Childhood; Chronic cough; Prediction; Prognosis; Classification; Phenotypes; Longitudinal studies; Clinical epidemiology; Latent class; Risk factors
Rueegg Corina S., Kuehni Claudia E., Gallati Sabina, Jurca Maja, Jung Andreas, Casaulta Carmen, Barben Juerg (2019), Comparison of two sweat test systems for the diagnosis of cystic fibrosis in newborns, in Pediatric Pulmonology
, 54(3), 264-272.
Jurca Maja, Pescatore Anina M., Goutaki Myrofora, Spycher Ben D., Beardsmore Caroline S., Kuehni Claudia E. (2017), Age-related changes in childhood wheezing characteristics: A whole population study, in Pediatric Pulmonology
, 52(10), 1250-1259.
Wang Jingying, Ramette Alban, Jurca Maja, Goutaki Myrofora, Beardsmore Caroline S., Kuehni Claudia E. (2017), Association between breastfeeding and eczema during childhood and adolescence: A cohort study, in PLOS ONE
, 12(9), e0185066-e0185066.
Wang Jingying, Ramette Alban, Jurca Maja, Goutaki Myrofora, Beardsmore Caroline S, Kuehni Claudia E (2017), Breastfeeding and respiratory tract infections during the first 2 years of life, in ERJ Open Research
, 3(2), 00143-2016.
Jurca Maja, Ramette Alban, Dogaru Cristian M., Goutaki Myrofora, Spycher Ben D., Latzin Philipp, Gaillard Erol A., Kuehni Claudia E. (2017), Prevalence of cough throughout childhood: A cohort study, in PLOS ONE
, 12(5), e0177485-e0177485.
Goutaki Myrofora, Meier Anna Bettina, Halbeisen Florian S, Lucas Jane S, Dell Sharon D, Maurer Elisabeth, Casaulta Carmen, Jurca Maja, Spycher Ben D, Kuehni Claudia E (2016), Clinical manifestations in primary ciliary dyskinesia: systematic review and meta-analysis., in The European respiratory journal
, 48(4), 1081-1095.
Rueegg Corina S, Barben Jürg, Hafen Gaudenz M, Moeller Alexander, Jurca Maja, Fingerhut Ralph, Kuehni Claudia E (2016), Newborn screening for cystic fibrosis - The parent perspective., in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
, 15(4), 443-51.
Barben Juerg, Rueegg Corina S, Jurca Maja, Spalinger Johannes, Kuehni Claudia E (2016), Measurement of fecal elastase improves performance of newborn screening for cystic fibrosis., in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
, 15(3), 313-7.
Pescatore Anina M, Spycher Ben D, Jurca Maja, Gaillard Erol A, Kuehni Claudia E (2014), Environmental and socioeconomic data do not improve the Predicting Asthma Risk in Children (PARC) tool., in The Journal of allergy and clinical immunology
, 135(5), 1395-1397.
Wang Jingying, Ramette Alban, Jurca Maja, Goutaki Myrofora, Beardsmore Caroline S, Kuehni Claudia E, Can breastfeeding protect children against respiratory tract infections in the first 2 years of life?, in ERJ Open Research
Background: Recurrent cough, colds and upper respiratory symptoms are common in early childhood and associated with a large burden to families, the health service and society. Increasing evidence links childhood respiratory morbidity to chronic obstructive pulmonary disease in adults. The underlying causes of chronic cough are diverse: some children have specific diseases such as cystic fibrosis, others cough in the context of childhood asthma, but many children have non-specific chronic cough of unclear aetiology. Yet, their cough can be severe and track over long periods. In the framework of a previous PhD project, we analysed respiratory morbidity in a cohort of children by applying latent class analysis to phenotypic features. We identified three distinct phenotypes of childhood wheeze, but also two phenotypes of cough: children with transient and children with persisting cough. Physiological traits, risk factors and long-term prognosis differed between the groups. Aims: This PhD project will focus on the descriptive and analytic epidemiology of childhood non-specific chronic cough, using original data from three ongoing population-based cohort studies. Specific aims are: i)To summarise the current evidence on prevalence, risk factors and natural history of non-specific chronic cough in childhood in a systematic review;ii)To describe prevalence, risk factors and physiological traits of chronic non-specific cough;iii)To define different phenotypes of cough by using latent class analysis;iv)To characterise identified phenotypes by describing time course, risk factors, prognosis and physiological traits;v)To validate the findings by replicating the analysis in independent cohorts; vi)To describe the public health impact, particularly on avoidable risk factors.Methods: Study population: This PhD will use datasets from three different population-based childhood cohorts: the Leicester 1990 and 1998 cohorts (N=1650 and 8700), and the Bern infant lung development (BILD) cohort (N=400). All include longitudinal data on respiratory symptoms and environmental exposures from birth to school age/early adulthood, and physiological measurements. These include age-appropriate lung function tests e.g. spirometry, multiple-breath washout, exhaled nitric oxide, skin prick tests, bronchial hyperreactivity, nasal swabs for respiratory viruses and overnight cough recording.Work steps: The PhD student will: (i) Systematically search and review the existing epidemiological literature on chronic non-specific cough; (ii) Analyse original data from the three cohort studies to describe incidence, prevalence, associated factors and prognosis of chronic cough at different ages, distinguishing between children with and without asthma/wheeze; define cough phenotypes by applying latent class analysis to these datasets; characterise identified phenotypes by time-course (age of onset, remission and persistence), clinical features and risk factors; (iii) Validate results using data from independent cohorts (subject to agreement, other European Birth Cohort Studies (GA²LEN; ENRIECO)). Research environment: The student will participate in the PhD training offered by the ISPM Bern and the Swiss School of Public Health (SSPH+). This project is embedded in ongoing research of the Leicester and BILD cohort studies, particularly: phenotype definition in childhood asthma; prognostic modelling; environmental exposures and respiratory health; and the role of respiratory viruses. Significance: This project will add significantly to the scarce evidence on burden of disease, risk factors and prognosis of chronic non-specific cough in childhood. From a clinical perspective, the identification of markers/parameters specific for certain phenotypes will enable a better identification of those children during clinical routine and provide a rationale for phenotype-specific treatment. From a public health point of view, the findings will help to develop strategies to reduce the burden of cough in childhood.