches in metabolism research, specifically highlighting the importance of metabolism, its control and interconnection to inflammatory processes in the context of cellular and organismal physiology and the development of human diseases ranging from cancer to diabetes and obesity. The teaching program and research efforts address also how a better mechanistic understanding of metabolism and metabolism-related disorders can lead to improved prevention, diagnosis and therapy for metabolic diseases.

Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
FGF21, energy expenditure and weight loss - How much brown fat do you need?
Straub Leon, Wolfrum Christian (2015), FGF21, energy expenditure and weight loss - How much brown fat do you need?, in Molecular metabolism, 4(9), 605-9.
The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes.
Belgardt Bengt-Frederik, Ahmed Kashan, Spranger Martina, Latreille Mathieu, Denzler Remy, Kondratiuk Nadiia, von Meyenn Ferdinand, Villena Felipe Nunez, Herrmanns Karolin, Bosco Domenico, Kerr-Conte Julie, Pattou Francois, Rülicke Thomas, Stoffel Markus (2015), The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes., in Nature medicine, 21(6), 619-27.
Cytosolic pH regulates cell growth through distinct gtpases, Arf1 and Gtr1, to promote ras/PKA and TORC1 activity
Dechant Reinhard, Dechant Reinhard, Saad Shady, Saad Shady, Ibáñez Alfredo J., Peter Matthias, Peter Matthias (2014), Cytosolic pH regulates cell growth through distinct gtpases, Arf1 and Gtr1, to promote ras/PKA and TORC1 activity, in Molecular Cell, 55(3), 409-421.
Bi-directional interconversion of brite and white adipocytes.
Rosenwald Matthias, Perdikari Aliki, Rülicke Thomas, Wolfrum Christian (2013), Bi-directional interconversion of brite and white adipocytes., in Nature cell biology, 15(6), 659-67.
Downregulation of duodenal SLC transporters and activation of proinflammatory signaling constitute the early response to high altitude in humans
Wojtal Kacper A., Cee Alexandra, Lang Silvia, Götze Oliver, Götze Oliver, Frühauf Heiko, Frühauf Heiko, Geier Andreas, Geier Andreas, Pastor-Anglada MarçAl, Torres-Torronteras Javier, Martí Ramon, Fried Michael, Lutz Thomas A., Lutz Thomas A., Lutz Thomas A., Maggiorini Marco, Gassmann Max, Gassmann Max, Gassmann Max, Rogler Gerhard, Rogler Gerhard, Vavricka Stephan R., Vavricka Stephan R., Vavricka Stephan R. (2013), Downregulation of duodenal SLC transporters and activation of proinflammatory signaling constitute the early response to high altitude in humans, in American Journal of Physiology - Gastrointestinal and Liver Physiology, 307(7), G673-G688.
Effects of retinoids in mouse models of colitis: Benefit or danger to the gastrointestinal tract
Frey-Wagner Isabelle, Fischbeck Anne, Cee Alexandra, Leonardi Irina, Gruber Sven, Becker Eugenia, Atrott Kirstin, Lang Silvia, Rogler Gerhard (2013), Effects of retinoids in mouse models of colitis: Benefit or danger to the gastrointestinal tract, in Inflammatory Bowel Diseases, 19(11), 2356-2365.
Hypoxia induces the expression of transketolase-like 1 in human colorectal cancer
Bentz S., Cee A., Endlicher E., Wojtal K. A., Naami A., Pesch T., Lang S., Schubert P., Fried M., Weber A., Coy J. F., Coy J. F., Goelder S., Knüchel R., Hausmann M., Rogler G. (2013), Hypoxia induces the expression of transketolase-like 1 in human colorectal cancer, in Digestion, 88(3), 182-192.
In scarcity and abundance: Metabolic signals regulating cell growth
Saad Shady, Saad Shady, Peter Matthias, Peter Matthias, Dechant Reinhard, Dechant Reinhard (2013), In scarcity and abundance: Metabolic signals regulating cell growth, in Physiology, 28(5), 298-309.

Collaboration

Group / person Country
Types of collaboration
Research groups Werner, Kopf and Rogler at ETH Zurich and University Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Research groups Peter, Frew (Krek and Moch) from ETH Zurich and University Zurich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Research groups Krützfeldt (University Zurich) and Stoffel (ETH Zurich) Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Targeting Mitochondria Worldcongress 2014 Talk given at a conference The oncoprotein URI1 suppresses PGAM5-mediated mitochondrial stress-induced apoptosis 29.10.2014 Berlin, Germany Krek Wilhelm;


Associated projects

Number Title Start Funding scheme
141761 Mechanisms of ectopic brown adipose tissue formation in normal and insulin resistant states 01.01.2013 ProDoc

Abstract

The new ProDoc ‘The Metabolic Basis of Disease’ is a 3-4 year M.Sc. to Ph.D. program. It focuses on the education of young scientists in Switzerland who wish to pursue a scientific career at the interface of modern biology and medical sciences. A group of leading scientists in this field provide their expertise for this new teaching program and propose several integrated research modules to introduce students to contemporary approaches in metabolism research, specifically highlighting the importance of metabolism, its control and interconnection to inflammatory processes in the context of cellular and organismal physiology and complex human diseases ranging from cancer to diabetes and obesity. The teaching program and research efforts address also how a better mechanistic understanding of metabolism and metabolism-related disorders can lead to improved prevention, diagnosis and therapy for metabolic diseases. The specific aims of the Ph.D. program are:(i) To bring together the best students worldwide interested to pursue a career in biomedical research as it relates to metabolism, inflammation and its role in physiologic and pathophysiologic processes. Through broad advertisement of the program and extensive and competitive assessment procedures, the program assures that students worldwide apply, but only the best will be accepted. (ii) To introduce students to a wide variety of cutting-edge technologies used in modern biological research and to present them contemporary approaches that integrate knowledge from different fields ranging from molecular physiology, hormonal and metabolic signaling and RNA biology to inflammation and disease pathology. In order to achieve this goal, all students will not only follow their own research project, but will also attend 2-3 core teaching modules. (iii) To qualify students for their future careers by offering specialized courses on science ethics, technology and knowledge transfer, scientific writing and presentation and other so-called transferable skill courses. (iv) To guarantee a high quality and efficient progress of the individual research projects by providing a strong mentoring system: shortly after having joined the program, each student chooses a thesis committee, and then writes up and defends a thesis proposal in front of the committee within the next 6 months. The thesis committee subsequently meets regularly with the student to follow his or her progress. (v) To assure that students are part of a vivid network that helps them to get the necessary scientific support, but also fosters social interactions. The new Ph.D. program will become part of the Life Science Zurich Graduate School. It will benefit from the common online application procedure and interview process of the Graduate School. Students of the program will also benefit from a number of transferable skill courses offered by other Ph.D. programs in Zurich. The Teaching Module of this ProDoc program will promote the education of young scientists in an emerging area of modern biomedical sciences and hence will add a new quality to our education, networking and mentoring system. The Research Modules are specifically designed to strengthen our profile in contemporary research dedicated to understanding the principles and mechanisms underlying metabolic control and its relationship to inflammation in the context of normal physiology and complex human diseases. Administratively, the new Ph.D. Program with its teaching and research modules will be an integral part of the Competence Center for Systems Physiology and Metabolic Diseases, a joint Center of the ETH and the University of Zurich. Thus participating students will be embedded in a coherent and functional scientific community in Zurich dedicated to world-class research and teaching.
-